82 Works

A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Abstract Background There is an annual increase in the incidence of invasive fungal disease (IFD) of the lung worldwide, but it is always a challenge for physicians to make an early diagnosis of IFD of the lung. Computed tomography (CT) may play a certain role in the diagnosis of IFD of the lung, however, there are no specific imaging signs for differentiating IFD of lung from bacterial pneumonia (BP). Methods A total of 214 patients...

In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Introduction: Although there have been significant advances in research and treatments over the past decades, cancer remains a leading cause of morbidity and mortality, mostly due to resistance to standard therapies. Pulsed electromagnetic field (PEMF), a newly emerged therapeutic strategy, has been highly regarded as less invasive and almost safe to patients, is now a clinically accepted form to treat diseases including cancer. Breast and lung cancer are the most prevalent forms of human cancers,...

Botulinum toxin treatment for bielschowsky acquired comitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Botulinum toxin treatment for bielschowsky acquired commitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC

Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello & Floriana Morgillo
Abstract Background Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting from therapy, even in patients with high PD-L1 expression. We have previously demonstrated that the combined inhibition of MEK and PD-L1 in NSCLC patients derived three dimensional cultures exerted significant synergistic effect in terms of immune-dependent cancer cell death. However, subsequent experiments analyzing the...

Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC

Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello & Floriana Morgillo
Abstract Background Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting from therapy, even in patients with high PD-L1 expression. We have previously demonstrated that the combined inhibition of MEK and PD-L1 in NSCLC patients derived three dimensional cultures exerted significant synergistic effect in terms of immune-dependent cancer cell death. However, subsequent experiments analyzing the...

Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Abstract Background As systematically developed statements regarding possible courses of action, health system guidance (HSG) can assist with making decisions about addressing problems or achieving goals in health systems. However, there are conceptual and methodological challenges in HSG implementation due to the complexity of health-system policy-making, the diversity of available evidence and vast differences in contexts. To address these gaps, we aim to develop a theoretical framework for supporting HSG implementation as part of a...

Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

Xiaowen Zhong, Chenyang Li, Guangzong Zhao, Mengmeng Li, Shuning Chen, Yang Cao, Qi Wang, Jiangchuan Sun, Shenyin Zhu & Shufang Chang
Abstract The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)3) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic/ultrasound dual-modality imaging and therapy. The combination of photothermal/photodynamic therapy and chemotherapy induced tumor antigen exposure and release...

CEF3 is involved in membrane trafficking and essential for secondary cell wall biosynthesis and its mutation enhanced biomass enzymatic saccharification in rice

Hongrui Jiang, Yan Ren, Junyao Guo, Huijie Yang, Xiaotong Zhu, Wenhao Li, Liangzhi Tao, Yue Zhan, Qi Wang, Yuejin Wu, Binmei Liu & Yafeng Ye
Abstract Background As one of the most important staple food crops, rice produces large of agronomic biomass residues that contain lots of secondary cell walls (SCWs). Membrane trafficking plays key roles in SCWs biosynthesis, but information association membrane trafficking and SCWs formation in plants is limited. Results In this study, we report the function characterization of a rice mutant, culm easily fragile 3 (cef3), that exhibits growth retardation and fragile culm phenotype with significantly altered...

Dietary supplementation of Macleaya cordata extract and Bacillus in combination improve laying performance by regulating reproductive hormones, intestinal microbiota and barrier function of laying hens

Fei Wang, Peng Zou, Shujie Xu, Qi Wang, Yuanhao Zhou, Xiang Li, Li Tang, Baikui Wang, Qian Jin, Dongyou Yu & Weifen Li
Abstract Background This study aimed to investigate whether the combination of Macleaya cordata extract (MCE) and Bacillus could improve the laying performance and health of laying hens better. Methods A total of 360 29-week-old Jingbai laying hens were randomly divided into 4 treatments: control group (basal diet), MCE group (basal diet + MCE), Probiotics Bacillus Compound (PBC) group (basal diet + compound Bacillus), MCE + PBC group (basal diet + MCE + compound Bacillus). The...

Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

Dian Xia, Qi Liu, Wen Jiao, Longfei Peng, Qi Wang, ZhouTing Tuo & Liangkuan Bi
Abstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We constructed a model for the prediction of clinical prognosis and immunotherapy response through integrative analysis of gene expression datasets from...

Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

Dian Xia, Qi Liu, Wen Jiao, Longfei Peng, Qi Wang, ZhouTing Tuo & Liangkuan Bi
Abstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We constructed a model for the prediction of clinical prognosis and immunotherapy response through integrative analysis of gene expression datasets from...

The H2A.Z-KDM1A complex promotes tumorigenesis by localizing in the nucleus to promote SFRP1 promoter methylation in cholangiocarcinoma cells

Qi Wang, Yongqiang Qi, Fei Xiong, Da Wang, Bing Wang & Yongjun Chen
Abstract Background Intrahepatic cholangiocarcinoma (ICC), originating from the bile ducts, is the second most common primary liver malignancy, and its incidence has recently increased. H2A.Z, a highly conserved H2A variant, is emerging as a key regulatory molecule in cancer. However, its underlying mechanism of action in ICC cells remains unclear. Methods Here, we examined the expression of H2A.Z and SFRP1 in normal intrahepatic cholangiocytes, ICC cell lines, ICC tissue microarrays, and fresh specimens. The correlations...

Evolution of optical vortices in gradient media and curved spaces

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Light propagation in gradient media and curved spaces induce intriguing phenomena, such as focusing and self-imaging, thus deriving a wide range of applications. However, these systems are limited to excitations without orbital angular momentum, which may obliterate unforeseen results. Here, we demonstrate the reconstructions (or called imaging to some extent) of optical vortices in two dimensional (2D) gradient media and three-dimensional (3D) curved spaces. We present the evolution of optical vortices in two types of...

Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease

Huimin Cai, Yana Pang, Qi Wang, Wei Qin, Cuibai Wei, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei & Longfei Jia
Abstract Background Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers for Alzheimer’s disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in bulk exosomes can aid in the diagnosis of AD. Methods The plasma exosomes were collected by ultracentrifuge. Protein samples were extracted from exosomes. Cerebrospinal fluid levels of amyloid β (Aβ)42 and phosphorylated tau (P-tau)181 were...

A polarization tunable transmitted full-color display enabling switchable bright and dark states

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

Evolution of optical vortices in gradient media and curved spaces

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Light propagation in gradient media and curved spaces induce intriguing phenomena, such as focusing and self-imaging, thus deriving a wide range of applications. However, these systems are limited to excitations without orbital angular momentum, which may obliterate unforeseen results. Here, we demonstrate the reconstructions (or called imaging to some extent) of optical vortices in two dimensional (2D) gradient media and three-dimensional (3D) curved spaces. We present the evolution of optical vortices in two types of...

A diffuse reflectance portable near infrared spectroscopy system for the determination of biuret content in urea fertilizer

Jing Liu, Shaohui Yu, Shupeng Hu, Ziyang Ling, Jiguang Gao, Binmei Liu, Lixiang Yu, Yang Yang, Ye Yang, Qi Wang, Xiaoyu Ni, Liping Zhao & Yuejin Wu
Simple, rapid, and reliable determination of the biuret content in urea fertilizer is very important for the development of fertilizer industry. A near infrared diffuse reflectance measurement system with a portable spectrometer was developed, in which the reference and dark background spectrum could also be recorded automatically in addition to the absorbance data. The key performances of the proposed NIR system have been tested on urea fertilizer. Numerical experiments showed that the coefficient of determination...

A polarization tunable transmitted full-color display enabling switchable bright and dark states

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

Nanowire-in-Bowl-shaped Piezoelectric Cavity Structure for SERS Directional Detection of Nanoplastics less than 50 nm

Enze Lv, Junkun Wang, Jing Li, Xiaofei Zhao, Yu Jing, shicai xu, Zhen Li, yuan man, Mei xue & JiHua Xu
The accurate detection of nanoplastics is crucial due to their harmful effects on the environment and human beings. In this research, we successfully constructed an Ag/CuO nanowire (NW)/BaTiO3@PVDF Bowl-shaped substrate with a nanowire-in-Bowl-shaped piezoelectric cavity structure that can modulate surface-enhanced Raman scattering (SERS) by the piezoelectric effect by the virtue of the molecular gripper of the CuO NW and optical field amplifier of the Bowl-shaped cavity. Due to its unique nanowire-in-Bowl-shaped structure and piezoelectrically modifiable...

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald & Maximilian M. L. Knott
Abstract Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable due to their lack of enzymatic activity. Here, we show in the EwS model that – capitalizing on neomorphic DNA-binding preferences – the addiction to the respective fusion transcription factor EWSR1-FLI1 can be leveraged to express therapeutic genes....

Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Qi Wang, Ying Zhu, Shitong Xie, Mohammad Golam Kibria, Qiangqiang Guo, Ahmed Atef Belal, Yanfei Li, Jingyi Zhang, Yaolong Chen, Holger J. Schünemann, Michael G. Wilson, Kehu Yang & John N. Lavis
Abstract Background As systematically developed statements regarding possible courses of action, health system guidance (HSG) can assist with making decisions about addressing problems or achieving goals in health systems. However, there are conceptual and methodological challenges in HSG implementation due to the complexity of health-system policy-making, the diversity of available evidence and vast differences in contexts. To address these gaps, we aim to develop a theoretical framework for supporting HSG implementation as part of a...

Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

Hua Yao, Xupeng Mu, Zhenhong Wei, Xiuying Li, Liya Wu, Yongri Jin, Xuwen Li, Jing Li & Jinlan Jiang
Abstract Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel...

Association between healthy lifestyle and the occurrence of cardiometabolic multimorbidity in hypertensive patients: a prospective cohort study of UK Biobank

Hejian Xie, Jinchen Li, Xuanmeng Zhu, Jing Li, Jinghua Yin, Tianqi Ma, Yi Luo, Lingfang He, Yongping Bai, Guogang Zhang, Xunjie Cheng & Chuanchang Li
Abstract Background Cardiometabolic multimorbidity (CMM) is becoming increasingly common in patients with hypertension, and it is well established that healthy lifestyle plays a key role in the prevention of hypertension. However, the association between combined lifestyle factors and CMM in patients with hypertension is uncertain. Methods This prospective analysis included the data (obtained from the UK biobank) of participants with hypertension who did not have coronary heart disease (CHD), stroke, or diabetes. The outcome was...

Association between healthy lifestyle and the occurrence of cardiometabolic multimorbidity in hypertensive patients: a prospective cohort study of UK Biobank

Hejian Xie, Jinchen Li, Xuanmeng Zhu, Jing Li, Jinghua Yin, Tianqi Ma, Yi Luo, Lingfang He, Yongping Bai, Guogang Zhang, Xunjie Cheng & Chuanchang Li
Abstract Background Cardiometabolic multimorbidity (CMM) is becoming increasingly common in patients with hypertension, and it is well established that healthy lifestyle plays a key role in the prevention of hypertension. However, the association between combined lifestyle factors and CMM in patients with hypertension is uncertain. Methods This prospective analysis included the data (obtained from the UK biobank) of participants with hypertension who did not have coronary heart disease (CHD), stroke, or diabetes. The outcome was...

Registration Year

  • 2023
    14
  • 2022
    68

Resource Types

  • Collection
    82

Affiliations

  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    82
  • Sichuan University
    82
  • Fudan University
    82
  • Capital Medical University
    82
  • Nanjing University
    82
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    82
  • Guangzhou University of Chinese Medicine
    82
  • Xuzhou Medical College
    82
  • Shandong University
    80
  • Zhejiang University
    78