Understanding the biological rhythms that influence young adult health is vital because the combination of biological changes and a circadian phase delay lead to young adults being at high risk of circadian misalignment. We have previously established a self-rating of biological rhythm disorder for adolescents (SBRDA). However, we did not externally validate the SBRDA against objective measures of biological rhythms such as dim light melatonin onset (DLMO)—the gold standard of the endogenous circadian phase. The...

We proposed polarization-sensitive second harmonic generation microscopy based on off-axis interferometry (OI-PSHG) by recording the complex-field of a wide-field SHG image and polarization measurement. Benefiting from the ability of recording the SHG signal from different positions simultaneously, the proposed method possesses higher imaging frame rate compared to raster scanning-based SHG microscopy. Molecular orientation (in terms of their symmetric axis) of tendon collagen fibril and myosin in muscle are resolved in three-dimension (3D) from a sub-set...

BoxCARS and pump-probe geometries are common implementations of two dimensional infrared (2D IR) spectroscopy. BoxCARS is background-free, generally offering greater signal to noise ratio, which enables measuring weak vibrational echo signals. Pulse shapers have been implemented in the pump probe geometry to accelerate data collection and suppress scatter and other unwanted signals by precise control of the pump pulse delay and carrier phase. Here, we introduce a 2D IR optical setup in the BoxCARS geometry...

Pulses as short as 44 fs (6 optical cycles) with a spectral width of 120 nm are generated from a mode-locked solid-state laser near 2 µm employing an orthorhombic Tm:GdScO3 perovskite crystal. The average power amounts to 188 mW at a repetition rate of ~ 77.6 MHz. The strong inhomogeneous line broadening in GdScO3 suggests optimum conditions for few-optical-cycle pulse generation of rare-earth ion doped GdScO3 bulk lasers.

This cross-sectional survey evaluated well-being and family dynamics before and during the COVID-19 pandemic in 1287 (16 + years of age, 68.3% female) Chinese participants. Structural equation modeling was used to test the association of well-being and systemic family dynamics, and related moderating factors. Results indicated some subscales of well-being and systemic family dynamics significantly worsened during the pandemic. A modified model fits well for both data before and during the pandemic in which well-being...

Optical pulling is an attractive concept due to the counterintuitive feature, the profound mechanism underneath and promising applications. In recent ten years, optical pulling of micro-nano objects have been fully demonstrated. However, optical pulling of a macroscopic object is challenging. Herein, laser pulling of a macroscopic object is presented in rarefied gas. The pulling force is originated from the Kundsen force when a gauss laser beam irradiates a macroscopic structure composed of the absorptive bulk...

We present an implantable metaverse featuring retinal prostheses in association with bionic vision processing. Unlike conventional retinal prostheses, whose electrodes are spaced equidistantly, our solution is to rearrange the electrodes to match the distribution of ganglion cells. To imitate a normal human vision, a scheme of bionic vision processing is developed. On top of a three-dimensional eye model, our bionic vision processing is able to visualize the monocular image, binocular image fusion, and parallax-induced depth...

Background:At present, simple reminiscence has been widely used in the field of neurocognitive disorders, life review/life review therapy has been widely used in the field of cancer, and both simple reminiscence and life review/life review therapy are suitable for psychological disorders such as depression and anxiety. However, the efficacy of reminiscence in treating cancer-related symptom has not been fully assessed.Objectives:To evaluate the effect of reminiscence therapy (RT) on relieving cancer-related symptoms such as anxiety and...

Background:At present, simple reminiscence has been widely used in the field of neurocognitive disorders, life review/life review therapy has been widely used in the field of cancer, and both simple reminiscence and life review/life review therapy are suitable for psychological disorders such as depression and anxiety. However, the efficacy of reminiscence in treating cancer-related symptom has not been fully assessed.Objectives:To evaluate the effect of reminiscence therapy (RT) on relieving cancer-related symptoms such as anxiety and...

Adult individuals frequently face difficulties in attracting and keeping mates, which is an important driver of singlehood. In the current research, we investigated the mating performance (i.e., how well people do in attracting and retaining intimate partners) and singlehood status in 14 different countries, namely Austria, Brazil, China, Greece, Hungary, Italy, Japan, Peru, Poland, Russia, Spain, Turkey, the UK, and Ukraine (N = 7,181). We found that poor mating performance was in high occurrence, with...

Single-molecule localization microscopy has enabled scientists to visualize cellular structures at the nanometer scale. However, researchers are facing great challenges to analyze images presented by point clouds. Existing algorithms for cluster identification are coordinate-based analyses requiring users to input cutoff thresholds based on the distance or density of the point cloud. These thresholds are often one’s best guess with repeated visual inspections, making the cluster assignment user-dependent. Here, we present a cluster identification algorithm mimicking...

BackgroundMore data is needed on the short- and medium-term efficacy and safety of the Willis covered stent in treating distal internal carotid artery (DICA) aneurysms and vertebral artery dissecting aneurysms (VADAs).MethodsRecords of all 42 patients with DICA aneurysms or VADAs treated with the Willis covered stents at our institute between July 2014 and January 2019 were retrospectively examined. The patients’ demographic information, symptoms, diagnosis, treatment procedure, immediate and follow-up clinical and angiographic outcomes were extracted.Results46...

BoxCARS and pump-probe geometries are common implementations of two dimensional infrared (2D IR) spectroscopy. BoxCARS is background-free, generally offering greater signal to noise ratio, which enables measuring weak vibrational echo signals. Pulse shapers have been implemented in the pump probe geometry to accelerate data collection and suppress scatter and other unwanted signals by precise control of the pump pulse delay and carrier phase. Here, we introduce a 2D IR optical setup in the BoxCARS geometry...

Rapid coherent Raman hyperspectral imaging shows great promise for applications in sensing, medical diagnostics and metabolism dynamic monitoring. However, the spectral acquisition speed of current multiplex CARS microscopy is generally limited by the spectrometer integration time, making it difficult to achieve the video frame rate imaging. On the other hand, as the detection speed increases, the signal-to-noise ratio (SNR) of single spectrum will decrease leading to a terrible imaging quality. In this letter, we report...

Rapid coherent Raman hyperspectral imaging shows great promise for applications in sensing, medical diagnostics and metabolism dynamic monitoring. However, the spectral acquisition speed of current multiplex CARS microscopy is generally limited by the spectrometer integration time, making it difficult to achieve the video frame rate imaging. On the other hand, as the detection speed increases, the signal-to-noise ratio (SNR) of single spectrum will decrease leading to a terrible imaging quality. In this letter, we report...

Optical pulling is an attractive concept due to the counterintuitive feature, the profound mechanism underneath and promising applications. In recent ten years, optical pulling of micro-nano objects have been fully demonstrated. However, optical pulling of a macroscopic object is challenging. Herein, laser pulling of a macroscopic object is presented in rarefied gas. The pulling force is originated from the Kundsen force when a gauss laser beam irradiates a macroscopic structure composed of the absorptive bulk...

Optical waveguide amplifiers are essential devices in integrated optical systems. Their gain bandwidths directly determine the operating wavelength of optical circuits. Due to the difficulty of developing wideband gain media, it has been a challenge to fabricate devices with broadband amplification capability, resulting in few reports on multi-band polymer waveguide amplifiers. Here, a polymer waveguide amplifier is demonstrated, which achieves loss compensation covering the whole (S+C)-band by using NaYF4:Tm,Yb@NaYF4@NaYF4:Er nanoparticles-doped SU-8 as the gain medium....

Multimode fibers (MMFs) are emerging as promising transmission media for delivering images. However, strong mode coupling inherent in MMFs induces difficulties in directly projecting two-dimensional images through MMFs. By training two subnetworks named Actor-net and Model-net synergetically, Ref. [1] alleviated this issue and demonstrated projecting images through MMFs with high fidelity. In this work, we make a step further by improving the generalization ability to greyscale images. The modified projector network contains three subnetworks, namely...

Sumatra is located at the western end of the Sunda Arc, which resulted from the subduction of the Indo-Australian Plate beneath the Eurasian Plate. In this study, we report detailed zircon U–Pb and Hf isotope data for Cenozoic igneous rocks from the entire island of Sumatra to better constrain the temporal and spatial distribution of arc magmatism. The new dataset, combined with literature information, identifies the following two magmatic stages: (1) Paleocene to Early Eocene...

Organoids, the 3D culture systems derived from stem cells, are promising models for human organs. But organoid study requires large-volume imaging with single cell resolution, which is beyond the spatial bandwidth limit of conventional optical microscopy. Herein, we propose a lensless holographic microscope empowered with a time and memory-saving algorithm. It solves the tradeoff between the imaging field of view, resolution and processing speed, and provides a practical tools for organoids’ study. We first build...

Learning-based computer-generated holography (CGH) algorithms appear as novel alternatives to generate phase-only holograms. However, most existing learning-based approaches underperform their iterative peers in terms of display quality. Here, we propose an unsupervised Fourier-inspired neural network that could generate phase-only holograms in real time and obtain high-fidelity reconstructed images. Both simulation and experiment were performed to showcase its capability. By explicitly leveraging Fourier transforms within the neural network architecture, global features of the holograms are more...

Effective manipulation of resonant mode, output power and modulation bandwidth of lasers are all of vital importance for practical application scenarios such as communication systems. We show that by breaking the parity-time (PT) symmetry, single mode operation lasing can be realized in an intrinsic multiple mode Fabry-Perot (FP) resonator. Two identical FP resonators are employed to establish a symmetric system and high output power can be achieved with lower fabrication difficulty and intracavity losses compared...

Effective manipulation of resonant mode, output power and modulation bandwidth of lasers are all of vital importance for practical application scenarios such as communication systems. We show that by breaking the parity-time (PT) symmetry, single mode operation lasing can be realized in an intrinsic multiple mode Fabry-Perot (FP) resonator. Two identical FP resonators are employed to establish a symmetric system and high output power can be achieved with lower fabrication difficulty and intracavity losses compared...

Effective manipulation of resonant mode, output power and modulation bandwidth of lasers are all of vital importance for practical application scenarios such as communication systems. We show that by breaking the parity-time (PT) symmetry, single mode operation lasing can be realized in an intrinsic multiple mode Fabry-Perot (FP) resonator. Two identical FP resonators are employed to establish a symmetric system and high output power can be achieved with lower fabrication difficulty and intracavity losses compared...

The dataset for the soil, leaf and fruit nutrient concentrations of pears in different orchards are displayed in the database. Soil data included pH, organic matter, total N, alkaline hydrolysable N, available P and available K concentrations of 3 different soil layers, 0–20 cm, 20–40 cm and 40–60 cm (named Soil 0–20 cm, Soil 20–40 cm and Soil 40–60 cm, respectively). Leaf and fruit data (named Leaf and Fruit, respectively) included N, P, K, Ca,...