3,561,478 Works

space-physics/igrf12: vendor code, standard template

Ph.D. Michael Hirsch
apply project template add initial geomag7.0 C code vendor datetime2yeardec

Population Assessment of Tobacco and Health (PATH) Study [United States] Public-Use Files

United States Department Of Health And Human Services. National Institutes Of Health. National Institute On Drug Abuse & United States Department Of Health And Human Services. Food And Drug Administration. Center For Tobacco Products

Population Assessment of Tobacco and Health (PATH) Study [United States] Public-Use Files

United States Department Of Health And Human Services. National Institutes Of Health. National Institute On Drug Abuse & United States Department Of Health And Human Services. Food And Drug Administration. Center For Tobacco Products

HypothesisWorks/hypothesis: Hypothesis for Python - version 4.44.1

David R. MacIver, Zac Hatfield-Dodds, Pyup.Io Bot, Alex Chan, Stuart Cook, Ryan Soklaski, David Chudzicki, Jwg4, Alex Willmer, Tyler , Kyle Reeve, Grigorios Giannakopoulos, Mulkieran, Christopher Armstrong, Tyler Gibbons, Jeremy Thurgood, Paul Stiverson, Emmanuel Leblond, SuperStormer, Alexander Shorin, Peter C Kroon, Tom Prince, Mathieu PATUREL, Dwest-Netflix, Tom McDermott … & Thomas Kluyver
This patch allows Hypothesis to run in environments that do not specify a "file", such as a "zipapp" (issue #2196). The canonical version of these notes (with links) is on readthedocs.

Polar expertise and the Antarcticans

RC Powell
I remember attending an event about polar governance in Canada nearly a decade ago, where an Antarctic marine scientist did not understand why representatives of the Government of Nunavut were cynical about some of his interventions. ‘But what’s wrong with good governance?’, he protested. The Nunavut policymakers saw the question as being one of whose models of governance. This interchange has always puzzled me. Jessica O’Reilly’s fascinating account of Antarctic scientists and policymakers, or ‘Antarcticans’,...

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington's disease.

Benjamin R Underwood, Zeyn W Green-Thompson, Peter J Pugh, Stanley E Lazic, Sarah Mason, Julian Griffin, Simon Jones, James Rowe, David Rubinsztein & Roger Barker
Objective: Preclinical data has shown that rilmenidine can regulate autophagy in models of Huntington’s disease (HD), providing a potential route to alter the disease course in patients. Consequently, a 2-year open label study examining the tolerability and feasibility of rilmenidine in mild-moderate HD was undertaken. Methods: 18 non-demented patients with mild to moderate HD took daily doses of 1mg Rilmenidine for six months and 2mg for a further 18 months followed by a 3-month wash...

Canopy structure and topography jointly constrain the microclimate of human-modified tropical landscapes.

Tommaso Jucker, Stephen R Hardwick, Sabine Both, Dafydd MO Elias, Robert M Ewers, David T Milodowski, Thomas Swinfield & David Coomes
Local-scale microclimatic conditions in forest understoreys play a key role in shaping the composition, diversity and function of these ecosystems. Consequently, understanding what drives variation in forest microclimate is critical to forecasting ecosystem responses to global change, particularly in the tropics where many species already operate close to their thermal limits and rapid land-use transformation is profoundly altering local environments. Yet our ability to characterise forest microclimate at ecologically-meaningful scales remains limited, as understorey conditions...

Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

Francis WB Sanders, Animesh Acharjee, Celia Walker, Luke Marney, Lee D Roberts, Fumiaki Imamura, Benjamin Jenkins, Jack Case, Sumantra Ray, Samuel Virtue, Antonio Vidal-Puig, Diana Kuh, Rebecca Hardy, Michael Allison, Nita Forouhi, Andrew Murray, Nicholas Wareham, Michele Vacca, Albert Koulman & Julian Griffin
Background: Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Our aims were to investigate whether a sub-set of TAGs were associated with hepatic steatosis and whether they arise from de novo lipogenesis (DNL) from the consumption of carbohydrates. Results: We conducted direct infusion mass spectrometry of lipids in...

A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.

Fumiaki Imamura, Stephen Sharp, Albert Koulman, Matthias B Schulze, Janine Kröger, Julian Griffin, José M Huerta, Marcela Guevara, Ivonne Sluijs, Antonio Agudo, Eva Ardanaz, Beverley Balkau, Heiner Boeing, Veronique Chajes, Christina C Dahm, Courtney Dow, Guy Fagherazzi, Edith JM Feskens, Paul W Franks, Diana Gavrila, Marc Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Tilman Kühn … & Nicholas Wareham
Background: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. Methods and findings: We measured plasma phospholipid fatty acids by gas-chromatography in 27,296 adults, including 12,132 incident cases of T2D over the follow-up period between baseline (1991-1998) to 2007 in eight European countries in EPIC-InterAct, a nested case-cohort study. Deriving the first...

Lipidomics Profiling of Human Adipose Tissue Identifies a Pattern of Lipids Associated with Fish Oil Supplementation.

Elizabeth G Stanley, Benjamin J Jenkins, Celia G Walker, Albert Koulman, Lucy Browning, Annette L West, Philip C Calder, Susan A Jebb & Julian Griffin
To understand the interaction between diet and health, biomarkers that accurately reflect consumption of foods of perceived health relevance are needed. The aim of this investigation was to use direct infusion-mass spectrometry (DI-MS) lipidomics to determine the effects of fish oil supplementation on lipid profiles of human adipose tissue. Adipose tissue samples from an n-3 polyunsaturated fatty acid (PUFA) supplementation study (n = 66) were analysed to compare the pattern following supplementation equivalent to 0...

Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries.

Sherly X Li, Fumiaki Imamura, Matthias B Schulze, Jusheng Zheng, Zheng Ye, Antonio Agudo, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Sara Grioni, Marc J Gunter, José María Huerta, Daniel B Ibsen, Marianne Uhre Jakobsen, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Cecilie Kyrø, Francesca Romana Mancini, Elena Molina-Portillo, Neil Murphy, Peter M Nilsson … & Nicholas Wareham
Abstract Aims/hypothesis: Gene-macronutrient interactions may contribute to the development of type 2 diabetes but evidence is inconclusive. Methods: We investigated interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and body mass index and macronutrient intake on the development of type 2 diabetes in EPIC-InterAct, a prospective case-cohort study across eight European countries (N=21,900 with 9,742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion...

Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

Maria Laura Santoru, Cristina Piras, Antonio Murgia, Vanessa Palmas, Tania Camboni, Sonia Liggi, Ivan Ibba, Maria Antonia Lai, Sandro Orrù, Sylvain Blois, Anna Lisa Loizedda, Julian Griffin, Paolo Usai, Pierluigi Caboni, Luigi Atzori & Aldo Manzin

Radiological staging in pregnant patients with cancer.

Ramona Woitek, Daniela Prayer, Azadeh Hojreh & Thomas Helbich

The Malicious Use of Artificial Intelligence: Forecasting, Prevention, and Mitigation

Miles Brundage, Shahar Avin, Jack Clark, Helen Toner, Peter Eckersley, Ben Garfinkel, Allan Dafoe, Paul Scharre, Thomas Zeitzoff, Bobby Filar, Hyrum Anderson, Heather Roff, Gregory C Allen, Jacob Steinhardt, Carrick Flynn, Seán Ó HÉigeartaigh, Simon Beard, Haydn Belfield, Sebastian Farquhar, Clare Lyle, Rebecca Crootof, Owain Evans, Michael Page, Joanna Bryson, Roman Yampolskiy … & Dario Amodei
This report surveys the landscape of potential security threats from malicious uses of AI, and proposes ways to better forecast, prevent, and mitigate these threats. After analyzing the ways in which AI may influence the threat landscape in the digital, physical, and political domains, we make four high-level recommendations for AI researchers and other stakeholders. We also suggest several promising areas for further research that could expand the portfolio of defenses, or make attacks less...

Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study.

Jusheng Zheng, Stephen Sharp, Fumiaki Imamura, Albert Koulman, Matthias B Schulze, Zheng Ye, Julian Griffin, Marcela Guevara, José María Huerta, Janine Kröger, Ivonne Sluijs, Antonio Agudo, Aurelio Barricarte, Heiner Boeing, Sandra Colorado-Yohar, Courtney Dow, Miren Dorronsoro, Pia T Dinesen, Guy Fagherazzi, Paul W Franks, Edith JM Feskens, Tilman Kühn, Verena Andrea Katzke, Timothy J Key, Kay-Tee Khaw … & Nicholas Wareham
ABSTRACT Background: Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic diseases, but evidence about associations of SFAs with metabolic markers of different pathogenic pathways is limited. We aimed to examine associations between plasma phospholipid SFAs and metabolic markers of lipid, hepatic, glycaemic and inflammation pathways. Methods: We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0+C17:0, even-chain: C14:0+C16:0+C18:0 and very-long-chain: C20:0+C22:0+C23:0+C24:0) in...

Analysis of shared heritability in common disorders of the brain.

Brainstorm Consortium, Verneri Anttila, Brendan Bulik-Sullivan, Hilary K Finucane, Raymond K Walters, Jose Bras, Laramie Duncan, Valentina Escott-Price, Guido J Falcone, Padhraig Gormley, Rainer Malik, Nikolaos A Patsopoulos, Stephan Ripke, Zhi Wei, Dongmei Yu, Phil H Lee, Patrick Turley, Benjamin Grenier-Boley, Vincent Chouraki, Yoichiro Kamatani, Claudine Berr, Luc Letenneur, Didier Hannequin, Philippe Amouyel, Anne Boland … & Robin Murray
Disorders of the brain can exhibit considerable epidemiological comorbidity and share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 215,683 patients and 657,164 controls, and their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, while neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identify significant sharing between disorders and a...

Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.

Hyon Jin Jeon, Gi Deok Pak, Justin Im, Ellis Owusu-Dabo, Yaw Adu-Sarkodie, Amy Gassama Sow, Abdramane Bassiahi Soura, Nagla Gasmelseed, Karen H Keddy, Morten Bjerregaard-Andersen, Frank Konings, Abraham Aseffa, John A Crump, Yun Chon, Robert F Breiman, Se Eun Park, Ligia Maria Cruz Espinoza, Hye Jin Seo, Jürgen May, Christian G Meyer, Jason R Andrews, Ursula Panzner, Vera Von Kalckreuth, Thomas F Wierzba, Raphaël Rakotozandrindrainy … & Florian Marks
Background: The WHO recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons aged ≥6 months to 45 years residing in typhoid fever (TF)-endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations in Africa. Methods: The Typhoid Fever Surveillance in Africa Program (TSAP) in 10 sub-Saharan African countries included blood culture-based surveillance in febrile people presenting at healthcare-facilities originating from defined catchment areas....

Potassium- and Rubidium-Passivated Alloyed Perovskite Films: Optoelectronic Properties and Moisture Stability.

Mojtaba Abdi-Jalebi, Zahra Andaji-Garmaroudi, Andrew J Pearson, Giorgio Divitini, Stefania Cacovich, Bertrand Philippe, Håkan Rensmo, Caterina Ducati, Richard Friend & Samuel Stranks
Halide perovskites passivated with potassium or rubidium show superior photovoltaic device performance compared to unpassivated samples. However, it is unclear which passivation route is more effective for film stability. Here, we directly compare the optoelectronic properties and stability of thin films when passivating triple-cation perovskite films with potassium or rubidium species. The optoelectronic and chemical studies reveal that the alloyed perovskites are tolerant towards higher loadings of potassium than rubidium. Whereas potassium complexes with bromide...

Coleção de Cultura de Bactérias Resistentes de Origem Alimentar - CCBROA


dzhw/metadatamanagement: Release Sprint 95

Daniel Katzberg, René Reitmann, Amine Limouri, Es-Flavia, MD Shakawath Hossain, Chris , Tgehrke-Edicos, Michael Spreu, YPeper, Robert Birkelbach, Snyk Bot, Ute H, Sandra Vietgen & Kimsommer
The following backlog items and bugs have been worked on for this release: https://github.com/dzhw/metadatamanagement/issues?q=milestone%3A%22Release+Sprint+95%22

Spontaneous spreading of active layers for organic solar cells

Colberts, F.J.M. (Fallon)
Movies show the fabrication of active layers for organic solar cells by the spontaneous spreading technique. Here, a Petri dish is filled with water serving as a substrate for film formation. The resulting film can be transferred to a device substrate. This method allows the fabrication of novel solar cell architectures by transferring multiple layers on top of each other. The results obtained by the spontaneous spreading method for the fabrication of organic solar cells...

Influence of optical aberrations on axial position determination by photometry

Thorsen, R.Ø. (Rasmus)
Supplementary data: “Influence of optical aberrations on axial position determination by photometry.”Rasmus Ø. Thorsen, Christiaan N. Hulleman, Mathias Hammer, David Grünwald, Sjoerd Stallinga, and Bernd RiegerMathias Hammer, David Grünwald, Sjoerd Stallinga, and Bernd Rieger

Spontaneous spreading movie of PCE10:[60]PCBM

Colberts, F.J.M. (Fallon)
Spontaneous spreading movie of a chlorobenzene solution containing the photoactive materials PCE10 and [60]PCBM to which DIO is added as co-solvent. Figure 4.21 and chapter 4.2 of the thesis. Parent DatasetSpontaneous spreading of active layers for organic solar cellsMovies show the fabrication of active layers for organic solar cells by the spontaneous spreading technique. Here, a Petri dish is filled with water serving as a substrate for film formation. The resulting film can be transferred...

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