We discovered that vitiligo was associated with sexual dysfunction in clinical diagnosis and treatment; however, no further analysis had been performed due to a lack of data. This study aimed to clarify the relationship between vitiligo and sexual dysfunction. We searched six databases (PubMed, Embase, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, and Wanfang Data Knowledge Service Platform) for nearly 40 years. According to the search strategy, 91 relevant studies were retrieved,...

20 reconstructed frames from the single-shot measurement with each one corresponding to the duration of 1 millisecond for the heart motions of zebrafish.

Quantitative simulation comparison about the robustness of proposed method.

Quantitative simulation comparison.

Additional file 3: Supplementarydata 1. Original pictures used to prepare the Figure 6

Additional file 1: Fig. S1. Starvation preferentially sensitizes different breast cancer subtypes versus near normal cells to chemotherapy. a. In vitro treatment overview: cells were glucose/serum starved (STS) for 48 h (blue bar), drugs were added during the last 24h (red bar). b. MTT survival assays after 48 h treatment with STS with or without addition of doxorubicin (DXR) in near normal MCF-10A cells and the indicated breast cancer cell lines. Data are presented as...

Additional file 2: Fig. S2. Differential accumulation of reactive oxygen species in malignant and near normal epithelial breast cells after starvation. a. Assessment of intracellular ROS production; fold change of intracellular ROS production compared to control in breast cancer cell lines upon STS, DXR or combined treatment (STS+DXR). Data are presented as mean fluorescent intensity +SD. *P ≤ 0.05. b. MTT survival assay after 48 h treatment with combined STS+DXR in absence or presence of...

Additional file 3: Fig. S3. Combined treatment decreases oxidative phosphorylation and increases glycolytic reserve in highly aggressive TNBC cells. a. Oxygen Consumption Rate (OCR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR alone or in combination with STS, using Seahorse Analyzer. Combination treatment selectively reduces basal respiration (corresponding to basal OCR), maximal respiration (corresponding to FCCP response) and spare respiratory capacity (the difference between maximal respiration and basal respiration). b. Extracellular Acidification Rate (ECAR)...

Additional file 2: Fig. S1. Typical grapevine trunk disease (GTD) symptoms in grapevines collected in this study. A The overall condition of symptomatic grapevines with yellow spots or tiger stripes on the leaves of multiple branches. B Foliar symptoms that initially appeared as chlorotic spots and subsequently coalesced and finally became necrotic. C Internal symptoms of the same vine with foliar symptoms showing dark brown necrosis. Fig. S2. Species accumulation curves for fungal communities based...

Additional file 2: Fig. S2. Expressions of the 117 PgHDZ gene transcripts in four-year-old plant roots of 42 cultivars. (a) Percentage of PgHDZ transcripts expressed in 42 cultivars with 117 transcripts randomly selected from the ginseng transcriptome as the reference. (b) Expression heatmap of the PgHDZ transcripts in different cultivars.

Additional file 3: Fig. S3. The average expression of the 19 PgHDZ transcripts expressed in all 42 cultivars, 14 tissues and four aged roots. The genes belonging to different subfamilies were shown, with the genes black font from subfamily I, the genes in pink font from subfamily II, and the genes in blue font from subfamily III.

Supplementary Material 1

Supplementary Material 2

Supplemental Document of the main text

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Additional file 2: Fig. S2. Differential accumulation of reactive oxygen species in malignant and near normal epithelial breast cells after starvation. a. Assessment of intracellular ROS production; fold change of intracellular ROS production compared to control in breast cancer cell lines upon STS, DXR or combined treatment (STS+DXR). Data are presented as mean fluorescent intensity +SD. *P ≤ 0.05. b. MTT survival assay after 48 h treatment with combined STS+DXR in absence or presence of...

Additional file 4: Fig. S4. Combined treatment induces differential metabolic reprogramming. a. Intracellular metabolites profile in MCF-10A and MDA-MB-231 treated with DXR or STS+DXR. Cells were harvested on day 0, day 1 and day 2. *P ≤ 0.05. b. Expression of ATP5A in triple negative cell lines MDA-MB-468 and HS578 upon DXR or STS+DXR assessed by immunofluorescence analysis. Left panel: representative micrograph where ATP5A is shown in green, nuclei were counterstained with DAPI (blue). Scale...

Additional file 5: Fig. S5. ATP5A1 silencing mimicks the effect of combined STS+DXR treatment in TNBC cells - FOXO1 silencing eliminate the selective sensitivity of TNBC cells to STS+DXR treatment. a. Transcriptional levels of ATP5A1 upon ATP5A1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. b. Transcriptional levels of FOXO1 upon FOXO1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. c....

Additional file 7: Table. S1. Weight (in grams) monitoring in control, caloric restricted (CR), DXR treated and CR+DXR treated mice.

Additional file 2: SupplementaryTable 1. Statistics of C. ensifolium leaf sequencingchallenged with 100 mM NaCl stress for 48 and 96 hours. SupplementaryTable 2. Pathway specific differentially expressed genes inC. ensifolium leaf challenged with 100 mM NaCl stress for 48 and 96 hours. SupplementaryTable 3. Differentially expressed transcription factors inC. ensifolium leaf challenged with 100 mM NaCl stress for 48 and 96 hours.

Additional file 2: Fig. S2. Expressions of the 117 PgHDZ gene transcripts in four-year-old plant roots of 42 cultivars. (a) Percentage of PgHDZ transcripts expressed in 42 cultivars with 117 transcripts randomly selected from the ginseng transcriptome as the reference. (b) Expression heatmap of the PgHDZ transcripts in different cultivars.

A 6dpf PTZ treated zebrafish larva is imaged over a 400 x 400 x 192 micron volume. Each volume contains 36 images and is acquired with a spacing of 5.33 microns. A 5 ms exposure time was used for this data.

A 6dpf PTZ treated zebrafish larva is imaged over a 400 x 400 x 192 micron volume. Each volume contains 36 images and is acquired with a spacing of 5.33 microns. A 5 ms exposure time was used for this data.

Video of non-DoT system simulation of scene 2 in 45 degree.

20 reconstructed frames from the single-shot measurement with each one corresponding to the duration of 1 millisecond for the heart motions of zebrafish.