21 Works

Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Andrew M. Novick, Korrina A. Duffy, Rachel L. Johnson, Mary D. Sammel, Wen Cao, Andrew A. Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A. Leslie Morrow & C. Neill Epperson
Abstract Background Progesterone administration has therapeutic effects in tobacco use disorder (TUD), with females benefiting more than males. Conversion of progesterone to the neurosteroid allopregnanolone is hypothesized to partly underlie the therapeutic effects of progesterone; however, this has not been investigated clinically. Methods Smokers (n = 18 males, n = 21 females) participated in a randomized, double-blind, placebo-controlled crossover study of 200 mg progesterone daily across 4 days of abstinence. The ratio of allopregnanolone:progesterone was...

Depression Transmission From Parents to Their Adult Children in China: The Mediating Role of Family Violence

Weiwei Wang & Huiping Zhang
Depression can be transmitted from parents to children through the gene–environment interaction. Previous studies have focused on the short-term effects of parental depression on children and adolescents while neglecting the long-term effects. Furthermore, as a major indicator of stressful environment, the mediating role of different types of family violence has rarely been studied. The purpose of this study was to examine the long-term effects of parental depressive symptoms on those of adult children and to...

Upper limb manual training for children with cerebral palsy: A systematic review and network meta-analysis of randomized controlled trials

Fu-An Yang, Ting-Hsuan Lee, Shih-Wei Huang, Tsan-Hon Liou, Reuben Escorpizo & Hung-Chou Chen
ObjectiveThere are different upper limb manual training protocols, namely constraint-induced movement therapy, modified constraint-induced movement therapy, hand–arm bimanual intensive training, hand–arm bimanual intensive training including lower extremity, action observation training, and mirror therapy, available for improving functional outcomes in children with cerebral palsy. However, the effect and priority of these strategies remain unclear.Data sourcesWe searched the PubMed, Cochrane Library, and Embase databases for relevant articles from inception to October 12, 2022.Review methodsTo assess the effect...

High-speed and low dark current silicon-waveguide-coupled III-V photodetectors selectively grown on SOI

Ying Xue, Yu Han, Yi Wang, Jie LI, Jingyi Wang, Zunyue Zhang, Xinlun Cai, Hon Tsang & Kei May Lau
Seamlessly integrating III-V active devices with Si passive components in a monolithic manner is the key for fully-integrated Si-photonics. In this article, we demonstrate high-performance III-V photodetectors directly grown on industry-standard (001)-oriented silicon-on-insulator wafers and intimately coupled with Si waveguides. The Si-waveguide coupled III-V photodetectors feature a low dark current of 60 pA corresponding to a current density of 0.002 A/cm2, a large photocurrent exceeding 1 mA, responsivities of 0.4 A/W at 1.3 μm and...

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

Theresa L. Montgomery, Korin Eckstrom, Katarina H. Lile, Sydney Caldwell, Eamonn R. Heney, Karolyn G. Lahue, Angelo D’Alessandro, Matthew J. Wargo & Dimitry N. Krementsov
Abstract Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut microbiota remains challenging. We and others have previously shown that colonization with the gut commensal and putative probiotic species, Lactobacillus reuteri, unexpectedly enhances host susceptibility to experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. To identify underlying mechanisms, we characterized the...

Upper limb manual training for children with cerebral palsy: A systematic review and network meta-analysis of randomized controlled trials

Fu-An Yang, Ting-Hsuan Lee, Shih-Wei Huang, Tsan-Hon Liou, Reuben Escorpizo & Hung-Chou Chen
ObjectiveThere are different upper limb manual training protocols, namely constraint-induced movement therapy, modified constraint-induced movement therapy, hand–arm bimanual intensive training, hand–arm bimanual intensive training including lower extremity, action observation training, and mirror therapy, available for improving functional outcomes in children with cerebral palsy. However, the effect and priority of these strategies remain unclear.Data sourcesWe searched the PubMed, Cochrane Library, and Embase databases for relevant articles from inception to October 12, 2022.Review methodsTo assess the effect...

Short-term efficacy of angiotensin receptor-neprilysin inhibitor treatment in patients with ST-segment elevation myocardial infarction with reduced ejection fraction after primary percutaneous coronary intervention: a propensity score matching study

Qun Zhang, Bao Qiao, Yu Han, Shukun Sun, Bailu Wang & Shujian Wei
Abstract Background Acute myocardial infarction (AMI) causes a series of pathophysiological changes, including myocardial necrosis, myocardial edema, and microvascular damage. These changes eventually lead to severe cardiovascular events, such as ventricular remodeling, heart failure, and papillary dysfunction. Impaired cardiac function after ST-segment elevation myocardial infarction (STEMI) often manifests as a decrease in left ventricular ejection fraction (LVEF). Clinical trials have shown that angiotensin receptor-neprilysin inhibitor (ARNI) treatment has the potential to improve LVEF in patients...

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

A Meta-Analytic Review of the Impact of Child Maltreatment on Self-Esteem: 1981 to 2021

Huiping Zhang, Weiwei Wang, Shiqin Liu, Yali Feng & Qingong Wei
An increasing number of studies have examined the relationship between child maltreatment and self-esteem. In this study, we assess the magnitude of this association through a meta-analytic approach. Four English databases (PubMed, PsycINFO, PsycARTICLES, and Web of Science), three Chinese databases (China National Knowledge Infrastructure, Wanfang, and Weipu), and grey literature were systematically searched. A total of 254 independent studies, including 550 effect sizes, met the inclusion criteria for this meta-analysis. Child maltreatment was significantly...

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

High-speed and low dark current silicon-waveguide-coupled III-V photodetectors selectively grown on SOI

Ying Xue, Yu Han, Yi Wang, Jie LI, Jingyi Wang, Zunyue Zhang, Xinlun Cai, Hon Tsang & Kei May Lau
Seamlessly integrating III-V active devices with Si passive components in a monolithic manner is the key for fully-integrated Si-photonics. In this article, we demonstrate high-performance III-V photodetectors directly grown on industry-standard (001)-oriented silicon-on-insulator wafers and intimately coupled with Si waveguides. The Si-waveguide coupled III-V photodetectors feature a low dark current of 60 pA corresponding to a current density of 0.002 A/cm2, a large photocurrent exceeding 1 mA, responsivities of 0.4 A/W at 1.3 μm and...

Short-term efficacy of angiotensin receptor-neprilysin inhibitor treatment in patients with ST-segment elevation myocardial infarction with reduced ejection fraction after primary percutaneous coronary intervention: a propensity score matching study

Qun Zhang, Bao Qiao, Yu Han, Shukun Sun, Bailu Wang & Shujian Wei
Abstract Background Acute myocardial infarction (AMI) causes a series of pathophysiological changes, including myocardial necrosis, myocardial edema, and microvascular damage. These changes eventually lead to severe cardiovascular events, such as ventricular remodeling, heart failure, and papillary dysfunction. Impaired cardiac function after ST-segment elevation myocardial infarction (STEMI) often manifests as a decrease in left ventricular ejection fraction (LVEF). Clinical trials have shown that angiotensin receptor-neprilysin inhibitor (ARNI) treatment has the potential to improve LVEF in patients...

Rational design of an essential diagnostics network to support Universal Health Coverage: a modeling analysis

Lee F. Schroeder, Yvonne Dei-Adomakoh, Kristen DeStigter, Emmanuel O. Idigbe, John Flanigan, Priscilla Mawuli Awo Ekpale, Ernest Adjei, Lina Roa, Michael L. Wilson & Susan Horton
Abstract Background Diagnostic investigations, including pathology and laboratory medicine (PALM) and radiology, have been largely absent from international strategies such as the Sustainable Development Goals. Further, there is little international guidance on which health system tiers different diagnostics should be placed, a critical step in developing a country-level diagnostics network. We describe a modeling strategy to produce tier-specific diagnostic recommendations based on disease burden, current treatment pathways, and existing infrastructure in a country. Methods The...

Rational design of an essential diagnostics network to support Universal Health Coverage: a modeling analysis

Lee F. Schroeder, Yvonne Dei-Adomakoh, Kristen DeStigter, Emmanuel O. Idigbe, John Flanigan, Priscilla Mawuli Awo Ekpale, Ernest Adjei, Lina Roa, Michael L. Wilson & Susan Horton
Abstract Background Diagnostic investigations, including pathology and laboratory medicine (PALM) and radiology, have been largely absent from international strategies such as the Sustainable Development Goals. Further, there is little international guidance on which health system tiers different diagnostics should be placed, a critical step in developing a country-level diagnostics network. We describe a modeling strategy to produce tier-specific diagnostic recommendations based on disease burden, current treatment pathways, and existing infrastructure in a country. Methods The...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Andrew M. Novick, Korrina A. Duffy, Rachel L. Johnson, Mary D. Sammel, Wen Cao, Andrew A. Strasser, Mehmet Sofuoglu, Alexandra Kuzma, James Loughead, A. Leslie Morrow & C. Neill Epperson
Abstract Background Progesterone administration has therapeutic effects in tobacco use disorder (TUD), with females benefiting more than males. Conversion of progesterone to the neurosteroid allopregnanolone is hypothesized to partly underlie the therapeutic effects of progesterone; however, this has not been investigated clinically. Methods Smokers (n = 18 males, n = 21 females) participated in a randomized, double-blind, placebo-controlled crossover study of 200 mg progesterone daily across 4 days of abstinence. The ratio of allopregnanolone:progesterone was...

Depression Transmission From Parents to Their Adult Children in China: The Mediating Role of Family Violence

Weiwei Wang & Huiping Zhang
Depression can be transmitted from parents to children through the gene–environment interaction. Previous studies have focused on the short-term effects of parental depression on children and adolescents while neglecting the long-term effects. Furthermore, as a major indicator of stressful environment, the mediating role of different types of family violence has rarely been studied. The purpose of this study was to examine the long-term effects of parental depressive symptoms on those of adult children and to...

A Meta-Analytic Review of the Impact of Child Maltreatment on Self-Esteem: 1981 to 2021

Huiping Zhang, Weiwei Wang, Shiqin Liu, Yali Feng & Qingong Wei
An increasing number of studies have examined the relationship between child maltreatment and self-esteem. In this study, we assess the magnitude of this association through a meta-analytic approach. Four English databases (PubMed, PsycINFO, PsycARTICLES, and Web of Science), three Chinese databases (China National Knowledge Infrastructure, Wanfang, and Weipu), and grey literature were systematically searched. A total of 254 independent studies, including 550 effect sizes, met the inclusion criteria for this meta-analysis. Child maltreatment was significantly...

High-speed and low dark current silicon-waveguide-coupled III-V photodetectors selectively grown on SOI

Ying Xue, Yu Han, Yi Wang, Jie LI, Jingyi Wang, Zunyue Zhang, Xinlun Cai, Hon Tsang & Kei May Lau
Seamlessly integrating III-V active devices with Si passive components in a monolithic manner is the key for fully-integrated Si-photonics. In this article, we demonstrate high-performance III-V photodetectors directly grown on industry-standard (001)-oriented silicon-on-insulator wafers and intimately coupled with Si waveguides. The Si-waveguide coupled III-V photodetectors feature a low dark current of 60 pA corresponding to a current density of 0.002 A/cm2, a large photocurrent exceeding 1 mA, responsivities of 0.4 A/W at 1.3 μm and...

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity

Theresa L. Montgomery, Korin Eckstrom, Katarina H. Lile, Sydney Caldwell, Eamonn R. Heney, Karolyn G. Lahue, Angelo D’Alessandro, Matthew J. Wargo & Dimitry N. Krementsov
Abstract Background Dysregulation of gut microbiota-associated tryptophan metabolism has been observed in patients with multiple sclerosis. However, defining direct mechanistic links between this apparent metabolic rewiring and individual constituents of the gut microbiota remains challenging. We and others have previously shown that colonization with the gut commensal and putative probiotic species, Lactobacillus reuteri, unexpectedly enhances host susceptibility to experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. To identify underlying mechanisms, we characterized the...

Registration Year

  • 2022
    21

Resource Types

  • Collection
    21

Affiliations

  • University of Vermont
    21
  • Shandong University
    8
  • Zhejiang University
    7
  • Huazhong University of Science and Technology
    6
  • Sichuan University
    4
  • Lanzhou Institute of Husbandry and Pharmaceutical Sciences
    4
  • Hohai University
    4
  • University of Colorado Anschutz Medical Campus
    4
  • Affiliated Hospital of Nantong University
    3
  • Fred Hutchinson Cancer Research Center
    3