2,006 Works

MAPK8IP2 is a potential prognostic biomarker and promote tumor progression in prostate cancer

Zhenhao Zeng, Wenrui He, Yi Jiang, Hao Jiang, Xiaofeng Cheng, Wen Deng, Xiaochen Zhou, Cheng Zhang & Gongxian Wang
Abstract Background MAPK8IP2 is one of the JNK-interacting proteins (JIPs) family members, and is involved in the regulation of the JNK and P38 MAPK signaling pathways. MAPK8IP2 has been reported to be closely associated with several cancers. However, the biological function of MAPK8IP2 in prostate cancer (PCa) remains unclear. Methods MAPK8IP2 expression in PCa and subgroups of PCa was analyzed by public databases. The prognostic role of MAPK8IP2 in prostate cancer was analyzed using the...

Integrated next-generation sequencing and comparative transcriptomic analysis of leaves provides novel insights into the ethylene pathway of Chrysanthemum morifolium in response to a Chinese isolate of chrysanthemum virus B

Xueting Zhong, Lianlian Yang, Jiapeng Li, Zhaoyang Tang, Choufei Wu, Liqin Zhang, Xueping Zhou, Yaqin Wang & Zhanqi Wang
Abstract Background Chrysanthemum virus B (CVB), a key member of the genus Carlavirus, family Betaflexiviridae, causes severe viral diseases in chrysanthemum (Chrysanthemum morifolium) plants worldwide. However, information on the mechanisms underlying the response of chrysanthemum plants to CVB is scant. Methods Here, an integrated next-generation sequencing and comparative transcriptomic analysis of chrysanthemum leaves was conducted to explore the molecular response mechanisms of plants to a Chinese isolate of CVB (CVB-CN) at the molecular level. Results...

MRI-assessed diaphragmatic function can predict frequent acute exacerbation of COPD: a prospective observational study based on telehealth-based monitoring system

Shuoshuo Wei, Rong Lu, Zhengping Zhang, Faxuan Wang, Hai Tan, Xiaohong Wang, Jinlan Ma, Yating Zhang, Ning Deng & Juan Chen
Abstract Background Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have considerably high mortality and re-hospitalisation rate. Diaphragmatic dysfunction (DD) is common in COPD patients. However, whether diaphragmatic dysfunction is related to acute exacerbation is yet to be elucidated. This study aimed to evaluate the diaphragm function by magnetic resonance imaging (MRI) in COPD patients and assess whether the impact of DD may help predict AECOPD. Methods 20 healthy adult volunteers and 80 COPD patients...

Profiling the transcriptomic signatures and identifying the patterns of zygotic genome activation – a comparative analysis between early porcine embryos and their counterparts in other three mammalian species

Yanhui Zhai, Hao Yu, Xinglan An, Zhiren Zhang, Meng Zhang, Sheng Zhang, Qi Li & Ziyi Li
Abstract Background The transcriptional changes around zygotic genome activation (ZGA) in preimplantation embryos are critical for studying mechanisms of embryonic developmental arrest and searching for key transcription factors. However, studies on the transcription profile of porcine ZGA are limited. Results In this study, we performed RNA sequencing in porcine in vivo developed (IVV) and somatic cell nuclear transfer (SCNT) embryo at different stages and compared the transcriptional activity of porcine embryos with mouse, bovine and...

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review

Wen Tian, Xingxiang Ren, Mei Han, Yuanyuan Zhang, Xu Gao, Zhihai Chen & Wei Zhang
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination rates are increasing globally. This study evaluated the relevant clinical manifestations of vaccinated COVID-19 patients. Methods: We searched carefully in 11 databases such as PubMed, Embase, Scopus, Cochrane Library, Web of Science, Ovid, China National Knowledge Infrastructure Database, Wan Fang Data, Sinomed, VIP Database, and Reading Showing Database up to 26 March 2022. To search for articles that have described the characteristics of vaccinated...

A novel serum spherical lectin from lamprey reveals a more efficient mechanism of immune initiation and regulation in jawless vertebrates

Jiali Lu, Jinsong Duan, Yinglun Han, Meng Gou, Jun Li, Qingwei Li & Yue Pang
Abstract The innate immune system is the body’s first line of defense against pathogens and involves antibody and complement system-mediated antigen removal. Immune-response-related complement molecules have been identified in lamprey, and the occurrence of innate immune response via the mannose-binding lectin-associated serine proteases of the lectin cascade has been reported. We have previously shown that lamprey (Lampetra japonica) serum can efficiently and specifically eliminate foreign pathogens. Therefore, we aimed to understand the immune mechanism of...

A novel serum spherical lectin from lamprey reveals a more efficient mechanism of immune initiation and regulation in jawless vertebrates

Jiali Lu, Jinsong Duan, Yinglun Han, Meng Gou, Jun Li, Qingwei Li & Yue Pang
Abstract The innate immune system is the body’s first line of defense against pathogens and involves antibody and complement system-mediated antigen removal. Immune-response-related complement molecules have been identified in lamprey, and the occurrence of innate immune response via the mannose-binding lectin-associated serine proteases of the lectin cascade has been reported. We have previously shown that lamprey (Lampetra japonica) serum can efficiently and specifically eliminate foreign pathogens. Therefore, we aimed to understand the immune mechanism of...

New Baitouweng decoction combined with fecal microbiota transplantation alleviates DSS-induced colitis in rats by regulating gut microbiota metabolic homeostasis and the STAT3/NF-κB signaling pathway

Xin Gu, Zhiwei Miao, Yantian Wang, Yue Yang, Tongtong Yang & Yi Xu
Abstract Aim of the study We aimed to elucidate the synergistic effect and potential mechanism of New Baitouweng Decoction (NBD) combined with fecal microbiota transplantation (FMT) in rats with DSS-induced ulcerative colitis (UC). Materials and methods Colitis was induced by 5% (w/v) dextran sulfate sodium (DSS) in drinking water for 7 days. NBD or NBD combined with FMT were administered to the colitis rats. Body weight and disease activity index were measured, and the colon...

Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis

Xinxiu Liang, Yuanqing Fu, Wen-ting Cao, Zhihong Wang, Ke Zhang, Zengliang Jiang, Xiaofang Jia, Chun-ying Liu, Hong-rou Lin, Haili Zhong, Zelei Miao, Wanglong Gou, Menglei Shuai, Yujing Huang, Shengdi Chen, Bing Zhang, Yu-ming Chen & Ju-Sheng Zheng
Abstract Background Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes, but evidence from large human cohorts is lacking. This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations. Methods We included 1430 participants from the Guangzhou Nutrition and Health Study (GNHS) with both gut microbiome and cognitive assessment data available as a...

Head movement kinematics are altered during balance stability exercises in individuals with vestibular schwannoma

Omid A. Zobeiri, Lin Wang, Jennifer L. Millar, Michael C. Schubert & Kathleen E. Cullen
Abstract Background Balance stabilization exercises are often prescribed to facilitate compensation in individuals with vestibular schwannoma (VS). However, both the assessment and prescription of these exercises are reliant on clinical observations and expert opinion rather than on quantitative evidence. The aim of this study was to quantify head motion kinematics in individuals with vestibular loss while they performed commonly prescribed balance stability exercises. Methods Using inertial measurement units, head movements of individuals with vestibular schwannoma...

Serum CTRP9 and high-molecular weight adiponectin are associated with ischemic stroke

Yan-Qing Zhang, Yan-Wei Zhang, Jian-Li Dai, Chen Li, Wen-Qing Wang, Hai-Feng Zhang, Wayne Bond Lau, Xiao-Ming Wang, Xiao-Gang Liu & Rong Li
Abstract Background C1q/TNF-related protein 9 (CTRP9) and adiponectin (APN) have beneficial metabolic regulatory and vasoprotective effects. This study explored alteration of CTRP9 and APN multimers during onset of ischemic stroke and development, to provide novel clinical and experimental basis for recognition and prevention of ischemic stroke. Methods There were 269 patients with ischemic stroke and 182 control subjects included in this study. Serum levels of CTRP9 and APN multimers in different disease stages were measured....

Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats

Changmin Wang, Ye Li, Yuhang Yi, Guiyu Liu, Ruojing Guo, Liyan Wang, Tian Lan, Wenjing Wang, Xiao Chen, Shihong Chen & Shu Yan Yu
Abstract Background Neuronal injury is considered a critical risk factor in the pathogenesis of most neurological and neuropsychiatric diseases. However, the underlying molecular mechanisms and identification of potential therapeutic targets for preventing neuronal injury associated with brain function remain largely uncharacterized. Therefore, identifying neural mechanisms would put new insights into the progression of this condition and provide novel therapeutic strategies for the treatment of these diseases. Methods Stereotactic injection of AAV virus was used to...

Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease

Lingling Li, Min Zhang, Chunyang Zhao, Yusheng Cheng, Chuanmei Liu & Minhua Shi
Abstract Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. COPD is associated with accelerated lung aging. Circadian clock is believed to play important roles in COPD. Although the circadian molecular clock regulates cellular senescence, there is no information available regarding the impact of COPD. The aim of this study is to investigate the role of the circadian clock protein BMAL1 and CLOCK in cellular senescence in order to understand the cellular mechanisms of...

Phylogenomics, plastome structure and species identification in Mahonia (Berberidaceae)

Ruchang Tong, Chaoxia Gui, Yu Zhang, Na Su, Xiaoqi Hou, Meng Liu, Zhaoping Yang, Bing Kang, Zhaoyang Chang, Florian Jabbour & Liang Zhao
Abstract Background Elucidating the phylogenetic relationships within species-rich genera is essential but challenging, especially when lineages are assumed to have been going through radiation events. Mahonia Nutt. (Berberidaceae) is a genus with cosmopolitan distribution, comprising approximately 100 species, two of which are known as Caulis Mahoniae (M. bealei and M. fortunei) with crucial pharmacological significance in Chinese herbal medicine. Mahonia is a taxonomically challenging genus, and intrageneric phylogenetic relationships still need to be explored using...

STEAP3 can predict the prognosis and shape the tumor microenvironment of clear cell renal cell carcinoma

Jiyue Wu, Qing Bi, Xiang Zheng, Huawei Cao, Changzhen Hao, Zejia Sun & Wei Wang
Abstract Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a common phenomenon in ccRCC and is closely related to the process of ccRCC. But still now, the exact function and underlying mechanisms of iron metabolism dysregulation in ccRCC have not been fully elucidated. In this study, we comprehensively investigated the prognostic value...

Spatiotemporal dynamics and potential ecological drivers of acute respiratory infectious diseases: an example of scarlet fever in Sichuan Province

Cheng Li, Rujun Liao, Wenhui Zhu, Guiyu Jiang, Yumeng Wang, Ling Li, Tao Zhang & Qiang Lv
Abstract Object Scarlet fever is an acute respiratory infectious disease that endangers public health and imposes a huge economic burden. In this paper, we systematically studied its spatial and temporal evolution and explore its potential ecological drivers. The goal of this research is to provide a reference for analysis based on surveillance data of scarlet fever and other acute respiratory infectious illnesses, and offer suggestions for prevention and control. Method This research is based on...

Reversible photochromic effect in natural gemstone sapphires

Tsung-Han Tsai, Zhen Wang & Hiroshi Takahashi
Photochromic sapphires show an optically controllable orange coloration under ambient temperature, which strongly affects the color appearance and market value of gemstone sapphires. An in-situ absorption spectroscopy combined with a tunable excitation light source has been developed to investigate the wavelength- and time dependence of sapphire’s photochromism. An excitation of ≤370 nm and ≥410 nm introduces and removes the orange coloration, respectively, accompanied by a stable absorption band at 470 nm. Both the color enhancement...

Integrated dose–response metabolomics with therapeutic effects and adverse reactions may demystify the dosage of traditional Chinese medicine

Yan-Yan Chen, Jia-Qian Chen, Yu-Ping Tang, Er-Xin Shang, Qi Zhao, Jun-Bo Zou, Ding-Qiao Xu, Shi-Jun Yue, Jie Yang, Rui-Jia Fu, Gui-Sheng Zhou & Jin-Ao Duan
Abstract Background Traditional Chinese medicine (TCM) has been used to treat various diseases for thousands of years. However, the uncertainty of dosage as well as the lack of systemic evaluation of pharmacology and toxicology is one major reason why TCM remains mysterious and is not accepted worldwide. Hence, we aimed to propose an integrated dose–response metabolomics strategy based on both therapeutic effects and adverse reactions to guide the TCM dosage in treatment. Methods The proposed...

Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis

Zhiyong Zhang, Yaojun Zheng, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Yayi Hou, Sunan Shen, Mingming Lv & Tingting Wang
Abstract Background Accumulating evidence implicates that gut fungi are associated with the pathogenesis of colorectal cancer (CRC). Our previous study has revealed that Candida tropicalis (C. tropicalis) promotes colorectal tumorigenesis by enhancing immunosuppressive function of myeloid-derived suppressor cells (MDSCs) and increasing accumulation of MDSCs, but the underlying mechanisms remain unestablished. Methods Bone marrow–derived MDSCs were stimulated with C. tropicalis. RNA-sequencing analysis was performed to screen the differentially expressed genes. Quantitative real-time PCR and western blot...

Prevalence Difference of Helicobacter pylori Infection Between Tibetan and Han Ethnics in China: A Meta-analysis on Epidemiologic Studies (SIGES)

Dan Bai, Kai Liu, Rui Wang, Wei-Han Zhang, Xin-Zu Chen & Jian-Kun Hu
China is a multi-ethnic country, and the prevalence of Helicobacter pylori (H pylori) infection may be diverse among ethnics. This meta-analysis was conducted to compare the prevalence of H pylori infection between Tibetans and Han ethnics. Ten studies that reported the prevalence of H pylori infection between Tibetans and Hans in China were eligible. The pooled prevalence of H pylori infection was 62.2% versus 55.3% among Tibetans and Hans, respectively. Tibetans had a higher risk...

Global, regional, and national burden of disease study of atrial fibrillation/flutter, 1990–2019: results from a global burden of disease study, 2019

Hong Li, Xuejing Song, Yi Liang, Xue Bai, Wu-Sha Liu-Huo, Chao Tang, Wen Chen & Lizhi Zhao
Abstract Background Data from the Global Burden of Disease, Injury, and Risk Factor Study 2019 (GBD 2019) was used to assess the burden and change in prevalence, incidence, deaths, disability-adjusted life years, and risk factors for atrial fibrillation/flutter in 204 countries and territories between 1990 and 2019. Methods Incidence, prevalence, deaths, disability-adjusted life years (DALYs), and their age-standardized rates of AF/AFL were analyzed by age, sex, socio-demographic index (SDI), and human development index (HDI) using...

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia & Chong Zhao
Abstract Background Radioresistance is the primary cause of nasopharyngeal carcinoma (NPC) treatment failure. Previous studies have focused on the deficits in cellular apoptosis as a mechanism for radioresistance; however, additional potential death modes involved in modulating radiosensitivity of NPC have not been explored. Methods Pyroptosis was assessed by phase-contrast imaging, LDH release assays, live cell imaging, and Western blotting. In vitro and in vivo assays were used to investigate the function of gasdermin E (GSDME)...

Relationship between serum homocysteine, fibrinogen, lipoprotein-a level, and peripheral arterial disease: a dose–response meta-analysis

Hecheng Wang, Pengpeng Wu, Deying Jiang, Hao Zhang, Jian Zhang, Yu Zong & Yanshuo Han
Abstract Aim At present, the relationship between serum homocysteine (Hcy), fibrinogen (FIB), lipoprotein-a (LPa), and PAD is uncertain, and there has been no meta-analysis to establish the dose–response relationship between their exposure levels and PAD. Methods and results Relevant literature published in PubMed, Embase, and Web of Science was retrieved. The robust error meta-regression method was used to assess the linear and non-linear dose–response relationship between exposure level and PAD risk. A total of 68...

Functional structure analysis and genome-wide identification of CNX gene family in cotton

Nan Xu, Hong Zhang, Yuexin Zhang, Yapeng Fan, Jing Wang, Waqar Afzal Malik, Cun Rui, Mingge Han, Xuke Lu, Xiugui Chen, Junjuan Wang, Delong Wang, Shuai Wang, Chao Chen, Lixue Guo, Lanjie Zhao & Wuwei Ye
Abstract Background Under abiotic stress conditions, cotton growth is inhibited and yield losses are severe. Identification of calnexin family members and function analysis under abiotic stress laid the foundation for the screening of stress-related candidate genes. Results A total of 60 CNX family members have been identified in Gossypium hirsutum, G. barbadense, G. arboreum, and G. raimondii, and they were divided into two categories: CNX and CRT genes. Through the construction of a phylogenetic tree,...

The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis

Yun Feng, Wenhua Li, Zhuoya Wang, Ruling Zhang, Yan Li, Lijuan Zang, Peiwen Wang, Zhenghong Li & Yuwei Dong
Abstract Background To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular mechanism. Methods Bioinformatics analyses were performed on transcriptome data of liver tissues from mice and patients with liver fibrosis for screening the hepatocyte pyroptosis-related differential genes. The in vivo NASH mouse model and in vitro NASH cellular model were established. The expression levels of Anxa2/ANXA2 were quantified. Then, the upstream transcription factor...

Registration Year

  • 2023
  • 2022
  • 2021
  • 2020

Resource Types

  • Collection


  • Sichuan University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Fudan University
  • Zhejiang University
  • Capital Medical University
  • Sun Yat-sen University
  • Huazhong University of Science and Technology
  • Chinese Academy of Sciences
  • Nanjing Medical University