Background. Despite the established effectiveness of expedited partner therapy (EPT) in partner treatment of bacterial sexually transmitted infections (STI), the practice is underutilized. Objective. To estimate the relative effectiveness of strategies to increase EPT uptake (numbers of partners treated for chlamydia). Methods. We developed a care cascade model of cumulative probabilities to estimate the number of partners treated under strategies to increase EPT uptake in Minnesota. The care cascade model used data from clinical trials,...

Computer holography is a promising technique for reproducing 3D viewing experiences on-demand by modulating an amplitude or phase hologram. Yet, the huge computational burden of both acquiring 3D wave data and simulating diffraction propagation places an explicit challenge to the total runtime of 3D hologram generation, making dynamic holography impractical. Here we demonstrate a deep-learning based method capable of synthesizing a photorealistic 3D hologram in real-time directly from the input of a single 2D image....

Ongoing environmental changes alter how natural selection shapes animal migration. Understanding how these changes play out theoretically can be done using evolutionary game theoretic (EGT) approaches, such as looking for evolutionarily stable strategies. Here, we first describe historical patterns of how EGT models have explored different drivers of migration. We find that there are substantial gaps in both the taxa (mammals, amphibians, reptiles, insects) and mechanisms (mutualism, interspecific competition) included in past EGT models of...

BackgroundThoracic aortic aneurysm (TAA) is a serious vascular disease causing the death of elder people. Accumulating studies have reported that circular RNAs (circRNAs) are implicated in the regulation of aortic aneurysms. However, the role of circ_0000595 in the progression of TAA is still unclear.MethodsQuantitative real-time PCR (qRT-PCR) and western blotting were implemented to assess circ_0000595, microRNA (miR)-582-3p, guanine nucleotide-binding protein alpha subunit (ADAM10), PCNA, Bax, and Bcl-2 expression. The proliferation of vascular smooth muscle cells...

The association of exosomal RNA profiling and pathogenesis of moyamoya disease (MMD) and intracranial Atherosclerotic disease (ICAD) is unknown. In this study, we investigated the RNA profiles of sEV (small extracellular vesicles)/exosomes in patients with MMD and ICAD. Whole blood samples were collected from 30 individuals, including 10 patients with MMD, 10 patients with ICAD, and 10 healthy individuals. Whole transcriptome analysis was performed using the GeneChip WT Pico Reagent kit. Transcriptional correlation was verified...

Topography measurement is essential for surface characterization, semiconductor metrology, and inspection applications. To date, performing high-throughput and accurate topography remains challenging due to the trade-off between field-of-view (FOV) and spatial resolution. Here we demonstrate a novel topography technique based on the reflection-mode Fourier ptychographic microscopy, termed Fourier ptychograhpic topography (FPT). We show that FPT provides both a wide FOV and high resolution, and achieves nanoscale height reconstruction accuracy. Our FPT prototype is based on a...

Topography measurement is essential for surface characterization, semiconductor metrology, and inspection applications. To date, performing high-throughput and accurate topography remains challenging due to the trade-off between field-of-view (FOV) and spatial resolution. Here we demonstrate a novel topography technique based on the reflection-mode Fourier ptychographic microscopy, termed Fourier ptychograhpic topography (FPT). We show that FPT provides both a wide FOV and high resolution, and achieves nanoscale height reconstruction accuracy. Our FPT prototype is based on a...

Background. Despite the established effectiveness of expedited partner therapy (EPT) in partner treatment of bacterial sexually transmitted infections (STI), the practice is underutilized. Objective. To estimate the relative effectiveness of strategies to increase EPT uptake (numbers of partners treated for chlamydia). Methods. We developed a care cascade model of cumulative probabilities to estimate the number of partners treated under strategies to increase EPT uptake in Minnesota. The care cascade model used data from clinical trials,...

Passive-state-preparation (PSP) continuous-variable quantum key distribution (CVQKD) protocol explores the intrinsic field fluctuations of a thermal source. Compared with traditional Gaussian-modulated coherent-state (GMCS) CVQKD, it does not need active modulations and has promising applications in chip integration and portable free-space quantum key distribution. In this Letter, we propose and experimentally realize a PSP CVQKD scheme with transmitted local oscillator (LO) through fluctuating transmittance free-space channel using off-the-shelf amplified spontaneous emission source for the first time....

Passive-state-preparation (PSP) continuous-variable quantum key distribution (CVQKD) protocol explores the intrinsic field fluctuations of a thermal source. Compared with traditional Gaussian-modulated coherent-state (GMCS) CVQKD, it does not need active modulations and has promising applications in chip integration and portable free-space quantum key distribution. In this Letter, we propose and experimentally realize a PSP CVQKD scheme with transmitted local oscillator (LO) through fluctuating transmittance free-space channel using off-the-shelf amplified spontaneous emission source for the first time....

BackgroundThoracic aortic aneurysm (TAA) is a serious vascular disease causing the death of elder people. Accumulating studies have reported that circular RNAs (circRNAs) are implicated in the regulation of aortic aneurysms. However, the role of circ_0000595 in the progression of TAA is still unclear.MethodsQuantitative real-time PCR (qRT-PCR) and western blotting were implemented to assess circ_0000595, microRNA (miR)-582-3p, guanine nucleotide-binding protein alpha subunit (ADAM10), PCNA, Bax, and Bcl-2 expression. The proliferation of vascular smooth muscle cells...

Background:Reliable classification of ischemic stroke (IS) etiological subtypes is required in research and clinical practice, but the predictive properties of these subtypes in population studies with incomplete investigations are poorly understood.Aims:To compare the prognosis of etiologically classified IS subtypes and use machine learning (ML) to classify incompletely investigated IS cases.Methods:In a 9-year follow-up of a prospective study of 512,726 Chinese adults, 22,216 incident IS cases, confirmed by clinical adjudication of medical records, were assigned subtypes...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Introduction:The differential diagnosis of pleural effusion is difficult, and studies have reported on the potential role of adenosine deaminase (ADA) in the differential diagnosis of undiagnosed pleural effusion. This retrospective study aimed to investigate the diagnostic role of ADA in pleural effusion.Methods:266 patients with pleural effusion from three centers were enrolled. The concentrations of ADA and lactate dehydrogenase (LDH) were measured in pleural fluids and serum samples of the patients. The diagnostic performance of ADA-based...

Computer holography is a promising technique for reproducing 3D viewing experiences on-demand by modulating an amplitude or phase hologram. Yet, the huge computational burden of both acquiring 3D wave data and simulating diffraction propagation places an explicit challenge to the total runtime of 3D hologram generation, making dynamic holography impractical. Here we demonstrate a deep-learning based method capable of synthesizing a photorealistic 3D hologram in real-time directly from the input of a single 2D image....

Topography measurement is essential for surface characterization, semiconductor metrology, and inspection applications. To date, performing high-throughput and accurate topography remains challenging due to the trade-off between field-of-view (FOV) and spatial resolution. Here we demonstrate a novel topography technique based on the reflection-mode Fourier ptychographic microscopy, termed Fourier ptychograhpic topography (FPT). We show that FPT provides both a wide FOV and high resolution, and achieves nanoscale height reconstruction accuracy. Our FPT prototype is based on a...

Teacher-level factors are theoretically linked to student outcomes in data-based instruction (DBI; Lembke et al., 2018). Professional development and ongoing support can increase teachers’ knowledge, skills, and beliefs related to DBI, as well as their instructional fidelity (McMaster et al., 2020). However, less is known about how each of these teacher-level factors influences student progress during an intervention. The purpose of this study was to examine the association between several important teacher-level factors—teachers’ writing instruction...

Objectives: We investigated the relationship between the cognitive status of participants’ spouses and participants’ own cognitive outcomes, controlling for mid-life factors. Methods: Participants (n = 1845; baseline age 66–90 years) from the prospective Atherosclerosis Risk in Communities Study were followed from 2011 to 2019. We used linear regression and Cox proportional hazard models to estimate whether spouses of people with MCI/dementia had lower cognitive functioning and elevated risk of incident dementia. Results: Having a spouse...

Ongoing environmental changes alter how natural selection shapes animal migration. Understanding how these changes play out theoretically can be done using evolutionary game theoretic (EGT) approaches, such as looking for evolutionarily stable strategies. Here, we first describe historical patterns of how EGT models have explored different drivers of migration. We find that there are substantial gaps in both the taxa (mammals, amphibians, reptiles, insects) and mechanisms (mutualism, interspecific competition) included in past EGT models of...

Background:Reliable classification of ischemic stroke (IS) etiological subtypes is required in research and clinical practice, but the predictive properties of these subtypes in population studies with incomplete investigations are poorly understood.Aims:To compare the prognosis of etiologically classified IS subtypes and use machine learning (ML) to classify incompletely investigated IS cases.Methods:In a 9-year follow-up of a prospective study of 512,726 Chinese adults, 22,216 incident IS cases, confirmed by clinical adjudication of medical records, were assigned subtypes...

AimsTo identify, visualize, and describe the prevalence of within-product patterns of tobacco use behaviors for e-cigarettes, cigarettes, and hookah (TP) by 3 age groups (ie, 12-14-year-old, 15-17-year-old, and 18-20-year-old) with U.S. nationally representative data.MethodsIn 2014-2015, never users of each (TP) and age group were followed-up longitudinally between 2015-2019 using five transition states: non-susceptible to (TP) use, susceptible to (TP) use, ever (TP) use, past 30-day (TP) use, and discontinued past 30-day (TP) use. Sankey diagrams...

Ongoing environmental changes alter how natural selection shapes animal migration. Understanding how these changes play out theoretically can be done using evolutionary game theoretic (EGT) approaches, such as looking for evolutionarily stable strategies. Here, we first describe historical patterns of how EGT models have explored different drivers of migration. We find that there are substantial gaps in both the taxa (mammals, amphibians, reptiles, insects) and mechanisms (mutualism, interspecific competition) included in past EGT models of...

Computer holography is a promising technique for reproducing 3D viewing experiences on-demand by modulating an amplitude or phase hologram. Yet, the huge computational burden of both acquiring 3D wave data and simulating diffraction propagation places an explicit challenge to the total runtime of 3D hologram generation, making dynamic holography impractical. Here we demonstrate a deep-learning based method capable of synthesizing a photorealistic 3D hologram in real-time directly from the input of a single 2D image....

Social withdrawal and isolation are frequently experienced among people with cognitive impairment, Alzheimer’s disease, and Alzheimer’s disease related dementias. Few assistive technologies exist to support persons with memory concerns’ (PWMC) continuing social engagement. This study aimed to understand PWMC and family caregivers’ initial perspectives on the feasibility and utility of a wearable technology-based social memory aid. We recruited 20 dyads, presented the memory aid, and conducted semi-structured interviews from June to August 2020 over Zoom...

Passive-state-preparation (PSP) continuous-variable quantum key distribution (CVQKD) protocol explores the intrinsic field fluctuations of a thermal source. Compared with traditional Gaussian-modulated coherent-state (GMCS) CVQKD, it does not need active modulations and has promising applications in chip integration and portable free-space quantum key distribution. In this Letter, we propose and experimentally realize a PSP CVQKD scheme with transmitted local oscillator (LO) through fluctuating transmittance free-space channel using off-the-shelf amplified spontaneous emission source for the first time....