4 Works

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

Minimization and optimization of α-amylase terminator for heterologous protein production in Bacillus licheniformis

Yi Rao, Jingyao Yang, Jiaqi Wang, Xinyuan Yang, Mengxi Zhang, Yangyang Zhan, Xin Ma, Dongbo Cai, Zhangqian Wang & Shouwen Chen
Abstract Terminators serve as the regulatory role in gene transcription termination; however, few researches about terminator optimization have been conducted, which leads to the lack of available and universal terminator for gene expression regulation in Bacillus. To solve this problem and expand synthetic biology toolbox of Bacillus licheniformis, the terminator T1 of endogenous α-amylase gene (amyL) was characterized in this research, with a termination efficiency of 87.81%. Then, we explored and optimized the termination strength...

Minimization and optimization of α-amylase terminator for heterologous protein production in Bacillus licheniformis

Yi Rao, Jingyao Yang, Jiaqi Wang, Xinyuan Yang, Mengxi Zhang, Yangyang Zhan, Xin Ma, Dongbo Cai, Zhangqian Wang & Shouwen Chen
Abstract Terminators serve as the regulatory role in gene transcription termination; however, few researches about terminator optimization have been conducted, which leads to the lack of available and universal terminator for gene expression regulation in Bacillus. To solve this problem and expand synthetic biology toolbox of Bacillus licheniformis, the terminator T1 of endogenous α-amylase gene (amyL) was characterized in this research, with a termination efficiency of 87.81%. Then, we explored and optimized the termination strength...

Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults

Kaare M. Gautvik, Ole K. Olstad, Ulrika Raue, Vigdis T. Gautvik, Karl J. Kvernevik, Tor P. Utheim, Solveig Ravnum, Camilla Kirkegaard, Håvard Wiig, Garan Jones, Luke C. Pilling, Scott Trappe, Truls Raastad & Sjur Reppe
Abstract Background A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied. Methods Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12–13 weeks heavy-load strength exercise using Affymetrix microarrays....

Registration Year

  • 2022
    4

Resource Types

  • Collection
    4

Affiliations

  • Ball State University
    4
  • Changchun Normal University
    2
  • Stanford University
    2
  • Oslo University Hospital
    2
  • Jilin University
    2
  • Sørlandet Hospital Arendal
    2
  • Northeast Electric Power University
    2
  • Sichuan University
    2
  • Affiliated Hospital of Xuzhou Medical College
    2
  • Fudan University
    2