Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based...

Abstract Background The cultivated Camellia sasanqua forms a divergent double flower pattern, and the stamen petaloid is a vital factor in the phenomenon. However, the regulation mechanism remains largely unclear. Results Here, a comprehensive comparative transcriptome analysis of the wild-type, “semi-double”, “peony double”, and “rose double” was performed. The cluster analysis of global gene expression level showed petal and stamen difficulty separable in double flower. The crucial pathway and genes related to double flower patterns...

Detection of virus-like particles quantitively under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such...

Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based...

Although service customization is widely adopted in the tourism industry to cater to the heterogeneous needs of customers, the high interaction in customization often results in a value decrease for the service provider and tourists (i.e., value codestruction). However, the literature has not fully explored the restoration process when value codestruction occurs during the consumption stage of customized tourism. Based on conservation of resources theory, this study identified a systematic value restoration framework by investigating...

Although service customization is widely adopted in the tourism industry to cater to the heterogeneous needs of customers, the high interaction in customization often results in a value decrease for the service provider and tourists (i.e., value codestruction). However, the literature has not fully explored the restoration process when value codestruction occurs during the consumption stage of customized tourism. Based on conservation of resources theory, this study identified a systematic value restoration framework by investigating...

Abstract Background Circular RNA (circRNA) is a type of stable non-coding RNA that modifies macrophage inflammation by sponging micro RNAs (miRNAs), binding to RNA-binding proteins, and undergoing translation into peptides. Activated M1 phenotype macrophages secrete matrix metalloproteinases to participate in softening of the cervix uteri to promote vaginal delivery. Methods In this study, the premature rupture of membranes (PROM) mouse model was used to analyze the role of macrophages in this process. Profiling of circRNAs...

Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation,...

Detection of virus-like particles quantitively under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such...

Detection of virus-like particles quantitively under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Abstract Background Circular RNA (circRNA) is a type of stable non-coding RNA that modifies macrophage inflammation by sponging micro RNAs (miRNAs), binding to RNA-binding proteins, and undergoing translation into peptides. Activated M1 phenotype macrophages secrete matrix metalloproteinases to participate in softening of the cervix uteri to promote vaginal delivery. Methods In this study, the premature rupture of membranes (PROM) mouse model was used to analyze the role of macrophages in this process. Profiling of circRNAs...

Abstract Background The cultivated Camellia sasanqua forms a divergent double flower pattern, and the stamen petaloid is a vital factor in the phenomenon. However, the regulation mechanism remains largely unclear. Results Here, a comprehensive comparative transcriptome analysis of the wild-type, “semi-double”, “peony double”, and “rose double” was performed. The cluster analysis of global gene expression level showed petal and stamen difficulty separable in double flower. The crucial pathway and genes related to double flower patterns...

At present, the traction force and traction speed of the drilling robot cannot be controlled. However, if the speed of the drilling robot is too high, the bit will be damaged because of the shock load. If the speed of the drilling robot is too low, the drilling efficiency will be very low. The existing control system and control algorithm of the drilling robot cannot meet the requirements of the drilling conditions. A control system...

At present, the traction force and traction speed of the drilling robot cannot be controlled. However, if the speed of the drilling robot is too high, the bit will be damaged because of the shock load. If the speed of the drilling robot is too low, the drilling efficiency will be very low. The existing control system and control algorithm of the drilling robot cannot meet the requirements of the drilling conditions. A control system...

ObjectiveTo establish a predictive model for poor prognosis after incomplete revascularization (ICR) in patients with multivessel coronary artery disease (MVD).MethodsClinical data of 757 patients with MVD and ICR after percutaneous coronary intervention (PCI) in the Affiliated Hospital of Chengde Medical University from January 2020 to August 2021 were retrospectively collected. The least absolute shrinkage and selection operator regression method was used to screen variables, and multivariate logistic regression was used to establish a predictive model....

As customer ratings have become ubiquitous and digital platforms can directly request ratings and tips from customers, it is important to understand how a customer rating influences tipping. The authors investigate whether, how, why, and when the order of rating and tipping affects both consumer behaviors in seven studies, including one quasi-field experiment, one archival data analysis, one randomized field experiment, and four randomized lab experiments. They show that asking customers to rate a service...

As customer ratings have become ubiquitous and digital platforms can directly request ratings and tips from customers, it is important to understand how a customer rating influences tipping. The authors investigate whether, how, why, and when the order of rating and tipping affects both consumer behaviors in seven studies, including one quasi-field experiment, one archival data analysis, one randomized field experiment, and four randomized lab experiments. They show that asking customers to rate a service...

Abstract Background The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation,...

ObjectiveTo establish a predictive model for poor prognosis after incomplete revascularization (ICR) in patients with multivessel coronary artery disease (MVD).MethodsClinical data of 757 patients with MVD and ICR after percutaneous coronary intervention (PCI) in the Affiliated Hospital of Chengde Medical University from January 2020 to August 2021 were retrospectively collected. The least absolute shrinkage and selection operator regression method was used to screen variables, and multivariate logistic regression was used to establish a predictive model....