Illegal booter services offer denial of service (DoS) attacks for a fee of a few tens of dollars a month. Internationally, police have implemented a range of different types of intervention aimed at those using and offering booter services, including arrests and website takedown. In order to measure the impact of these interventions we look at the usage reports that booters themselves provide and at measurements of reflected UDP DoS attacks, leveraging a five year...

Existing solutions are ineffective in detecting zero day exploits targeting Customer Premise Equipment (CPE) and Internet of Things (IoT) devices. We present honware, a high-interaction honeypot framework which can emulate a wide range of devices without any access to the manufacturers' hardware. Honware automatically processes a standard firmware image (as is commonly provided for updates), customises the filesystem and runs the system with a special pre-built Linux kernel. It then logs attacker traffic and records...

Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor (PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Epigenetic changes in PGR-A and PGR-B may be related to...

Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor (PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Epigenetic changes in PGR-A and PGR-B may be related to...

Objective:The transfer of long noncoding RNAs (lncRNAs) via exosomes to modulate recipient cells represents an important mechanism for disease progression. Antisense hypoxia-inducible factor (aHIF) is a well-known angiogenesis-related lncRNA. Here, we aimed to investigate the clinical implications of aHIF and exosomal aHIF in endometriosis and the involvement of exosome-shuttled aHIF in endometriosis angiogenesis.Study Design:The distribution and expression of aHIF in ectopic, eutopic, and normal endometria was evaluated. Serum exosomal aHIF levels in patients with endometriosis...

Objective:The transfer of long noncoding RNAs (lncRNAs) via exosomes to modulate recipient cells represents an important mechanism for disease progression. Antisense hypoxia-inducible factor (aHIF) is a well-known angiogenesis-related lncRNA. Here, we aimed to investigate the clinical implications of aHIF and exosomal aHIF in endometriosis and the involvement of exosome-shuttled aHIF in endometriosis angiogenesis.Study Design:The distribution and expression of aHIF in ectopic, eutopic, and normal endometria was evaluated. Serum exosomal aHIF levels in patients with endometriosis...

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+CD25+FoxP3+ Tregs from...

There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+CD25+FoxP3+ Tregs from...

Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...

Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...

Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A4 (LXA4) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. In this study, the overexpression of COX-2 was observed in ectopic endometrium of endometriosis patients compared to the normal endometrium of controls. Lipoxin A4 efficiently suppressed IL-1β-induced COX-2 protein expression in ectopic...

Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A4 (LXA4) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. In this study, the overexpression of COX-2 was observed in ectopic endometrium of endometriosis patients compared to the normal endometrium of controls. Lipoxin A4 efficiently suppressed IL-1β-induced COX-2 protein expression in ectopic...

This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...

This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...

This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...

Bedrich Schnirch, remarkable Czech designer, has realized more constructions of chain bridges. Already in year 1826 has been granted to him a patent of hanged roofs; in our region he has realized more constructions of this type. In year 1965 has been found in Banská Bystrica one of the known hanged roof constructions, which is in utilization till this time and is serving good to its purpose. Description of existing hanged roof in Banská Bystrica.

The Data Repository of the H2020/TINNGO Project (http://www.tinngo.eu/) is used to store large volumes of gender-related transport data, acquired from 10 national hubs of a pan-European Gender Observatory.

ShuTu (Chinese for "dendrite") is a software platform for semi-automated reconstruction of neuronal morphology. It is designed for neurons stained following patch-clamp recording and biocytin filling/staining. With an additional preprocessing step, it can also handle fluorescence images from confocal stacks. Even when there is only a single neuron in the imaged volume, automated reconstruction is tricky, because of background. Thus, ShuTu was developed to facilitate a two-step process: automated reconstruction, followed by manual correction. The...

This dataset provides in situ airborne measurements of atmospheric carbon monoxide (CO), carbon dioxide (CO2), methane (CH4), and water vapor concentrations, plus air temperature, barometric pressure, relative humidity, and wind speed values over Alaska and the Yukon and Northwest Territories of Canada during the Arctic Carbon Aircraft Profile (Arctic-CAP) monthly sampling campaigns from April-November 2017. Observations have been averaged to a 10-second interval and are reported with the number of samples (N) and standard deviation....

Learning to read is foundational for literacy development, yet many children in primary school fail to become efficient readers despite normal intelligence and schooling. This condition, referred to as developmental dyslexia, has been hypothesized to occur because of deficits in vision, attention, auditory and temporal processes, and phonology and language. Here, we used a developmentally plausible computational model of reading acquisition to investigate how the core deficits of dyslexia determined individual learning outcomes for 622...

The Rosenberg Self-Esteem Inventory (Rosenberg, 1965) was used to study college students' self-esteem in relation to age at parents' separation, perceived frequency of interparental conflict, conflict management style, depression, and aggression. One hundred fifty-one undergraduate participants were administered the Thomas-Kilmann Conflict Mode Instrument (Kilmann & Thomas, 1977) to measure avoiding, accommodating, competing, compromising and collaborating. Perceived high frequency of interparental conflict was associated with lower self-esteem in females. Results replicated R. F. Hanson's (1991) finding...

Für eine rationale und demokratische Risikopolitik sind alle drei Elemente notwendig: wissenschaftliche Expertise, die Einbeziehung der legitimen Interessen der betroffenen Akteure innerhalb der Arena und die repräsentative Erhebung von sozialer Wünschbarkeit möglicher politischer Optionen durch partizipative Verfahren. Solche Verfahren müssen sich daran messen lassen, wie es ihnen gelingt, das Wissen über negative und positive Auswirkungen sozialen Handelns als Entscheidungsgrundlage zu akzeptieren, ohne es als alleiniges Entscheidungskriterium zu nutzen und gleichzeitig die sozialen und politischen Präferenzen...