109 Works

A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Abstract Background There is an annual increase in the incidence of invasive fungal disease (IFD) of the lung worldwide, but it is always a challenge for physicians to make an early diagnosis of IFD of the lung. Computed tomography (CT) may play a certain role in the diagnosis of IFD of the lung, however, there are no specific imaging signs for differentiating IFD of lung from bacterial pneumonia (BP). Methods A total of 214 patients...

In Vitro and in Vivo Study of the Effect of Osteogenic Pulsed Electromagnetic Fields on Breast and Lung Cancer Cells

Mike Y. Chen, Jing Li, Nianli Zhang, Erik I. Waldorff, James T. Ryaby, Philip Fedor, Yongsheng Jia & Yujun Wang
Introduction: Although there have been significant advances in research and treatments over the past decades, cancer remains a leading cause of morbidity and mortality, mostly due to resistance to standard therapies. Pulsed electromagnetic field (PEMF), a newly emerged therapeutic strategy, has been highly regarded as less invasive and almost safe to patients, is now a clinically accepted form to treat diseases including cancer. Breast and lung cancer are the most prevalent forms of human cancers,...

Botulinum toxin treatment for bielschowsky acquired comitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Botulinum toxin treatment for bielschowsky acquired commitant esotropia in adults

Likun Ai, Xiaoli Chen, Ruilin Guo, Jing Li, Jinghui Wang, Yi Feng, Yiqin Guo & Jianan Wang
Abstract Background Many researchers have noticed that there is an increasing trend of Bielschowsky acquired comitant esotropia (ACE) in recent years related to excessive near work, but the exact pathogenesis and treatment methods have not been reported yet. Therefore, we aimed to characterize the clinical features of this ACE in adults and to evaluate the efficacy of botulinum toxin (BTX) injections in these patients. Methods This was a prospective consecutive case series of 47 patients...

Reconsidering T component of cancer staging for T3/T4 non-small-cell lung cancer with additional nodule

Fang Wang, Hang Su, Haoran E, Likun Hou, Minglei Yang, Long Xu, Jiani Gao, Mengmeng Zhao, Junqi Wu, Jiajun Deng, Xiaofeng Xie, Yifan Zhong, Yingze Li, Tingting Wang, Chunyan Wu, Dong Xie & Chang Chen
Background:Non-small-cell lung cancer (NSCLC) with additional nodule(s) located in the same lobe or ipsilateral different lobe were designated as T3 and T4, respectively, which was merely defined by anatomical location of additional nodule(s), regardless of other prognostic factors.Methods:A total of 4711 patients with T1-4, N0-2, M0 NSCLC undergoing complete resection were identified between 2009 and 2014, including 145 patients with additional nodule(s) in the same lobe (T3-Add) and 174 patients with additional tumor nodule(s) in...

Tailoring Lithium Fluoride Interface for Dendrite-Free Lithium Anode to Prolong the Cyclic Stability of Lithium–Sulfur Pouch Cells

Li Zhang, Yu Jiao, Fan Wang, Mingjie Zhou, Yin Hu, Yichao Yan, Fei Li, Tianyu Lei, Bo Chen & Wei Chen
Abstract Lithium–sulfur (Li–S) cells have been regarded as attractive alternatives to achieve higher energy densities because of their theoretical specific energy far beyond the lithium-ion cells. However, the achieved results of Li–S cells are exaggerating the cycle performance in their pouch formats because the considerable works are based on the coin cells where flood electrolyte and endless Li supply ensure the Li metal with nature structure features, resulting in a negligible effect on cycle performance...

Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues

Emel Rothzerg, Wenyu Feng, Dezhi Song, Hengyuan Li, Qingjun Wei, Archa Fox, David Wood, Jiake Xu & Yun Liu
Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved in tumour progression, metastasis and chemoresistance. To this date, there are limited findings to suggest that paraspeckles, NEAT1 and heterogeneous nuclear ribonucleoproteins (hnRNPs) directly or indirectly play roles in osteosarcoma progression. Herein, we analysed NEAT1, paraspeckle proteins (SFPQ, PSPC1 and NONO) and hnRNP members (HNRNPK, HNRNPM,...

Single-Cell Transcriptome Analysis Reveals Paraspeckles Expression in Osteosarcoma Tissues

Emel Rothzerg, Wenyu Feng, Dezhi Song, Hengyuan Li, Qingjun Wei, Archa Fox, David Wood, Jiake Xu & Yun Liu
Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved in tumour progression, metastasis and chemoresistance. To this date, there are limited findings to suggest that paraspeckles, NEAT1 and heterogeneous nuclear ribonucleoproteins (hnRNPs) directly or indirectly play roles in osteosarcoma progression. Herein, we analysed NEAT1, paraspeckle proteins (SFPQ, PSPC1 and NONO) and hnRNP members (HNRNPK, HNRNPM,...

Multiomics analyses reveals Anaplasma phagocytophilum Ats-1 induces anti-apoptosis and energy metabolism by upregulating the respiratory chain-mPTP axis in eukaryotic mitochondria

Ruirui Li, Zhongchen Ma, Wei Zheng, Zhen Wang, Jihai Yi, Yangyang Xiao, Yong Wang & Chuangfu Chen
Abstract Background Anaplasma translocated substrate 1 (Ats-1) is an effector of type 4 secretory systems (T4SS) and the main virulence factor of Anaplasma phagocytophilum. Ats-1 is involved in the regulation of host cell biological processes, but the specific molecular mechanism of its action is unclear. Results In this study, we identified Ats-1 as involved in mitochondrial respiratory regulation of HEK293T cells by multi-omics analysis. After intracellular expression of Ats-1, adenosine triphosphate levels and the proliferation...

Expansion of a vertical effective field-of-view for an optical 360° holographic display

Jun Wang, Jie Zhou, yang wu, XiangLi Lei & Yuqi Zhang
Cylindrical holography, as a promising 360° display technology, has already attracted a lot of attention. In a previous study, an optical 360° cylindrical holography has been achieved in the visible spectrum using a planar spatial light modulator (SLM) and a 45° conical mirror. Although 360° field-of-view (FOV) is successfully achieved in the horizontal direction, in the previous study, the vertical FOV remains as small as the planar holography, and its expansion is not only necessary...

De novo mutations within metabolism networks of amino acid/protein/energy in Chinese autistic children with intellectual disability

Wen-Xiong Chen, Bin Liu, Lijie Zhou, Xiaoli Xiong, Jie Fu, Zhi-Fang Huang, Ting Tan, Mingxi Tang, Jun Wang & Ya-Ping Tang
Abstract Background Autism spectrum disorder (ASD) is often accompanied by intellectual disability (ID). Despite extensive studies, however, the genetic basis for this comorbidity is still not clear. In this study, we tried to develop an analyzing pipeline for de novo mutations and possible pathways related to ID phenotype in ASD. Whole-exome sequencing (WES) was performed to screen de novo mutations and candidate genes in 79 ASD children together with their parents (trios). The de novo...

Implementing a Canadian shared-care ADHD program in Beijing: Barriers and facilitators to consider prior to start-up

Sayna Bahraini, Alexander R. Maisonneuve, Yirong Liu, André Samson, Qian Ying, Fei Li, Li Yang & Philippe Robaey
Abstract Background The shared care pathway for ADHD is a program developed in Canada with two main strategies: (a) implement a shared care pathway between general practitioners (GPs) and specialists, and (b) step up or down care so that the patient is treated at the most appropriate level of care, depending on the complexity or outcome of their illness. The current study aims to identify the challenges and facilitators of implementing this program in a...

B3GALT4 remodels the tumor microenvironment through GD2-mediated lipid raft formation and the c-met/AKT/mTOR/IRF-1 axis in neuroblastoma

Yong-Liang Sha, Yun Liu, Jia-Xing Yang, Yang-Yang Wang, Bao-Cheng Gong, Yan Jin, Tong-Yuan Qu, Fan-Tong Xia, Lei Han & Qiang Zhao
Abstract Background Beta-1,3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory role in tumor biology. However, the role of B3GALT4 in modulating the tumor microenvironment (TME) of neuroblastoma (NB) remains unknown. Methods Public datasets and clinical NB samples were collected to evaluate the expression and clinical significance of GD2 and B3GALT4 in NB patients. CCK-8, colony formation, and transwell assays and experiments in tumor-bearing mouse models were conducted to investigate the function of B3GALT4. Flow cytometry, ELISA, immunohistochemistry,...

NeRD: a multichannel neural network to predict cellular response of drugs by integrating multidimensional data

Xiaoxiao Cheng, Chong Dai, Yuqi Wen, Xiaoqi Wang, Xiaochen Bo, Song He & Shaoliang Peng
Abstract Background Considering the heterogeneity of tumors, it is a key issue in precision medicine to predict the drug response of each individual. The accumulation of various types of drug informatics and multi-omics data facilitates the development of efficient models for drug response prediction. However, the selection of high-quality data sources and the design of suitable methods remain a challenge. Methods In this paper, we design NeRD, a multidimensional data integration model based on the...

Significant performance enhancement of UV-Vis self-powered CsPbBr3 quantum dot-based photodetectors induced by ligand modification and P3HT embedding

Meng Wang, Dehai Liang, Wen Ma, Qionghua Mo, Zhigang Zang, Qingkai Qian & wensi cai
In this work, we report a novel strategy in improving the performance of UV-Vis self-powered CsPbBr₃ quantum dots (QDs) photodetectors (PDs) by ligand modification and P3HT embedding. Compared with those based on pure QDs, modified PDs show a shorten of response time by nearly 10 times, and an increase of maximum responsivity and specific detectivity for nearly 45 and 97 times, respectively. Such PDs also show a high stability with 90% of the initial photocurrent...

Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence

Qing Ma, Hui Wang, Edmund T. Rolls, Shitong Xiang, Jiong Li, Yuzhu Li, Qiongjie Zhou, Wei Cheng & Fei Li
Abstract Background Gestational age (GA) is associated with later cognition and behavior. However, it is unclear how specific cognitive domains and brain structural development varies with the stepwise change of gestational duration. Methods This large-scale longitudinal cohort study analyzed 11,878 early adolescents’ brain volume maps at 9–10 years (baseline) and 5685 at 11–12 years (a 2-year follow-up) from the Adolescent Brain Cognitive Development (ABCD) study. According to gestational age, adolescents were divided into five categorical...

Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses

Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C. Johnson, Bjorn Bakker, Diana C. J. Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A. Boemo, Floris Foijer & Sarah E. McClelland
Abstract Background A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication. How replication stress and genomic instability are connected is not known. Aphidicolin-induced replication stress induces breakages at common fragile sites, but the exact causes of fragility are debated, and acute genomic consequences of replication stress are not fully explored. Results We characterize DNA copy number alterations (CNAs) in single, diploid non-transformed cells, caused by one cell...

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Mingke Li, Yawei Dai, Shuai Hu, Yansong Li, Dasheng Lu, Rui Zheng & Kai Wang
IntroductionBleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established. This study aimed at determining the association between blood calcium levels and perioperative hemorrhage after heart valve replacement therapy.MethodsBased on preoperative blood calcium levels, patients were grouped into the hypocalcemia...

Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang & Liang Tao
Abstract Background Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been increasingly identified to be associated with tumorigenic processes of CRC. Identifying epigenetically dysregulated lncRNAs and characterizing their effects during carcinogenesis are focuses of cancer research. Methods Differentially methylated loci and expressed lncRNAs were identified by integrating DNA methylome and transcriptome analyses using The Cancer Genome Atlas database. Bisulfite sequencing...

Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang & Liang Tao
Abstract Background Aberrant DNA methylation is an epigenetic marker that has been linked to the pathogenesis of colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) have been increasingly identified to be associated with tumorigenic processes of CRC. Identifying epigenetically dysregulated lncRNAs and characterizing their effects during carcinogenesis are focuses of cancer research. Methods Differentially methylated loci and expressed lncRNAs were identified by integrating DNA methylome and transcriptome analyses using The Cancer Genome Atlas database. Bisulfite sequencing...

Layer-dependent excitonic valley polarization properties in MoS2-WS2 heterostructures

Shaofei Li, Haihong Zheng, Biao Wu, Junnan Ding, jun He, Liu Zongwen & Yanping Liu
Layered transition metal dichalcogenides (TMDCs) pave the way for fundamental research on atomically thin materials and optoelectronic devices. Due to their intrinsic 2D nature, few-layer TMDCs heterostructures exhibit several unique physical properties that are extremely sensitive to the number of layers. However, studies on the effects of interlayer coupling on excitons and valley polarization are still insufficient. Here, we investigate the polarization of the excitonics valley in MoS2-WS2 heterostructures using circular polarization-resolved photoluminescence. The valley...

Global Phase Diagram of Bound States in the Continuum

Peng Hu, Jiajun Wang, Qiao Jiang, Jun Wang, Lei Shi, Dezhuan Han, Zhao-Qing Zhang, Che Ting Chan & Jian Zi
A global phase diagram of bound states in the continuum (BICs) in photonic-crystal slabs is obtained based on a universal classification of BICs by their different Friedrich-Wintgen origins. Previously, BICs in photonic-crystal slabs are classified into three types: single-resonance parametric, symmetry-protected and Friedrich-Wintgen BICs. Here, we show that the single-resonance parametric BICs come from the coupling between the guided resonance (GR) and Fabry-Pérot (FP) modes, and the symmetry-protected BICs from the coupling between two degenerate...

Evolution of optical vortices in gradient media and curved spaces

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Light propagation in gradient media and curved spaces induce intriguing phenomena, such as focusing and self-imaging, thus deriving a wide range of applications. However, these systems are limited to excitations without orbital angular momentum, which may obliterate unforeseen results. Here, we demonstrate the reconstructions (or called imaging to some extent) of optical vortices in two dimensional (2D) gradient media and three-dimensional (3D) curved spaces. We present the evolution of optical vortices in two types of...

Correlation Monitoring Method and model of Science-Technology-Industry in the AI Field: A Case of the Neural Network

Xiaoli Wang, Yun Liu, Lingdi Chen & Yifan Zhang
This article aims to analyze the correlation status and development trend among science, technology and industry in the Artificial Intelligence (AI) subfield. First, it constructs the classification system and retrieval strategy for the AI subfield, and performs data cleaning and data finishing. Second, it designs the criteria and judgment method of the Industry Development Stages (IDS) in the AI subfield with the Delphi survey method. Third, it designs the monitoring method and model of the...

Evolution of optical vortices in gradient media and curved spaces

Yuhang Yin, Qilin Duan, Jing Li, Chengwei Qiu & Huanyang Chen
Light propagation in gradient media and curved spaces induce intriguing phenomena, such as focusing and self-imaging, thus deriving a wide range of applications. However, these systems are limited to excitations without orbital angular momentum, which may obliterate unforeseen results. Here, we demonstrate the reconstructions (or called imaging to some extent) of optical vortices in two dimensional (2D) gradient media and three-dimensional (3D) curved spaces. We present the evolution of optical vortices in two types of...

Registration Year

  • 2023
    9
  • 2022
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  • Beijing University of Chemical Technology
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  • Shanghai Jiao Tong University
    92
  • Zhejiang University
    86
  • Southern Medical University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Fudan University
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  • First Affiliated Hospital of Zhengzhou University
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  • Chinese Academy of Sciences
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  • Capital Medical University
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  • Shandong University
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