53 Works

Developing and validating the digital skills scale for school children (DSS-SC)

Xiaojing Li & Roujia Hu
As an important indicator of digital divide, the digital skills have been measured by many instruments on the netizens or adults in western countries. However, there are still few concerns on children in developing countries. This paper aimed to develop a reliable and valid digital skills scale for school children (DSS-SC) based on solid theoretical ground and robust empirical evidence. A cross-sectional study was conducted by cluster random sampling among Chinese urban-rural school children (N...

Developing and validating the digital skills scale for school children (DSS-SC)

Xiaojing Li & Roujia Hu
As an important indicator of digital divide, the digital skills have been measured by many instruments on the netizens or adults in western countries. However, there are still few concerns on children in developing countries. This paper aimed to develop a reliable and valid digital skills scale for school children (DSS-SC) based on solid theoretical ground and robust empirical evidence. A cross-sectional study was conducted by cluster random sampling among Chinese urban-rural school children (N...

Additional file 8 of Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao & Bo Cheng
Additional file 8 Supplementary Fig. 8. Analyses of KRAB-Zfp related Satellite DNA cluster identified in the Kauzlaric’s paper [32]. (A) Comparison of the cluster distribution of our work and the Kauzlaric’s paper. The clusters defined by both studies are pointed with red arrows; the clusters only defined by our work are pointed with blue arrows; and the clusters only defined by the Kauzlaric’s paper are pointed with green arrows, mainly including the KRAB-Zfp related Satellite...

Visualization 1.mp4

Fanfei Li, Jingcheng Hu, Shaohui Zhang, Yao Hu, Qun Hao & CHENXU XIA
The measurement result video of clenching human fist. The hyperlinked part of the video in the manuscript has been marked in the text: "Visualization 1".

Visualization 1.mp4

Tao Cao, Shaozhen Liu, Ziyue Guo, Kailin Hu, Jikun Yan, Zhihong Liu, Zhou Li, Qi Xu, Kun Chen & Jiahui Peng
Shot-to-shot pulse evolution during the mode-locking transition of a Ti:sapphire oscillator. The upper panel shows the result obtained by detecting the unstretched pulses, and the lower one shows the TS-DFT result, which adopts the same data as those used in Fig. 1(b) of the main text. Time synchronization of these two channels has been implemented to make sure the pulse energy reaches the maximum at the same time in both cases (see Fig. 2(c) of...

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell & Lars-Gunnar Larsson
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. However, it remains unclear whether MYC and RAS cooperate in this way in human cells, where MYC and RAS are not sufficient for transformation. To address this question, we...

Additional file 1 of Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding & Zhongbing Lu
Additional file1. Fig. S1. The morphology and size distribution of PM2.5. A Scanning electron microscopy image of PM2.5. Scale bar = 500 nm. B Particle size distribution in the ultrapure water was analyzed by dynamic light scattering. Fig. S2. The body mass curves of PM2.5-exposed mice. During the exposure period, body weight of Ddah1−/− mice and wild type (WT) littermates (A), and body weight of human DDAH1 transgenic mice (DDAH1-Tg) and WT littermates were recorded...

Additional file 4 of Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao & Bo Cheng
Additional file 4 Supplementary Fig. 4. Sequence conservation analyses of various KRAB-Zfp clusters. The amino acid sequences (top) and the corresponding nucleic acid sequences (bottom) according to the linker and nearby regions are shown in the pale purple box. The related sequences are extracted from all the KRAB-Zfps arranged in the 50 clusters across the mouse genome (a), or the indicated clusters on chromosome 2 (Clusters 1, 2, 3) (b), and on chromosome 4 (Clusters...

Effective soil washing for Cu removal in industrial soil remediation

Ruzhuang Zhang, Ziqian Xu, Xingbin Fang & Ming Li
Soil contamination caused by heavy metals has become a serious environmental and health-related problem to human. Copper (Cu) is essential to human and plants in appropriate amount but toxicant if excessive. Although soil washing has been developed for a long time for heavy metal remediation, there are few studies focusing on Cu, especially in the case of extreme concentration of metal and dissolved organic matters (DOM). Thus, based on the literature reviews about soil washing,...

Additional file 1 of A comparative study to determine the association of gut microbiome with schizophrenia in Zhejiang, China

Fuyang Yan, Lehong Xia, Li Xu, Liyun Deng & Guolin Jin
Additional file 1: Figure S1. (A) Rarefaction curve analysis of archaeal 16S rRNA gene clone libraries. (B) Rank abundance curves of archaeal 16S rRNA gene clone libraries. Sample color codes are presented in the legend. Figure S2. Microbial composition and abundance at phylum level (A) and genus level (B) for gut microbiota in SZ (Case) and NC (Control) groups. The bars represent the average relative abundance of each genera, having significant differences between the two...

Multiple retrograde tracing methods compatible with 3DISCO clearing

Shuai Han, Dongdong Li, Yuhui Kou, Zhongguo Fu & Xiaofeng Yin
Exploring the spatial relationship of various neuron pools in the spinal cord is crucial and difficult due to its complexity. The single-labelling tracing and sectioning were employed in previous studies exploring the distribution of spinal motor neuron pools, which could only delineate one single motor neuron pool in one specimen and could not achieve intact-tissue observation. Here, with combination of neuroanatomy tracing techniques and the optical clearing technique, we developed a multiple retrograde tracing method...

sj-pptx-1-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-1-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

Additional file 1 of Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang & Yi Xu
Additional file 1: Figure S1. Full-length blots/gels of ABCA1, MMP9, AQP4, CYP46, and beta-actin are presented. Figure S2. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and beta-actin are presented. Figure S3. Full-length blots/gels of ABCA1 and beta-actin are presented. Figure S4. Full-length blots/gels of MMP9, AQP4, CYP46 and β-actin are presented. Figure S5. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and β-actin are presented.

Additional file 6 of Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao & Bo Cheng
Additional file 6 Supplementary Fig. 6. Specificity tests of sgRNAs in qPCR assays. qPCR results for detecting the intergenetic regions between non-target KRAB-Zfps using the genomic DNA templates extracted from the cells expressing the indicated sgRNA before and after gene editing (−Dox and + Dox). The set of data are correlated to Fig. 5B.

Additional file 1 of Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen, Shunying Zhu, Yueqing Xie, Hua Jiang, Jianwei Zhu & Mingyuan Wu
Supplementary Material 1

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts

Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell & Lars-Gunnar Larsson
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. However, it remains unclear whether MYC and RAS cooperate in this way in human cells, where MYC and RAS are not sufficient for transformation. To address this question, we...

Efficacy and safety of evolocumab in Chinese patients with primary hypercholesterolemia and mixed dyslipidemia: 12-week primary results of the HUA TUO 华佗 randomized clinical trialed Item

Adis journals on behalf of, Jiyan Chen, Hong Tan, Weimin Li, Zhouqing Huang, Yajun Han, Xuecheng Huang, Dongye Li, Xiaochun Xing, Maria Laura Monsalvo, You Wu, Jackie Mao & Lily Xin
Article full text
The article associated with this page has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days.
The above graphical abstract and the Chinese and Japanese translations of the abstract represent the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and...

Fig.1.tif

Hui Cheng, Xinlin Chen, Zhong jincheng, Jia Li, Ping Qiu & Ke Wang
Supplemental materials

Early Itch Response with Abrocitinib is Associated with Later Efficacy Outcomes in Patients with Moderate-to-Severe Atopic Dermatitis: Subgroup Analysis of the Randomized Phase III JADE 3 COMPARE Trial

Adis Journals on behalf of:, Sonja Ständer, Shawn G. Kwatra, Jonathan I. Silverberg, Eric L. Simpson, Jacob P. Thyssen, Gil Yosipovitch, Fan Zhang, Michael C. Cameron, Ricardo Rojo Cella, Hernan Valdez, Marco DiBonaventura & Claire Feeney
Article full text The above features represent the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please see the full text online (see “read the peer-reviewed publication” opposite). © The authors, CC-BY-NC 2022

Effective soil washing for Cu removal in industrial soil remediation

Ruzhuang Zhang, Ziqian Xu, Xingbin Fang & Ming Li
Soil contamination caused by heavy metals has become a serious environmental and health-related problem to human. Copper (Cu) is essential to human and plants in appropriate amount but toxicant if excessive. Although soil washing has been developed for a long time for heavy metal remediation, there are few studies focusing on Cu, especially in the case of extreme concentration of metal and dissolved organic matters (DOM). Thus, based on the literature reviews about soil washing,...

Additional file 1 of Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang & Yi Xu
Additional file 1: Figure S1. Full-length blots/gels of ABCA1, MMP9, AQP4, CYP46, and beta-actin are presented. Figure S2. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and beta-actin are presented. Figure S3. Full-length blots/gels of ABCA1 and beta-actin are presented. Figure S4. Full-length blots/gels of MMP9, AQP4, CYP46 and β-actin are presented. Figure S5. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and β-actin are presented.

Additional file 6 of Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors

Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian & Jie Wang
Additional file 6. The original blots.

Additional file 5 of Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao & Bo Cheng
Additional file 5 Supplementary Fig. 5. Screening efficient sgRNAs for knocking out KRAB-Zfp cluster(s) by CRISPR-Cas9. (A) The sequences and detailed information of the 11 linker-targeting sgRNAs constructed in the reporter plasmid in Fig. 4A. There are two “NGG” sites within the linker regions and they were used as PAM sites for the two sets of sgRNAs. The nucleotides identical across the whole set of sgRNA targets are labeled in black and the variable nucleotides...

Additional file 8 of Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Yang Zhang, Fei He, Yanning Zhang, Qian Dai, Qintong Li, Jing Nan, Ruidong Miao & Bo Cheng
Additional file 8 Supplementary Fig. 8. Analyses of KRAB-Zfp related Satellite DNA cluster identified in the Kauzlaric’s paper [32]. (A) Comparison of the cluster distribution of our work and the Kauzlaric’s paper. The clusters defined by both studies are pointed with red arrows; the clusters only defined by our work are pointed with blue arrows; and the clusters only defined by the Kauzlaric’s paper are pointed with green arrows, mainly including the KRAB-Zfp related Satellite...

Registration Year

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Affiliations

  • West China Hospital of Sichuan University
    53
  • Fudan University
    35
  • Sichuan University
    34
  • Sun Yat-sen University
    33
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    30
  • Shanghai Jiao Tong University
    26
  • Chinese Academy of Agricultural Sciences
    25
  • Shanghai University of Traditional Chinese Medicine
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  • Huazhong University of Science and Technology
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  • Capital Medical University
    22