A 6dpf PTZ treated zebrafish larva is imaged over a 400 x 400 x 192 micron volume. Each volume contains 36 images and is acquired with a spacing of 5.33 microns. A 5 ms exposure time was used for this data.

A 6dpf PTZ treated zebrafish larva is imaged over a 400 x 400 x 192 micron volume. Each volume contains 36 images and is acquired with a spacing of 5.33 microns. A 5 ms exposure time was used for this data.

Additional file 7. Fig. S1. Detection of 6 sample solutions by high performance liquid chromatography.

Additional file 1: Fig. S1. The animal experimental protocol. DSS, dextran sulfate sodium; GC-K, ginsenoside compound K. Fig. S2. The frequency of Foxp3 + Treg cells among the CD4 + T cells (CD3 + CD4 + CD25 + cells) in spleen(A) and blood(B) of mice detected by flow cytometry; The frequency of IL-17a + Th17 cells among the CD4 + T cells (CD3 + CD4 + cells) in spleen(C) and blood(D) of mice detected by...

Additional file 3: Fig. S3. Combined treatment decreases oxidative phosphorylation and increases glycolytic reserve in highly aggressive TNBC cells. a. Oxygen Consumption Rate (OCR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR alone or in combination with STS, using Seahorse Analyzer. Combination treatment selectively reduces basal respiration (corresponding to basal OCR), maximal respiration (corresponding to FCCP response) and spare respiratory capacity (the difference between maximal respiration and basal respiration). b. Extracellular Acidification Rate (ECAR)...

Additional file 1.

Additional file 2: Fig. S1. Typical grapevine trunk disease (GTD) symptoms in grapevines collected in this study. A The overall condition of symptomatic grapevines with yellow spots or tiger stripes on the leaves of multiple branches. B Foliar symptoms that initially appeared as chlorotic spots and subsequently coalesced and finally became necrotic. C Internal symptoms of the same vine with foliar symptoms showing dark brown necrosis. Fig. S2. Species accumulation curves for fungal communities based...

Additional file 2: Figure S1. The survival curves of 154 patients with pT1b esophageal squamous cellcarcinoma stratified by the count of D2-40-LI of one representative paraffinblock (RD2-40-LI).

Trapping of a 3μm SiO2 sphere and a yeast by a double-tapered optical fiber probe. Turn on the laser source and move the probe close to a 3μm SiO2 sphere, the sphere will be attracted to the fiber tip. Then move the probe with a 3μm SiO2 sphere close to a yeast, and it will be attracted to the SiO2 sphere. When the fiber probe is moving, two microparticles will move along with it. Finally,...

Supplemental material, sj-pptx-1-cpa-10.1177_07067437231154993 for A Meta-Research of Randomized Controlled Trials in the Field of Mental Health: Comparing Pharmacological to Non-Pharmacological Interventions from 1955 to 2020 by Sheng Chen, PhD, Alina Lee, MSc, and Wei Wang, PhD in The Canadian Journal of Psychiatry

When a 980 nm laser with the out power of 12.743 mW is coupled to the structure via MMF, the bubble moves down vertically and then suspends in the thick HCF. When the laser is turned off, the micro-bubble returns to the top of the thick HCF.

After the driven power is increased to 17.570 mW, the bubble takes 1.1 s to move to the bottom of the thick HCF and subsequently stays still. When the laser is turned off, the micro-bubble returns to the top of the thick HCF after 1.0 s.

Additional file 1. Original, full-length gel and lot images of Fig. 4A.

Additional file 1.

Additional file 7. Fig. S1. Detection of 6 sample solutions by high performance liquid chromatography.

Additional file 1: Fig. S1. Starvation preferentially sensitizes different breast cancer subtypes versus near normal cells to chemotherapy. a. In vitro treatment overview: cells were glucose/serum starved (STS) for 48 h (blue bar), drugs were added during the last 24h (red bar). b. MTT survival assays after 48 h treatment with STS with or without addition of doxorubicin (DXR) in near normal MCF-10A cells and the indicated breast cancer cell lines. Data are presented as...

Additional file 2: Fig. S2. Differential accumulation of reactive oxygen species in malignant and near normal epithelial breast cells after starvation. a. Assessment of intracellular ROS production; fold change of intracellular ROS production compared to control in breast cancer cell lines upon STS, DXR or combined treatment (STS+DXR). Data are presented as mean fluorescent intensity +SD. *P ≤ 0.05. b. MTT survival assay after 48 h treatment with combined STS+DXR in absence or presence of...

Additional file 3: Fig. S3. Combined treatment decreases oxidative phosphorylation and increases glycolytic reserve in highly aggressive TNBC cells. a. Oxygen Consumption Rate (OCR) measurements in MCF-10A and MDA-MB-231 cells treated with DXR alone or in combination with STS, using Seahorse Analyzer. Combination treatment selectively reduces basal respiration (corresponding to basal OCR), maximal respiration (corresponding to FCCP response) and spare respiratory capacity (the difference between maximal respiration and basal respiration). b. Extracellular Acidification Rate (ECAR)...

Additional file 2: Fig. S1. Typical grapevine trunk disease (GTD) symptoms in grapevines collected in this study. A The overall condition of symptomatic grapevines with yellow spots or tiger stripes on the leaves of multiple branches. B Foliar symptoms that initially appeared as chlorotic spots and subsequently coalesced and finally became necrotic. C Internal symptoms of the same vine with foliar symptoms showing dark brown necrosis. Fig. S2. Species accumulation curves for fungal communities based...

Supplemental material, sj-pptx-1-cpa-10.1177_07067437231154993 for A Meta-Research of Randomized Controlled Trials in the Field of Mental Health: Comparing Pharmacological to Non-Pharmacological Interventions from 1955 to 2020 by Sheng Chen, PhD, Alina Lee, MSc, and Wei Wang, PhD in The Canadian Journal of Psychiatry

Trapping of a 3μm SiO2 sphere and a yeast by a double-tapered optical fiber probe. Turn on the laser source and move the probe close to a 3μm SiO2 sphere, the sphere will be attracted to the fiber tip. Then move the probe with a 3μm SiO2 sphere close to a yeast, and it will be attracted to the SiO2 sphere. When the fiber probe is moving, two microparticles will move along with it. Finally,...

Additional file 1. Original, full-length gel and lot images of Fig. 4A.

Additional file 4: Fig. S4. Combined treatment induces differential metabolic reprogramming. a. Intracellular metabolites profile in MCF-10A and MDA-MB-231 treated with DXR or STS+DXR. Cells were harvested on day 0, day 1 and day 2. *P ≤ 0.05. b. Expression of ATP5A in triple negative cell lines MDA-MB-468 and HS578 upon DXR or STS+DXR assessed by immunofluorescence analysis. Left panel: representative micrograph where ATP5A is shown in green, nuclei were counterstained with DAPI (blue). Scale...

Additional file 5: Fig. S5. ATP5A1 silencing mimicks the effect of combined STS+DXR treatment in TNBC cells - FOXO1 silencing eliminate the selective sensitivity of TNBC cells to STS+DXR treatment. a. Transcriptional levels of ATP5A1 upon ATP5A1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. b. Transcriptional levels of FOXO1 upon FOXO1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. c....

Additional file 6: Fig. S6. Caloric restriction combined with chemotherapy retards tumor growth and suppresses metastatic potential in a triple-negative breast cancer mouse model. a. MTT survival assays of 4T1 mouse breast cancer cells treated with DXR alone or in combination with STS (STS+DXR). Data are presented as mean survival percentage. *P ≤ 0.05. b. Assessment of intracellular ROS production. Data are presented as mean of the fold change ±SD of intracellular ROS production in...