2,331,255 Works

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

Alejandra Bruna, Oscar Rueda, Wendy Greenwood, Ankita Sati Batra, Maurizio Callari, Rajbir Nath Batra, Katherine Pogrebniak, Jose Sandoval, John W Cassidy, Ana Tufegdzic-Vidakovic, Stephen Sammut, Linda Jones, Elena Provenzano, Richard Baird, Peter Eirew, James Hadfield, Matthew Eldridge, Anne McLaren-Douglas, Andrew Barthorpe, Howard Lightfoot, Mark J O’Connor, Joe Gray, Javier Cortes, Jose Baselga, Elisabetta Marangoni … & Carlos Caldas
The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, the intra-tumor genomic clonal architecture present...

USNM Diptera collection flyer

Torsten Dikow
Flyer about the USNM Diptera collection at the National Museum of Natural History, Smithsonian Institution

USNM Diptera collection flyer

Torsten Dikow
Flyer about the USNM Diptera collection at the National Museum of Natural History, Smithsonian Institution

Eesti õigekeelsussõnaraamat ÕS 2013

Maire Raadik
Kajastab kehtivat eesti kirjakeele normi. Raadik, Maire; Erelt, Tiiu; Leemets, Tiina; Mäearu, Sirje (2013). Eesti õigekeelsussõnaraamat ÕS 2013. Tallinn: Eesti Keele Sihtasutus.

Susan Southard: Unveiling the aftermath of nuclear war

Dawn Stover
In this interview, author and theater director Susan Southard discusses her book Nagasaki: Life After Nuclear War, an award-winning history of the atomic bombing of Nagasaki and its enduring impact over 70 years. Southard talks about the physical and emotional impacts of the bombing on its survivors; the differences between the Hiroshima and Nagasaki bombings; and the controversy surrounding the American narrative that the bombings were necessary to end the war and save American lives....

Susan Southard: Unveiling the aftermath of nuclear war

Dawn Stover
In this interview, author and theater director Susan Southard discusses her book Nagasaki: Life After Nuclear War, an award-winning history of the atomic bombing of Nagasaki and its enduring impact over 70 years. Southard talks about the physical and emotional impacts of the bombing on its survivors; the differences between the Hiroshima and Nagasaki bombings; and the controversy surrounding the American narrative that the bombings were necessary to end the war and save American lives....

Midlife in the United States (MIDUS 1), 1995-1996

Orville Gilbert Brim, Paul B. Baltes, Larry L. Bumpass, Paul D. Cleary, David L. Featherman, William R. Hazzard, Ronald C. Kessler, Margie E. Lachman, Hazel Rose Markus, Michael G. Marmot, Alice S. Rossi, Carol D. Ryff & Richard A. Shweder
These data are being distributed as they were received from the data depositor to facilitate early access to the study for research purposes. This collection has not been fully processed by NACDA or ICPSR at this time. The files have been zipped by ICPSR for release, but not checked or processed except for the removal of direct identifiers. As the study is processed and given enhanced features by ICPSR, users will be able to access...

Midlife in the United States (MIDUS 1), 1995-1996

Orville Gilbert Brim, Paul B. Baltes, Larry L. Bumpass, Paul D. Cleary, David L. Featherman, William R. Hazzard, Ronald C. Kessler, Margie E. Lachman, Hazel Rose Markus, Michael G. Marmot, Alice S. Rossi, Carol D. Ryff & Richard A. Shweder
These data are being distributed as they were received from the data depositor to facilitate early access to the study for research purposes. This collection has not been fully processed by NACDA or ICPSR at this time. The files have been zipped by ICPSR for release, but not checked or processed except for the removal of direct identifiers. As the study is processed and given enhanced features by ICPSR, users will be able to access...

Midlife in the United States (MIDUS 1), 1995-1996

Orville Gilbert Brim, Paul B. Baltes, Larry L. Bumpass, Paul D. Cleary, David L. Featherman, William R. Hazzard, Ronald C. Kessler, Margie E. Lachman, Hazel Rose Markus, Michael G. Marmot, Alice S. Rossi, Carol D. Ryff & Richard A. Shweder
These data are being distributed as they were received from the data depositor to facilitate early access to the study for research purposes. This collection has not been fully processed by NACDA or ICPSR at this time. The files have been zipped by ICPSR for release, but not checked or processed except for the removal of direct identifiers. As the study is processed and given enhanced features by ICPSR, users will be able to access...

National Survey of Early Care and Education (NSECE), [United States], 2010-2012

NSECE Project Team (National Opinion Research Center)
The National Survey of Early Care and Education (NSECE) is a set of four integrated, nationally representative surveys conducted in 2012. These were surveys of (1) households with children under 13, (2) home-based providers (3) center-based providers, and (4) the center-based provider workforce. The NSECE documents the nation's current utilization and availability of early care and education (including school-age care), in order to deepen the understanding of the extent to which families' needs and preferences...

National Survey of Early Care and Education (NSECE), [United States], 2010-2012

NSECE Project Team (National Opinion Research Center)
The National Survey of Early Care and Education (NSECE) is a set of four integrated, nationally representative surveys conducted in 2012. These were surveys of (1) households with children under 13, (2) home-based providers (3) center-based providers, and (4) the center-based provider workforce. The NSECE documents the nation's current utilization and availability of early care and education (including school-age care), in order to deepen the understanding of the extent to which families' needs and preferences...

National Survey of Early Care and Education (NSECE), [United States], 2010-2012

NSECE Project Team (National Opinion Research Center)
The National Survey of Early Care and Education (NSECE) is a set of four integrated, nationally representative surveys conducted in 2012. These were surveys of (1) households with children under 13, (2) home-based providers (3) center-based providers, and (4) the center-based provider workforce. The NSECE documents the nation's current utilization and availability of early care and education (including school-age care), in order to deepen the understanding of the extent to which families' needs and preferences...

National Survey of Early Care and Education (NSECE), [United States], 2010-2012

NSECE Project Team (National Opinion Research Center)
The National Survey of Early Care and Education (NSECE) is a set of four integrated, nationally representative surveys conducted in 2012. These were surveys of (1) households with children under 13, (2) home-based providers (3) center-based providers, and (4) the center-based provider workforce. The NSECE documents the nation's current utilization and availability of early care and education (including school-age care), in order to deepen the understanding of the extent to which families' needs and preferences...

RAIN: Pan-European gridded data sets of extreme weather probability of occurrence under present and future climate

European Severe Storms Laboratory, Faculty Of Civil Engineering TU Delft, Institute Of Meteorology Freie Universität Berlin & Finnish Meteorological Institute
This collection contains results of Work Package 2 "Hazard Identification" of project RAIN (" Risk Analysis of Infrastructure Networks in response to extreme weather"). Pan-European gridded data sets of the probability of occurrence of river floods, coastal floods, heavy precipitation, windstorms, heavy snowfall, blizzards, crown snow load, freezing rain, forest fires, thunderstorms, hailstorms, tornadoes and convective wind gusts under present and future climate.

Observation of the Benthos

saverio vicario
Details need to be added, test is ongoing

A Study of Online Teaching & Learning Experiences in Higher Education: A Case Study of an American University VLE.

Ian Carnaghan
This 2007 study documents research on the usability of Adobe Connect as Virtual Learning Environment or VLE within existing courses at UMUC. The purpose of the research was to evaluate online teaching and learning experiences based on existing models of teaching online. The student population, which consists mainly of non-traditional adult learners, influenced the methods of research and analysis. The paper builds on educational themes or ingredients to successful online learning to determine what, if...

Semidefinite relaxation approaches for the quadratic assignment problem

Marko Lange
Diese Doktorarbeit behandelt bekannte und neue Relaxationstechniken für das quadratische Zuordnungsproblem, eines der schwierigsten zu lösenden NP-schweren Probleme der Kombinatorik. Der Schwerpunkt der Arbeit liegt auf neuen Ansätzen zur Approximation durch Semidefinite Optimierungsprobleme.

Saproxylic insects caught in window traps and hatched from polypores in small and large old forests in southern Norway

Tone Birkemoe, Anne Sverdrup-Thygeson & Marianne Hansen
The dataset includes beetle species caught in window traps in 5 old forests fragments in southern Norway and 1 in Southern Sweden. Five traps were used per forest and sampling occurred from mid May to mid August 2014 at 4 out of the 6 sites. The two remaining sites were sampled from mid June to mid August. In addition to the traps, the dataset includes insect species hathced from 114 polypore Fomitopsis pinicola collected in...

An unusual finding in a 57-year-old woman with new onset hypertension and a diastolic murmur.

Jason Tarkin, James Rudd, David Jayne, Rosemary A Rusk & Deepa Gopalan
This is the final version of the article. It first appeared from BMJ group via https://doi.org/ 10.1136/heartjnl-2016-309661

Interview: Professor Peter Weissberg, Medical Director of the BHF

James Rudd
Dr James Rudd, Heart’s Digital Media Editor, interviewed Professor Peter Weissberg, Medical Director of the British Heart Foundation (BHF), in May 2016. As the largest independent funder of cardiovascular research in the UK (around £100 million annually), Peter has sage advice for young researchers considering a career in cardiovascular science. He looks back at some highlights from his 12 years at the BHF. Finally, Peter explains why there has never be en a better time...

An update on the potential health benefits of carotenes

Jae Kwang Kim
test magazin, Vol 15 (2016)

Can bacterium UD1023 lessen the uptake and bioaccumulation of heavy metals in plants? An update

Kamal Niaz, Faheem Maqbool, Haji Bahadar & Mohammad Abdollahi
test magazin, Vol 15 (2016)

DNA methylation assessment as a prognostic factor in invasive breast cancer using methylation-specific multiplex ligation dependent probe amplification

Halaleh Shakeri, Jalal Gharesouran, Ashraf Fakhrjou, Ali Esfahani & Seyyed Mojtaba Mohaddes Ardebili
DNA methylation of promoter regions is a common molecular mechanism for inactivation of tumor suppressor genes that participates in carcinogenesis. Determining the methylation status of genes in cancer and their association with clinical features play an essential role in early diagnosis, prognosis and determine appropriate treatment for patients. The purpose of the present study was to evaluate the methylation of tumor suppressor genes in patients with invasive ductal carcinoma (IDC). Furthermore, we evaluated the association...

Selected novel 5'-amino-2'-hydroxy-1, 3-diaryl-2-propen-1-ones arrest cell cycle of HCT-116 in G0/G1 phase

Lalitha Simon, K. K. Srinivasan, Nitesh Kumar, Neetinkumar D. Reddy, Subhankar Biswas, C. Mallikarjuna Rao & Sudheer Moorkoth
A series of 5'-amino-2'-hydroxy-1,3-diaryl-2-propen-1-ones (AC1-AC15) were synthesized by Claisen-Schmidt condensation of 5'-acetamido-2'-hydroxy acetophenone with various substituted aromatic aldehydes. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectrometry and evaluated for their selective cytotoxicity using MTT assay on two cancer cell lines namely breast cancer cell line (MCF-7), colon cancer cell line (HCT-116) and one normal kidney epithelial cell line (Vero). Among the tested compounds, AC-10 showed maximum cytotoxic effect on MCF-7 cell...

Localized Langerhans cell histiocytosis masquerading as Brodie's abscess in a 2-year-old child: a case report

Wei-Fang Chang, Yi-Chih Hsu, Yi-Der Wu, Chun-Lang Kuo & Guo-Shu Huang
Langerhans cell histiocytosis (LCH), formerly known as histiocytosis X, refers to a spectrum of diseases characterized by idiopathic proliferation of histiocytes that produce either focal (localized LCH) or systemic manifestations (Hand-Schüller-Christian disease and Letterer-Siwe disease). Localized LCH accounts for approximately 60-70 % of all LCH cases. Osseous involvement is the most common manifestation and typically involves the flat bones, along with lesions of the skull, pelvis, and ribs. Localized LCH in bone shows a wide...

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