31 Works

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Nicolas van Larebeke, Gudrun Koppen, Sam Decraemer, Ann Colles, Liesbeth Bruckers, Elly Den Hond, Eva Govarts, Bert Morrens, Thomas Schettgen, Sylvie Remy, Dries Coertjens, Tim Nawrot, Vera Nelen, Willy Baeyens & Greet Schoeters
Abstract Background PFAS are persistent, bioaccumulative compounds repelling water, oil and stains which are widely used. There is mounting evidence linking exposure to a range of adverse health outcomes including renal, hepatic, immunotoxic, reproductive, endocrine disrupting and carcinogenic effects. PFAS possibly also induce neurobehavioral and developmental effects. Within Flanders Environment and Health Studies (FLEHS) internal exposure to PFAS and relevant health effects are assessed since 2008. Results Adolescents 14–15 y (2010–2011) living in an industrially...

Psychosocial factors related to sleep in adolescents and their willingness to participate in the development of a healthy sleep intervention: a focus group study

Ann Vandendriessche, Maïté Verloigne, Laura Boets, Jolien Joriskes, Ann DeSmet, Karlien Dhondt & Benedicte Deforche
Abstract Background Over the last decades, adolescents’ sleep has deteriorated, suggesting the need for effective healthy sleep interventions. To develop such interventions, it is important to first gather insight into the possible factors related to sleep. Moreover, previous research has indicated that chances of intervention effectivity could be increased by actively involving adolescents when developing such interventions. This study examined psychosocial factors related to sleep in adolescents and investigated adolescents’ willingness to participate in the...

Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia

Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs & Lode Godderis
Abstract Background Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening. COMT regulates nociceptive processing and inflammation, key pathophysiological features of Chronic Fatigue Syndrome and Fibromyalgia (CFS/FM). We aimed to determine the interactions between genetic and epigenetic mechanisms regulating COMT and its influence on inflammatory markers and symptoms in patients with CFS/FM. Methods. A case-control study with repeated-measures design was used to reduce the chance of false positive and...

Ultra-broadband and high-efficiency Planar Chiral Metamaterial

Shahid Hussain, Qingquan Liu, Zubaria Maroof, Ruonan Ji & Shao-Wei Wang
To date, only helix-like assemblies are known of delivering broadband and efficient optical chirality, however, as their dimensions shrink to the nanoscale, it becomes increasingly difficult to realize three-dimensional (3D) building blocks and accurate alignments. Besides, a continuous optical channel requirement hinders the downsizing for integrated photonics. Here, we introduce an alternative approach based on two assembled layers of dielectric-metal nanowires to demonstrate that chiroptic effects similar to helix-like metamaterials can be realized with an...

Level and comfort of caregiver–young adolescent communication on sexual and reproductive health: a cross-sectional survey in south-western Uganda

Cecilia Akatukwasa, Viola N. Nyakato, Dorcus Achen, Elizabeth Kemigisha, Daniel Atwine, Wendo Mlahagwa, Stella Neema, Gad Ndaruhutse Ruzaaza, Gily Coene, Godfrey Z. Rukundo & Kristien Michielsen
Abstract Background Communication on sexual and reproductive health (SRH) between caregivers and their young adolescent children plays a significant role in shaping attitudes and behaviours that are critical to laying the foundations for positive and safe SRH behaviours in later adolescence. Nevertheless, this communication is often limited, particularly in countries where adolescent sexuality is taboo. This study assessed the topics discussed (‘level’) and the comfort of caregivers with communicating with young adolescents on SRH, and...

Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Abstract Background Quantification of actinium-225 through gamma counter measurements, when there is no secular equilibrium between actinium-225 and its gamma emitting daughters bismuth-213 and/or francium-221, can provide valuable information regarding the possible relocation of recoiled daughters such that related radiotoxicity effects can be evaluated. This study proposes a multiple time-point protocol using the bismuth-213 photopeak with measurements before secular equilibrium between actinium-225 and bismuth-213, and a single time-point protocol using both the francium-221 and bismuth-213...

Incorporating ‘reason for use’ into the prescribing process of medication: a survey on the opinion of patients in Flanders, Belgium

Marijke Peeters, Elias Iturrospe, Dominique Jans, Alexander L. N. van Nuijs & Hans De Loof
Abstract Background A longstanding debate exists about including a ‘reason for use’ on prescriptions for medication. Little is known, however, about patients’ opinions on this subject. Methods An internet-based questionnaire, consisting mainly of Likert scale questions, was distributed online to the general public in Belgium. Results from 1034 responses were analyzed using descriptive statistics. Results Opinions from patients toward including a ‘reason for use’ on medication prescriptions were generally positive. A clear majority of 62%...

Consultation of parents and healthcare professionals in end-of-life decision-making for neonates and infants: a population-level mortality follow-back physician survey

Laure Dombrecht, Filip Cools, Joachim Cohen, Luc Deliens, Linde Goossens, Gunnar Naulaers, Kim Beernaert & Kenneth Chambaere
Abstract Background End-of-life decisions with potential life-shortening effect in neonates and infants are common. We aimed to evaluate how often and in what manner neonatologists consult with parents and other healthcare providers in these cases, and whether consultation is dependent on the type of end-of-life decision made. Methods Based on all deaths under the age of one that occurred between September 2016 and December 2017 in Flanders, Belgium, a nationwide mortality follow-back survey was performed....

European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

Simona Sacco, Christian Lampl, Faisal Mohammad Amin, Mark Braschinsky, Christina Deligianni, Derya Uludüz, Jan Versijpt, Anne Ducros, Raquel Gil-Gouveia, Zaza Katsarava, Paolo Martelletti, Raffaele Ornello, Bianca Raffaelli, Deirdre M. Boucherie, Patricia Pozo-Rosich, Margarita Sanchez-del-Rio, Alexandra Sinclair, Antoinette Maassen van den Brink & Uwe Reuter
Abstract Background Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body The Consensus process included a preliminary literature review, a Delphi round and...

Genetic and epigenetic regulation of Catechol-O-methyltransferase in relation to inflammation in chronic fatigue syndrome and Fibromyalgia

Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs & Lode Godderis
Abstract Background Catechol-O-methyltransferase (COMT) has been shown to influence clinical pain, descending modulation, and exercise-induced symptom worsening. COMT regulates nociceptive processing and inflammation, key pathophysiological features of Chronic Fatigue Syndrome and Fibromyalgia (CFS/FM). We aimed to determine the interactions between genetic and epigenetic mechanisms regulating COMT and its influence on inflammatory markers and symptoms in patients with CFS/FM. Methods. A case-control study with repeated-measures design was used to reduce the chance of false positive and...

Influencing factors on instrumental activities of daily living functioning in people with mild cognitive disorder – a secondary investigation of cross-sectional data

Marina Bruderer-Hofstetter, Ellen Gorus, Elise Cornelis, André Meichtry & Patricia De Vriendt
Abstract Background Finding a strategy to reduce the impact of cognitive decline on everyday functioning in persons suffering from cognitive impairment is a public health priority. Instrumental activities of daily living (IADL) are key to everyday functioning. Hence, it is essential to understand the influencing factors on IADL to develop specific interventions to improve everyday functioning in persons with mild cognitive disorder. Therefore, this study aimed to 1) explore different influencing factors on IADL functioning...

Consultation of parents and healthcare professionals in end-of-life decision-making for neonates and infants: a population-level mortality follow-back physician survey

Laure Dombrecht, Filip Cools, Joachim Cohen, Luc Deliens, Linde Goossens, Gunnar Naulaers, Kim Beernaert & Kenneth Chambaere
Abstract Background End-of-life decisions with potential life-shortening effect in neonates and infants are common. We aimed to evaluate how often and in what manner neonatologists consult with parents and other healthcare providers in these cases, and whether consultation is dependent on the type of end-of-life decision made. Methods Based on all deaths under the age of one that occurred between September 2016 and December 2017 in Flanders, Belgium, a nationwide mortality follow-back survey was performed....

Ultra-broadband and high-efficiency Planar Chiral Metamaterial

Shahid Hussain, Qingquan Liu, Zubaria Maroof, Ruonan Ji & Shao-Wei Wang
To date, only helix-like assemblies are known of delivering broadband and efficient optical chirality, however, as their dimensions shrink to the nanoscale, it becomes increasingly difficult to realize three-dimensional (3D) building blocks and accurate alignments. Besides, a continuous optical channel requirement hinders the downsizing for integrated photonics. Here, we introduce an alternative approach based on two assembled layers of dielectric-metal nanowires to demonstrate that chiroptic effects similar to helix-like metamaterials can be realized with an...

Caregiver Experiences Navigating the Diagnostic Journey in a Rapidly Progressing Dementia

Alissa Bernstein Sideman, Joni Gilissen, Krista L Harrison, Sarah B Garrett, Michael J Terranova, Christine S Ritchie & Michael D Geschwind
IntroductionPeople with suspected Alzheimer’s disease and related dementias (ADRD) and their families experience a burdensome process while seeking a diagnosis. These challenges are problematic in the most common dementia syndromes, but they can be even more distressing in rarer, atypical syndromes such as rapidly progressive dementias (RPDs), which can be fatal within months from onset. This study is an examination of the diagnostic journey experience from the perspective of caregivers of people who died from...

Researching two Compassionate Cities: study protocol for a mixed-methods process and outcome evaluation

Bert Quintiens, Tinne Smets, Kenneth Chambaere, Lieve Van Den Block, Luc Deliens & Joachim Cohen
Background/Objectives:Compassionate Cities are social ecology approaches that apply a set of actions, targeting a broad range of stakeholders, with the intention of renormalising caring, dying, loss and grieving in everyday life. While several initiatives have been described in the literature, a rigorous evaluation of their processes and outcomes is lacking. This article describes the protocol for a mixed-methods study to evaluate the development process and the outcomes of two Compassionate Cities in Flanders, Belgium.Methods and...

Blood transcriptomics to facilitate diagnosis and stratification in pediatric rheumatic diseases – a proof of concept study

My Kieu Ha, Esther Bartholomeus, Luc Van Os, Julie Dandelooy, Julie Leysen, Olivier Aerts, Vasiliki Siozopoulou, Eline De Smet, Jan Gielen, Khadija Guerti, Michel De Maeseneer, Nele Herregods, Bouchra Lechkar, Ruth Wittoek, Elke Geens, Laura Claes, Mahmoud Zaqout, Wendy Dewals, Annelies Lemay, David Tuerlinckx, David Weynants, Koen Vanlede, Gerlant van Berlaer, Marc Raes, Helene Verhelst … & Benson Ogunjimi
Abstract Background Transcriptome profiling of blood cells is an efficient tool to study the gene expression signatures of rheumatic diseases. This study aims to improve the early diagnosis of pediatric rheumatic diseases by investigating patients’ blood gene expression and applying machine learning on the transcriptome data to develop predictive models. Methods RNA sequencing was performed on whole blood collected from children with rheumatic diseases. Random Forest classification models were developed based on the transcriptome data...

Blood transcriptomics to facilitate diagnosis and stratification in pediatric rheumatic diseases – a proof of concept study

My Kieu Ha, Esther Bartholomeus, Luc Van Os, Julie Dandelooy, Julie Leysen, Olivier Aerts, Vasiliki Siozopoulou, Eline De Smet, Jan Gielen, Khadija Guerti, Michel De Maeseneer, Nele Herregods, Bouchra Lechkar, Ruth Wittoek, Elke Geens, Laura Claes, Mahmoud Zaqout, Wendy Dewals, Annelies Lemay, David Tuerlinckx, David Weynants, Koen Vanlede, Gerlant van Berlaer, Marc Raes, Helene Verhelst … & Benson Ogunjimi
Abstract Background Transcriptome profiling of blood cells is an efficient tool to study the gene expression signatures of rheumatic diseases. This study aims to improve the early diagnosis of pediatric rheumatic diseases by investigating patients’ blood gene expression and applying machine learning on the transcriptome data to develop predictive models. Methods RNA sequencing was performed on whole blood collected from children with rheumatic diseases. Random Forest classification models were developed based on the transcriptome data...

Influencing factors on instrumental activities of daily living functioning in people with mild cognitive disorder – a secondary investigation of cross-sectional data

Marina Bruderer-Hofstetter, Ellen Gorus, Elise Cornelis, André Meichtry & Patricia De Vriendt
Abstract Background Finding a strategy to reduce the impact of cognitive decline on everyday functioning in persons suffering from cognitive impairment is a public health priority. Instrumental activities of daily living (IADL) are key to everyday functioning. Hence, it is essential to understand the influencing factors on IADL to develop specific interventions to improve everyday functioning in persons with mild cognitive disorder. Therefore, this study aimed to 1) explore different influencing factors on IADL functioning...

The cultural adaptation of the go wish card game for use in Flanders, Belgium: a public health tool to identify and discuss end-of-life preferences

Charlèss Dupont, Tinne Smets, Fanny Monnet, Malin Eneslätt, Carol Tishelman & Lieve Van den Block
Abstract Background Public health tools like the Go Wish card game from the US, have been found useful to support people in reflecting on their end-of-life preferences, but a cultural adaptation is essential for their success. In the present study, we explore the necessary cultural adaptations to the Go Wish cards by applying an extensive, systematic, and community-engaging negotiating procedure to facilitate the use of the cards in the general population of Flanders, Belgium. Methods...

The cultural adaptation of the go wish card game for use in Flanders, Belgium: a public health tool to identify and discuss end-of-life preferences

Charlèss Dupont, Tinne Smets, Fanny Monnet, Malin Eneslätt, Carol Tishelman & Lieve Van den Block
Abstract Background Public health tools like the Go Wish card game from the US, have been found useful to support people in reflecting on their end-of-life preferences, but a cultural adaptation is essential for their success. In the present study, we explore the necessary cultural adaptations to the Go Wish cards by applying an extensive, systematic, and community-engaging negotiating procedure to facilitate the use of the cards in the general population of Flanders, Belgium. Methods...

European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

Simona Sacco, Christian Lampl, Faisal Mohammad Amin, Mark Braschinsky, Christina Deligianni, Derya Uludüz, Jan Versijpt, Anne Ducros, Raquel Gil-Gouveia, Zaza Katsarava, Paolo Martelletti, Raffaele Ornello, Bianca Raffaelli, Deirdre M. Boucherie, Patricia Pozo-Rosich, Margarita Sanchez-del-Rio, Alexandra Sinclair, Antoinette Maassen van den Brink & Uwe Reuter
Abstract Background Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body The Consensus process included a preliminary literature review, a Delphi round and...

Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Nicolas van Larebeke, Gudrun Koppen, Sam Decraemer, Ann Colles, Liesbeth Bruckers, Elly Den Hond, Eva Govarts, Bert Morrens, Thomas Schettgen, Sylvie Remy, Dries Coertjens, Tim Nawrot, Vera Nelen, Willy Baeyens & Greet Schoeters
Abstract Background PFAS are persistent, bioaccumulative compounds repelling water, oil and stains which are widely used. There is mounting evidence linking exposure to a range of adverse health outcomes including renal, hepatic, immunotoxic, reproductive, endocrine disrupting and carcinogenic effects. PFAS possibly also induce neurobehavioral and developmental effects. Within Flanders Environment and Health Studies (FLEHS) internal exposure to PFAS and relevant health effects are assessed since 2008. Results Adolescents 14–15 y (2010–2011) living in an industrially...

Incorporating ‘reason for use’ into the prescribing process of medication: a survey on the opinion of patients in Flanders, Belgium

Marijke Peeters, Elias Iturrospe, Dominique Jans, Alexander L. N. van Nuijs & Hans De Loof
Abstract Background A longstanding debate exists about including a ‘reason for use’ on prescriptions for medication. Little is known, however, about patients’ opinions on this subject. Methods An internet-based questionnaire, consisting mainly of Likert scale questions, was distributed online to the general public in Belgium. Results from 1034 responses were analyzed using descriptive statistics. Results Opinions from patients toward including a ‘reason for use’ on medication prescriptions were generally positive. A clear majority of 62%...

Psychosocial factors related to sleep in adolescents and their willingness to participate in the development of a healthy sleep intervention: a focus group study

Ann Vandendriessche, Maïté Verloigne, Laura Boets, Jolien Joriskes, Ann DeSmet, Karlien Dhondt & Benedicte Deforche
Abstract Background Over the last decades, adolescents’ sleep has deteriorated, suggesting the need for effective healthy sleep interventions. To develop such interventions, it is important to first gather insight into the possible factors related to sleep. Moreover, previous research has indicated that chances of intervention effectivity could be increased by actively involving adolescents when developing such interventions. This study examined psychosocial factors related to sleep in adolescents and investigated adolescents’ willingness to participate in the...

Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter

Dayana Castillo Seoane, Marijke De Saint-Hubert, Stephen Ahenkorah, Clarita Saldarriaga Vargas, Maarten Ooms, Lara Struelens & Michel Koole
Abstract Background Quantification of actinium-225 through gamma counter measurements, when there is no secular equilibrium between actinium-225 and its gamma emitting daughters bismuth-213 and/or francium-221, can provide valuable information regarding the possible relocation of recoiled daughters such that related radiotoxicity effects can be evaluated. This study proposes a multiple time-point protocol using the bismuth-213 photopeak with measurements before secular equilibrium between actinium-225 and bismuth-213, and a single time-point protocol using both the francium-221 and bismuth-213...

Registration Year

  • 2022
    31

Resource Types

  • Collection
    31

Affiliations

  • Vrije Universiteit Brussel
    31
  • Ghent University
    10
  • University of Antwerp
    8
  • Ghent University Hospital
    8
  • Universitair Ziekenhuis Brussel
    8
  • Capital Medical University
    5
  • Amsterdam UMC Location VUmc
    4
  • KU Leuven
    3
  • Charité - University Medicine Berlin
    2
  • Provincial Institute for Hygiene
    2