1,706 Works

A CT-based nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodule according to the 2021 WHO classification

Qilong Song, Biao Song, Xiaohu Li, Bin Wang, Yuan Li, Wu Chen, Zhaohua Wang, Xu Wang, Yongqiang Yu, Xuhong Min & Dongchun Ma
Abstract Purpose To establish a nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodules (SSNs) according to the 2021 WHO classification. Methods A total of 656 patients who underwent SSNs resection were retrospectively enrolled. Among them, 407 patients were assigned to the derivation cohort and 249 patients were assigned to the validation cohort. Univariate and multi-variate logistic regression algorithms were utilized to identity independent risk factors of adenocarcinomas. A nomogram based on...

The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: study protocol for a randomized controlled trial

Qingsheng Wang, Runjing Dai, Hailiang Zhang, Xiaomei Jiang, Xiaojing Ma, Xiangrong Zhang, Shisan Bao, Dong Ren & Jingchun Fan
Abstract Introduction Tobacco hazard is one of the most serious public health problems, accounting for up to 6 million deaths worldwide p.a. We aim to determine the efficacy and safety of acupuncture and/or nicotine replacement therapy on smoking cessation. Methods We will recruit 96 participants who are willing to quit smoking by acupuncture and/or nicotine replacement therapy in Chengguan, Xigu and Heping Districts, Lanzhou city, for multicenter randomized, double-blind, double-dummy controlled clinical trial. Following obtained...

Microbiota and metabolites alterations in proximal and distal gastric cancer patients

Yan Yang, Daofeng Dai, Wen Jin, Yingying Huang, Yingzi Zhang, Yiran Chen, Wankun Wang, Wu Lin, Xiangliu Chen, Jing Zhang, Haohao Wang, Haibin Zhang & Lisong Teng
Abstract Background Globally, gastric cancer is the third most common cancer and the third leading cause of cancer death. Proximal and distal gastric cancers have distinct clinical and biological behaviors. The microbial composition and metabolic differences in proximal and distal gastric cancers have not been fully studied and discussed. Methods In this study, the gastric microbiome of 13 proximal gastric cancer tissues, 16 distal gastric cancer tissues, and their matched non-tumor tissues were characterized using...

Enhance the Efficiency of Graphene-based THz Modulator by Optimizing the Brewster Angle

Xingyue Li, zhaohui zhang, Xiaoyan Zhao, Tianyao Zhang, Luqi Tao, Zhengyong Huang, Ying Li, Xianhao Wu, Lu Yin & Yuan Yuan
The gate-controllable electronical property of graphene provides a possibility of active tuning property for THz modulator. However, the common modulation technology which only depends on voltage cannot solve the problem of power consumption limitation in communication applications. Here, we demonstrated a Brewster angle-controlled graphene-based THz modulator, which could achieve a relatively high modulation depth with low voltage. First, we explored the complex relationships among the Brewster angles, reflection coefficients and the conductivities of graphene. Then,...

Perspective clipping and fast rendering of light field images for holographic stereograms using RGBD data

Xin Liu, Yimin Lou, Juanmei Hu, Jianlong Kou & Fengmin Wu
The production of holographic stereogram (HS) requires a huge amount of light field data. How to efficiently clip and render these image data remains a challenge in the field. This work focuses on the perspective clipping and fast rendering algorithm of light field images using RGBD data without explicit 3D reconstruction. The RGBD data is expanded to RGBDθ data by introducing a light cone for each point, which gives a new degree of freedom for...

SPARC plays an important role in the oviposition and nymphal development in Nilaparvata lugens Stål

Weixia Wang, Tingheng Zhu, Pinjun Wan, Qi Wei, Jiachun He, Fengxiang Lai & Qiang Fu
Abstract Background The brown planthopper (Nilaparvata lugens Stål)is a notorious rice pest in many areas of Asia. Study on the molecular mechanisms underlying its development and reproduction will provide scientific basis for effective control. SPARC (Secreted Protein, Acidic and Rich in Cysteine) is one of structural component of the extracellular matrix, which influences a diverse array of biological functions. In this study, the gene for SPARC was identified and functionally analysed from N.lugens. Results The...

The bidirectional association of C-peptide with cardiovascular risk in nondiabetic adults and patients with newly diagnosed type 2 diabetes mellitus: a retrospective cohort study

Shuang-Tong Yan, Jing Sun, Zhao-Yan Gu, Xin-Yu Miao, Li-Chao Ma, Ban-Ruo Sun, Xiao-Min Fu, Hong-Zhou Liu, Guang Yang, Fu-Sheng Fang & Hong Li
Abstract Background Recent literature reported the biological role of C-peptide, but this role is still controversial and unclear. The primary aim of this study was to investigate associations between C-peptide and cardiovascular biomarkers as well as events. Methods A total of 55636 participants who had a health examination from 2017 to 2021 were included. Of them, 6727 participants visited the hospital at least twice. Cardiovascular biomarkers like high-sensitivity C-reactive protein (hs-CRP) and high-sensitivity cardiac troponin...

A successful hybrid deep learning model aiming at promoter identification

Ying Wang, Qinke Peng, Xu Mou, Xinyuan Wang, Haozhou Li, Tian Han, Zhao Sun & Xiao Wang
Abstract Background The zone adjacent to a transcription start site (TSS), namely, the promoter, is primarily involved in the process of DNA transcription initiation and regulation. As a result, proper promoter identification is critical for further understanding the mechanism of the networks controlling genomic regulation. A number of methodologies for the identification of promoters have been proposed. Nonetheless, due to the great heterogeneity existing in promoters, the results of these procedures are still unsatisfactory. In...

Pseudomonas aeruginosa biofilm dispersion by the mouse antimicrobial peptide CRAMP

Yang Zhang, Peng Cheng, Shiyuan Wang, Xiaofen Li, Lianci Peng, Rendong Fang, Jing Xiong, Hui Li, Cui Mei, Jiye Gao, Zhenhui Song, Dengfeng Xu, Lizhi Fu, Chenghong Li, Xueqing Wu, Yuzhang He & Hongwei Chen
Abstract Pseudomonas aeruginosa (P. aeruginosa) is a known bacterium that produces biofilms and causes severe infection. Furthermore, P. aeruginosa biofilms are extremely difficult to eradicate, leading to the development of chronic and antibiotic-resistant infections. Our previous study showed that a cathelicidin-related antimicrobial peptide (CRAMP) inhibits the formation of P. aeruginosa biofilms and markedly reduces the biomass of preformed biofilms, while the mechanism of eradicating bacterial biofilms remains elusive. Therefore, in this study, the potential mechanism...

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald & Maximilian M. L. Knott
Abstract Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable due to their lack of enzymatic activity. Here, we show in the EwS model that – capitalizing on neomorphic DNA-binding preferences – the addiction to the respective fusion transcription factor EWSR1-FLI1 can be leveraged to express therapeutic genes....

Normalization and de-noising of single-cell Hi-C data with BandNorm and scVI-3D

Ye Zheng, Siqi Shen & Sündüz Keleş
Abstract Single-cell high-throughput chromatin conformation capture methodologies (scHi-C) enable profiling of long-range genomic interactions. However, data from these technologies are prone to technical noise and biases that hinder downstream analysis. We develop a normalization approach, BandNorm, and a deep generative modeling framework, scVI-3D, to account for scHi-C specific biases. In benchmarking experiments, BandNorm yields leading performances in a time and memory efficient manner for cell-type separation, identification of interacting loci, and recovery of cell-type relationships,...

Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics

Jie Mei, Yun Cai, Ofek Mussafi, Mingfeng Zheng, Yongrui Xu, Ruo Chen, Guanyu Jiang, Wenjun Mao, Wei Xia & Yuan Wan
Abstract Non-small cell lung cancer (NSCLC) is a heterogeneous disease, and its demarcation contributes to various therapeutic outcomes. However, a small subset of tumors shows different molecular features that are in contradiction with pathological classification. Unsupervised clustering was performed to subtype NSCLC using the transcriptome data from the TCGA database. Next, immune microenvironment features of lung adenocarcinoma (LUAD), lung squamous carcinoma (LUSC), and lung adenoid squamous carcinoma (LASC) were characterized. In addition, diagnostic biomarkers to...

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

Nan Zhang, Hong‑Ping Zhu, Wei Huang, Xiang Wen, Xin Xie, Xian Jiang, Cheng Peng, Bo Han & Gu He
Abstract Peripheral myelin protein 22 (PMP22) and epithelial membrane proteins (EMP-1, -2, and -3) belong to a small hydrophobic membrane protein subfamily, with four transmembrane structures. PMP22 and EMPs are widely expressed in various tissues and play important roles in cell growth, differentiation, programmed cell death, and metastasis. PMP22 presents its highest expression in the peripheral nerve and participates in normal physiological and pathological processes of the peripheral nervous system. The progress of molecular genetics...

Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

Junling Gao, Tong Lei, Hongyun Wang, Kai Luo, Yuanli Wang, Bingqing Cui, Zhuoran Yu, Xiaoqi Hu, Fang Zhang, Yingjie Chen, Wenjun Ding & Zhongbing Lu
Abstract Background Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary disease. In patients with those diseases, circulating asymmetric dimethylarginine (ADMA) levels are increased, which contributes to airway nitric oxide deficiency, oxidative stress and inflammation. Overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1), an enzyme degrading ADMA, exerts protective effects in animal models. However, the impact of DDAH1/ADMA on...

Furosemide improves the stone clearance rate of extracorporeal shockwave lithotripsy for kidney stones but not ureteral stones: a systematic review and meta-analysis

Feng Yao, Ke Li, ShiQuan Huang, XueSong Cheng & XiaoLiang Jiang
Introduction:We conducted a meta-analysis (MA) to investigate the effects of furosemide on the prognosis of extracorporeal shockwave lithotripsy (SWL) therapy to remove renal (RS) and ureteric stones (US).Methods:We screened scientific databases including PubMed, Clinicalkey, Google Scholar, Medline, Embase, and Cochrane, from the date of establishment until March 2022, to search for randomized controlled trials evaluating SWL, in combination with furosemide (experimental group) or with SWL alone (control group), in treating RS or US. Our search...

Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1

Jian Gao, Yong-Qiang Ao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Hai-Kun Wang, Jia-Hao Jiang & Jian-Yong Ding
Abstract Background Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients. Here, we aimed to uncover a potential role of exosomal circular RNAs (circRNAs) in LUAD refractory to PD1 blockade. Methods circRNA sequencing and qRT-PCR were performed to determine the level of exosomal circRNAs in LUAD patients subsequently treated with anti-PD1. Then, the RNA pulldown, RNA immunoprecipitation,...

The U.S. COVID-19 County Policy Database: a novel resource to support pandemic-related research

Rita Hamad, Kristin A. Lyman, Feng Lin, Madelaine F. Modrow, Pelin Ozluk, Kristen M. J. Azar, Amie Goodin, Carmen R. Isasi, Heather E. Kitzman, Sara J. Knight, Gregory M. Marcus, Cheryl N. McMahill-Walraven, Paul Meissner, Vinit Nair, Emily C. O’Brien, Jeffrey E. Olgin, Noah D. Peyser, Gosia Sylwestrzak, Natasha Williams, Mark J. Pletcher & Thomas Carton
Abstract Background It is increasingly recognized that policies have played a role in both alleviating and exacerbating the health and economic consequences of the COVID-19 pandemic. There has been limited systematic evaluation of variation in U.S. local COVID-19-related policies. This study introduces the U.S. COVID-19 County Policy (UCCP) Database, whose objective is to systematically gather, characterize, and assess variation in U.S. county-level COVID-19-related policies. Methods In January-March 2021, we collected an initial wave of cross-sectional...

Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway

Hongchao Wang, Lijie Wang, Fuli Hu, Pengfei Wang, Yanan Xie, Fang Li & Bingyan Guo
Abstract Background Diabetic cardiomyopathy is characterized by left ventricle dysfunction, cardiomyocyte apoptosis, and interstitial fibrosis and is a serious complication of diabetes mellitus (DM). Autophagy is a mechanism that is essential for maintaining normal heart morphology and function, and its dysregulation can produce pathological effects on diabetic hearts. Neuregulin-4 (Nrg4) is an adipokine that exerts protective effects against metabolic disorders and insulin resistance. The aim of this study was to explore whether Nrg4 could ameliorate...

Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Abstract Background Irisin has been proposed to have a beneficial influence on the metabolic status of animals and humans. However, the relationship between circulating irisin levels and the risks of metabolic components in humans remains unclear. In the present meta-analysis, we aimed to evaluate the association between circulating irisin and metabolic parameters in nonobese, nondiabetic adults. Methods We searched PubMed, Embase, the Cochrane Library, Web of Science and ClinicalTrial.gov using the main search terms and...

Molecular characteristics of a coxsackievirus A12 strain in Zhejiang of China, 2019

Linjie Hu, Lu Zhou, Pingping Wang, Hairenguli Maimaiti & Yihan Lu
Abstract Background Enterovirus A (EV-A), such as enterovirus A71 (EV-A71), generally causes hand, foot, and mouth disease (HFMD). However, limited studies focused on uncommon enterovirus serotypes such as coxsackievirus A12 (CV-A12). This study aimed to provide evidence to determine the molecular characteristics of a CV-A12 strain isolated in Zhejiang province, China. Methods In routine surveillance of HFMD, we identified a child case with CV-A12 infection in 2019 in Zhejiang province, China. Enterovirus was examined by...

Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
Mid-infrared (MIR) single-photon detection is emerging as an important technology for various applications. Superconducting nanowire single photon detectors (SNSPDs) fabricated with superconducting films with energy gaps of a few meV are natural broadband single-photon detectors. Recently, extending SNSPDs’ operation wavelengths into the MIR region is highly attractive. γ-Nb₄N₃ has a reduced N content and lower energy gap than the commonly used δ-NbN, making SNSPDs based on γ-Nb₄N₃ film more sensitive to low energy photons. We...

Real-time realistic computer-generated hologram with accurate depth precision and a large depth range

Chongli Zhong, Xinzhu Sang, Binbin Yan, Hui Li, Duo Chen & Xiujuan Qin
Holographic display is an ideal technology for near-eye display to realize virtual and augmented reality applications, because it can provide all depth perception cues. However, depth performance is sacrificed by exiting computer-generated hologram (CGH) methods for real-time calculation. In this paper, volume representation and improved ray tracing algorithm are proposed for real-time CGH generation with enhanced depth performance. Using the single fast Fourier transform (S-FFT) method, the volume representation enables a low calculation burden and...

Discovery of an autophagy inducer J3 to lower mutant huntingtin and alleviate Huntington’s disease-related phenotype

Jiahui Long, Xia Luo, Dongmei Fang, Haikun Song, Weibin Fang, Hao Shan, Peiqing Liu, Boxun Lu, Xiao-Ming Yin, Liang Hong & Min Li
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein encoded from extra tracts of CAG repeats in exon 1 of the HTT gene. mHTT proteins are neurotoxic to render the death of neurons and a series of disease-associated phenotypes. The mHTT is degraded through autophagy pathway and ubiquitin–proteasome system (UPS). This study identified a small molecule, J3, as an autophagy inducer by high-content screening. The results revealed...

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer

Shuangjie Liu, Zhuonan Liu, Chiyuan Piao, Zhe Zhang, Chuize Kong, Lei Yin & Xi Liu
Abstract Background Protein arginine methyltransferases (PRMTs) regulate protein biological activity by modulating arginine methylation in cancer and are increasingly recognized as potential drug targets. Inhibitors targeting PRMTs are currently in the early phases of clinical trials and more candidate drugs are needed. Flavokawain A (FKA), extracted from kava plant, has been recognized as a potential chemotherapy drug in bladder cancer (BC), but its action mechanism remains unclear. Methods We first determined the role of a...

Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Abstract Background Most cancer disability-adjusted life year (DALY) studies worldwide have used broad, generic disability weights (DWs); however, differences exist among populations and types of cancers. Using breast cancer as example, this study aimed to estimate the population-level DALYs in females in China and the impact of screening as well as applying local DWs. Methods Using multisource data, a prevalence-based model was constructed. (1) Overall years lived with disability (YLDs) were estimated by using numbers...

Registration Year

  • 2022

Resource Types

  • Collection


  • Fudan University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Zhejiang University
  • Sichuan University
  • Sun Yat-sen University
  • Huazhong University of Science and Technology
  • Capital Medical University
  • Chinese Academy of Sciences
  • Nanjing Medical University