Enhance the Efficiency of Graphene-based THz Modulator by Optimizing the Brewster AngleXingyue Li, zhaohui zhang, Xiaoyan Zhao, Tianyao Zhang, Luqi Tao, Zhengyong Huang, Ying Li, Xianhao Wu, Lu Yin & Yuan Yuan
The gate-controllable electronical property of graphene provides a possibility of active tuning property for THz modulator. However, the common modulation technology which only depends on voltage cannot solve the problem of power consumption limitation in communication applications. Here, we demonstrated a Brewster angle-controlled graphene-based THz modulator, which could achieve a relatively high modulation depth with low voltage. First, we explored the complex relationships among the Brewster angles, reflection coefficients and the conductivities of graphene. Then,...
Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathwayHongchao Wang, Lijie Wang, Fuli Hu, Pengfei Wang, Yanan Xie, Fang Li & Bingyan Guo
Abstract Background Diabetic cardiomyopathy is characterized by left ventricle dysfunction, cardiomyocyte apoptosis, and interstitial fibrosis and is a serious complication of diabetes mellitus (DM). Autophagy is a mechanism that is essential for maintaining normal heart morphology and function, and its dysregulation can produce pathological effects on diabetic hearts. Neuregulin-4 (Nrg4) is an adipokine that exerts protective effects against metabolic disorders and insulin resistance. The aim of this study was to explore whether Nrg4 could ameliorate...
Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013–2019) of the Population Assessment of Tobacco and Health (PATH) StudyLaura M. Paulin, Michael J. Halenar, Kathryn C. Edwards, Kristin Lauten, Cassandra A. Stanton, Kristie Taylor, Dorothy Hatsukami, Andrew Hyland, Todd MacKenzie, Martin C. Mahoney, Ray Niaura, Dennis Trinidad, Carlos Blanco, Wilson M. Compton, Lisa D. Gardner, Heather L. Kimmel, Dana Lauterstein, Daniela Marshall & James D. Sargent
Abstract Background We examined the association of non-cigarette tobacco use on chronic obstructive pulmonary disease (COPD) risk in the Population Assessment of Tobacco and Health (PATH) Study. Methods There were 13,752 participants ≥ 40 years with Wave 1 (W1) data for prevalence analyses, including 6945 adults without COPD for incidence analyses; W1–5 (2013–2019) data were analyzed. W1 tobacco use was modeled as 12 mutually-exclusive categories of past 30-day (P30D) single and polyuse, with two reference...
Validation of photoacoustic/ultrasound dual imaging in evaluating blood oxygen saturationSi Liu, Rui Zhang, Tao Han, Yinhao Pan, Guangjie Zhang, Xing Long, Chenyang Zhao, Ming Wang, Xuelan Li & Fang Yang
Photoacoustic imaging (PAI) was performed to evaluate oxygen saturation (sO₂) of blood-mimicking phantoms, femoral arteries in beagles, and radial arteries in humans at various sO₂ plateaus. The accuracy (root mean square error) of PAI sO₂ compared with reference sO₂ was calculated. In blood-mimicking phantoms, PAI achieved an accuracy of 1.49% and a mean absolute error (MAE) of 1.09% within 25 mm depth, and good linearity (R = 0.968; p < 0.001) was obtained between PAI...
Supplementary material from \"New macronarian from the Middle Jurassic of Chongqing, China: phylogenetic and biogeographic implications for neosauropod dinosaur evolution\"Hui Dai, Chao Tan, Qingyu Ma, Ning Li, Haidong Yu, Can Xiong, Zhaoying Wei, Ping Wang, Jian Yi, Guangbiao Wei, Hailu You & Xinxin Ren
Macronaria is a clade of gigantic body-sized sauropod dinosaurs widely distributed from the Late Jurassic to the Late Cretaceous globally. However, its origin, early diversification, and dispersal are still controversial. Here, we report a new macronarian Yuzhoulong qurenensis gen. et sp. nov. excavated from the Middle Jurassic (Bathonian) Lower Shaximiao Formation. Yuzhoulong qurenensis bears a unique combination of features, such as two accessory fossae that exist on the posterior surface of dorsal diapophyses of anterior...
Mining on Alzheimer’s diseases related knowledge graph to identity potential AD-related semantic triples for drug repurposingYi Nian, Xinyue Hu, Rui Zhang, Jingna Feng, Jingcheng Du, Fang Li, Larry Bu, Yuji Zhang, Yong Chen & Cui Tao
Abstract Background To date, there are no effective treatments for most neurodegenerative diseases. Knowledge graphs can provide comprehensive and semantic representation for heterogeneous data, and have been successfully leveraged in many biomedical applications including drug repurposing. Our objective is to construct a knowledge graph from literature to study the relations between Alzheimer’s disease (AD) and chemicals, drugs and dietary supplements in order to identify opportunities to prevent or delay neurodegenerative progression. We collected biomedical annotations...
Deep progressive learning achieves whole-body low-dose 18F-FDG PET imagingTaisong Wang, Wenli Qiao, Ying Wang, Jingyi Wang, Yang Lv, Yun Dong, Zheng Qian, Yan Xing & Jinhua Zhao
Abstract Objectives To validate a total-body PET-guided deep progressive learning reconstruction method (DPR) for low-dose 18F-FDG PET imaging. Methods List-mode data from the retrospective study (n = 26) were rebinned into short-duration scans and reconstructed with DPR. The standard uptake value (SUV) and tumor-to-liver ratio (TLR) in lesions and coefficient of variation (COV) in the liver in the DPR images were compared to the reference (OSEM images with full-duration data). In the prospective study, another...
Hand surgery and hand therapy clinical practice guideline for epidermolysis bullosaRachel Box, Catina Bernardis, Alexander Pleshkov, Nicky Jessop, Catherine Miller, Jennifer Skye, Virginia O’Brien, Matthew Veerkamp, Anna Carolina Ferreira da Rocha & Roger Cornwall
Abstract What is already known about this topic? Epidermolysis bullosa (EB) causes blistering and scarring of the hands resulting in contractures fused web spaces and altered function. Surgery is needed to release contractures and web spaces and hand therapy is essential to maintain results, approaches for both differ. What does this study add? These guidelines aim to provide information on the surgical and conservative therapeutic hand management of children and adults diagnosed with EB. They...
Mapping responsive genomic elements to heat stress in a maize diversity panelZhikai Liang, Zachary A. Myers, Dominic Petrella, Julia Engelhorn, Thomas Hartwig & Nathan M. Springer
Abstract Background Many plant species exhibit genetic variation for coping with environmental stress. However, there are still limited approaches to effectively uncover the genomic region that regulates distinct responsive patterns of the gene across multiple varieties within the same species under abiotic stress. Results By analyzing the transcriptomes of more than 100 maize inbreds, we reveal many cis- and trans-acting eQTLs that influence the expression response to heat stress. The cis-acting eQTLs in response to...
The diagnostic and prognostic value of radiomics and deep learning technologies for patients with solid pulmonary nodules in chest CT imagesRui Zhang, Ying Wei, Feng Shi, Jing Ren, Qing Zhou, Weimin Li & Bojiang Chen
Abstract Background Solid pulmonary nodules are different from subsolid nodules and the diagnosis is much more challenging. We intended to evaluate the diagnostic and prognostic value of radiomics and deep learning technologies for solid pulmonary nodules. Methods Retrospectively enroll patients with pathologically-confirmed solid pulmonary nodules and collect clinical data. Obtain pre-treatment high-resolution thoracic CT and manually delineate the nodule in 3D. Then, all patients were randomly divided into training and testing sets at a ratio...
Examining evidence of time-dependent treatment effects: an illustration using regression methodsKim M. Jachno, Stephane Heritier, Robyn L. Woods, Suzanne Mahady, Andrew Chan, Andrew Tonkin, Anne Murray, John J. McNeil & Rory Wolfe
Abstract Background For the design and analysis of clinical trials with time-to-event outcomes, the Cox proportional hazards model and the logrank test have been the cornerstone methods for many decades. Increasingly, the key assumption of proportionality—or time-fixed effects—that underpins these methods has been called into question. The availability of novel therapies with new mechanisms of action and clinical trials of longer duration mean that non-proportional hazards are now more frequently encountered. Methods We compared several...
Building cross-border collaborations to increase diversity and accelerate rare disease drug development – meeting report from the inaugural IndoUSrare Annual Conference 2021Harvinder Kour Khera, Nisha Venugopal, Ramya T. Karur, Rakesh Mishra, Reena V. Kartha & Harsha K. Rajasimha
The inaugural IndoUSrare Annual Conference was held virtually from 29 November to 2 December 2021 and was organized by the Indo US Organization for Rare Diseases (IndoUSrare). The event saw participation from over 250 stakeholders of rare diseases who joined in virtually by audio/video on the Zoom platform from around the world, with a majority of attendees concentrated in the Indian subcontinent and the United States. The conference was held over 4 days from 10:00...
Comparison of meiotic transcriptomes of three maize inbreds with different origins reveals differences in cell cycle and recombinationNelson Garcia, Lu Yin, Stefanie Dukowic-Schulze, Claire Milsted, Penny M. A. Kianian, Shahryar Kianian, Wojciech P. Pawlowski & Changbin Chen
Abstract Background Cellular events during meiosis can differ between inbred lines in maize. Substantial differences in the average numbers of chiasmata and double-strand breaks (DSBs) per meiotic cell have been documented among diverse inbred lines of maize: CML228, a tropical maize inbred line, B73 and Mo17, temperate maize lines. To determine if gene expression might explain these observed differences, an RNA-Seq experiment was performed on CML228 male meiocytes which was compared to B73 and Mo17...
Establishment of a Predictive Model for Poor Prognosis of Incomplete Revascularization in Patients with Coronary Heart Disease and Multivessel DiseaseHuan Lian, Zhuoyan Zhao, Kelin Ma, Zhenjiang Ding, Lixian Sun & Ying Zhang
ObjectiveTo establish a predictive model for poor prognosis after incomplete revascularization (ICR) in patients with multivessel coronary artery disease (MVD).MethodsClinical data of 757 patients with MVD and ICR after percutaneous coronary intervention (PCI) in the Affiliated Hospital of Chengde Medical University from January 2020 to August 2021 were retrospectively collected. The least absolute shrinkage and selection operator regression method was used to screen variables, and multivariate logistic regression was used to establish a predictive model....
Campaign Advertising and the Cultivation of Crime Worry: Testing Relationships With Two Large Datasets From the 2016 U.S. Election CycleJiawei Liu, Rosemary J. Avery, Erika F. Fowler, Laura Baum, Sarah E. Gollust, Colleen L. Barry, Brendan Welch, Emmett Tabor, Nathaniel W. Lee & Jeff Niederdeppe
Previous research has documented that political information in the mass media can shape attitudes and behaviors beyond voter choice and election turnout. The current study extends this body of work to examine associations between televised political campaign advertising (one of the most common forms of political communication people encounter) and worry about crime and violence in the context of the 2016 U.S. presidential election. We merge two large datasets—Kantar/CMAG data on televised campaign advertisement airings...
A database of water chemistry in eastern Siberian riversPing Wang, Shiqi Liu, Qiwei Huang, Olga Gabysheva & Zehong Li
The database includes major ion (Ca, Mg, Na, K, HCO3, SO4, and Cl) data spanning 1940-2019, with 9487 groups of chemical results from 1434 water samples collected mainly in six large river basins in eastern Siberia.
Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline updateAlexandria Bennett, Andrew Beck, Nicole Shaver, Roland Grad, Allana LeBlanc, Heather Limburg, Casey Gray, Ahmed Abou-Setta, Scott Klarenbach, Navindra Persaud, Guylène Thériault, Brett D. Thombs, Keith J. Todd, Neil Bell, Philipp Dahm, Andrew Loblaw, Lisa Del Giudice, Xiaomei Yao, Becky Skidmore, Elizabeth Rolland-Harris, Melissa Brouwers, Julian Little & David Moher
Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. Methods Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific...
Meta-analysis methods for risk difference: A comparison of different modelsJuanru Guo, Mengli Xiao, Haitao Chu & Lifeng Lin
Risk difference is a frequently-used effect measure for binary outcomes. In a meta-analysis, commonly-used methods to synthesize risk differences include: (1) the two-step methods that estimate study-specific risk differences first, then followed by the univariate common-effect model, fixed-effects model, or random-effects models; and (2) the one-step methods using bivariate random-effects models to estimate the summary risk difference from study-specific risks. These methods are expected to have similar performance when the number of studies is large...
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University of Minnesota93
University of Chinese Academy of Sciences40
Chinese Academy of Medical Sciences & Peking Union Medical College38
Capital Medical University36
Southern Medical University36
First Affiliated Hospital of Chongqing Medical University30
Chinese Academy of Sciences30