2 Works
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts
Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell & Lars-Gunnar Larsson
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. However, it remains unclear whether MYC and RAS cooperate in this way in human cells, where MYC and RAS are not sufficient for transformation. To address this question, we...
MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts
Fan Zhang, Siti Mariam Zakaria, Vedrana Högqvist Tabor, Madhurendra Singh, Susanna Tronnersjö, Jacob Goodwin, Galina Selivanova, Jiri Bartek, Alina Castell & Lars-Gunnar Larsson
The MYC and RAS oncogenes are sufficient for transformation of normal rodent cells. This cooperativity is at least in part based on suppression of RAS-induced cellular senescence by MYC and block of MYC-induced apoptosis by RAS – thereby canceling out two main barriers against tumor development. However, it remains unclear whether MYC and RAS cooperate in this way in human cells, where MYC and RAS are not sufficient for transformation. To address this question, we...
Affiliations
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Sun Yat-sen University2
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West China Hospital of Sichuan University2
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Central South University2
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Northwest Normal University2
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The University of Texas at Austin2
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Jilin University2
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Northwest University2
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Institute of Plant Protection2
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Second Affiliated Hospital of Dalian Medical University2
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Fudan University2