We theoretically and experimentally study the optical trapping of two different microparticles by a double-tapered optical fiber probe(DOFP) which is fabricated by the interfacial etching method. A SiO₂ microsphere and a yeast, or two SiO₂ microspheres with different diameters, are trapped. We calculate and measure the trapping forces on the two microparticles, discuss the impacts of the geometrical size and refractive index on the trapping forces. Both the theoretical calculation and experimental measurements indicate that...

We propose and theoretically investigate the coupled concentric ring resonators on a thickness-constrained GaP on Insulator (GaP-OI) integrated photonic platform. Anomalous dispersion is fulfilled by mode hybridization in the coupled structure on a 200 nm thick GaP-OI resonator which originally only exhibits normal dispersion. The anomalous dispersion profile for the anti-symmetric mode is flattened and broadened in favor of Kerr frequency comb generation by optimizing the waveguide width and the coupling gap size synergistically. We...

Multi-mode converters, which can achieve spatial mode conversion in multimode waveguide, play a key role in multi-mode photonics and mode-division multiplexing (MDM). However, rapid design of high-performance mode converters with ultra-compact footprint and ultra-broadband operation bandwidth is still a challenge. In this work, through combining adaptive genetic algorithm (AGA) and finite element simulations, we present an intelligent inverse design algorithm and successfully designed a set of arbitrary-order mode converters with low excess losses (ELs) and...

Owing to its relatively low absorption loss and high data transmission rate, wireless blue light communication is becoming an increasingly attractive technology for underwater applications. Here, we demonstrate an underwater optical wireless communication (UOWC) system that communicates using blue light-emitting diodes (LEDs) with a dominant wavelength of 455 nm. Under an on–off keying modulation scheme, the waterproof UOWC system achieves a bidirectional communication rate of 4 Mbps based on the transmission control protocol (TCP) and...

Optical lattices with spatially regular structures have recently attracted considerable attention across physics and optics communities. In particular, due to the increasing emergence of new structured light fields, diverse lattices with rich topology are being generated via multi-beam interference. Here, we report a specific ring lattice with radial lobe structures generated via superposition of two ring Airy vortex beams (RAVBs). We show that the lattice morphology evolves upon propagation in free space, switching from a...

Optical lattices with spatially regular structures have recently attracted considerable attention across physics and optics communities. In particular, due to the increasing emergence of new structured light fields, diverse lattices with rich topology are being generated via multi-beam interference. Here, we report a specific ring lattice with radial lobe structures generated via superposition of two ring Airy vortex beams (RAVBs). We show that the lattice morphology evolves upon propagation in free space, switching from a...

Owing to the high rates of relapse and migration, ovarian cancer (OC) has been recognized as the most lethal gynecological malignancy worldwide. The activity of the epidermal growth factor receptor (EGFR) signaling pathway is frequently associated with OC cell proliferation and migration. Despite this knowledge, inhibition of EGFR signaling in OC patients failed to achieve satisfactory therapeutic effects. In this study, we identified that bruceine D (BD) and EGFR inhibitor, afatinib, combination resulted in synergistic...

Fringe skeletons extraction method maybe the most straightforward method for electronic speckle pattern interferometry (ESPI) phase extraction. Due to the ESPI fringe patterns have the characteristics of high noise, low contrast and different fringe shapes, it is very difficult to extract skeletons from ESPI fringe patterns with high accuracy. To deal with this problem, we propose a skeletons extraction method based on deep learning, called channel transformer U-Net, for directly extracting skeletons from the noisy...

Vertical-cavity surface-emitting lasers (VCSELs) have been widely adopted in a variety of applications in recent years, with even more applications currently under research and development as a result of the emergence of visible-light VCSELs. Most of these applications make use of the ease of fabrication of large two-dimensional arrays of lasers, a feature unique to VCSELs that makes them scalable and versatile. However, applications that rely on the uniformity of the emitted beam in the...

ObjectiveTo conduct a meta-analysis assessing the efficacy and safety of cyclosporine-based combinations for primary immune thrombocytopenia (ITP).MethodsRandomized controlled clinical trials were collected by systematically searching databases (PubMed®, MEDLINE®, EMBASE, The Cochrane Library, China National Knowledge Infrastructure) from inception to June 2022. All studies included patients with ITP who received cyclosporine-based regimens. We performed comprehensive analyses of the overall response rate (ORR), complete response (CR) rate, partial response (PR) rate, relapse rate, platelet count, and adverse...

Multimode fibers (MMFs) are emerging as promising transmission media for delivering images. However, strong mode coupling inherent in MMFs induces difficulties in directly projecting two-dimensional images through MMFs. By training two subnetworks named Actor-net and Model-net synergetically, Ref. [1] alleviated this issue and demonstrated projecting images through MMFs with high fidelity. In this work, we make a step further by improving the generalization ability to greyscale images. The modified projector network contains three subnetworks, namely...

The characterization and manipulation of the polarization states at single photon level are of great importance in research fields such as quantum information processing and quantum key distribution, where the photons are normally delivered using single mode optical fibers. To date, the demonstrated polarimetry measurement techniques based on a superconducting nanowire single photon detector (SNSPD) require the SNSPD to be either highly sensitive or highly insensitive to the photon’s polarization state, therefore placing an unavoidable...

Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

The accurate detection of nanoplastics is crucial due to their harmful effects on the environment and human beings. In this research, we successfully constructed an Ag/CuO nanowire (NW)/BaTiO3@PVDF Bowl-shaped substrate with a nanowire-in-Bowl-shaped piezoelectric cavity structure that can modulate surface-enhanced Raman scattering (SERS) by the piezoelectric effect by the virtue of the molecular gripper of the CuO NW and optical field amplifier of the Bowl-shaped cavity. Due to its unique nanowire-in-Bowl-shaped structure and piezoelectrically modifiable...

Learning-based computer-generated holography (CGH) algorithms appear as novel alternatives to generate phase-only holograms. However, most existing learning-based approaches underperform their iterative peers in terms of display quality. Here, we propose an unsupervised Fourier-inspired neural network that could generate phase-only holograms in real time and obtain high-fidelity reconstructed images. Both simulation and experiment were performed to showcase its capability. By explicitly leveraging Fourier transforms within the neural network architecture, global features of the holograms are more...

BackgroundThe anatomical positioning of the graft during anterior cruciate ligament reconstruction (ACLR) is of great significance for restoring normal knee kinematics and preventing early joint degeneration. Therefore, the adjustment of the mispositioned guide pin becomes extremely important. Our research aims to test the time-zero biomechanical properties in adjusting inaccurate guide pins to the center of the tibial footprint in anatomical anterior cruciate ligament single-bundle reconstruction.MethodsPorcine tibias and bovine extensor tendons were used to simulate a...

Surface plasmon excitations in metallic hole array have been extensively studied in the context of light-matter interaction since the generated Bloch surface plasmon polariton (Bloch-SPP) exhibits unique properties of nanoscale light confinement, near-field enhancements, and long-range metal surface propagation. In this work, we experimentally demonstrate a plasmonic device that exhibits highly directional emission in visible light, using Ag film with thickness of 100 nm is deposited on the subwavelength porous alumina array as a plasmonic...

Light-emitting diodes (LEDs) are the 4th plant supplemental lighting source. Pulsed lighting is benefit to increase energy utilization efficiency in greenhouse production. A pulsed-lighting LED luminaire with geometrical optical solution is proposed to overcome the shortcoming with pulse width modulation (PWM) solution. In addition, this luminaire also achieves uniform lighting by designing freeform surfaces. In the illumination area, the lighting frequency is 117.6 Hz and the illuminance uniformity is 0.789, which is better than 0.75...

Light-emitting diodes (LEDs) are the 4th plant supplemental lighting source. Pulsed lighting is benefit to increase energy utilization efficiency in greenhouse production. A pulsed-lighting LED luminaire with geometrical optical solution is proposed to overcome the shortcoming with pulse width modulation (PWM) solution. In addition, this luminaire also achieves uniform lighting by designing freeform surfaces. In the illumination area, the lighting frequency is 117.6 Hz and the illuminance uniformity is 0.789, which is better than 0.75...

The evaluation of megakaryocytes is an important part of the work up on bone marrow smear examination. It has significance in the differential diagnosis, therapeutic efficacy assessment, and predication of prognosis of many hematologic diseases. The process of manual identification of megakaryocytes are tedious and lack of reproducibility; therefore, a reliable method of automated megakaryocytic identification is urgently needed. Three hundred and thirty-three bone marrow aspirate smears were digitized by Morphogo system. Pathologists annotated megakaryocytes...

The age of information and communication technology (ICT) has witnessed the prevalence of computer-based reading. Previous studies yielded mixed results concerning the relationship between ICT perceived competence, ICT use and digital reading performance, and the underlying mechanism was rarely explored. This study aimed to explore the relationship between ICT perceived competence and adolescents’ digital reading performance and the potential mediating roles of three types of ICT use. Multilevel mediation analyses were conducted for 199,646 15-year-old...

Background: Lymph node downstaging and the achievement of total-pCR (ypT0/is ypN0) after neoadjuvant therapy are of great importance in HER-2 positive breast cancer. We aim to provide an overall review of neoadjuvant regimens for lymph node downstaging and to indirectly compare the total-pCR by various neoadjuvant regimens with network meta-analysis in HER2-positive patients according to their clinical lymph node status. Methods: Five English databases were searched comprehensively and systematically for relevant RCTs and case-control studies....

Body colour is an important economic trait for commercial fishes. Recently, a new colour morph displaying market-favoured yellow skin (termed as yellow-mutant, YM) of Northern snakehead (Channa argus) was discovered in China. We confirmed that YM snakehead is an albino with complete loss of melanin in the skin and eyes by histological and ultrastructural observations, and inherited as a recessive Mendelian trait. By applying genomic analysis approaches, in combination with gene knockdown and rescue experiments,...

Computer holography is a promising technique for reproducing 3D viewing experiences on-demand by modulating an amplitude or phase hologram. Yet, the huge computational burden of both acquiring 3D wave data and simulating diffraction propagation places an explicit challenge to the total runtime of 3D hologram generation, making dynamic holography impractical. Here we demonstrate a deep-learning based method capable of synthesizing a photorealistic 3D hologram in real-time directly from the input of a single 2D image....

Intestine is a place that a site of immune cells priming at birth. Therefore, spatial transcriptomics was performed to define how the transcriptomic landscape is spatially organized in the posterior intestine of Sebastes schlegelii following Edwardsiella piscicida infection. At the healthy condition, we identified a previously unappreciated molecular regionalization of the posterior intestine. Following bacterial infection, most immune-related genes were identified in mucosa layers. Moreover, investigation of immune-related genes and genes in immune-related KEGG pathways...