Objectives: To determine the frequency and correlates of apathy in amyotrophic lateral sclerosis (ALS) and its influence on the prognosis of the disease. Methods: Three databases were searched: MEDLINE, PubMed, and Google Scholar. Quantitative synthesis of the frequency of apathy in ALS was conducted using random effects in Stata (College Station, TX). Meta-regression and subgroup analyses were conducted to investigate the association between frequency of apathy in ALS and different covariates. Results: Fifty-two studies (51...

Astragalus membranaceus is a traditional Chinese medicine and has been widely used in treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness. Astragaloside IV (AS-IV), one of the major active components extracted from Astragalus membranaceus, has a series of pharmacological effects, including inhibiting inflammation, regulating energy metabolism, reducing oxidative stress and apoptosis. However, the effect of AS-IV on myocardial infarction (MI) and the underlying molecular mechanism remains unclear. The purpose of our study...

A well-developed root system plays a positive role in wheat yield. Here, we identified quantitative trait loci (QTL) for total root length (TRL), root average diameter (RD) and number of root tips (RTN) based on the previously developed genetic map of a recombinant inbred line (RIL) population in bread wheat and phenotype data from two individual trials. A stable and major QTL, Qtrl-AS-5A for TRL was detected explaining 17.19 to 17.78% of the phenotypic variation....

Video showing sunrise seagrass wasting disease survey via snorkeling on San Juan Island, Washington.

Video showing sunrise seagrass wasting disease survey via snorkeling on San Juan Island, Washington.

Animation of phase distribution evolution of the z-polarized component in the three orthogonal planes for the highly confined spatiotemporal field corresponding to the preconditioned radially polarized incident wavepacket.

Animation of the spatial polarization evolution of the focused wavepacket corresponding to the preconditioned azimuthally polarized incident wavepacket.

Additional file 1. Preparation for iTRAQ quantitative proteomics study.

Additional file 4. High correlation between the two technical replicates. The scatterplot of two technical replicates treated with 20/80/160 Gy heavy ion irradiation.

Additional file 5. String analysis of 113 overlapped differential proteins in our dataset.

A 360° dynamic holographic video

Background. Far-field electrograms from superior vena cava (SVC) can be present in right superior pulmonary vein (RSPV) after pulmonary vein (PV) isolation. Objectives. To analyze the characteristics of far-field SVC potentials in RSPV after PV isolation and the local anatomy difference between patients with and without the potentials. Methods. Patients undergoing PV isolation were retrospectively reviewed, contrast-enhanced computed tomography (CT) was performed before procedure for observing the anatomical relationship between RSPV and SVC. The prevalence...

The above video represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

The above video represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

Background. Far-field electrograms from superior vena cava (SVC) can be present in right superior pulmonary vein (RSPV) after pulmonary vein (PV) isolation. Objectives. To analyze the characteristics of far-field SVC potentials in RSPV after PV isolation and the local anatomy difference between patients with and without the potentials. Methods. Patients undergoing PV isolation were retrospectively reviewed, contrast-enhanced computed tomography (CT) was performed before procedure for observing the anatomical relationship between RSPV and SVC. The prevalence...

Supplemental material, sj-pptx-1-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

Supplemental material, sj-pptx-2-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

We previously described using a “Y” incision and rectangular patch to enlarge the aortic annulus by 2-3 valve sizes for aortic valve replacement (AVR) with bioprosthesis (1) or mechanical valve (2) in patients with trileaflet aortic valve (TAV). As we are becoming more experienced, we are able to enlarge the aortic annulus by 4 valve sizes routinely in either TAV or bicuspid aortic valve (BAV). In this video we used a case of TAV to...

Animation of phase distribution evolution of the x-polarized component along the y-axis and that of the y-polarized component along the x-axis in azimuthally polarized two dimensional STOV.

Additional file 1: Figure S1. Female RAGE deficiency improved glucose and insulin tolerance in normal diet mice. (A) Glucose tolerance tests (GTT) and Area under the curve (AUC) in each group. n = 6 per group. *p < 0.05 vs. female RAGE−/−-HFD-F mice; #p < 0.05 vs. female RAGE−/−-ND-F mice. (B) Insulin tolerance tests (ITT) and AUC in each group. n = 6 per group. *p < 0.05 vs. female RAGE−/−-HFD-F mice; #p < 0.05...

Animation of the spatial polarization evolution of the focused wavepacket corresponding to the preconditioned azimuthally polarized incident wavepacket.

The multi-plane AR display effect of the HUD prototype.

Additional file 5. String analysis of 113 overlapped differential proteins in our dataset.

Additional file 6. KEGG and GO enrichment analysis of 452 differential proteins in our dataset.

The above video represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).