The United Nations International Children’s Emergency Fund (UNICEF) initiatives of Child-Friendly Cities have operated in more than 3000 cities around the world. However, the concept of making the city child-friendly has not been extensively recognized in China. This article aims to report a regeneration project in a migrant workers’ community, the Mingdong, and is used to illustrate the reactions of residents to youth participation (youth civic engagement) and the project through an international workshop. The...

Here, we experimentally demonstrate quantum coherent superposition of two different birthplaces of a four-photon state, where multi-photon frustrated interference emerges from the quantum indistinguishability by path identity. The quantum state is created in four probabilistic photon-pair sources on one integrated silicon photonic chip, two combinations of which can create photon quadruplets. Coherent elimination and revival of distributed four-photons are fully controlled by tuning phases. The experiment gives rise to peculiar quantum interference of two possible...

Optical waveguide amplifiers are essential devices in integrated optical systems. Their gain bandwidths directly determine the operating wavelength of optical circuits. Due to the difficulty of developing wideband gain media, it has been a challenge to fabricate devices with broadband amplification capability, resulting in few reports on multi-band polymer waveguide amplifiers. Here, a polymer waveguide amplifier is demonstrated, which achieves loss compensation covering the whole (S+C)-band by using NaYF4:Tm,Yb@NaYF4@NaYF4:Er nanoparticles-doped SU-8 as the gain medium....

Background:Misdiagnosis and underdiagnosis of pulmonary hypertension caused by fibrosing mediastinitis (PH-FM) are considerably prevalent due to unspecific symptoms and as well as the lack of awareness of this fatal disease.Objectives:The aim of this study was to evaluate the diagnostic accuracy of the chest X-ray (CXR) for screening the patients with PH-FM from those with pulmonary hypertension (PH).Design:This was a retrospective observational cohort study.Methods:The patients with suspected PH were recruited between October 2014 and October 2020....

Learning-based computer-generated holography (CGH) algorithms appear as novel alternatives to generate phase-only holograms. However, most existing learning-based approaches underperform their iterative peers in terms of display quality. Here, we propose an unsupervised Fourier-inspired neural network that could generate phase-only holograms in real time and obtain high-fidelity reconstructed images. Both simulation and experiment were performed to showcase its capability. By explicitly leveraging Fourier transforms within the neural network architecture, global features of the holograms are more...

Recently, the concept of two-qubit controlled phase gate via off-resonant modulated driving has been introduced into the neutral atom qubit platform, with respect to both single-photon and two-photon ground-Rydberg transitions. In order to reach a better performance practically, further developments are in need to overcome a few known limitations in previous discussions. Here, we thoroughly analyze a variety of modulation styles for two-photon transitions, demonstrating the versatility of off-resonant modulated driving protocols. Furthermore, we show...

Pulses as short as 44 fs (6 optical cycles) with a spectral width of 120 nm are generated from a mode-locked solid-state laser near 2 µm employing an orthorhombic Tm:GdScO3 perovskite crystal. The average power amounts to 188 mW at a repetition rate of ~ 77.6 MHz. The strong inhomogeneous line broadening in GdScO3 suggests optimum conditions for few-optical-cycle pulse generation of rare-earth ion doped GdScO3 bulk lasers.

Objective quantification of photoreceptor cell morphology, such as cell diameter and outer segment length, is crucial for early, accurate, and sensitive diagnosis and prognosis of retinal neurodegenerative diseases. Adaptive optics optical coherence tomography (AO-OCT) provides three-dimensional (3-D) visualization of photoreceptor cells in the living human eye. The current gold standard for extracting cell morphology from AO-OCT images involves the tedious process of 2-D manual marking. To automate this process and extend to 3-D analysis of...

Background:Current studies on the role of sex in the prognosis of acute vertebrobasilar artery occlusion (VBAO) are limited. We aimed to explore whether there are sex differences on outcomes in patients treated with endovascular therapy (EVT) for VBAO.Methods:Patients from December 2015 to December 2018 with acute VBAO within 24 h of the estimated occlusion time in 21 stroke centers in China were retrospectively analyzed. Baseline data between sexes were compared in the total population cohort...

Bright γ-ray sources are of great significance for fundamental research, medicine and industry. However, γ-ray production by bremsstrahlung, Compton scattering, and synchrotron radiation is often subjected to large divergence, wide size and/or low efficiency, making it difficult to achieve high-brightness γ-ray sources. Here we have found an efficient mechanism to generate γ-rays with unprecedented brilliance by use of an ultrarelativistic electron beam with nC charge incident onto a solid surface at grazing incidence. With this...

Bright γ-ray sources are of great significance for fundamental research, medicine and industry. However, γ-ray production by bremsstrahlung, Compton scattering, and synchrotron radiation is often subjected to large divergence, wide size and/or low efficiency, making it difficult to achieve high-brightness γ-ray sources. Here we have found an efficient mechanism to generate γ-rays with unprecedented brilliance by use of an ultrarelativistic electron beam with nC charge incident onto a solid surface at grazing incidence. With this...

Objective: Angina pectoris (AP), affecting over 523 million people, can be alleviated by corydalis rhizome (CR), usually combined with chuanxiong rhizome (CXR), angelica dahuricae radix (ADR), or astragali radix (AR) to enhance the effect. This study aims to distinguish the different mechanisms among 3 drug pairs to treat AP. Methods: The drug pair-disease intersection targets, compound targets, protein–protein interaction (PPI), and herb-compound-target-pathway network were obtained by Cytoscape, STRING, Gene Ontology (GO), and Kyoto Encyclopedia of...

This paper presents an additive Gompertz-Weibull (AGW) distribution, a four-parameter hybrid probability distribution, and its applications in reliability engineering. The failure rate (FR) function of the proposed model demonstrates an increasing trend and a variety of bathtub shapes with or without a low and yet long-stable segment, making it appropriate for modelling a wide variety of real-world problems. Some relationships between the AGW’s FR and its mean residual life functions are examined. For parameter estimation,...

BackgroundThe anatomical positioning of the graft during anterior cruciate ligament reconstruction (ACLR) is of great significance for restoring normal knee kinematics and preventing early joint degeneration. Therefore, the adjustment of the mispositioned guide pin becomes extremely important. Our research aims to test the time-zero biomechanical properties in adjusting inaccurate guide pins to the center of the tibial footprint in anatomical anterior cruciate ligament single-bundle reconstruction.MethodsPorcine tibias and bovine extensor tendons were used to simulate a...

Introduction:Brain metastasis (BM) is a significant risk factor for survival and prognosis in non-small cell lung cancer (NSCLC). While surgical resection and radiotherapy are the primary treatment modalities, the overall prognosis in NSCLC patients with BM remains poor, and all therapies lead to adverse events. East Asian herbal medicine (EAHM) has broad prospects as an adjuvant treatment, but its efficacy and safety remain controversial. We propose to conduct a systematic review and meta-analysis to summarize...

The pursuit of the common good is an important endeavor in business and marketing. The benefits of this pursuit to society are reflected in the increasing number of journal special issues dedicated to common good–related research and the recent observation that the marketing discipline is supportive of business research as a catalyst for positive change. Despite its importance, little is known about the nature of the common good within marketing scholarship. This article presents a...

The acquisition of neuronal activities across varying depths with high spatiotemporal resolution is essential for understanding the functional neural circuits in living animals. To address this challenge, we developed SImultaneous MultiPLanE imaging light-sheet fluorescence microscopy (SIMPLE-LSFM) by introducing a digital micromirror device into the illumination arm, which generated multiple sheets in the sample space to simultaneously excite multiple axial depths. Combined with the spherical-aberration-assisted point spread function and the encoded depth information of the detection...

Background: It remains controversial whether the application of chemotherapy has an impact on recurrent nasopharyngeal carcinoma (rNPC) patients with salvage radiotherapy. Here, we aimed to evaluate treatment outcomes of rNPC patients and derive a prognostic model to assess the benefit of chemotherapy in patients with re-radiotherapy. Methods: This study was conducted as a retrospective study. In total, 340 rNPC patients treated with salvage intensity-modulated radiotherapy (IMRT) or radiochemotherapy (RCT) from October 2006 to September 2019...

Direct femtosecond laser writing of ferroelectric domain structures has been an indispensable technique for engineering the second-order optical nonlinearity of materials in three dimensions. It utilizes localized thermoelectric field motivated by nonlinear absorption at the position of laser focus to manipulate domains. However, the impact of laser wavelengths, which is pivotal in nonlinear absorption, on the inverted domains are still sketchy. Herein, the light-induced ferroelectric domain inversion is experimentally studied. It is shown that the...

Direct femtosecond laser writing of ferroelectric domain structures has been an indispensable technique for engineering the second-order optical nonlinearity of materials in three dimensions. It utilizes localized thermoelectric field motivated by nonlinear absorption at the position of laser focus to manipulate domains. However, the impact of laser wavelengths, which is pivotal in nonlinear absorption, on the inverted domains are still sketchy. Herein, the light-induced ferroelectric domain inversion is experimentally studied. It is shown that the...

Direct femtosecond laser writing of ferroelectric domain structures has been an indispensable technique for engineering the second-order optical nonlinearity of materials in three dimensions. It utilizes localized thermoelectric field motivated by nonlinear absorption at the position of laser focus to manipulate domains. However, the impact of laser wavelengths, which is pivotal in nonlinear absorption, on the inverted domains are still sketchy. Herein, the light-induced ferroelectric domain inversion is experimentally studied. It is shown that the...

We aim to evaluate the marginal effects of covariates on time-to-disability in the elderly under the semi-competing risks framework, as death dependently censors disability, not vice versa. It becomes particularly challenging when time-to-disability is subject to interval censoring due to intermittent assessments. A left truncation issue arises when the age time scale is applied. We develop a flexible two-parameter copula-based semiparametric transformation model for semi-competing risks data subject to interval censoring and left truncation. The...

Fluorescence sensors for europium (Eu) ions are seldom reported. We study the synthesis of water-soluble quaternary I-III-VI QDs and investigate their fluorescence sensor application for detecting Eu ions. The as synthesized glutathione (GSH) capped AgZnInS (AZIS) QDs show great sensitivity and selectivity to Europium (Eu) ions among 13 different metal cations. Detail experiment results indicate that the fluorescence response of the AZIS QDs to increasing [Eu3+] include intensity quenching and peak wavelength blue-shift. The effective...

A new continuous flow synthetic method for preparing indole and its derivatives are successfully developed to overcome the disadvantages of traditional batch methods, such as low conversion rates, long reaction times, and amplification effects. The method represents a sustainable and efficient preparation of indole and its derivatives without the need for additional catalysts. By investigating the effects of the reaction temperature, the solvent, the equivalence ratio, and the residence time, high conversion rates and excellent...

Abstract Pathogenic variants in MYO15A are known to cause autosomal recessive nonsyndromic hearing loss (ARNSHL), DFNB3. We have previously reported on one ARNSHL family including two affected siblings and identified MYO15A c.5964+3G > A and c.8375 T > C (p.Val2792Ala) as the possible deafness-causing variants. Eight year follow up identified one new affected individual in this family, who also showed congenital, severe to profound sensorineural hearing loss. By whole exome sequencing, we identified a new...