Additional file 8 Supplementary Fig. 8. Analyses of KRAB-Zfp related Satellite DNA cluster identified in the Kauzlaric’s paper [32]. (A) Comparison of the cluster distribution of our work and the Kauzlaric’s paper. The clusters defined by both studies are pointed with red arrows; the clusters only defined by our work are pointed with blue arrows; and the clusters only defined by the Kauzlaric’s paper are pointed with green arrows, mainly including the KRAB-Zfp related Satellite...

A foetus with a mass in the oral cavity: a rare case of oral eruption cyst

A foetus with a mass in the oral cavity: a rare case of oral eruption cyst

Supplementary Material 1

Supplementary Material 1

Supplementary Material 2

Supplementary Material 2

Additional file 1: Figure S1. Clinical model to determine surgical algorithm for ovarian cancer patients. A diagnostic surgery is first conducted to determine feasibility of optimal cytoreduction in women found to have ovarian cancer. If patients are determined by the surgeon to have disease burden that is likely to achieve optimally cytoreduction (R0), then patients undergo Primary Debulking Surgery (PDS). If optimal debulking is determined to be unlikely (R1), patients have tissue specimens collected at...

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We mistakenly diagnosed a patient with pulmonary embolism as ST-elevation acute myocardial infarction. The case complained of chest pain with ST-elevation in leads AVR, III, AVF, V1, V3R, V4R and V5R. In addition, we also found ST- elevation AVR, III>ST- elevation AVF, QIII>QAVF and QV1. Multi-site pulmonary embolism can lead to type 2 myocardial infarction or special type of myocardial infarction with non-obstructive coronary arteries through multiple pathological mechanisms.

We mistakenly diagnosed a patient with pulmonary embolism as ST-elevation acute myocardial infarction. The case complained of chest pain with ST-elevation in leads AVR, III, AVF, V1, V3R, V4R and V5R. In addition, we also found ST- elevation AVR, III>ST- elevation AVF, QIII>QAVF and QV1. Multi-site pulmonary embolism can lead to type 2 myocardial infarction or special type of myocardial infarction with non-obstructive coronary arteries through multiple pathological mechanisms.

Supplemental materials

Additional file 6 Supplementary Fig. 6. Specificity tests of sgRNAs in qPCR assays. qPCR results for detecting the intergenetic regions between non-target KRAB-Zfps using the genomic DNA templates extracted from the cells expressing the indicated sgRNA before and after gene editing (−Dox and + Dox). The set of data are correlated to Fig. 5B.

Supplementary Media for Self-Supervised Deep Learning Two-Photon Microscopy

Supplemental materials

Additional file 5 Supplementary Fig. 5. Screening efficient sgRNAs for knocking out KRAB-Zfp cluster(s) by CRISPR-Cas9. (A) The sequences and detailed information of the 11 linker-targeting sgRNAs constructed in the reporter plasmid in Fig. 4A. There are two “NGG” sites within the linker regions and they were used as PAM sites for the two sets of sgRNAs. The nucleotides identical across the whole set of sgRNA targets are labeled in black and the variable nucleotides...

Additional file 8 Supplementary Fig. 8. Analyses of KRAB-Zfp related Satellite DNA cluster identified in the Kauzlaric’s paper [32]. (A) Comparison of the cluster distribution of our work and the Kauzlaric’s paper. The clusters defined by both studies are pointed with red arrows; the clusters only defined by our work are pointed with blue arrows; and the clusters only defined by the Kauzlaric’s paper are pointed with green arrows, mainly including the KRAB-Zfp related Satellite...

Animation of FIg. 3

Additional file 1: Figure S1. Full-length blots/gels of ABCA1, MMP9, AQP4, CYP46, and beta-actin are presented. Figure S2. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and beta-actin are presented. Figure S3. Full-length blots/gels of ABCA1 and beta-actin are presented. Figure S4. Full-length blots/gels of MMP9, AQP4, CYP46 and β-actin are presented. Figure S5. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and β-actin are presented.

Additional file 1: Supplementary Fig. 1. A circular genomic map displays the distribution of all KRAB-ZFP genes across the human genome. The width of each pink bar positively correlates to the number of KRAB-ZFP genes in a cluster.

Colorectal cancer is one of the most common cancers in the United States and treatment options are limited for patients who develop liver metastases. Several chemotherapeutic regimens have been used for transvascular liver-directed therapy in the treatment of colorectal liver metastases without clear evidence of superiority of one therapy over another. We describe the development of a novel nanoemulsion through combining irinotecan (IRI), a first line systemic agent used for the treatment of colon cancer,...

Additional file 1: Supplementary Fig. 1. A circular genomic map displays the distribution of all KRAB-ZFP genes across the human genome. The width of each pink bar positively correlates to the number of KRAB-ZFP genes in a cluster.

Additional file 4 Supplementary Fig. 4. Sequence conservation analyses of various KRAB-Zfp clusters. The amino acid sequences (top) and the corresponding nucleic acid sequences (bottom) according to the linker and nearby regions are shown in the pale purple box. The related sequences are extracted from all the KRAB-Zfps arranged in the 50 clusters across the mouse genome (a), or the indicated clusters on chromosome 2 (Clusters 1, 2, 3) (b), and on chromosome 4 (Clusters...

Additional file 2.

Additional file 5 Supplementary Fig. 5. Screening efficient sgRNAs for knocking out KRAB-Zfp cluster(s) by CRISPR-Cas9. (A) The sequences and detailed information of the 11 linker-targeting sgRNAs constructed in the reporter plasmid in Fig. 4A. There are two “NGG” sites within the linker regions and they were used as PAM sites for the two sets of sgRNAs. The nucleotides identical across the whole set of sgRNA targets are labeled in black and the variable nucleotides...