611,293 Works

FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons

Jia-Yi Wei, Pei-Chi Chung, Sao-Yu Chu & Hung–Hsiang Yu
Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neurons (vPNs). Using the two-color labeling system, twin-spot MARCM, we determined the temporal birth order of each vPN type, and this characterization served as a...

FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons

Jia-Yi Wei, Pei-Chi Chung, Sao-Yu Chu & Hung–Hsiang Yu
Diverse types of neurons must be specified in the developing brain to form the functional neural circuits that are necessary for the execution of daily tasks. Here, we describe the participation of Forkhead box class O (FOXO) in cell fate specification of a small subset of Drosophila ventral olfactory projection neurons (vPNs). Using the two-color labeling system, twin-spot MARCM, we determined the temporal birth order of each vPN type, and this characterization served as a...

Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration

Lyndsay E. A. Young, Chelsea Shoben, Kyra Ricci & Daniel C. Williams
In C. elegans, neurodegeneration induced by excitotoxicity or aggregation of misfolded proteins is dependent on genes involved in calcium release from the endoplasmic reticulum. Reactive oxygen species (ROS) can also induce neurodegeneration, but the relationship between ROS-mediated neurodegeneration and calcium has not been established. We activated KillerRed in the GABA neurons of C. elegans to produce ROS that leads to functional loss and structural degeneration of these neurons and demonstrated that the severity of neurodegeneration...

Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration

Lyndsay E. A. Young, Chelsea Shoben, Kyra Ricci & Daniel C. Williams
In C. elegans, neurodegeneration induced by excitotoxicity or aggregation of misfolded proteins is dependent on genes involved in calcium release from the endoplasmic reticulum. Reactive oxygen species (ROS) can also induce neurodegeneration, but the relationship between ROS-mediated neurodegeneration and calcium has not been established. We activated KillerRed in the GABA neurons of C. elegans to produce ROS that leads to functional loss and structural degeneration of these neurons and demonstrated that the severity of neurodegeneration...

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

Yanan Wang, Tianyu Han, Mingxi Gan, Meng Guo, Caifeng Xie, Jiangbo Jin, Song Zhang, Pengcheng Wang, Jiaqing Cao & Jian-Bin Wang
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of...

A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer

Yanan Wang, Tianyu Han, Mingxi Gan, Meng Guo, Caifeng Xie, Jiangbo Jin, Song Zhang, Pengcheng Wang, Jiaqing Cao & Jian-Bin Wang
The anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase, is responsible for the transition from metaphase to anaphase and the exit from mitosis. The anaphase promoting complex subunit 10 (APC10), a subunit of the APC/C, executes a vital function in substrate recognition. However, no research has reported the connection between APC10 and cancer until now. In this study, we uncovered a novel, unprecedented role of APC10 in tumor progression, which is independent of...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C Clement, Cara A Reynolds, Bindi Patel, Laura Santambrogio, Ana M Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The negative effect of lipid challenge on autophagy inhibits T cell responses

Ignacio Guerrero-Ros, Cristina C. Clement, Cara A. Reynolds, Bindi Patel, Laura Santambrogio, Ana M. Cuervo & Fernando Macian
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here,...

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

The effects of perceived stress on hope in women with breast cancer and the role of psychological hardiness.

Abbas Abdollahi
The data is in format of SPSS. It is about the moderating role of hardiness in the link between perceived stress and hope in breast cancer patients

Ultraconserved elements resolve genus-level relationships in a major Australasian bird radiation (Aves: Meliphagidae)

Michael J. Andersen, Jenna M. McCullough, Nicholas R. Friedman, A. Townsend Peterson, Robert G. Moyle, Leo Joseph & Árpád S. Nyári
The honeyeaters are the most species-rich clade of birds east of Wallace’s Line. They occupy a wide range of habitats, from desert to rainforest, and occur throughout Australia, New Guinea, and oceanic islands across Wallacea and the Pacific. Honeyeater natural history is well characterised, but comparative studies of this group are hampered by the lack of a well-supported phylogeny. Here, we infer the first genome-scale, genus-level phylogeny of the honeyeaters using 4397 ultraconserved elements from...

Ultraconserved elements resolve genus-level relationships in a major Australasian bird radiation (Aves: Meliphagidae)

Michael J. Andersen, Jenna M. McCullough, Nicholas R. Friedman, A. Townsend Peterson, Robert G. Moyle, Leo Joseph & Árpád S. Nyári
The honeyeaters are the most species-rich clade of birds east of Wallace’s Line. They occupy a wide range of habitats, from desert to rainforest, and occur throughout Australia, New Guinea, and oceanic islands across Wallacea and the Pacific. Honeyeater natural history is well characterised, but comparative studies of this group are hampered by the lack of a well-supported phylogeny. Here, we infer the first genome-scale, genus-level phylogeny of the honeyeaters using 4397 ultraconserved elements from...

Bodega Marine Laboratory and Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Stebbins Cold Canyon Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Boyd Deep Canyon Desert Research Center

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Chickering American River Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Burns Pinon Ridge Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Kendall-Frost Mission Bay Marsh Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Hastings Natural History Reservation

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

Coal Oil Point Natural Reserve

Information Manager UCNRS
MISSION STATEMENT: The UC Natural Reserve System is a network of protected natural areas throughout California. Its 39 sites include more than 756,000 acres, making it the largest university-administered reserve system in the world. Most major state ecosystems are represented, from coastal tidepools to inland deserts, and lush wetlands to Sierra Nevada forests. The reserves also serve as a gateway to more than a million acres of public lands. Founded in 1965 to provide undisturbed...

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