10 Works

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch & Liesbet Geris
Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has emerged as a potential therapeutic strategy. Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively...

In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials

Ho-min Park, Yunseol Park, Urta Berani, Eunkyu Bang, Joris Vankerschaver, Arnout Van Messem, Wesley De Neve & Hyunjin Shim
Abstract RNA–protein interactions are crucial for diverse biological processes. In prokaryotes, RNA–protein interactions enable adaptive immunity through CRISPR-Cas systems. These defence systems utilize CRISPR RNA (crRNA) templates acquired from past infections to destroy foreign genetic elements through crRNA-mediated nuclease activities of Cas proteins. Thanks to the programmability and specificity of CRISPR-Cas systems, CRISPR-based antimicrobials have the potential to be repurposed as new types of antibiotics. Unlike traditional antibiotics, these CRISPR-based antimicrobials can be designed to...

TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens

J. Zhang, L. Sun, M.H.H. Withanage, S.M. Ganesan, M.A. Williamson, J.T. Marchesan, Y. Jiao, F.R. Teles, N. Yu, Y. Liu, D. Wu, K.L. Moss, A.K. Mangalam, E. Zeng, Y.L. Lei & S. Zhang
Recent genome-wide association studies have suggested novel risk loci associated with periodontitis, which is initiated by dysbiosis in subgingival plaque and leads to destruction of teeth-supporting structures. One such genetic locus was the tumor necrosis factor receptor–associated factor 3 interacting protein 2 (TRAF3IP2), a gene encoding the gate-keeping interleukin (IL)–17 receptor adaptor. In this study, we first determined that carriers of the lead exonic variant rs13190932 within the TRAF3IP2 locus combined with a high plaque...

TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens

J. Zhang, L. Sun, M.H.H. Withanage, S.M. Ganesan, M.A. Williamson, J.T. Marchesan, Y. Jiao, F.R. Teles, N. Yu, Y. Liu, D. Wu, K.L. Moss, A.K. Mangalam, E. Zeng, Y.L. Lei & S. Zhang
Recent genome-wide association studies have suggested novel risk loci associated with periodontitis, which is initiated by dysbiosis in subgingival plaque and leads to destruction of teeth-supporting structures. One such genetic locus was the tumor necrosis factor receptor–associated factor 3 interacting protein 2 (TRAF3IP2), a gene encoding the gate-keeping interleukin (IL)–17 receptor adaptor. In this study, we first determined that carriers of the lead exonic variant rs13190932 within the TRAF3IP2 locus combined with a high plaque...

Population dynamics and demographic history of Eurasian collared lemmings

Edana Lord, Aurelio Marangoni, Mateusz Baca, Danijela Popović, Anna V. Goropashnaya, John R. Stewart, Monika V. Knul, Pierre Noiret, Mietje Germonpré, Elodie-Laure Jimenez, Natalia I. Abramson, Sergey Vartanyan, Stefan Prost, Nickolay G. Smirnov, Elena A. Kuzmina, Remi-André Olsen, Vadim B. Fedorov & Love Dalén
Abstract Background Ancient DNA studies suggest that Late Pleistocene climatic changes had a significant effect on population dynamics in Arctic species. The Eurasian collared lemming (Dicrostonyx torquatus) is a keystone species in the Arctic ecosystem. Earlier studies have indicated that past climatic fluctuations were important drivers of past population dynamics in this species. Results Here, we analysed 59 ancient and 54 modern mitogenomes from across Eurasia, along with one modern nuclear genome. Our results suggest...

In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials

Ho-min Park, Yunseol Park, Urta Berani, Eunkyu Bang, Joris Vankerschaver, Arnout Van Messem, Wesley De Neve & Hyunjin Shim
Abstract RNA–protein interactions are crucial for diverse biological processes. In prokaryotes, RNA–protein interactions enable adaptive immunity through CRISPR-Cas systems. These defence systems utilize CRISPR RNA (crRNA) templates acquired from past infections to destroy foreign genetic elements through crRNA-mediated nuclease activities of Cas proteins. Thanks to the programmability and specificity of CRISPR-Cas systems, CRISPR-based antimicrobials have the potential to be repurposed as new types of antibiotics. Unlike traditional antibiotics, these CRISPR-based antimicrobials can be designed to...

Predictors of nursing home admission in the older population in Belgium: a longitudinal follow-up of health interview survey participants

Finaba Berete, Stefaan Demarest, Rana Charafeddine, Karin De Ridder, Johan Vanoverloop, Herman Van Oyen, Olivier Bruyère & Johan Van der Heyden
Abstract Background This study examines predictors of nursing home admission (NHA) in Belgium in order to contribute to a better planning of the future demand for nursing home (NH) services and health care resources. Methods Data derived from the Belgian 2013 health interview survey were linked at individual level with health insurance data (2012 tot 2018). Only community dwelling participants, aged ≥65 years at the time of the survey were included in this study (n...

Population dynamics and demographic history of Eurasian collared lemmings

Edana Lord, Aurelio Marangoni, Mateusz Baca, Danijela Popović, Anna V. Goropashnaya, John R. Stewart, Monika V. Knul, Pierre Noiret, Mietje Germonpré, Elodie-Laure Jimenez, Natalia I. Abramson, Sergey Vartanyan, Stefan Prost, Nickolay G. Smirnov, Elena A. Kuzmina, Remi-André Olsen, Vadim B. Fedorov & Love Dalén
Abstract Background Ancient DNA studies suggest that Late Pleistocene climatic changes had a significant effect on population dynamics in Arctic species. The Eurasian collared lemming (Dicrostonyx torquatus) is a keystone species in the Arctic ecosystem. Earlier studies have indicated that past climatic fluctuations were important drivers of past population dynamics in this species. Results Here, we analysed 59 ancient and 54 modern mitogenomes from across Eurasia, along with one modern nuclear genome. Our results suggest...

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

Raphaëlle Lesage, Mauricio N. Ferrao Blanco, Roberto Narcisi, Tim Welting, Gerjo J. V. M. van Osch & Liesbet Geris
Abstract Background Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration. Targeting this phenotypic transition has emerged as a potential therapeutic strategy. Chondrocyte phenotype maintenance and switch are controlled by an intricate network of intracellular factors, each influenced by a myriad of feedback mechanisms, making it challenging to intuitively...

Predictors of nursing home admission in the older population in Belgium: a longitudinal follow-up of health interview survey participants

Finaba Berete, Stefaan Demarest, Rana Charafeddine, Karin De Ridder, Johan Vanoverloop, Herman Van Oyen, Olivier Bruyère & Johan Van der Heyden
Abstract Background This study examines predictors of nursing home admission (NHA) in Belgium in order to contribute to a better planning of the future demand for nursing home (NH) services and health care resources. Methods Data derived from the Belgian 2013 health interview survey were linked at individual level with health insurance data (2012 tot 2018). Only community dwelling participants, aged ≥65 years at the time of the survey were included in this study (n...

Registration Year

  • 2022
    10

Resource Types

  • Collection
    10

Affiliations

  • University of Liège
    10
  • Ghent University
    4
  • South African National Biodiversity Institute
    2
  • University of Aberdeen
    2
  • Erasmus MC
    2
  • University of Alaska Fairbanks
    2
  • Natural History Museum Vienna
    2
  • Delft University of Technology
    2
  • Ural Branch of the Russian Academy of Sciences
    2
  • Veracyte (United States)
    2