10,079 Works

MOESM1 of Proteomic and metabolomic analyses reveal metabolic responses to 3-hydroxypropionic acid synthesized internally in cyanobacterium Synechocystis sp. PCC 6803

Yunpeng Wang, Lei Chen & Weiwen Zhang
Additional file 1: Figure S1. Comparison of cell growth of the WT and the engineered Synechocystis strains in this study.

Additional file 2: Figure S1. of A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines

SG Shapiro, DW Knapp & Matthew Breen
Clustered heat map of cell line differential expression. Unsupervised hierarchical clustering of gene expression profiles among healthy urothelium and cell lines highlighted numerous dysregulated genes among cell lines. Clustering along the Y-axis is by probe set, and clustering along the X-axis is according to expression profile similarity. Different colored blocks along the Y-axis group genes with a similar gene expression pattern. Above the X-axis, the top row of colored blocks denotes individual samples, while those...

Additional file 3: Figure S1. of Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients

Jithendra Bailur, Evelyna Derhovanessian, Brigitte Gueckel & Graham Pawelec
CD8+ and CD4+ T-cell response to Her-2: A representative plot of control and Her-2-stimulated cytokine (eg.TNF-producing CD8+ T-cells and CD4+ T-cells). (PPTX 89Â kb)

Contributions of Uncertainty in Droplet Nucleation to the Indirect Effect in Global Models

Daniel Rothenberg, Chien Wang & Alexander Avramov
Anthropogenic aerosol perturbations to clouds and climate (the indirect effect, or AIE) contribute significant uncertainty towards understanding contemporary climate change. Despite refinements over the past two decades, modern global aerosol-climate models widely disagree on the magnitude of AIE, and wholly disagree with satellite estimates. Part of the spread in estimates of AIE arises from a lack of constraints on what exactly comprised the pre-industrial atmospheric aerosol burden, but another component is attributable to inter-model differences...

Contributions of Uncertainty in Droplet Nucleation to the Indirect Effect in Global Models

Daniel Rothenberg, Chien Wang & Alexander Avramov
Anthropogenic aerosol perturbations to clouds and climate (the indirect effect, or AIE) contribute significant uncertainty towards understanding contemporary climate change. Despite refinements over the past two decades, modern global aerosol-climate models widely disagree on the magnitude of AIE, and wholly disagree with satellite estimates. Part of the spread in estimates of AIE arises from a lack of constraints on what exactly comprised the pre-industrial atmospheric aerosol burden, but another component is attributable to inter-model differences...

MOESM2 of Anthocyanin-rich Seoritae extract ameliorates renal lipotoxicity via activation of AMP-activated protein kinase in diabetic mice

Eun Koh, Ji Lim, Min Kim, Sungjin Chung, Seok Shin, Bum Choi, Hye Kim, Seong Hwang, Sae Kim, Cheol Park & Yoon Chang
Additional file 2: Result of anthocyanin effect on intracellular signalling in the cultured mesangial cells.

Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise

Anna Maria Nuzzo, Domenica Giuffrida, Bianca Masturzo, Paolo Mele, Ettore Piccoli, Carola Eva, Tullia Todros & Alessandro Rolfo
Herein, we evaluated whether Placental Mesenchymal Stromal Cells (PDMSCs) derived from normal and Preeclamptic (PE) placentae presented differences in the expression of G1/S-phase regulators p16INK4A, p18INK4C, CDK4 and CDK6. Finally, we investigated normal and PE-PDMSCs paracrine effects on JunB, Cyclin D1, p16INK4A, p18INK4C, CDK4 and CDK6 expressions in physiological term villous explants. PDMSCs were isolated from physiological (n = 20) and PE (n = 24) placentae. Passage three normal and PE-PDMSC and conditioned media (CM)...

Additional file 2: Figure S2. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by Ă -lapachone

Gaurab Chakrabarti, Zachary Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier Scaglioni, Lewis Cantley, Ralph DeBerardinis, Alec Kimmelman, Costas Lyssiotis & David Boothman
BPTES sensitivity. (A) Growth inhibition in MiaPaCa2 cells, as monitored by loss of ATP, to short-term (48Â h) or long-term (96Â h) BPTES treatments.

Additional file 4: Figure S4. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti, Zachary Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier Scaglioni, Lewis Cantley, Ralph DeBerardinis, Alec Kimmelman, Costas Lyssiotis & David Boothman
Assessment of drug effects on PDA tumors and animals. (A) Change in tumor volumes per animal at day 22 compared to day 1. (B) Mouse weights during treatment for vehicle (n = 6), CB-839 (n = 8), ß-lap (n = 8) and ß-lap plus CB-839 (n = 10). (C) Tumor glutamate levels, n = 3 mice per group. (D) Quantification of relative PAR and γH2AX from tumor tissue lysate according to the western blot in Fig. 5d.

Additional file 3: Figure S3. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti, Zachary Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier Scaglioni, Lewis Cantley, Ralph DeBerardinis, Alec Kimmelman, Costas Lyssiotis & David Boothman
Combination treatment leads to increased ROS by depleting reduced glutathione. (A) Relative GSH levels ±500 nM BPTES pre-treatment followed by ß-lap treatment. (B) Relative H2O2 production with ±500 nM BPTES pre-treatment followed by ß-lap treatment. (C) CellROX® quantification of total ROS at 15 min of ±4 μM ß-lap, ±DIC, and ±BPTES (48-h pre-treatment).

Additional file 1: Figure S1. of Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

Gaurab Chakrabarti, Zachary Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier Scaglioni, Lewis Cantley, Ralph DeBerardinis, Alec Kimmelman, Costas Lyssiotis & David Boothman
ß-Lap mechanism and GOT2 to GLUD1 Kaplan–Meier curve. (A) ß-lap mechanism of action. In the cytosol of cancer cells, one equivalent of β-lap undergoes a futile redox cycle with NQO1 to produce ~120 equivalents of H2O2, in 2–5 min (depending on cancer cell), which results in DNA damage, PARP1 hyperactivation, NAD+ and ATP depletion, and ultimately caspase-independent apoptosis (a form of cell death known as programmed necrosis). NAD, nicotinamide adenine dinucleotide; NADPH, nicotinamide adenine dinucleotide...

Pdmsmicrorod_Detection

Javier Antonio Soler Romero
Migration assay HaCat cell line with PDMS micro-bar

Additional file 6: Figure S3. of A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

AnaĂŻs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, RenĂŠ Bensadoun, Jean-Claude Chomel & Lucie Karayan-Tapon
Relation between patients outcome and radiosensitivity of GSCs. GSCs from group 1 and group 2 are described in the results section; PFS, Progression-free survival. (PPTX 94 kb)

Game Relasi - Matematika Kelas VIII.rar

Al Bahri
Game ini ditujukan untuk memvisualisasikan materi relasi pada matematika kelas VIII. Siswa diharapkan lebih mudah dalam memahami materi terkait relasi dengan menarik

Amplitude of the wavefront propagating through the volume with phase-shifting particles.

Tatiana Vovk
Amplitude of the wavefront propagating through the volume with phase-shifting particles. Sizes of the screen 3.072 x 3.072 mm^2 (512 x 512 pixels), lambda = 632.8 nm.

Flat-top super-Gaussian beam propagation for the distance z = 1 m.

Tatiana Vovk
Flat-top super-Gaussian beam propagation for the distance z = 1 m. Sizes of the screen 3.072 x 3.072 mm^2 (512 x 512 pixels), lambda =632.8 nm, sigma'' = 240 pixels, m = 8.

Amplitude of the wavefront propagating through the volume with phase-shifting particles.

Tatiana Vovk
Amplitude of the wavefront propagating through the volume with phase-shifting particles. Sizes of the screen 3.072 x 3.072 mm^2 (512 x 512 pixels), lambda = 632.8 nm.

Flat-top super-Gaussian beam propagation for the distance z = 1 m.

Tatiana Vovk
Flat-top super-Gaussian beam propagation for the distance z = 1 m. Sizes of the screen 3.072 x 3.072 mm^2 (512 x 512 pixels), lambda =632.8 nm, sigma'' = 240 pixels, m = 8.

Scientific Data Management and Open Science

Carly Strasser
Presentation for July 2016 CLIR Postdoc Symposium at Bryn Mawr.

Scientific Data Management and Open Science

Carly Strasser
Presentation for July 2016 CLIR Postdoc Symposium at Bryn Mawr.

Technical Registry Data in Wikidata

Katherine Thornton
Slide deck for a presentation to the Software Preservation Network describing work-to-date getting technical registry data related to file formats, software, and configured environments into Wikidata.

Technical Registry Data in Wikidata

Katherine Thornton
Slide deck for a presentation to the Software Preservation Network describing work-to-date getting technical registry data related to file formats, software, and configured environments into Wikidata.

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