Additional file 1: Supplementary Figure S1. Localization of TP53 mutations at CpG and non-CpG sites in GC samples from Eastern Europe, China, and Japan (exon 4-8). Mutation-distribution maps were created using the cBioPortal mutation mapper ( http://www.cbioportal.org/mutation_mapper ). Black dots indicate truncating mutations (nonsense and frameshift mutations). The light purple dot indicates a silent mutation. P53_TAD, TP53 transcriptional activation domain; P53, TP53 DNA-binding domain; P53 tetramer, TP53 tetramer domain.

Additional file 4: Supplementary Figure S4. Designations of populations based on TCGA classification. The majority of the data were from the “White” population. The “Asian” population was not defined, especially whether they were only residing in Asia or not. NA, not available.

Additional file 4: Supplementary Figure S4. Designations of populations based on TCGA classification. The majority of the data were from the “White” population. The “Asian” population was not defined, especially whether they were only residing in Asia or not. NA, not available.

Additional file 5: Supplementary Figure S5. Mutation spectrum of the TP53 gene in GC in each population. Six substitution types are depicted in the bar graph as follows: C > A (light blue), C > G (black), C > T (red), T > A (gray), T > C (yellow-green), and T > G (pale orange).

The denoising result for the biological dynamic process under a low-does illumination condition( the photon flux in photons per pixel p = 500 photons/pix).

Additional file 1: Figure S1: Study design and Identification of CACNA1G gene based on the pharmaco-epigenomic method. Figure S2: Methylation levels of (A) ADAMTS1, (B) BNC1, (C) CACNA1G genes in the Cancer Genome Atlas [Díez-Villanueva A, Mallona I, Peinado MA. Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer. Epigenetics Chromatin 2015;8:22. https://doi.org/10.1186/s13072-015-0014-8 ].

Additional file 4: Fig. S4. Combined treatment induces differential metabolic reprogramming. a. Intracellular metabolites profile in MCF-10A and MDA-MB-231 treated with DXR or STS+DXR. Cells were harvested on day 0, day 1 and day 2. *P ≤ 0.05. b. Expression of ATP5A in triple negative cell lines MDA-MB-468 and HS578 upon DXR or STS+DXR assessed by immunofluorescence analysis. Left panel: representative micrograph where ATP5A is shown in green, nuclei were counterstained with DAPI (blue). Scale...

Additional file 5: Fig. S5. ATP5A1 silencing mimicks the effect of combined STS+DXR treatment in TNBC cells - FOXO1 silencing eliminate the selective sensitivity of TNBC cells to STS+DXR treatment. a. Transcriptional levels of ATP5A1 upon ATP5A1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. b. Transcriptional levels of FOXO1 upon FOXO1 silencing in MCF10A and MDA-MB-231. Data are presented as mean expression values. *P ≤ 0.05. c....

Additional file 6: Fig. S6. Caloric restriction combined with chemotherapy retards tumor growth and suppresses metastatic potential in a triple-negative breast cancer mouse model. a. MTT survival assays of 4T1 mouse breast cancer cells treated with DXR alone or in combination with STS (STS+DXR). Data are presented as mean survival percentage. *P ≤ 0.05. b. Assessment of intracellular ROS production. Data are presented as mean of the fold change ±SD of intracellular ROS production in...

Additional file 2: Fig. S1. BUSCO assessment of unigene assembly. Fig. S2. The root samples were respectively collected at 0 h (CN), 6 h (IN), 12 h (KN) and 24 h (LN) after GXS16 inoculation, and the KEGG pathway enrichment of DEGs in the comparison of IN vs CN, KN vs IN, and LN vs KN.

Additional file 1: Fig. S1. The animal experimental protocol. DSS, dextran sulfate sodium; GC-K, ginsenoside compound K. Fig. S2. The frequency of Foxp3 + Treg cells among the CD4 + T cells (CD3 + CD4 + CD25 + cells) in spleen(A) and blood(B) of mice detected by flow cytometry; The frequency of IL-17a + Th17 cells among the CD4 + T cells (CD3 + CD4 + cells) in spleen(C) and blood(D) of mice detected by...

Additional file 2

Additional file 2

Supplemental material, sj-pptx-2-cix-10.1177_11769351231161478 for RNA-seq and Single-Cell Transcriptome Analyses of TRAIL Receptors Gene Expression in Human Osteosarcoma Cells and Tissues by Wenyu Feng, Haiyingjie Lin, Emel Rothzerg, Dezhi Song, Wenxiang Zhao, Tingting Ning, Qingjun Wei, Jinmin Zhao, David Wood, Yun Liu and Jiake Xu in Cancer Informatics

Supplemental material, sj-pptx-3-cix-10.1177_11769351231161478 for RNA-seq and Single-Cell Transcriptome Analyses of TRAIL Receptors Gene Expression in Human Osteosarcoma Cells and Tissues by Wenyu Feng, Haiyingjie Lin, Emel Rothzerg, Dezhi Song, Wenxiang Zhao, Tingting Ning, Qingjun Wei, Jinmin Zhao, David Wood, Yun Liu and Jiake Xu in Cancer Informatics

The above video represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

Supplemental materials

Intensity and phase profiles as a function of z in the counter-propagation for the TC combination of m1=-5 and m2=+5.

Intensity and phase profiles as a function of z in the counter-propagation for the TC combination of m1=-5 and m2=+5.

Reconstruction results with 20 frames of zebrafish heart from a snapshot measurement.

Pattern hair loss distribution: a novel presentation for alopecia areata

Additional file 2: Figure S1. The survival curves of 154 patients with pT1b esophageal squamous cellcarcinoma stratified by the count of D2-40-LI of one representative paraffinblock (RD2-40-LI).

Additional file 1. Supplementary figure.

Additional file 1: Figure S1. Full-length blots/gels of ABCA1, MMP9, AQP4, CYP46, and beta-actin are presented. Figure S2. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and beta-actin are presented. Figure S3. Full-length blots/gels of ABCA1 and beta-actin are presented. Figure S4. Full-length blots/gels of MMP9, AQP4, CYP46 and β-actin are presented. Figure S5. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and β-actin are presented.

Additional file 3. The Gaussian fitting curve of log2 ratio of the intensities of two replicates of 20/0 (A), 80/0 (B) and 160/0 (C). The red and blue curves represent the experimental and Gaussian fitting curve, respectively.