24 Works

Plasma proteome profiling identifies changes associated to AD but not to FTD

R. Babapour Mofrad, M. del Campo, C. F. W. Peeters, L. H. H. Meeter, H. Seelaar, M. Koel-Simmelink, I. H. G. B. Ramakers, H. A. M. Middelkoop, P. P. De Deyn, J. A. H. R. Claassen, J. C. van Swieten, C. Bridel, J. J. M. Hoozemans, P. Scheltens, W. M. van der Flier, Y. A. L. Pijnenburg & Charlotte E. Teunissen
Abstract Background Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of Tau (FTLD-Tau) or TAR DNA binding43 (FTLD-TDP) proteins. Plasma biomarkers are strongly needed for specific diagnosis and potential treatment monitoring of FTD. We aimed to identify specific FTD plasma biomarker profiles discriminating FTD from AD and controls, and between FTD pathological subtypes. In addition, we compared plasma results with results in post-mortem frontal cortex of FTD cases to...

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Isis Ricaño-Ponce, Anca-Lelia Riza, Aline H. de Nooijer, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Ioana Streata, Mihaela Roskanovic, Inge Grondman, Florentina Dumitrescu, Vinod Kumar, Mihai G. Netea & Mihai Ioana
Abstract Background Sepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to stratify patients for personalized immune-based treatments and better prognostic prediction. Using gene expression data, different inflammatory profiles have been identified. However, it remains unknown whether these endotypes mirror inflammatory proteome profiling, which would be more feasible to assess in clinical practice. We aim to identify different inflammatory endotypes based on circulating...

Adaptability and learning Intraprofessional collaboration of residents during the COVID-19 pandemic

C. L. Bus, R. van der Gulden, M. Bolk, J. de Graaf, M. van den Hurk, N. N. D. Scherpbier-de Haan, C. R. M. G. Fluit, W. Kuijer-Siebelink & N. Looman
Abstract Context The COVID-19 pandemic created a worldwide public health emergency, in which hospitals created new COVID departments and doctors from different disciplines had to work together. In the Netherlands, a large proportion of doctors in these departments were residents. With knowledge of the disease developing only gradually, the influx of COVID-19 patients called for adaptability, innovative work behavior, and intraprofessional collaboration (intraPC) between residents and between residents and medical specialists. Research goal This study...

RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine

E. C. Wood, Amy K. Glen, Lindsey G. Kvarfordt, Finn Womack, Liliana Acevedo, Timothy S. Yoon, Chunyu Ma, Veronica Flores, Meghamala Sinha, Yodsawalai Chodpathumwan, Arash Termehchy, Jared C. Roach, Luis Mendoza, Andrew S. Hoffman, Eric W. Deutsch, David Koslicki & Stephen A. Ramsey
Abstract Background Biomedical translational science is increasingly using computational reasoning on repositories of structured knowledge (such as UMLS, SemMedDB, ChEMBL, Reactome, DrugBank, and SMPDB in order to facilitate discovery of new therapeutic targets and modalities. The NCATS Biomedical Data Translator project is working to federate autonomous reasoning agents and knowledge providers within a distributed system for answering translational questions. Within that project and the broader field, there is a need for a framework that can...

Trauma-focused therapies for post-traumatic stress in psychosis: study protocol for the RE.PROCESS randomized controlled trial

Simone R. Burger, Tineke van der Linden, Amy Hardy, Paul de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Catherine van Zelst, Jennifer D. Gottlieb, Kim T. Mueser, Agnes van Minnen, Ad de Jongh, Machteld Marcelis, Mark van der Gaag & David van den Berg
Abstract Introduction Many people with psychotic disorders experience symptoms of post-traumatic stress disorder (PTSD). In recent years, several trauma-focused therapies (TFTs), including cognitive restructuring (CR), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR) have been studied and found to be safe and effective in reducing PTSD symptoms in individuals with psychosis. However, studies were conducted in different countries, with varying inclusion criteria, therapy duration, control groups, and trial outcomes. RE.PROCESS will be the...

autoRasch: An R Package to Do Semi-Automated Rasch Analysis

Feri Wijayanto, Ioan Gabriel Bucur, Perry Groot & Tom Heskes
The R package autoRasch has been developed to perform a Rasch analysis in a (semi-)automated way. The automated part of the analysis is achieved by optimizing the so-called in-plus-out-of-questionnaire log-likelihood (IPOQ-LL) or IPOQ-LL-DIF when differential item functioning (DIF) is included. These criteria measure the quality of fit on a pre-collected survey, depending on which items are included in the final instrument. To compute these criteria, autoRasch fits the generalized partial credit model (GPCM) or the...

In-hospital initiation of PCSK9 inhibitor and short-term lipid control in patients with acute myocardial infarction

Bowen Lou, Hui Liu, Yongbai Luo, Gulinigaer Tuerhong Jiang, Haoyu Wu, Chen Wang, Yue Wu, Bo Zhou, Zuyi Yuan, Jianqing She & Junhui Liu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to improve cardiovascular outcomes when added to conventional statin therapy. This study aims to investigate the efficacy and safety of in-hospital initiation of PCSK9 inhibitors among patients with acute myocardial infarction (AMI) based on real-world experience. Methods and results Data were collected from the Biobank of the First Affiliated Hospital of Xi’an Jiaotong University between January 2016 and December 2020. A total of...

In-hospital initiation of PCSK9 inhibitor and short-term lipid control in patients with acute myocardial infarction

Bowen Lou, Hui Liu, Yongbai Luo, Gulinigaer Tuerhong Jiang, Haoyu Wu, Chen Wang, Yue Wu, Bo Zhou, Zuyi Yuan, Jianqing She & Junhui Liu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been shown to improve cardiovascular outcomes when added to conventional statin therapy. This study aims to investigate the efficacy and safety of in-hospital initiation of PCSK9 inhibitors among patients with acute myocardial infarction (AMI) based on real-world experience. Methods and results Data were collected from the Biobank of the First Affiliated Hospital of Xi’an Jiaotong University between January 2016 and December 2020. A total of...

Adaptability and learning Intraprofessional collaboration of residents during the COVID-19 pandemic

C. L. Bus, R. van der Gulden, M. Bolk, J. de Graaf, M. van den Hurk, N. N. D. Scherpbier-de Haan, C. R. M. G. Fluit, W. Kuijer-Siebelink & N. Looman
Abstract Context The COVID-19 pandemic created a worldwide public health emergency, in which hospitals created new COVID departments and doctors from different disciplines had to work together. In the Netherlands, a large proportion of doctors in these departments were residents. With knowledge of the disease developing only gradually, the influx of COVID-19 patients called for adaptability, innovative work behavior, and intraprofessional collaboration (intraPC) between residents and between residents and medical specialists. Research goal This study...

RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine

E. C. Wood, Amy K. Glen, Lindsey G. Kvarfordt, Finn Womack, Liliana Acevedo, Timothy S. Yoon, Chunyu Ma, Veronica Flores, Meghamala Sinha, Yodsawalai Chodpathumwan, Arash Termehchy, Jared C. Roach, Luis Mendoza, Andrew S. Hoffman, Eric W. Deutsch, David Koslicki & Stephen A. Ramsey
Abstract Background Biomedical translational science is increasingly using computational reasoning on repositories of structured knowledge (such as UMLS, SemMedDB, ChEMBL, Reactome, DrugBank, and SMPDB in order to facilitate discovery of new therapeutic targets and modalities. The NCATS Biomedical Data Translator project is working to federate autonomous reasoning agents and knowledge providers within a distributed system for answering translational questions. Within that project and the broader field, there is a need for a framework that can...

Choice Boosts Curiosity

Patricia Romero Verdugo, Lieke L. F. van Lieshout, Floris P. de Lange & Roshan Cools
In our connected era, we spend significant time and effort satisfying our curiosity. Often, we choose which information we seek, but sometimes the selection is made for us. We hypothesized that humans exhibit enhanced curiosity in the context of choice. We designed a task in which healthy participants saw two lotteries on each trial. On some trials, participants chose which lottery to play. On other trials, the lottery was selected for them. Participants then indicated...

Facial expression recognition is linked to clinical and neurofunctional differences in autism

Hannah Meyer-Lindenberg, Carolin Moessnang, Bethany Oakley, Jumana Ahmad, Luke Mason, Emily J. H. Jones, Hannah L. Hayward, Jennifer Cooke, Daisy Crawley, Rosemary Holt, Julian Tillmann, Tony Charman, Simon Baron-Cohen, Tobias Banaschewski, Christian Beckmann, Heike Tost, Andreas Meyer-Lindenberg, Jan K. Buitelaar, Declan G. Murphy, Michael J. Brammer & Eva Loth
Abstract Background Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. Methods Between 255 and 488 participants aged 6–30...

Enhancing the role of the social network in activity (re)engagement post-stroke: a focus group study with rehabilitation professionals

Dinja J. van der Veen, Sandra Jellema, Philip J. van der Wees, Maud J. L. Graff, Bert J. M. de Swart & Esther M. J. Steultjens
Abstract Background People post-stroke are at risk of not being able to participate in valued activities. It is important that rehabilitation professionals prepare people post-stroke for the transition home and provide needed support when they live at home. Several authors have suggested that members of the broad social network should play an active role in rehabilitation. This includes informing them about the importance of activity (re)engagement post-stroke and learning strategies to provide support. It is...

autoRasch: An R Package to Do Semi-Automated Rasch Analysis

Feri Wijayanto, Ioan Gabriel Bucur, Perry Groot & Tom Heskes
The R package autoRasch has been developed to perform a Rasch analysis in a (semi-)automated way. The automated part of the analysis is achieved by optimizing the so-called in-plus-out-of-questionnaire log-likelihood (IPOQ-LL) or IPOQ-LL-DIF when differential item functioning (DIF) is included. These criteria measure the quality of fit on a pre-collected survey, depending on which items are included in the final instrument. To compute these criteria, autoRasch fits the generalized partial credit model (GPCM) or the...

Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study

Isis Ricaño-Ponce, Anca-Lelia Riza, Aline H. de Nooijer, Andrei Pirvu, Stefania Dorobantu, Adina Dragos, Ioana Streata, Mihaela Roskanovic, Inge Grondman, Florentina Dumitrescu, Vinod Kumar, Mihai G. Netea & Mihai Ioana
Abstract Background Sepsis is a heterogeneous syndrome due to a variable range of dysregulated processes in the host immune response. Efforts are made to stratify patients for personalized immune-based treatments and better prognostic prediction. Using gene expression data, different inflammatory profiles have been identified. However, it remains unknown whether these endotypes mirror inflammatory proteome profiling, which would be more feasible to assess in clinical practice. We aim to identify different inflammatory endotypes based on circulating...

Trauma-focused therapies for post-traumatic stress in psychosis: study protocol for the RE.PROCESS randomized controlled trial

Simone R. Burger, Tineke van der Linden, Amy Hardy, Paul de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Catherine van Zelst, Jennifer D. Gottlieb, Kim T. Mueser, Agnes van Minnen, Ad de Jongh, Machteld Marcelis, Mark van der Gaag & David van den Berg
Abstract Introduction Many people with psychotic disorders experience symptoms of post-traumatic stress disorder (PTSD). In recent years, several trauma-focused therapies (TFTs), including cognitive restructuring (CR), prolonged exposure (PE), and eye movement desensitization and reprocessing (EMDR) have been studied and found to be safe and effective in reducing PTSD symptoms in individuals with psychosis. However, studies were conducted in different countries, with varying inclusion criteria, therapy duration, control groups, and trial outcomes. RE.PROCESS will be the...

Choice Boosts Curiosity

Patricia Romero Verdugo, Lieke L. F. van Lieshout, Floris P. de Lange & Roshan Cools
In our connected era, we spend significant time and effort satisfying our curiosity. Often, we choose which information we seek, but sometimes the selection is made for us. We hypothesized that humans exhibit enhanced curiosity in the context of choice. We designed a task in which healthy participants saw two lotteries on each trial. On some trials, participants chose which lottery to play. On other trials, the lottery was selected for them. Participants then indicated...

Effects of a support group leader education program jointly developed by health professionals and patients on peer leader self-efficacy among leaders of scleroderma support groups: a two-arm parallel partially nested randomised controlled trial

Brett D. Thombs, Brooke Levis, Marie-Eve Carrier, Laura Dyas, Julia Nordlund, Lydia Tao, Kylene Aguila, Angelica Bourgeault, Violet Konrad, Maureen Sauvé, Kerri Connolly, Richard S. Henry, Nora Østbø, Alexander W. Levis, Linda Kwakkenbos, Vanessa L. Malcarne, Ghassan El-Baalbaki, Marie Hudson, Amanda Wurz, S. Nicole Culos-Reed, Robert W. Platt & Andrea Benedetti
Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

Facial expression recognition is linked to clinical and neurofunctional differences in autism

Hannah Meyer-Lindenberg, Carolin Moessnang, Bethany Oakley, Jumana Ahmad, Luke Mason, Emily J. H. Jones, Hannah L. Hayward, Jennifer Cooke, Daisy Crawley, Rosemary Holt, Julian Tillmann, Tony Charman, Simon Baron-Cohen, Tobias Banaschewski, Christian Beckmann, Heike Tost, Andreas Meyer-Lindenberg, Jan K. Buitelaar, Declan G. Murphy, Michael J. Brammer & Eva Loth
Abstract Background Difficulties in social communication are a defining clinical feature of autism. However, the underlying neurobiological heterogeneity has impeded targeted therapies and requires new approaches to identifying clinically relevant bio-behavioural subgroups. In the largest autism cohort to date, we comprehensively examined difficulties in facial expression recognition, a key process in social communication, as a bio-behavioural stratification biomarker, and validated them against clinical features and neurofunctional responses. Methods Between 255 and 488 participants aged 6–30...

Enhancing the role of the social network in activity (re)engagement post-stroke: a focus group study with rehabilitation professionals

Dinja J. van der Veen, Sandra Jellema, Philip J. van der Wees, Maud J. L. Graff, Bert J. M. de Swart & Esther M. J. Steultjens
Abstract Background People post-stroke are at risk of not being able to participate in valued activities. It is important that rehabilitation professionals prepare people post-stroke for the transition home and provide needed support when they live at home. Several authors have suggested that members of the broad social network should play an active role in rehabilitation. This includes informing them about the importance of activity (re)engagement post-stroke and learning strategies to provide support. It is...

Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders

Tyson M. Perez, Paul Glue, Divya B. Adhia, Muhammad S. Navid, Jiaxu Zeng, Peter Dillingham, Mark Smith, Imran K. Niazi, Calvin K. Young & Dirk De Ridder
Abstract Background The core intrinsic connectivity networks (core-ICNs), encompassing the default-mode network (DMN), salience network (SN) and central executive network (CEN), have been shown to be dysfunctional in individuals with internalizing disorders (IDs, e.g. major depressive disorder, MDD; generalized anxiety disorder, GAD; social anxiety disorder, SOC). As such, source-localized, closed-loop brain training of electrophysiological signals, also known as standardized low-resolution electromagnetic tomography (sLORETA) neurofeedback (NFB), targeting key cortical nodes within these networks has the potential...

Plasma proteome profiling identifies changes associated to AD but not to FTD

R. Babapour Mofrad, M. del Campo, C. F. W. Peeters, L. H. H. Meeter, H. Seelaar, M. Koel-Simmelink, I. H. G. B. Ramakers, H. A. M. Middelkoop, P. P. De Deyn, J. A. H. R. Claassen, J. C. van Swieten, C. Bridel, J. J. M. Hoozemans, P. Scheltens, W. M. van der Flier, Y. A. L. Pijnenburg & Charlotte E. Teunissen
Abstract Background Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of Tau (FTLD-Tau) or TAR DNA binding43 (FTLD-TDP) proteins. Plasma biomarkers are strongly needed for specific diagnosis and potential treatment monitoring of FTD. We aimed to identify specific FTD plasma biomarker profiles discriminating FTD from AD and controls, and between FTD pathological subtypes. In addition, we compared plasma results with results in post-mortem frontal cortex of FTD cases to...

Effects of a support group leader education program jointly developed by health professionals and patients on peer leader self-efficacy among leaders of scleroderma support groups: a two-arm parallel partially nested randomised controlled trial

Brett D. Thombs, Brooke Levis, Marie-Eve Carrier, Laura Dyas, Julia Nordlund, Lydia Tao, Kylene Aguila, Angelica Bourgeault, Violet Konrad, Maureen Sauvé, Kerri Connolly, Richard S. Henry, Nora Østbø, Alexander W. Levis, Linda Kwakkenbos, Vanessa L. Malcarne, Ghassan El-Baalbaki, Marie Hudson, Amanda Wurz, S. Nicole Culos-Reed, Robert W. Platt & Andrea Benedetti
Abstract Background More people with rare diseases likely receive disease education and emotional and practical support from peer-led support groups than any other way. Most rare-disease support groups are delivered outside of the health care system by untrained leaders. Potential benefits may not be achieved and harms, such as dissemination of inaccurate information, may occur. Our primary objective was to evaluate the effects of a rare-disease support group leader education program, which was developed collaboratively...

Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders

Tyson M. Perez, Paul Glue, Divya B. Adhia, Muhammad S. Navid, Jiaxu Zeng, Peter Dillingham, Mark Smith, Imran K. Niazi, Calvin K. Young & Dirk De Ridder
Abstract Background The core intrinsic connectivity networks (core-ICNs), encompassing the default-mode network (DMN), salience network (SN) and central executive network (CEN), have been shown to be dysfunctional in individuals with internalizing disorders (IDs, e.g. major depressive disorder, MDD; generalized anxiety disorder, GAD; social anxiety disorder, SOC). As such, source-localized, closed-loop brain training of electrophysiological signals, also known as standardized low-resolution electromagnetic tomography (sLORETA) neurofeedback (NFB), targeting key cortical nodes within these networks has the potential...

Registration Year

  • 2022
    24

Resource Types

  • Collection
    24

Affiliations

  • Radboud University Nijmegen
    24
  • Radboud University Nijmegen Medical Centre
    10
  • University of Groningen
    4
  • University of Cambridge
    4
  • University Medical Center Groningen
    4
  • South London and Maudsley NHS Foundation Trust
    3
  • King's College London
    3
  • Maastricht University
    3
  • Harvard University
    3
  • University of Quebec at Montreal
    2