10 Works

One class classification for the detection of β2 adrenergic receptor agonists using single-ligand dynamic interaction data

Luca Chiesa & Esther Kellenberger
Abstract G protein-coupled receptors are involved in many biological processes, relaying the extracellular signal inside the cell. Signaling is regulated by the interactions between receptors and their ligands, it can be stimulated by agonists, or inhibited by antagonists or inverse agonists. The development of a new drug targeting a member of this family requires to take into account the pharmacological profile of the designed ligands in order to elicit the desired response. The structure-based virtual...

Synchronization of small-scale seismic clusters reveals large-scale plate deformation

Hayrullah Karabulut, Michel Bouchon & Jean Schmittbuhl
Abstract It has long been observed that periods of intense seismic activity in a region alternate with periods of relative quiescence, but establishing whether or not this intermittency is driven by broad-scale physical processes occurring in the Earth, remains a challenge. Here, we address this question of long-range triggering by a large-scale analysis of evolution of the seismicity between 2003 and 2017 in the Anatolia region. Two multi-year periods of synchronous high seismicity rate in...

Synchronization of small-scale seismic clusters reveals large-scale plate deformation

Hayrullah Karabulut, Michel Bouchon & Jean Schmittbuhl
Abstract It has long been observed that periods of intense seismic activity in a region alternate with periods of relative quiescence, but establishing whether or not this intermittency is driven by broad-scale physical processes occurring in the Earth, remains a challenge. Here, we address this question of long-range triggering by a large-scale analysis of evolution of the seismicity between 2003 and 2017 in the Anatolia region. Two multi-year periods of synchronous high seismicity rate in...

Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Abstract Background Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis of the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. We performed a post hoc analysis of HYPERION trial data to assess potential associations linking postresuscitation shock after non-shockable cardiac arrest to hypothermia at 33 °C on favourable functional outcome. Methods We divided the patients into groups with vs. without postresuscitation (defined...

Doppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation

Pierre-Grégoire Guinot, Pierre-Alain Bahr, Stefan Andrei, Bogdan A. Popescu, Vincenza Caruso, Paul-Michel Mertes, Vivien Berthoud, Maxime Nguyen & Belaid Bouhemad
Abstract Background Fluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relationship between the consequent fluid loss and clinical improvement. The aim of the study was to evaluate the ability of the portal pulsatility index, the renal venous impedance index, and the VEXUS score (venous ultrasound congestion score) to predict appropriate diuretic-induced fluid depletion....

Doppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation

Pierre-Grégoire Guinot, Pierre-Alain Bahr, Stefan Andrei, Bogdan A. Popescu, Vincenza Caruso, Paul-Michel Mertes, Vivien Berthoud, Maxime Nguyen & Belaid Bouhemad
Abstract Background Fluid overload and venous congestion are associated with morbi-mortality in the ICU (intensive care unit). Administration of diuretics to correct the fluid balance is common, although there is no strong relationship between the consequent fluid loss and clinical improvement. The aim of the study was to evaluate the ability of the portal pulsatility index, the renal venous impedance index, and the VEXUS score (venous ultrasound congestion score) to predict appropriate diuretic-induced fluid depletion....

One class classification for the detection of β2 adrenergic receptor agonists using single-ligand dynamic interaction data

Luca Chiesa & Esther Kellenberger
Abstract G protein-coupled receptors are involved in many biological processes, relaying the extracellular signal inside the cell. Signaling is regulated by the interactions between receptors and their ligands, it can be stimulated by agonists, or inhibited by antagonists or inverse agonists. The development of a new drug targeting a member of this family requires to take into account the pharmacological profile of the designed ligands in order to elicit the desired response. The structure-based virtual...

Physical activity and gestational weight gain: a systematic review of observational studies

Virginie Hamann, Philippe Deruelle, Christophe Enaux, Séverine Deguen & Wahida Kihal-Talantikite
Abstract Background Now that excessive weight gain during pregnancy is recognized as leading to complications during pregnancy that affect foetal growth, limiting weight gain during pregnancy has become a public health concern. Our aim was to perform a systematic review to assess whether observational studies reported associations between Physical Activity (PA) and Gestational Weight Gain (GWG). We were particularly interested in whether insufficient PA might be associated with high GWG. Methods Using Preferred Reporting Items...

Physical activity and gestational weight gain: a systematic review of observational studies

Virginie Hamann, Philippe Deruelle, Christophe Enaux, Séverine Deguen & Wahida Kihal-Talantikite
Abstract Background Now that excessive weight gain during pregnancy is recognized as leading to complications during pregnancy that affect foetal growth, limiting weight gain during pregnancy has become a public health concern. Our aim was to perform a systematic review to assess whether observational studies reported associations between Physical Activity (PA) and Gestational Weight Gain (GWG). We were particularly interested in whether insufficient PA might be associated with high GWG. Methods Using Preferred Reporting Items...

Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Ines Ziriat, Aurélie Le Thuaut, Gwenhael Colin, Hamid Merdji, Guillaume Grillet, Patrick Girardie, Bertrand Souweine, Pierre-François Dequin, Thierry Boulain, Jean-Pierre Frat, Pierre Asfar, Bruno Francois, Mickael Landais, Gaëtan Plantefeve, Jean-Pierre Quenot, Jean-Charles Chakarian, Michel Sirodot, Stéphane Legriel, Nicolas Massart, Didier Thevenin, Arnaud Desachy, Arnaud Delahaye, Vlad Botoc, Sylvie Vimeux, Frederic Martino … & Jean Baptiste Lascarrou
Abstract Background Outcomes of postresuscitation shock after cardiac arrest can be affected by targeted temperature management (TTM). A post hoc analysis of the “TTM1 trial” suggested higher mortality with hypothermia at 33 °C. We performed a post hoc analysis of HYPERION trial data to assess potential associations linking postresuscitation shock after non-shockable cardiac arrest to hypothermia at 33 °C on favourable functional outcome. Methods We divided the patients into groups with vs. without postresuscitation (defined...

Registration Year

  • 2022
    10

Resource Types

  • Collection
    10

Affiliations

  • University of Strasbourg
    10
  • Centre Hospitalier Universitaire Dijon Bourgogne
    4
  • University of Burgundy
    4
  • Hôpitaux Universitaires de Strasbourg
    4
  • Centre Hospitalier Universitaire de Tours
    2
  • Hôpital Cochin
    2
  • Kandilli Observatory and Earthquake Research Institute
    2
  • Institut des Sciences de la Terre
    2
  • Centre for Research in Epidemiology and Population Health
    2
  • Centre Hospitalier Universitaire de Limoges
    2