14 Works

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events. Methods Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9...

Association between exercise and risk of cardiovascular diseases in patients with non-cystic fibrosis bronchiectasis

Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon & Hyun Lee
Abstract Background: Although cardiovascular comorbidities negatively impact survival in patients with bronchiectasis, there is limited evidence to recommend exercise in this population. We aimed to evaluate whether exercise habit changes are related to reduced cardiovascular disease risk and explore an optimal exercise amount. Methods: This study identified 165,842 patients with newly diagnosed bronchiectasis during 2010–2016 who underwent two health examinations and were followed up until December 2020. The exposure was the change in weekly habits...

PrEP-related stigma and PrEP use among gay, bisexual and other men who have sex with men in Ontario and British Columbia, Canada

Oscar Javier Pico-Espinosa, Mark Hull, Paul MacPherson, Daniel Grace, Mark Gaspar, Nathan Lachowsky, Saira Mohammed, James Demers, Marshall Kilduff, Robinson Truong & Darrell H. S. Tan
Abstract Background We aimed to explore the association between PrEP-related stereotypes and perceived disapproval (hereafter PrEP-related stigma), and PrEP use. Methods We used data from a cross-sectional online survey among adult gay, bisexual, other men who have sex with men in Ontario and British Columbia, Canada. Participants were recruited 2019–2020 in-person from sexual health clinics and outreach programs, and online through dating mobile applications and websites. We used logistic regression models to explore the relationship...

Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996

Tao Zhang, Guowei Cai, Xiaoting Rong, Jingwen Xu, Bingya Jiang, Hao Wang, Xinxin Li, Lu Wang, Ran Zhang, Wenni He & Liyan Yu
Abstract Background Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the family Didymellaceae, is ubiquitous that colonizes different types of substrates and is associated with phyllosphere or decaying vegetation. Species of this genus are prolific producers of bioactive substances. The epicoccamides, as biosynthetically distinct mannosylated tetramate, were first isolated in 2003 from Epicoccum sp. In...

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events. Methods Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9...

B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian & Ziming Zhang
Abstract Background Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited. In recent years, a new cellular therapy, CAR-T, a cellular immunotherapy with genetically engineered T cells bearing chimeric antigen receptor targeting specific tumor-associated antigen, has been proved to be an effective therapy against acute lymphoblastic leukemia. Thus, CAR-T is a potentially effective therapy for osteosarcoma treatment. Methods...

Trends and factors associated with influenza vaccination in subjects with asthma: analysis of the Korea National Health and Nutrition Examination Survey between 2010 and 2019

Sang Hyuk Kim, Hye Yun Park, Hwasik Jung, Sungmin Zo, Saerom Kim, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Hyun Lee & Sun Hye Shin
Background:Despite the importance of influenza vaccination, its rates in subjects with asthma are suboptimal, especially in the young population.Methods:Among 72,843 adults aged ⩾18 years from the Korea National Health and Nutrition Examination Survey conducted between 2010 and 2019, 1643 with asthma were included. The yearly trends and factors associated with influenza vaccination were analyzed in subjects with asthma. In addition, stratified analyses were performed by age group (<65 versus ⩾65 years).Results:During the study period, the...

Association between exercise and risk of cardiovascular diseases in patients with non-cystic fibrosis bronchiectasis

Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon & Hyun Lee
Abstract Background: Although cardiovascular comorbidities negatively impact survival in patients with bronchiectasis, there is limited evidence to recommend exercise in this population. We aimed to evaluate whether exercise habit changes are related to reduced cardiovascular disease risk and explore an optimal exercise amount. Methods: This study identified 165,842 patients with newly diagnosed bronchiectasis during 2010–2016 who underwent two health examinations and were followed up until December 2020. The exposure was the change in weekly habits...

PrEP-related stigma and PrEP use among gay, bisexual and other men who have sex with men in Ontario and British Columbia, Canada

Oscar Javier Pico-Espinosa, Mark Hull, Paul MacPherson, Daniel Grace, Mark Gaspar, Nathan Lachowsky, Saira Mohammed, James Demers, Marshall Kilduff, Robinson Truong & Darrell H. S. Tan
Abstract Background We aimed to explore the association between PrEP-related stereotypes and perceived disapproval (hereafter PrEP-related stigma), and PrEP use. Methods We used data from a cross-sectional online survey among adult gay, bisexual, other men who have sex with men in Ontario and British Columbia, Canada. Participants were recruited 2019–2020 in-person from sexual health clinics and outreach programs, and online through dating mobile applications and websites. We used logistic regression models to explore the relationship...

Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996

Tao Zhang, Guowei Cai, Xiaoting Rong, Jingwen Xu, Bingya Jiang, Hao Wang, Xinxin Li, Lu Wang, Ran Zhang, Wenni He & Liyan Yu
Abstract Background Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the family Didymellaceae, is ubiquitous that colonizes different types of substrates and is associated with phyllosphere or decaying vegetation. Species of this genus are prolific producers of bioactive substances. The epicoccamides, as biosynthetically distinct mannosylated tetramate, were first isolated in 2003 from Epicoccum sp. In...

Is Neoliberalism Killing Us? A Cross Sectional Study of the Impact of Neoliberal Beliefs on Health and Social Wellbeing in the Midst of the COVID-19 Pandemic

Kiffer G. Card & Kirk J. Hepburn
Neoliberal ideology is linked to poorer collective health and well-being. At the individual level, however, neoliberal beliefs may actually promote self-efficacy, self-esteem, and self-reliance. We examined the effects of three beliefs underlying neoliberalism—(a) Personal Wherewithal, (b) Natural Competition, and (c) Anti-Government Interference—to understand the unique pathways by which neoliberalism affects health and well-being at the individual level. Participants were recruited using paid advertisements on social media in May/June 2020. Multivariable regression identified associations between each...

Trends and factors associated with influenza vaccination in subjects with asthma: analysis of the Korea National Health and Nutrition Examination Survey between 2010 and 2019

Sang Hyuk Kim, Hye Yun Park, Hwasik Jung, Sungmin Zo, Saerom Kim, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Hyun Lee & Sun Hye Shin
Background:Despite the importance of influenza vaccination, its rates in subjects with asthma are suboptimal, especially in the young population.Methods:Among 72,843 adults aged ⩾18 years from the Korea National Health and Nutrition Examination Survey conducted between 2010 and 2019, 1643 with asthma were included. The yearly trends and factors associated with influenza vaccination were analyzed in subjects with asthma. In addition, stratified analyses were performed by age group (<65 versus ⩾65 years).Results:During the study period, the...

B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian & Ziming Zhang
Abstract Background Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited. In recent years, a new cellular therapy, CAR-T, a cellular immunotherapy with genetically engineered T cells bearing chimeric antigen receptor targeting specific tumor-associated antigen, has been proved to be an effective therapy against acute lymphoblastic leukemia. Thus, CAR-T is a potentially effective therapy for osteosarcoma treatment. Methods...

Is Neoliberalism Killing Us? A Cross Sectional Study of the Impact of Neoliberal Beliefs on Health and Social Wellbeing in the Midst of the COVID-19 Pandemic

Kiffer G. Card & Kirk J. Hepburn
Neoliberal ideology is linked to poorer collective health and well-being. At the individual level, however, neoliberal beliefs may actually promote self-efficacy, self-esteem, and self-reliance. We examined the effects of three beliefs underlying neoliberalism—(a) Personal Wherewithal, (b) Natural Competition, and (c) Anti-Government Interference—to understand the unique pathways by which neoliberalism affects health and well-being at the individual level. Participants were recruited using paid advertisements on social media in May/June 2020. Multivariable regression identified associations between each...

Registration Year

  • 2022
    14

Resource Types

  • Collection
    14

Affiliations

  • St. Paul's Hospital
    14
  • Yunnan University
    6
  • Second Affiliated Hospital of Guangzhou Medical University
    6
  • University of Newcastle Australia
    6
  • University of Michigan–Ann Arbor
    6
  • Huazhong University of Science and Technology
    6
  • Minjiang University
    6
  • University of Rochester Medical Center
    6
  • Beihang University
    5
  • Inner Mongolia University
    5