An ultra-sensitive sensor, based on cascaded Polydimethylsiloxane (PDMS) and capillary cavities, has been realized for simultaneous temperature and gas pressure . A PDMS-based Fabry-Perot Interferometer (FPI1) with free spectral range (FSR1) of 4.40 nm was used as a sensing cavity, the sensitivity of which to temperature and pressure is 0.65 nm/℃ and 4.64 nm/MPa, respectively. A capillary-based FPI2 with FSR2=4.24 nm was used as a reference cavity, which is insensitive to neither temperature nor pressure....

The cellular redox state is essential for inhibiting ferroptosis. Progranulin (PGRN) plays an important role in maintaining the cellular redox state after ischemic brain injury. However, the effect of PGRN on ferroptosis and its underlying mechanism after cerebral ischemia remains unclear. This study assesses whether PGRN affects ferroptosis and explores its mechanism of action on ferroptosis after cerebral ischemia. We found endogenous PGRN expression in microglia increased on day 3 after ischemia. In addition, PGRN...

Background: Emerging evidence suggests that long noncoding RNAs (lncRNAs) play an important role in the progression of multiple human cancers including breast cancer. In this study, we aimed to research novel functions of long intergenic noncoding RNA 460 (LINC00460) on cell proliferation and ferroptosis in breast cancer. Method: UALCAN, TANRIC, and GSE16446 data were used to analyze the expression of LINC00460 in breast cancer tissues. Furthermore, real-time quantitative PCR, western blot, cell proliferation assay, iron...

We propose and theoretically investigate the coupled concentric ring resonators on a thickness-constrained GaP on Insulator (GaP-OI) integrated photonic platform. Anomalous dispersion is fulfilled by mode hybridization in the coupled structure on a 200 nm thick GaP-OI resonator which originally only exhibits normal dispersion. The anomalous dispersion profile for the anti-symmetric mode is flattened and broadened in favor of Kerr frequency comb generation by optimizing the waveguide width and the coupling gap size synergistically. We...

While the ability to coordinate movements temporally with rhythmic auditory stimuli is universal, previous investigators showed that accurate rhythm reproduction depends on temporal complexity. To date, the effect of multiple pitches on the timing of rhythmic movements has been assumed. Exploring a possible sustained entrainment effect of auditory stimuli on sequential movement might further elucidate the role of temporal complexity and its interaction with multiple pitch engagement. Thus, we investigated the sustained effect of auditory...

BackgroundAcanthopanacis Cortex (AC) is a valuable Chinese medicine, which exerts beneficial effects on anti-fatigue, anti-stress, and inflammatory modulation in the periphery. However, the central nervous system (CNS) function of AC has not been clearly illustrated. As communication between the peripheral immune system and the CNS converges, it promotes a heightened neuroinflammatory environment that contributes to depression. We investigated the effect of AC against depression through neuroinflammatory modulation.MethodsNetwork pharmacology was used to screen for target compounds...

BackgroundThis meta-analysis aimed to explore the impact of red blood cell (RBC) transfusion on mortality during extracorporeal membrane oxygenation (ECMO). Previous studies investigated the prognostic impact of RBC transfusion during ECMO on the risk of mortality, but no meta-analysis has been published before.MethodsThe PubMed, Embase, and the Cochrane library were systematically searched for papers published up to 13 December 2021, using the MeSH terms “ECMO”, “‘Erythrocytes”, and “Mortality” to identify meta-analyses. Total or daily RBC...

Teacher preparation programs play an important role in preparing future special education teachers in the implementation of evidence-based interventions for students with disabilities. The purpose of this study was to examine the social validity and effects of two training strategies––video performance feedback and self-monitoring—on systematic instruction implementation of 51 pre-service special education teachers enrolled in a cross-categorical program. Systematic instruction implementation focused on two common response prompting systems––constant time delay and system of least prompts––across...

Infant neglect is a common type of child maltreatment. According to the Social Information Processing theory, maternal executive function (EF) and reflective function (RF) are assumed to be important contributing factors to infant neglect. However, empirical evidence about this assumption is sparse. This was a cross-sectional study. A total of 1010 eligible women participated. The Behavior Rating Inventory of Executive Function—Adult Version, Parental Reflective Function Questionnaire, and Signs of Neglect in Infants Assessment Scale (SIGN)...

ObjectiveNonsuicidal Self-Injury (NSSI) in China has increasingly interested clinicians, although few studies have investigated its risk and protective factors. This study examined the risk factors of NSSI among Chinese adolescents.MethodsThe researchers recruited adolescent participants with NSSI from a hospital outpatient clinic to form a case group and recruited adolescents without NSSI who provided informed consent from the school to form a control group. Participants completed a questionnaire, and data were analyzed using logistic regression.ResultsA total...

Objective:to examine the validity of a novel dyspnea scale, Edmonton Dyspnea Inventory in idiopathic pulmonary fibrosis (IPF). Methods: Edmonton Dyspnea Inventory (EDI), is a clinical instrument to measure dyspnea severity with activities of daily living, exercise and rest using a numeric rating scale (0 -10). Consecutive IPF patients (2012-2018) with baseline MRC and EDI were included. To validate EDI, psychometric analysis was conducted. Correlations between EDI, MRC and lung function were examined. Group-based trajectory modeling...

Triple-negative breast cancer (TNBC), which accounts for 10%–20% of breast cancer cases, is characterized by a higher metastasis rate, higher recurrence risk, and worse prognosis. Traditional treatments such as chemotherapy, surgery, and radiotherapy have limited therapeutic effects. Although immune checkpoint blockade (ICB) therapy represented by anti-programmed death 1 (aPD-1) antibody has made further progress in treating TNBC, its therapeutic effect is still not optimistic. Ataxia telangiectasia mutated (ATM) is a critical factor in the DNA...

Computer-generated holography offers a promising route to three-dimensional (3D) video displays. To realize a realistic-looking 3D display, the critical challenge is to create a 3D hologram that enables high-density multi-plane projection with full depth control. However, two long-existing issues in current digital holographic techniques, low axial resolution and high inter-plane crosstalk, prevent fine depth control and therefore limit the ultimate quality. Here, we report three-dimensional scattering-assisted dynamic holography (3D-SDH) that further breaks the depth-control limit...

Computer-generated holography offers a promising route to three-dimensional (3D) video displays. To realize a realistic-looking 3D display, the critical challenge is to create a 3D hologram that enables high-density multi-plane projection with full depth control. However, two long-existing issues in current digital holographic techniques, low axial resolution and high inter-plane crosstalk, prevent fine depth control and therefore limit the ultimate quality. Here, we report three-dimensional scattering-assisted dynamic holography (3D-SDH) that further breaks the depth-control limit...

Context:Postural control deficits arising from injured ankles are central to chronic ankle instability (CAI) and its persistent symptoms. This is usually measured by recording the center of pressure (CoP) trajectory during static single-leg stance using a stable force plate. However, existing studies have produced conflicting results on whether this mode of measurement adequately reveals the postural deficits in CAI.Objective:To determine whether postural control during static single-leg stance is impaired in CAI patients when compared with...

C5–C7 light hydrocarbons are important components in petroleum and are extensively employed as an auxiliary approach in petroleum research. Consensus on the mechanism of light hydrocarbon generation has not yet been achieved. In this study, 20 gas samples were collected from the western part and northern margin of the Qaidam Basin. The molecular and carbon isotopic compositions of C1–C3 gaseous hydrocarbons and C5–C7 light hydrocarbons, as well as the carbon isotopes of oils were analyzed....

Background:Underdiagnosis and undertreatment pose major barriers to optimal management of chronic obstructive pulmonary disease (COPD) in China.Objective:The REAL trial was performed to generate reliable information on real-world COPD management, outcomes and risk factors among Chinese patients. Here, we present study outcomes related to COPD management.Design:It is a 52-week, prospective, observational, multicentre study.Methods:Outpatients (aged ⩾40 years) enrolled from 50 secondary and tertiary hospitals across six geographic regions of China were followed up for 12 months, with...

Abstract Background The overall survival rate of patients with advanced ovarian cancer (OC) has remained static for several decades. Advanced ovarian cancer is known for its poor prognosis due to extensive metastasis. Epigenetic alterations contribute to tumour progression and therefore are of interest for potential therapeutic strategies. Methods Following our previous study, we identified that CHD4, a chromatin remodelling factor, plays a strong role in ovarian cancer cell metastasis. We investigated the clinical significance of...

Abstract Background Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, untreatable neurodegeneration. SSADH-D is primarily studied using simplified models, such as HEK293 cells overexpressing genes of interest, but such overexpression can result in protein aggregation or pathway saturation that may not be representative of actual underlying disease phenotypes. Methods We used a CRISPR/Cas9 approach to generate human iPSC...

Abstract Background Perioperative pain management is one of the most challenging issues for patients with spinal neoplasms. Inadequate postoperative analgesia usually leads to severe postsurgical pain, which could cause patients to suffer from many other related complications. Meanwhile, there is no appropriate analgesic strategy for patients with spinal neoplasms. Methods/design This is a protocol for a randomized double-blind controlled trial to evaluate the effect of esketamine combined with pregabalin on postsurgical pain in spinal surgery....

Abstract Background Fine-scale genetic structure of ethnolinguistically diverse Chinese populations can fill the gap in the missing diversity and evolutionary landscape of East Asians, particularly for anthropologically informed Chinese minorities. Hmong–Mien (HM) people were one of the most significant indigenous populations in South China and Southeast Asia, which were suggested to be the descendants of the ancient Yangtze rice farmers based on linguistic and archeological evidence. However, their deep population history and biological adaptative features...

Abstract Background The nature of student learning in problem-based learning (PBL) largely depends on the quality of the case scenarios presented to them. The effect of case scenarios with higher challenge degree, especially common disease with atypical symptoms (CDAS)- and rare disease (RD)-based case scenarios, on undergraduate medical students remains unclear. This study compared the impact of all scenarios pertaining to common disease with typical symptoms (CDTS) case scenarios, CDTS interspersed with CDAS case scenarios,...

Abstract Ethnopharmacological relevance Sepsis is a systemic inflammatory response syndrome caused by an infection in the body, and accompanying acute kidney injury (AKI) is a common complication of sepsis. It is associated with increased mortality and morbidity. Forsythia Fructus, the dried fruit of Forsythia suspensa (Thunb.) Vahl, is a commonly used traditional Chinese medicine. Aims of the study This study aimed to elucidate the protective effect of Forsythiaside A (FTA) on sepsis-induced AKI by downregulating...

Abstract Background Different countries have differences in social and cultural context and health system, which may affect the clinical characteristics of psychiatric inpatients. This study was the first to compare cross-cultural differences in the clinical characteristics of psychiatric inpatients in three hospitals from Western China and America. Methods Overall, 905 and 1318 patients from three hospitals, one in America and two in Western China, respectively, were included. We used a standardised protocol and data collection...

Abstract Recent studies have shown the relevance of gut microbiota in the occurrence and development of colorectal cancer (CRC), but the causal relationship remains unclear in the human population. The present study aims to assess the causal relationship from the gut microbiota to CRC and to identify specific causal microbe taxa via genome-wide association study (GWAS) summary statistics based two-sample Mendelian randomization (MR) analyses. Microbiome GWAS (MGWAS) in the TwinsUK 1,126 twin pairs was used...