1,828,120 Works

Data from: In-solution hybridization for mammalian mitogenome enrichment: pros, cons and challenges associated with multiplexing degraded DNA

Melissa T. R. Hawkins, Courtney A. Hofman, Taylor Callicrate, Molly M. McDonough, Mirian T. N. Tsuchiya, Eliécer E. Gutierrez, Kristofer M. Helgen & Jesús E. Maldonado
Here, we present a set of RNA-based probes for whole mitochondrial genome in-solution enrichment, targeting a diversity of mammalian mitogenomes. This probes set was designed from seven mammalian orders and tested to determine the utility for enriching degraded DNA. We generated 63 mitogenomes representing five orders and 22 genera of mammals that yielded varying coverage ranging from 0 to >5400X. Based on a threshold of 70% mitogenome recovery and at least 10× average coverage, 32...
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Data from: Genomic DNA transposition induced by human PGBD5

Anton G. Henssen, Elizabeth Henaff, Eileen Jiang, Amy R. Eisenberg, Julianne R. Carson, Camila M. Villasante, Mondira Ray, Eric Still, Melissa Burns, Jorge Gandara, Cedric Feschotte, Christopher E. Mason & Alex Kentsis
Transposons are mobile genetic elements that are found in nearly all organisms, including humans. Mobilization of DNA transposons by transposase enzymes can cause genomic rearrangements, but our knowledge of human genes derived from transposases is limited. In this study, we find that the protein encoded by human PGBD5, the most evolutionarily conserved transposable element-derived gene in vertebrates, can induce stereotypical cut-and-paste DNA transposition in human cells. Genomic integration activity of PGBD5 requires distinct aspartic acid...
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Data from: An ultrasound image-based dynamic fusion modeling method for predicting the quantitative impact of in vivo liver motion on intraoperative HIFU therapies: investigations in a porcine model

William Apoutou N'Djin, Jean-Yves Chapelon, David Melodelima & W. Apoutou N'Djin
Organ motion is a key component in the treatment of abdominal tumors by High Intensity Focused Ultrasound (HIFU), since it may influence the safety, efficacy and treatment time. Here we report the development in a porcine model of an Ultrasound (US) image-based dynamic fusion modeling method for predicting the effect of in vivo motion on intraoperative HIFU treatments performed in the liver in conjunction with surgery. A speckle tracking method was used on US images...
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Data from: Characterization of regional left ventricular function in nonhuman primates using magnetic resonance imaging biomarkers: a test-retest repeatability and inter-subject variability study

Smita Sampath, Michael Klimas, Dai Feng, Richard Baumgartner, Elaine Manigbas, Ai-Leng Liang, Jeffrey L. Evelhoch & Chih-Liang Chin
Pre-clinical animal models are important to study the fundamental biological and functional mechanisms involved in the longitudinal evolution of heart failure (HF). Particularly, large animal models, like nonhuman primates (NHPs), that possess greater physiological, biochemical, and phylogenetic similarity to humans are gaining interest. To assess the translatability of these models into human diseases, imaging biomarkers play a significant role in non-invasive phenotyping, prediction of downstream remodeling, and evaluation of novel experimental therapeutics. This paper sheds...
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Data from: A lower jaw of Palaeoxonodon from the Middle Jurassic of the Isle of Skye, Scotland, sheds new light on the diversity of British stem therians

Roger A. Close, Brian M. Davis, Stig Walsh, Andrzej S. Wolniewicz, Matt Friedman & Roger B. J. Benson
The Middle Jurassic was a key interval of mammalian evolutionary history that witnessed the diversification of the therian stem-group. Great Britain has yielded a significant record of mammalian fossils from this interval, represented by numerous isolated jaws and teeth from the Bathonian of Oxfordshire and the Isle of Skye. This record captures a key period in early cladotherian evolution, with amphitheriids, peramurans and “stem zatherians” displaying intermediate talonid morphologies that document the evolutionary assembly of...
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Data from: The relative power of genome scans to detect local adaptation depends on sampling design and statistical method

Katie E. Lotterhos & Michael C. Whitlock
Although genome scans have become a popular approach towards understanding the genetic basis of local adaptation, the field still does not have a firm grasp on how sampling design and demographic history affect the performance of genome scans on complex landscapes. To explore these issues, we compared 20 different sampling designs in equilibrium (i.e. island model and isolation by distance) and nonequilibrium (i.e. range expansion from one or two refugia) demographic histories in spatially heterogeneous...
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Data from: A transient ischemic environment induces reversible compaction of chromatin

Ina Kirmes, Aleksander Szczurek, Kirti Prakash, Iryna Charapitsa, Christina Heiser, Michael Musheev, Florian Schock, Karolina Fornalczyk, Dongyu Ma, Udo Birk, Christoph Cremer & George Reid
Background: Cells detect and adapt to hypoxic and nutritional stress through immediate transcriptional, translational and metabolic responses. The environmental effects of ischemia on chromatin nanostructure were investigated using single molecule localization microscopy of DNA binding dyes and of acetylated histones, by the sensitivity of chromatin to digestion with DNAseI, and by fluorescence recovery after photobleaching (FRAP) of core and linker histones. Results: Short-term oxygen and nutrient deprivation of the cardiomyocyte cell line HL-1 induces a...
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Data from: Multi-contrast submillimetric 3-Tesla hippocampal subfield segmentation protocol and dataset

Jessie Kulaga-Yoskovitz, Boris C. Bernhardt, Seok-Jun Hong, Tommaso Mansi, Kevin E. Liang, Andre J. W. Van Der Kouwe, Jonathan Smallwood, Andrea Bernasconi & Neda Bernasconi
The hippocampus is composed of distinct anatomical subregions that participate in multiple cognitive processes and are differentially affected in prevalent neurological and psychiatric conditions. Advances in high-field MRI allow for the non-invasive identification of hippocampal substructure. These approaches, however, demand time-consuming manual segmentation that relies heavily on anatomical expertise. Here, we share manual labels and associated high-resolution MRI data (MNI-HISUB25; submillimetric T1- and T2-weighted images, detailed sequence information, and stereotaxic probabilistic anatomical maps) based on...
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Scorpiones Collection - Instituto Nacional de Pesquisas da Amazônia (INPA)

Marcio Luiz De Oliveira
Scorpiones collection from Instituto Nacional de Pesquisas da Amazônia.
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Opiliones Collection - Instituto Nacional de Pesquisas da Amazônia (INPA)

Marcio Luiz De Oliveira
Opiniones collection from Instituto Nacional de Pesquisas da Amazônia.
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Herpetology Collection - Instituto Nacional de Pesquisas da Amazônia

Fernanda Werneck
Herpetology collection from Instituto Nacional de Pesquisas da Amazônia.
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Amblypygi Collection - Instituto Nacional de Pesquisas da Amazônia (INPA)

Marcio Luiz De Oliveira
Amblypygi collection from Instituto Nacional de Pesquisas da Amazônia.
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Diptera Collection - Instituto Nacional de Pesquisas da Amazônia (INPA)

Marcio Luiz De Oliveira
Diptera collection from Instituto Nacional de Pesquisas da Amazônia.
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Hymenoptera Collection - Instituto Nacional de Pesquisas da Amazônia (INPA)

Marcio Luiz De Oliveira
Hymenoptera collection from Instituto Nacional de Pesquisas da Amazônia.
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MANUAL RINGKAS MANAJEMEN SITUS JURNAL DENGAN OJS

Wahid Nashihuddin
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MANUAL RINGKAS PENGELOLAAN KONTEN JURNAL DENGAN OJS

Wahid Nashihuddin
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MANUAL RINGKAS PENERBITAN JURNAL DENGAN OJS

Wahid Nashihuddin
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Data From RIDER_PHANTOM_MRI

Edward Jackson
The RIDER Phantom MRI data set contains repeat phantom studies. The phantom used for all data acquisitions was a version of the EuroSpin II Test Object 5 as distributed by Diagnostic Sonar, Ltd (Livingston, West Lothian, Scotland). The phantom was comprised of 18 25-mm doped gel filled tubes and 1 20-mm tube containing 0.25 mM GdDTPA. Scanners evaluated: Scanner A – 1.5T GE 8-channel HD with BRM gradient subsystem (33 mT/m amplitude; 120 T/m-s) Scanner...
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Data From RIDER_PHANTOM_PET-CT

Peter Muzi, Michelle Wanner & Paul Kinahan
The RIDER Phantom PET-CT collection consists of repeat measurement PET/CT phantom scan collections carried out under the aegis of the Society of Nuclear Medicine (SNM) to discern the uniformity of clinical imaging instrumentation at various sites. They were obtained in cooperation with SNM as a resource for increased quantitative understanding of machine acquisition, analytic reproducibility and image processing. The phantom was manufactured by Sanders Medical(www.sandersmedical.com) in December of 2006. The phantom was based on a...
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Eze bei Monaco

Werner Friedli
Download und Nutzung frei
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Eisenerzer Alpen mit Lahnerleitenspitze und Speikkogel, Steiermark, Blick nach Süden (S)

Werner Friedli
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Dolomiten, Plattkofel-Langkofel

Werner Friedli
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Monte Rosa von Süd-Ost

Werner Friedli
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Grosser Möseler, Zillertaler Alpen

Werner Friedli
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Föhnwolken, Höhe: 3500 - 4000m, Zeit: 13.30, Ort: Freiamt

Werner Friedli
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Registration Year

  • 2015
    1,828,120

Resource Types

  • Dataset
    954,873
  • Text
    388,107
  • Other
    138,767
  • Collection
    46,895
  • Image
    43,266
  • Event
    5,851
  • Software
    4,995
  • PhysicalObject
    1,668
  • Audiovisual
    1,330
  • Workflow
    750
  • Film
    298
  • InteractiveResource
    175
  • Model
    94
  • Sound
    36
  • DataPaper
    1

Affiliations

  • Centre for Ecology and Hydrology
    77
  • Imperial College London
    53
  • Agricultural Development Advisory Service (United Kingdom)
    14
  • Rothamsted Research
    14
  • James Hutton Institute
    14
  • Forest Research
    14
  • Natural Resources Wales
    14
  • Agri Food and Biosciences Institute
    14
  • University of Birmingham
    6
  • University of Southampton
    5
  • University of Surrey
    4
  • University of Glasgow
    4
  • Jaramogi Oginga Odinga University of Science and Technology
    4
  • University of Bristol
    4
  • Lancaster University
    3