63 Works

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cells overcome lipid peroxidation to sustain their metastatic colonization in the liver. Methods Orthotopic colorectal liver metastasis (CRLM) and CRC liver colonization mouse models were constructed to determine the roles of lipid peroxidation and AADAC in CRC liver colonization. The levels of...

Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy

Xiaoshuang Li, Doudou Liu, Hao Chen, Bin Zeng, Qiting Zhao, Yuhan Zhang, Yuting Chen, Jianyu Wang & H. Rosie Xing
Abstract Background Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells (CSCs) and cancer cells plays an important role in metastatic dissemination. Whether cancer stem cells can alter the metastatic properties of non-CSC cells; and whether exosomal crosstalk can mediate such interaction, have not been demonstrated in melanoma prior to this report. Results The results revealed...

Supplementary material from \"Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance\"

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different aspects of AML and link in vitro studies to clinical trials. We generated a double transgenic zebrafish that enables hoxa9 overexpression in blood cells under the draculin (drl) regulatory element and an inducible expression of meis1 through a heat shock...

Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia

Di Cui, Xilong Cui, Xiaoliang Xu, Wenjing Zhang, Yu Yu, Yingxin Gao, Chuanzhong Mei & Weiwei Zheng
Abstract The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important role in cell adhesion and movement. Recent studies have shown that it is overexpressed in prostate cancer, liver cancer, and oral squamous cell carcinoma, and is closely related to tumor progression and metastasis. This study integrated bioinformatics and functional analysis to reveal the prognosis and potential functions of TLN1 in AML....

A machine learning-based data mining in medical examination data: a biological features-based biological age prediction model

Qing Yang, Sunan Gao, Junfen Lin, Ke Lyu, Zexu Wu, Yuhao Chen, Yinwei Qiu, Yanrong Zhao, Wei Wang, Tianxiang Lin, Huiyun Pan & Ming Chen
Abstract Background Biological age (BA) has been recognized as a more accurate indicator of aging than chronological age (CA). However, the current limitations include: insufficient attention to the incompleteness of medical data for constructing BA; Lack of machine learning-based BA (ML-BA) on the Chinese population; Neglect of the influence of model overfitting degree on the stability of the association results. Methods and results Based on the medical examination data of the Chinese population (45–90 years),...

Gestational diabetes mellitus, prenatal maternal depression, and risk for postpartum depression: an Environmental influences on Child Health Outcomes (ECHO) Study

Lauren C. Shuffrey, Maristella Lucchini, Santiago Morales, Ayesha Sania, Christine Hockett, Emily Barrett, Kecia N. Carroll, Camille C. Cioffi, Dana Dabelea, Sean Deoni, Anne L. Dunlop, Arielle Deutsch, William P. Fifer, Morgan R. Firestein, Monique M. Hedderson, Melanie Jacobson, Rachel S. Kelly, Jean M. Kerver, W. Alex Mason, Hooman Mirzakhani, Thomas G. O’Connor, Leonardo Trasande, Scott Weiss, Rosalind Wright, Yeyi Zhu … & Catherine Monk
Abstract Background Prior research has demonstrated bidirectional associations between gestational diabetes mellitus (GDM) and perinatal maternal depression. However, the association between GDM, prenatal depression, and postpartum depression (PPD) has not been examined in a prospective cohort longitudinally. Methods Participants in the current analysis included 5,822 women from the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) Research Program: N = 4,606 with Neither GDM nor Prenatal Maternal Depression (Reference Category); N =...

The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy

Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang & Zongan Liang
Purpose There is limited treatment for lung squamous cell carcinoma (LUSC), so there is an urgent need to find new antitumor drugs. Materials and Methods We downloaded datasets from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases. We used GEO2R and the “limma” package to screen differentially expressed genes. We used the Cytoscape software to screen out hub genes. We screened herbs that act on hub genes on the Chinese medicine website....

Impact of the national hepatitis B immunization program in China: a modeling study

Zhixi Liu, Mengying Li, David W. Hutton, Abram L. Wagner, Ye Yao, Wenlong Zhu, Lingsheng Cao, Shenglan Tang, Jinhua Pan, Yesheng Wang, Qi Zhao, Hong Ren, Ying Wang & Weibing Wang
Abstract Background Elimination of hepatitis B virus (HBV) is a striking challenge for countries with high or moderate disease burden. Therefore, using China as a practical case to share experiences for similar countries may accelerate the achievement of the WHO 2030 target of 90% reduction in HBV-related incidence. We aim to evaluate the impact of national HBV immunization strategies in China; and the feasibility to achieve WHO 2030 targets under different scenarios. Methods We constructed...

Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture

Zhaohui Luan, Shuang Liu, Wei Wang, Kaige Xu, Shaosong Ye, Ruijue Dan, Hong Zhang, Zhenzhen Shu, Tongchuan Wang, Chaoqiang Fan, Malcolm Xing & Shiming Yang
Abstract Background Wound closure in the complex body environment places higher requirements on suture’s mechanical and biological performance. In the scenario of frequent mechanical gastric motility and extremely low pH, single functional sutures have limitations in dealing with stomach bleeding trauma where the normal healing will get deteriorated in acid. It necessitates to advance suture, which can regulate wounds, resist acid and intelligently sense stomach pH. Methods Based on fish swim bladder, a double-stranded drug-loaded...

Illumination uniformity of an LD and LED hybrid lighting system applied to plant growth

Ke Xu, Lina Zeng, Zaijin Li, Hao Chen, Zhongliang Qiao, Yi Qu, Guojun Liu & Lin Li
Aiming at developing a current plant lighting source with both the suitable illumination area and high illumination uniformity, we proposed a lighting system for plant growth based on the combination of LD and LED lighting mode. We added a triangular prism shaped base plate element to the previous array type optical structure to increase the light coupling degree and expand the illumination area in this way. Taguchi method was used in our design and experiment,...

Illumination uniformity of an LD and LED hybrid lighting system applied to plant growth

Ke Xu, Lina Zeng, Zaijin Li, Hao Chen, Zhongliang Qiao, Yi Qu, Guojun Liu & Lin Li
Aiming at developing a current plant lighting source with both the suitable illumination area and high illumination uniformity, we proposed a lighting system for plant growth based on the combination of LD and LED lighting mode. We added a triangular prism shaped base plate element to the previous array type optical structure to increase the light coupling degree and expand the illumination area in this way. Taguchi method was used in our design and experiment,...

Vascular endothelial growth factor and the risk of venous thromboembolism: a genetic correlation and two-sample Mendelian randomization study

Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Biyan Wang, Qiuyue Tian, Xiaoni Meng, Jinxia Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang & Youxin Wang
Abstract Background The relationship between vascular endothelial growth factor (VEGF) and the risk of venous thromboembolism (VTE) has always been one of the concerns in the medical field. However, the causal inferences from published observational studies on this issue may be affected by confounders or reverse causality. We performed a two-sample bidirectional Mendelian randomization (MR) to infer the associations between VEGF and VTE. Methods Summary statistics from genome-wide association studies (GWAS) for VEGF and VTE...

Chest X-ray features facilitate screening for pulmonary hypertension caused by fibrosing mediastinitis

Mingfang Zhou, Bo Li, Yaling Chen, Aqian Wang, Yining Zhu, Yu Li, Hongling Su, Jingchun Fan, Yan Zhang & Yunshan Cao
Background:Misdiagnosis and underdiagnosis of pulmonary hypertension caused by fibrosing mediastinitis (PH-FM) are considerably prevalent due to unspecific symptoms and as well as the lack of awareness of this fatal disease.Objectives:The aim of this study was to evaluate the diagnostic accuracy of the chest X-ray (CXR) for screening the patients with PH-FM from those with pulmonary hypertension (PH).Design:This was a retrospective observational cohort study.Methods:The patients with suspected PH were recruited between October 2014 and October 2020....

Non-prescribed antibiotic use for children at community levels in low- and middle-income countries: a systematic review and meta-analysis

Dumessa Edessa, Nega Assefa, Yadeta Dessie, Fekede Asefa, Girmaye Dinsa & Lemessa Oljira
Abstract Background Non-prescribed antibiotic use is an emerging risky practice around the globe. An inappropriate use involving nonprescription access is one cause of the rapid increase in antibiotic resistance. Children commonly encounter many self-limiting illnesses for which they frequently use antibiotics without prescription. However, no specific and conclusive evidence exists to inform actions against this unsafe practice. We thus aimed to estimate the pooled proportion of non-prescribed antibiotic use for children at community levels in...

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

Rongquan Sun, Zhifei Lin, Xiangyu Wang, Lu Liu, Meisi Huo, Rui Zhang, Jing Lin, Chao Xiao, Yitong Li, Wenwei Zhu, Lu Lu, Jubo Zhang & Jinhong Chen
Abstract Background Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed to investigate how colorectal cancer (CRC) cells overcome lipid peroxidation to sustain their metastatic colonization in the liver. Methods Orthotopic colorectal liver metastasis (CRLM) and CRC liver colonization mouse models were constructed to determine the roles of lipid peroxidation and AADAC in CRC liver colonization. The levels of...

Cancer-associated fibroblast-specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma

Tongyan Liu, Chencheng Han, Panqi Fang, Zhifei Ma, Xiaoxiao Wang, Hao Chen, Siwei Wang, Fanchen Meng, Cheng Wang, Erbao Zhang, Guozhang Dong, Hongyu Zhu, Wenda Yin, Jie Wang, Xianglin Zuo, Mantang Qiu, Jinke Wang, Xu Qian, Hongbing Shen, Lin Xu, Zhibin Hu & Rong Yin
Abstract Background Besides featured glucose consumption, recent studies reveal that cancer cells might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); however, the underlying mechanisms remain unclear. Methods Fibroblast-specific long noncoding RNAs were screened using RNA-seq data of our NJLCC cohort, TCGA, and CCLE datasets. The expression and package of LINC01614 into exosomes were identified using flow cytometric sorting, fluorescence in situ hybridization (FISH), and quantitative reverse transcription polymerase chain reaction (RT-PCR). The...

Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China

Chuanxi Li, Zhe Zhao, Yu Yan, Qiyong Liu, Qi Zhao & Wei Ma
Abstract Background Limited evidence is available about the association between tropical cyclones and dengue incidence. This study aimed to examine the effects of tropical cyclones on the incidence of dengue and to explore the vulnerable populations in Guangzhou, China. Methods Weekly dengue case data, tropical cyclone and meteorological data during the tropical cyclones season (June to October) from 2015 to 2019 were collected for the study. A quasi-Poisson generalized linear model combined with a distributed...

Design of a VIS-NIR superachromatic triplet with five-color correction for a broadband interferometer

Qi Lu, Yifan Ding, Wei Wang, Shijie Liu & Min Xu
In general, 𝑘 lenses with different materials can achieve at most (𝑘+1)-color correction (𝑘≥2). In this paper, a superachromat containing three lenses is designed to achieve five-color correction in the 600 - 1600 nm waveband, where the maximum chromatic focal shift is controlled within 1/100,000 of the focal length, achieving an almost unprecedented result. Conditions for lens power combination of three thin lenses in contact are firstly derived based on the Buchdahl dispersion equation, then...

Phylogenomics, plastome degradation and mycoheterotrophy evolution of Neottieae (Orchidaceae), with emphasis on the systematic position and Loess Plateau-Changbai Mountains disjunction of Diplandrorchis

Huan-Wen Peng, Lian Lian, Jun Zhang, Andrey S. Erst & Wei Wang
Abstract Background Mycoheterotrophy is a unique survival strategy adapted to dense forests and has attracted biologists’ attention for centuries. However, its evolutionary origin and related plastome degradation are poorly understood. The tribe Neottieae contains various nutrition types, i.e., autotrophy, mixotrophy, and mycoheterotrophy. Here, we present a comprehensive phylogenetic analysis of the tribe based on plastome and nuclear ITS data. We inferred the evolutionary shift of nutrition types, constructed the patterns of plastome degradation, and estimated...

The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviruses, account for 8% of the human genome, but most have lost their transcriptional abilities under physiological conditions. However, mounting evidence shows that several expressed HERVs do exert biological functions. Here, we systematically characterize physiologically expressed HERVs and examine whether they may give insight into the molecular fundamentals of human development and disease. Results We systematically identify 13,889 expressed HERVs across normal body sites and...

Identification of the origin of tumor in vein: comparison between CEUS LI-RADS v2017 and v2016 for patients at high risk

Wen-juan Tong, Mei-qing Cheng, Man-xia Lin, Hang-tong Hu, Jia-min Pan, Hui Huang, Ying Wang, Xiao-yan Xie, Ming-de Lu, Ming Kuang, Yang Huang & Wei Wang
Abstract Objectives To compare the diagnostic performance of the Contrast-Enhanced Ultrasound (CEUS) Liver Imaging Report and Data System (LI-RADS) v2016 and v2017 in identifying the origin of tumor in vein (TIV). Methods From April 2014 to December 2018, focal liver lesions (FLLs) accompanied by TIV formation in patients at high risk for hepatocellular carcinoma (HCC) were enrolled. Histologic evaluation or composite imaging reference standard were served as the reference standard. Each case was categorized according...

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Bing Lu, Lingyu Shen, Haiqiong Zhu, Ling Xi, Wei Wang & Xiaojun Ouyang
Abstract Objective Hyperhomocysteinemia (HHcy) is considered to increase the risk of sarcopenia (S) and remains controversial. In this study, we aimed to investigate the prevalence of S among older Chinese adults and explore whether homocysteine (Hcy) was independently associated with S. Methods This cross-sectional study was performed among older adults hospitalized in the Geriatric Hospital of Nanjing Medical University between June 2017 and December 2021. We measured all participants’ serum Hcy levels, hand grip strength,...

Al₂O₃-YAG:Ce/YAG composite ceramic phosphor in a transmissive configuration for high-brightness laser-driven lighting

Pengfei Sang, Le Zhang, Jian Kang, yanbin li, shiwei chen, peng yang, Bingheng Sun, Yang Li & Hao Chen
High-power, high-brightness laser lighting promotes new requirements for light-conversion materials, such as high thermal conductivity, high saturation threshold and compact encapsulation. In this paper, we designed and fabricated a novel composite structure ceramic including a 1.0×1.0 mm2 Al₂O₃-YAG:Ce ceramic and a φ=16.0 mm transparent YAG ceramic for the transmissive configuration in laser lighting. When pumped by blue laser from 0~60 W mm2, all the samples exhibited no luminous saturation phenomenon, and the 10.0 wt.%Al₂O₃-YAG:Ce/YAG composite...

Supplementary material from \"Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance\"

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different aspects of AML and link in vitro studies to clinical trials. We generated a double transgenic zebrafish that enables hoxa9 overexpression in blood cells under the draculin (drl) regulatory element and an inducible expression of meis1 through a heat shock...

Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine

Yan-Yan Chen, Jia-Qian Chen, Yu-Ping Tang, Er-Xin Shang, Qi Zhao, Jun-Bo Zou, Ding-Qiao Xu, Shi-Jun Yue, Jie Yang, Rui-Jia Fu, Gui-Sheng Zhou & Jin-Ao Duan
Abstract Background Traditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as well as the lack of systemic evaluation of pharmacology and toxicology is one major reason why TCM remains mysterious and is not accepted worldwide. Hence, we aimed to propose an integrated dose–response metabolomics strategy based on both therapeutic effects and adverse reactions to guide the TCM dosage in treatment. Methods The proposed...

Registration Year

  • 2022
    63

Resource Types

  • Collection
    63

Affiliations

  • University of Tennessee Health Science Center
    63
  • Sun Yat-sen University
    55
  • Fudan University
    55
  • Sichuan University
    53
  • Capital Medical University
    51
  • Huazhong University of Science and Technology
    47
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    47
  • Air Force Medical University
    45
  • Shanghai Jiao Tong University
    45
  • Fudan University Shanghai Cancer Center
    43