1,739 Works

Effectiveness of Continuous Positive Airway Pressure Versus Mandibular Advancement Device in Severe Obstructive Sleep Apnea Patients With Mandibular Retrognathia: A Prospective Clinical Trial

Haichun Lai, Wei Huang, Wei Chen & Desheng Wang
Aim:Some obstructive sleep apnea (OSA) patients may have mandibular retrognathia (ANB > 4.7° and SNB < 76.2°). Currently, there are no studies that have compared the effectiveness of continuous positive airway pressure (CPAP) versus mandibular advancement device (MAD) in severe OSA patients with mandibular retrognathia. We explored the efficacy of CPAP versus MAD for the treatment of severe OSA patients with mandibular retrognathia.Methods:A total of 105 patients were enrolled. Outcomes were assessed by using polysomnography,...

Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Fangyuan Li, Hua Lu, Xinxin Wang, Qi Zhang, Qianchen Liu & Tong Wang
Abstract Background Thin endometrium negatively impacts the reproductive function. Current treatments for thin endometrium do not always improve endometrial receptivity. Preliminary evidence suggests that electroacupuncture could have potential therapy for thin endometrium in infertile women. Thus, this randomized controlled trial was designed to test whether electroacupuncture can improve endometrial receptivity in infertile women with thin endometrium. Methods This study is a randomized, single-blinded, controlled, clinical trial. A total of 142 eligible patients will be recruited...

Identification of molecular subtypes based on inflammatory response in lower-grade glioma

Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong & Jiade J. Lu
Abstract Background Inflammatory response is an important characteristic affecting prognosis and therapeutic response in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory response are still under exploitation. Methods The RNA sequencing, somatic mutation, and corresponding clinical data from 1205 LGG patients were obtained from the TCGA, CGGA, and Rembrandt cohorts. Consensus clustering was performed to identify molecular subtypes associated with inflammation. Prognosis, clinicopathologic features, immune cell infiltration, and somatic mutation profile were compared...

Mucosal-associated invariant T cells predict increased acute graft-versus-host-disease incidence in patients receiving allogeneic hematopoietic stem cell transplantation

Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han & Sizhou Feng
Abstract Background Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) development. However, the role of donor MAIT cells on aGVHD development and subsequent functional change still remain unclear. Methods The study recruited 86 patients with hematological malignancies who underwent allogeneic hematopoietic cell transplantation (HCT) from May 1, 2018 to June 30, 2019. MAIT cells, their subset,...

Transcriptome analysis reveals the roles of phytohormone signaling in tea plant (Camellia sinensis L.) flower development

Xiaohan Xu, Jing Tao, Anqi Xing, Zichen Wu, Yuqin Xu, Yi Sun, Jiangyuan Zhu, Xiang Dai & Yuhua Wang
Abstract Background Tea plant (Camellia sinensis (L.) O. Kuntze) is an important economic tea crop, but flowering will consume a lot of nutrients of C. sinensis, which will seriously affect the nutritional growth of C. sinensis. However, there are few studies on the development mechanism of C. sinensis flower, and most studies focus on a single C. sinensis cultivar. Results Here, we identified a 92-genes’ C. sinensis flower development core transcriptome from the transcriptome of...

Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy

Jingui Hu, Tao Liu, Fei Fu, Zekun Cui, Qiong Lai, Yuanyuan Zhang, Boyang Yu, Fuming Liu, Junping Kou & Fang Li
Abstract Background Adipose tissue-derived adipokines are involved in various crosstalk between adipose tissue and other organs. Omentin1, a novel adipokine, exerts vital roles in the maintenance of body metabolism, insulin resistance and the like. However, the protective effect of omentin1 in myocardial ischemia (MI)-induced heart failure (HF) and its specific mechanism remains unclear and to be elucidated. Methods The model of MI-induced HF mice and oxygen glucose deprivation (OGD)-injured cardiomyocytes were performed. Mice with overexpression...

Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation

Dongting Yao, Jiuru Zhao, Qianqian Zhang, Tao Wang, Meng Ni, Sudong Qi, Qianwen Shen, Wei Li, Baihe Li, Xiya Ding & Zhiwei Liu
Abstract Background Intrauterine inflammation (IUI) alters epigenetic modifications in offspring, leading to lung injury. However, the epigenetic mechanism underlying IUI-induced lung injury remains uncertain. In the present study, we aim to investigate the effect of IUI on lung development, and to identify the key molecule involved in this process and its epigenetic regulatory mechanism. Results Serpine1 was upregulated in the lung tissue of neonatal mice with IUI. Intranasal delivery of Serpine1 siRNA markedly reversed IUI-induced...

Microfracture Augmentation With Direct In Situ Radial Shockwave Stimulation With Appropriate Energy Has Comparable Repair Performance With Tissue Engineering in the Porcine Osteochondral Defect Model

Zhidong Zhao, Ji Li, Xiaowei Bai, Yuxing Wang, Qi Wang, Ningyu Lv, Huayi Gao, Zheng Guo, Heng Zhu, Quanyi Guo & Zhongli Li
Background:The first-line clinical strategy for small cartilage/osteochondral defects is microfracture (MF). However, its repair efficacy needs improvement.Hypothesis:Appropriate energy radial shockwave stimulation in MF holes would greatly improve repair efficacy in the porcine osteochondral defect model, and it may obtain comparable performance with common tissue engineering techniques.Study Design:Controlled laboratory study.Methods:Osteochondral defect models (8-mm diameter, 3-mm depth) were established in the weightbearing area of Bama pigs’ medial femoral condyles. In total, 25 minipigs were randomly divided into...

Microfracture Augmentation With Direct In Situ Radial Shockwave Stimulation With Appropriate Energy Has Comparable Repair Performance With Tissue Engineering in the Porcine Osteochondral Defect Model

Zhidong Zhao, Ji Li, Xiaowei Bai, Yuxing Wang, Qi Wang, Ningyu Lv, Huayi Gao, Zheng Guo, Heng Zhu, Quanyi Guo & Zhongli Li
Background:The first-line clinical strategy for small cartilage/osteochondral defects is microfracture (MF). However, its repair efficacy needs improvement.Hypothesis:Appropriate energy radial shockwave stimulation in MF holes would greatly improve repair efficacy in the porcine osteochondral defect model, and it may obtain comparable performance with common tissue engineering techniques.Study Design:Controlled laboratory study.Methods:Osteochondral defect models (8-mm diameter, 3-mm depth) were established in the weightbearing area of Bama pigs’ medial femoral condyles. In total, 25 minipigs were randomly divided into...

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Abstract Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In the present study, we screened for the expression of oxidative stress-responsive miRNAs in the development of DCM. Furthermore, we aimed to explore the mechanism and therapeutic potential of miR-92a-2-5p in preventing diabetes-induced myocardial damage. Methods...

Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy

Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo & Guokun Wang
Abstract Background Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In the present study, we screened for the expression of oxidative stress-responsive miRNAs in the development of DCM. Furthermore, we aimed to explore the mechanism and therapeutic potential of miR-92a-2-5p in preventing diabetes-induced myocardial damage. Methods...

Whole-exome sequencing analysis identifies distinct mutational profile and novel prognostic biomarkers in primary gastrointestinal diffuse large B-cell lymphoma

Shan-Shan Li, Xiao-Hui Zhai, Hai-Ling Liu, Ting-Zhi Liu, Tai-Yuan Cao, Dong-Mei Chen, Le-Xin Xiao, Xiao-Qin Gan, Ke Cheng, Wan-Jia Hong, Yan Huang, Yi-Fan Lian & Jian Xiao
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma, and about 10% of DLBCL cases primarily occur in the gastrointestinal tract. Previous reports have revealed that primary gastrointestinal-DLBCL (pGI-DLBCL) harbors different genetic mutations from other nodal or extranodal DLBCL. However, the exonic mutation profile of pGI-DLBCL has not been fully addressed. Methods We performed whole-exome sequencing of matched tumor tissues and blood samples from 53 pGI-DLBCL patients. The exonic mutation...

Supplementary material from \"Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance\"

Wei Wang, Hongji Li, Mengling Huang, Xue Wang, Wei Li, Xiaoqing Qian & Lili Jing
HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different aspects of AML and link in vitro studies to clinical trials. We generated a double transgenic zebrafish that enables hoxa9 overexpression in blood cells under the draculin (drl) regulatory element and an inducible expression of meis1 through a heat shock...

Implantation of adipose-derived mesenchymal stem cell sheets promotes axonal regeneration and restores bladder function after spinal cord injury

Jiasheng Chen, Lin Wang, Meng Liu, Guo Gao, Weixin Zhao, Qiang Fu & Ying Wang
Abstract Background Cell-based therapy using adipose-derived mesenchymal stem cells (ADSCs) is a promising treatment strategy for neurogenic bladder (NB) associated with spinal cord injury (SCI). However, therapeutic efficacy is low because of inefficient cell delivery. Cell sheets improve the efficacy of cell transplantation. Therefore, this study was conducted to investigate the therapeutic efficacy of transplanting ADSC sheets into an SCI rat model and focused on the function and pathological changes of the bladder. Methods ADSC...

Dynamic 3D measurement based on orthogonal fringe projection and geometric constraints

Qingkang Bao, Jian Li, Xufeng Li, Tianyu Zhang, Hong Zhao & Chunwei Zhang
Geometric constraint algorithms can solve phase ambiguity for fringe projection profilometry. However, they either require multiple cameras or suffer from a small measurement depth range. To overcome these limitations, this letter proposes an algorithm combining orthogonal fringe projection and geometric constraints. A novel scheme is developed to assess the reliabilities of the potential homologous points, which works with depth segmentation to determine the final homologous points. With full consideration of lens distortions, the algorithm reconstructs...

CEF3 is involved in membrane trafficking and essential for secondary cell wall biosynthesis and its mutation enhanced biomass enzymatic saccharification in rice

Hongrui Jiang, Yan Ren, Junyao Guo, Huijie Yang, Xiaotong Zhu, Wenhao Li, Liangzhi Tao, Yue Zhan, Qi Wang, Yuejin Wu, Binmei Liu & Yafeng Ye
Abstract Background As one of the most important staple food crops, rice produces large of agronomic biomass residues that contain lots of secondary cell walls (SCWs). Membrane trafficking plays key roles in SCWs biosynthesis, but information association membrane trafficking and SCWs formation in plants is limited. Results In this study, we report the function characterization of a rice mutant, culm easily fragile 3 (cef3), that exhibits growth retardation and fragile culm phenotype with significantly altered...

Highly sensitive terahertz sensing with 3D-printed metasurfaces empowered by a toroidal dipole

Wei Yin, zhonglei shen, Yuqing Cui, Huibo Hao, Hao Zhang, Shengnan Li, Feng Gao, Shuting Fan, Liuyang Zhang & xuefeng chen
Label-free terahertz (THz) sensing with metasurfaces has attracted considerable attention in recent years, however, ultrahigh sensing sensitivity remains to be a huge challenge for practical applications. To improve the sensitivity of these devices, herein we have proposed an out-of-plane metasurface-assisted THz sensor consisting of periodically arranged bar-like meta-atoms. Benefiting from elaborate out-of-plane structures, the proposed THz sensor with high sensing sensitivity of 325 GHz/RIU can be easily fabricated via a simple three-step fabrication process. And,...

MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning

Chang Li, Degui Zhi, Kai Wang & Xiaoming Liu
Abstract Multiple computational approaches have been developed to improve our understanding of genetic variants. However, their ability to identify rare pathogenic variants from rare benign ones is still lacking. Using context annotations and deep learning methods, we present pathogenicity prediction models, MetaRNN and MetaRNN-indel, to help identify and prioritize rare nonsynonymous single nucleotide variants (nsSNVs) and non-frameshift insertion/deletions (nfINDELs). We use independent test sets to demonstrate that these new models outperform state-of-the-art competitors and achieve...

Pivotal interplays between fecal metabolome and gut microbiome reveal functional signatures in cerebral ischemic stroke

Lanlan Zhao, Cheng Wang, Shanxin Peng, Xiaosong Zhu, Ziyi Zhang, Yanyan Zhao, Jinling Zhang, Guoping Zhao, Tao Zhang, Xueyuan Heng & Lei Zhang
Abstract Background Integrative analysis approaches of metagenomics and metabolomics have been widely developed to understand the association between disease and the gut microbiome. However, the different profiling patterns of different metabolic samples in the association analysis make it a matter of concern which type of sample is the most closely associated with gut microbes and disease. To address this lack of knowledge, we investigated the association between the gut microbiome and metabolomic profiles of stool,...

A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer

Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao & Xin Wang
Background: Luminal B-like human epidermal growth factor receptor 2 negative (Luminal B [HER2−]) is the most common molecular subtype of breast cancer (BC). Since the relationship between Luminal B (HER2−) BC and liver metastasis (LM) is poorly defined, this retrospective study aimed to develop an LM risk nomogram for patients with lymph node-related (N + Luminal B [HER2−]) BC. Methods: Data were obtained for patients initially diagnosed with BC from the Tianjin Medical University Cancer...

Identification of castration-dependent and -independent driver genes and pathways in castration-resistant prostate cancer (CRPC)

Yan Li, Hui Shi, Zhenjun Zhao & Minghui Xu
Abstract Background Prostate cancer (PCa) is one of the most diagnosed cancers in the world. PCa inevitably progresses to castration-resistant prostate cancer (CRPC) after androgen deprivation therapy treatment, and castration-resistant state means a shorter survival time than other causes. Here we aimed to define castration-dependent and -independent diver genes and molecular pathways in CRPC which are responsible for such lethal metastatic events. Methods By employing digital gene expression (DGE) profiling, the alterations of the epididymal...

STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Abstract Background Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear. Methods Micro-RNA-130b-3p (miR-130b-3p) expression in mTORC1-activated and control cells was examined by quantitative real-time PCR (qRT-PCR). MiR-130b-3p levels and their correlation with mTORC1 activity were evaluated by analyzing publicly available databases and in-house head and neck squamous cell carcinoma (HNSCC) tissues. The role of miR-130b-3p in mTORC1-mediated angiogenesis and tumor...

Activity Enhancement of Photo-generated Carrier in CsPbBr3 Nanocrystals Improved by Cd Element

Lianfei Yao, Xue Lou, Ning Sui, Wei Zhang, Hongwei Xiao, Xiaochun Chi, Hanzhuang Zhang & Yinghui Wang
Doping Cd element into perovskite materials is an effective strategy to improve the photoelectric property. However, the further discussion for carrier dynamic behavior in perovskites affected by Cd element remains not sufficient. In this research letter, based on steady and transient spectroscopy, it is found that adding Cd element into CsPbBr3 nanocrystals can enhance the activity of photo-generated carriers and accompany with the optimization of crystal structure. The former improves the carrier heating effect, which...

Activity Enhancement of Photo-generated Carrier in CsPbBr3 Nanocrystals Improved by Cd Element

Lianfei Yao, Xue Lou, Ning Sui, Wei Zhang, Hongwei Xiao, Xiaochun Chi, Hanzhuang Zhang & Yinghui Wang
Doping Cd element into perovskite materials is an effective strategy to improve the photoelectric property. However, the further discussion for carrier dynamic behavior in perovskites affected by Cd element remains not sufficient. In this research letter, based on steady and transient spectroscopy, it is found that adding Cd element into CsPbBr3 nanocrystals can enhance the activity of photo-generated carriers and accompany with the optimization of crystal structure. The former improves the carrier heating effect, which...

STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Abstract Background Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear. Methods Micro-RNA-130b-3p (miR-130b-3p) expression in mTORC1-activated and control cells was examined by quantitative real-time PCR (qRT-PCR). MiR-130b-3p levels and their correlation with mTORC1 activity were evaluated by analyzing publicly available databases and in-house head and neck squamous cell carcinoma (HNSCC) tissues. The role of miR-130b-3p in mTORC1-mediated angiogenesis and tumor...

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