650,579 Works

Booting the booters: Evaluating the effects of police interventions in the market for Denial-of-Service attacks

Ben Collier, Daniel Thomas, Richard Clayton & Alice Hutchings
Illegal booter services offer denial of service (DoS) attacks for a fee of a few tens of dollars a month. Internationally, police have implemented a range of different types of intervention aimed at those using and offering booter services, including arrests and website takedown. In order to measure the impact of these interventions we look at the usage reports that booters themselves provide and at measurements of reflected UDP DoS attacks, leveraging a five year...
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Honware: A Virtual Honeypot Framework for Capturing CPE and IoT Zero Days

Alexander Vetterl & Richard Clayton
Existing solutions are ineffective in detecting zero day exploits targeting Customer Premise Equipment (CPE) and Internet of Things (IoT) devices. We present honware, a high-interaction honeypot framework which can emulate a wide range of devices without any access to the manufacturers' hardware. Honware automatically processes a standard firmware image (as is commonly provided for updates), customises the filesystem and runs the system with a special pre-built Linux kernel. It then logs attacker traffic and records...
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Progesterone Receptor B (PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis

Carlos Valério Rocha-Junior, Michele Gomes Da Broi, Cristiana Libardi Miranda-Furtado, Paula Andrea Navarro, Rui Alberto Ferriani & Juliana Meola
Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor (PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Epigenetic changes in PGR-A and PGR-B may be related to...
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Progesterone Receptor B (PGR-B) Is Partially Methylated in Eutopic Endometrium From Infertile Women With Endometriosis

Carlos Valério Rocha-Junior, Michele Gomes Da Broi, Cristiana Libardi Miranda-Furtado, Paula Andrea Navarro, Rui Alberto Ferriani & Juliana Meola
Endometriosis is frequently related to infertility and little is known about the mechanisms underlying this association. Some studies point to an endometrial factor involved in this condition, which could compromise embryo implantation. Progesterone plays crucial role in endometrial receptivity by acting through progesterone receptor (PGR) isoforms PR-A and PR-B whose expression is epigenetically regulated by DNA methylation, in a specific promoter region for each isoform. Epigenetic changes in PGR-A and PGR-B may be related to...
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The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis

Jun-Jun Qiu, Xiao-Jing Lin, Ting-Ting Zheng, Xiao-Yan Tang, Ying Zhang & Ke-Qin Hua
Objective:The transfer of long noncoding RNAs (lncRNAs) via exosomes to modulate recipient cells represents an important mechanism for disease progression. Antisense hypoxia-inducible factor (aHIF) is a well-known angiogenesis-related lncRNA. Here, we aimed to investigate the clinical implications of aHIF and exosomal aHIF in endometriosis and the involvement of exosome-shuttled aHIF in endometriosis angiogenesis.Study Design:The distribution and expression of aHIF in ectopic, eutopic, and normal endometria was evaluated. Serum exosomal aHIF levels in patients with endometriosis...
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The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis

Jun-Jun Qiu, Xiao-Jing Lin, Ting-Ting Zheng, Xiao-Yan Tang, Ying Zhang & Ke-Qin Hua
Objective:The transfer of long noncoding RNAs (lncRNAs) via exosomes to modulate recipient cells represents an important mechanism for disease progression. Antisense hypoxia-inducible factor (aHIF) is a well-known angiogenesis-related lncRNA. Here, we aimed to investigate the clinical implications of aHIF and exosomal aHIF in endometriosis and the involvement of exosome-shuttled aHIF in endometriosis angiogenesis.Study Design:The distribution and expression of aHIF in ectopic, eutopic, and normal endometria was evaluated. Serum exosomal aHIF levels in patients with endometriosis...
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Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model

Greene Donald Royster, Justine C. Harris, Amanda Nelson, Yessenia Castro, R. Patrick Weitzel, John Tisdale, Ryan J. Heitmann, Alan H. DeCherney & Erin F. Wolff
There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+CD25+FoxP3+ Tregs from...
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Rapamycin Corrects T Regulatory Cell Depletion and Improves Embryo Implantation and Live Birth Rates in a Murine Model

Greene Donald Royster, Justine C. Harris, Amanda Nelson, Yessenia Castro, R. Patrick Weitzel, John Tisdale, Ryan J. Heitmann, Alan H. DeCherney & Erin F. Wolff
There are few treatments for patients with recurrent pregnancy loss (RPL) or recurrent implantation failure (RIF). Women with RPL and unexplained infertility have lower T regulatory cell (Treg) expression when compared to fertile controls. A murine model has been developed with depletion of regulatory T cells (DEREG) after administration of diphtheria toxin (DT), resulting in smaller litter sizes, secondary to embryo implantation failure. Numerous murine studies have shown that adoptive transfer of CD4+CD25+FoxP3+ Tregs from...
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Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring

Patrycja A. Jazwiec, Xinglin Li, Brad Matushewski, Bryan S. Richardson & Deborah M. Sloboda
Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...
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Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring

Patrycja A. Jazwiec, Xinglin Li, Brad Matushewski, Bryan S. Richardson & Deborah M. Sloboda
Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...
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Fetal Growth Restriction Is Associated With Decreased Number of Ovarian Follicles and Impaired Follicle Growth in Young Adult Guinea Pig Offspring

Patrycja A. Jazwiec, Xinglin Li, Brad Matushewski, Bryan S. Richardson & Deborah M. Sloboda
Background:The mechanisms mediating the impacts of fetal growth restriction (FGR) on follicular development are commonly studied in mouse/rat models, where ovarian development occurs largely during the early postnatal period. These models have shown that FGR is associated with premature follicle loss, early pubertal onset, and accelerated ovarian aging. Whether the same occurs in precocious species is unknown.Objective:Since guinea pig follicle development occurs in utero in a manner consistent with human ovarian development, we sought to...
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Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis

Songjuan Dai, Maobi Zhu, Rongfeng Wu, Dianchao Lin, Zhixiong Huang, Lulu Ren, Sijing Huang, Lei Cheng & Qionghua Chen
Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A4 (LXA4) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. In this study, the overexpression of COX-2 was observed in ectopic endometrium of endometriosis patients compared to the normal endometrium of controls. Lipoxin A4 efficiently suppressed IL-1β-induced COX-2 protein expression in ectopic...
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Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis

Songjuan Dai, Maobi Zhu, Rongfeng Wu, Dianchao Lin, Zhixiong Huang, Lulu Ren, Sijing Huang, Lei Cheng & Qionghua Chen
Endometriosis is an inflammation-dependent gynecologic disorder. Increased cyclooxygenase-2 (COX-2) expression plays an important role in the development and progression of endometriosis. Lipoxin A4 (LXA4) is an endogenous anti-inflammation lipid and showed inhibitory effects on the development of endometriosis; however, the mechanism remains unclear. In this study, the overexpression of COX-2 was observed in ectopic endometrium of endometriosis patients compared to the normal endometrium of controls. Lipoxin A4 efficiently suppressed IL-1β-induced COX-2 protein expression in ectopic...
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iCite Database Snapshots (NIH Open Citation Collection)

ICite, B. Ian Hutchins & George Santangelo
This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.

iCite Database Snapshots (NIH Open Citation Collection)

ICite, B. Ian Hutchins & George Santangelo
This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.

iCite Database Snapshots (NIH Open Citation Collection)

ICite, B. Ian Hutchins & George Santangelo
This is a database snapshot of the iCite database (in CSV and JSON formats). Also provided is a zipped CSV file containing just the citation links in the NIH Open Citation Collection. iCite provides bibliometrics and metadata on publications indexed in PubMed, organized into three modules:
Influence: Delivers metrics of scientific influence, field-adjusted and benchmarked to NIH publications as the baseline

Translation: Measures how Human, Animal, or Molecular/Cellular Biology-oriented each paper is; tracks and predicts citation by...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.

Über ein im Jahre 1826 gebautes Hängedach

Pavel Ferencik
Bedrich Schnirch, remarkable Czech designer, has realized more constructions of chain bridges. Already in year 1826 has been granted to him a patent of hanged roofs; in our region he has realized more constructions of this type. In year 1965 has been found in Banská Bystrica one of the known hanged roof constructions, which is in utilization till this time and is serving good to its purpose. Description of existing hanged roof in Banská Bystrica.
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This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.

Association of mutation, copy number alteration, and subtype markers with pathways

Broad Institute TCGA Genome Data Analysis Center
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GO-DaRe

Re3data.Org
The Data Repository of the H2020/TINNGO Project (http://www.tinngo.eu/) is used to store large volumes of gender-related transport data, acquired from 10 national hubs of a pan-European Gender Observatory.
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ShuTu: an Open-Source Software for Neuron Reconstruction Mouse CA3 pyramidal neuron II 100X Parts 1 - 4

Nelson Spruston, David Hunt, Dezhe Jin, Ting Zhao, Rachel Pearcy & Ching-Lung Hsu
ShuTu (Chinese for "dendrite") is a software platform for semi-automated reconstruction of neuronal morphology. It is designed for neurons stained following patch-clamp recording and biocytin filling/staining. With an additional preprocessing step, it can also handle fluorescence images from confocal stacks. Even when there is only a single neuron in the imaged volume, automated reconstruction is tricky, because of background. Thus, ShuTu was developed to facilitate a two-step process: automated reconstruction, followed by manual correction. The...
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ABoVE: Atmospheric Profiles of CO, CO2 and CH4 Concentrations from Arctic-CAP, 2017

C. SWEENEY & K. MCKAIN
This dataset provides in situ airborne measurements of atmospheric carbon monoxide (CO), carbon dioxide (CO2), methane (CH4), and water vapor concentrations, plus air temperature, barometric pressure, relative humidity, and wind speed values over Alaska and the Yukon and Northwest Territories of Canada during the Arctic Carbon Aircraft Profile (Arctic-CAP) monthly sampling campaigns from April-November 2017. Observations have been averaged to a 10-second interval and are reported with the number of samples (N) and standard deviation....
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Understanding Dyslexia Through Personalized Large-Scale Computational Models

Conrad Perry, Marco Zorzi & Johannes C. Ziegler
Learning to read is foundational for literacy development, yet many children in primary school fail to become efficient readers despite normal intelligence and schooling. This condition, referred to as developmental dyslexia, has been hypothesized to occur because of deficits in vision, attention, auditory and temporal processes, and phonology and language. Here, we used a developmentally plausible computational model of reading acquisition to investigate how the core deficits of dyslexia determined individual learning outcomes for 622...
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College students' self-esteem, conflict management style, depression and aggression

Louise Laumbach Luft
The Rosenberg Self-Esteem Inventory (Rosenberg, 1965) was used to study college students' self-esteem in relation to age at parents' separation, perceived frequency of interparental conflict, conflict management style, depression, and aggression. One hundred fifty-one undergraduate participants were administered the Thomas-Kilmann Conflict Mode Instrument (Kilmann & Thomas, 1977) to measure avoiding, accommodating, competing, compromising and collaborating. Perceived high frequency of interparental conflict was associated with lower self-esteem in females. Results replicated R. F. Hanson's (1991) finding...
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Die gesellschaftliche Erfahrung und Bewertung von Risiken : eine Ortsbestimmung

Ortwin Renn
Für eine rationale und demokratische Risikopolitik sind alle drei Elemente notwendig: wissenschaftliche Expertise, die Einbeziehung der legitimen Interessen der betroffenen Akteure innerhalb der Arena und die repräsentative Erhebung von sozialer Wünschbarkeit möglicher politischer Optionen durch partizipative Verfahren. Solche Verfahren müssen sich daran messen lassen, wie es ihnen gelingt, das Wissen über negative und positive Auswirkungen sozialen Handelns als Entscheidungsgrundlage zu akzeptieren, ohne es als alleiniges Entscheidungskriterium zu nutzen und gleichzeitig die sozialen und politischen Präferenzen...
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Registration Year

  • 2005
    1
  • 2006
    118
  • 2007
    136
  • 2008
    530
  • 2009
    703
  • 2010
    983
  • 2011
    973
  • 2012
    2,966
  • 2013
    8,349
  • 2014
    180,669
  • 2015
    46,895
  • 2016
    102,045
  • 2017
    99,246
  • 2018
    112,963
  • 2019
    93,979

Resource Types

  • Collection
    650,579

Affiliations

  • Imperial College London
    401
  • Cardiff University
    11
  • London School of Hygiene & Tropical Medicine
    4
  • German Meteorological Service
    4
  • University of Iowa
    4
  • University of Beira Interior
    4
  • Lodz University of Technology
    2
  • Lund University
    2
  • University of Cambridge
    2
  • Integrated Carbon Observation System
    2
  • Laboratoire des Sciences du Climat et de l'Environnement
    2
  • University of Trás-os-Montes and Alto Douro
    2
  • Finnish Meteorological Institute
    2
  • University of Wuppertal
    1
  • University of California, Merced
    1