65 Works

Predicting falls in older adults: an umbrella review of instruments assessing gait, balance, and functional mobility

D. Beck Jepsen, K. Robinson, G. Ogliari, M. Montero-Odasso, N. Kamkar, J. Ryg, E. Freiberger & T. Masud
Abstract Background To review the validated instruments that assess gait, balance, and functional mobility to predict falls in older adults across different settings. Methods Umbrella review of narrative- and systematic reviews with or without meta-analyses of all study types. Reviews that focused on older adults in any settings and included validated instruments assessing gait, balance, and functional mobility were included. Medical and allied health professional databases (MEDLINE, PsychINFO, Embase, and Cochrane) were searched from inception...

Venetoclax combined with low dose cytarabine compared to standard of care intensive chemotherapy for the treatment of favourable risk adult acute myeloid leukaemia (VICTOR): Study protocol for an international, open-label, multicentre, molecularly-guided randomised, phase II trial

Richard Dillon, Shanna Maycock, Aimee Jackson, Sonia Fox, Sylvie Freeman, Charles Craddock, Catherine Thomas, Emma Homer, Jane Leahy, Anna Mamwell, Nicola Potter, Nigel Russell, Andrew Wei, Hans Beier Ommen, Claire Hemmaway, Steve Knapper & Lucinda Billingham
Abstract Background For patients with acute myeloid leukaemia (AML), the only potentially curative treatment is intensive chemotherapy (IC). This is highly toxic, particularly for patients > 60 years, potentially leading to prolonged hospitalisations requiring intensive supportive care, and sometimes treatment-related death. This also results in extensive healthcare costs and negatively impacts quality of life (QoL). Venetoclax with low-dose cytarabine (VEN + LDAC) is a novel, low-intensity treatment for AML patients who cannot receive IC. VEN...

Healthcare use and healthcare costs for patients with advanced cancer; the international ACTION cluster-randomised trial on advance care planning

Ida J Korfage, Suzanne Polinder, Nancy Preston, Johannes JM van Delden, Sandra (A)JLM Geraerds, Lesley Dunleavy, Kristof Faes, Guido Miccinesi, Giulia Carreras, Caroline Moeller Arnfeldt, Marijke C Kars, Giuseppe Lippi, Urska Lunder, Ceu Mateus, Kristian Pollock, Luc Deliens, Mogens Groenvold, Agnes van der Heide & Judith AC Rietjens
Background:Advance care planning supports patients to reflect on and discuss preferences for future treatment and care. Studies of the impact of advance care planning on healthcare use and healthcare costs are scarce.Aim:To determine the impact on healthcare use and costs of an advance care planning intervention across six European countries.Design:Cluster-randomised trial, registered as ISRCTN63110516, of advance care planning conversations supported by certified facilitators.Setting/participants:Patients with advanced lung or colorectal cancer from 23 hospitals in Belgium, Denmark,...

Healthcare use and healthcare costs for patients with advanced cancer; the international ACTION cluster-randomised trial on advance care planning

Ida J Korfage, Suzanne Polinder, Nancy Preston, Johannes JM van Delden, Sandra (A)JLM Geraerds, Lesley Dunleavy, Kristof Faes, Guido Miccinesi, Giulia Carreras, Caroline Moeller Arnfeldt, Marijke C Kars, Giuseppe Lippi, Urska Lunder, Ceu Mateus, Kristian Pollock, Luc Deliens, Mogens Groenvold, Agnes van der Heide & Judith AC Rietjens
Background:Advance care planning supports patients to reflect on and discuss preferences for future treatment and care. Studies of the impact of advance care planning on healthcare use and healthcare costs are scarce.Aim:To determine the impact on healthcare use and costs of an advance care planning intervention across six European countries.Design:Cluster-randomised trial, registered as ISRCTN63110516, of advance care planning conversations supported by certified facilitators.Setting/participants:Patients with advanced lung or colorectal cancer from 23 hospitals in Belgium, Denmark,...

Surgical site infection after intracorporeal anastomosis for left-sided colon cancer: study protocol for a non-inferiority multicenter randomized controlled trial (STARS)

Liang He, Meng Li, Jia-xin Zhang, Wei-hua Tong, Yan Chen & Quan Wang
Abstract Background Surgical site infection (SSI), as one of the most common hospital-acquired infection, is usually associated with increased morbidity, mortality, and health care burden. SSI is a significant perioperative complication after colon cancer surgery, particularly for left-sided colon cancer. This paper describes the background and design of the “Surgical Site Infection after intracorporeal anastomosis for Left-sided Colon Cancer: study protocol for a non-inferiority multicenter Randomized Controlled Trial (STARS).” The STARS trial aims to compare...

Surgical site infection after intracorporeal anastomosis for left-sided colon cancer: study protocol for a non-inferiority multicenter randomized controlled trial (STARS)

Liang He, Meng Li, Jia-xin Zhang, Wei-hua Tong, Yan Chen & Quan Wang
Abstract Background Surgical site infection (SSI), as one of the most common hospital-acquired infection, is usually associated with increased morbidity, mortality, and health care burden. SSI is a significant perioperative complication after colon cancer surgery, particularly for left-sided colon cancer. This paper describes the background and design of the “Surgical Site Infection after intracorporeal anastomosis for Left-sided Colon Cancer: study protocol for a non-inferiority multicenter Randomized Controlled Trial (STARS).” The STARS trial aims to compare...

Design decisions and data completeness for experience sampling methods used in psychosis: systematic review

Emilia Deakin, Fiona Ng, Emma Young, Naomi Thorpe, Christopher Newby, Carol Coupland, Michael Craven & Mike Slade
Abstract Background The experience sampling method (ESM) is an intensive longitudinal research method. Participants complete questionnaires at multiple times about their current or very recent state. The design of ESM studies is complex. People with psychosis have been shown to be less adherent to ESM study protocols than the general population. It is not known how to design studies that increase adherence to study protocols. A lack of typology makes it is hard for researchers...

Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt

Basem Mohamed Ahmed, Mahmoud Mohamed Bayoumi, Mohamed Ali Farrag, Mahmoud Aly Elgamal, Janet Mary Daly & Haitham Mohamed Amer
Abstract Background Equine influenza is an important cause of respiratory disease in equids. The causative virus; EIV, is highly variable and can evolve by accumulation of mutations, particularly in the haemagglutinin (HA) gene. Currently, H3N8 is the sole subtype circulating worldwide with Florida clade 1 (FC1) is most prevalent in the Americas and FC2 in Asia and Europe. In Egypt, EIV was detected in two occasions: subtype H7N7 in 1989 and subtype H3N8 (FC1) in...

Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt

Basem Mohamed Ahmed, Mahmoud Mohamed Bayoumi, Mohamed Ali Farrag, Mahmoud Aly Elgamal, Janet Mary Daly & Haitham Mohamed Amer
Abstract Background Equine influenza is an important cause of respiratory disease in equids. The causative virus; EIV, is highly variable and can evolve by accumulation of mutations, particularly in the haemagglutinin (HA) gene. Currently, H3N8 is the sole subtype circulating worldwide with Florida clade 1 (FC1) is most prevalent in the Americas and FC2 in Asia and Europe. In Egypt, EIV was detected in two occasions: subtype H7N7 in 1989 and subtype H3N8 (FC1) in...

Non-suicidal self-injury and its relation to suicide through acquired capability: investigating this causal mechanism in a mainly late-diagnosed autistic sample

Rachel L. Moseley, Nicola J. Gregory, Paula Smith, Carrie Allison, Sarah Cassidy & Simon Baron-Cohen
Abstract Background Non-suicidal self-injury (NSSI) has been linked with a higher risk of suicide attempts in autistic and non-autistic people. In the general population, NSSI may confer acquired capability for suicide by eroding one’s fear and avoidance of pain and death. The present study aimed to explore acquired capability as the mediator of increased suicide risk conferred by NSSI in autistic and non-autistic adults. Methods Autistic and non-autistic adults (n = 314, n = 312)...

A dual deep neural network for auto-delineation in cervical cancer radiotherapy with clinical validation

Shihong Nie, Yuanfeng Wei, Fen Zhao, Ya Dong, Yan Chen, Qiaoqi Li, Wei Du, Xin Li, Xi Yang & Zhiping Li
Abstract Background Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We aimed to develop an AI-assisted system for automatic contouring of the clinical target volume (CTV) and organs-at-risk (OARs) in cervical cancer radiotherapy and conduct clinical-based observations. Methods We first retrospectively collected data of 203 patients with cervical cancer from West China Hospital. The proposed method named...

Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials

Abid Malik, Brian Drumm, Lucio D’Anna, Isabelle Brooks, Benjamin Low, Oishik Raha, Khawar Shabbir, Orsolya Vittay, Joseph Kwan, Zoe Brown, Omid Halse, Sohaa Jamil, Dheeraj Kalladka, Marius Venter, Harri Jenkins, Neil Rane, Abhinav Singh, Maneesh Patel, Charles Hall, Gavin Fatania, Dylan Roi, Kyriakos Lobotesis & Soma Banerjee
Abstract Background The evidence for mechanical thrombectomy in acute basilar artery occlusion has until now remained inconclusive with basilar artery strokes associated with high rates of death and disability. This systematic review and meta-analysis will summarize the available evidence for the effectiveness of mechanical thrombectomy in acute basilar artery occlusion compared to best medical therapy. Methods We conducted a systematic review and meta-analysis of randomized controlled trials using Embase, Medline and the Cochrane Central Register...

Effectiveness and cost effectiveness of digital hearing aids in patients with tinnitus and hearing loss: a randomised feasibility trial (THE HUSH Trial)

Rachel H. Haines, Trish Hepburn, Wei Tan, Clare Jackson, James Lathe, Jennifer White, Christine Almey, Richard Nicholson, David Stockdale, Paul Leighton, Marilyn James & Magdalena Sereda
Abstract Background Education and advice is provided for tinnitus management in all UK audiology clinics. Sound therapy, including provision of hearing aids may be offered, but this is often dependent on a clinician’s decision rather than UK policy. This inconsistent management reflects a lack of evidence around the effectiveness of hearing aids for tinnitus. This open-label, two-arm multicentre randomised controlled feasibility trial gathered data around recruitment, acceptability and outcome assessments to determine the feasibility of...

Venetoclax combined with low dose cytarabine compared to standard of care intensive chemotherapy for the treatment of favourable risk adult acute myeloid leukaemia (VICTOR): Study protocol for an international, open-label, multicentre, molecularly-guided randomised, phase II trial

Richard Dillon, Shanna Maycock, Aimee Jackson, Sonia Fox, Sylvie Freeman, Charles Craddock, Catherine Thomas, Emma Homer, Jane Leahy, Anna Mamwell, Nicola Potter, Nigel Russell, Andrew Wei, Hans Beier Ommen, Claire Hemmaway, Steve Knapper & Lucinda Billingham
Abstract Background For patients with acute myeloid leukaemia (AML), the only potentially curative treatment is intensive chemotherapy (IC). This is highly toxic, particularly for patients > 60 years, potentially leading to prolonged hospitalisations requiring intensive supportive care, and sometimes treatment-related death. This also results in extensive healthcare costs and negatively impacts quality of life (QoL). Venetoclax with low-dose cytarabine (VEN + LDAC) is a novel, low-intensity treatment for AML patients who cannot receive IC. VEN...

Radiomics features for assessing tumor-infiltrating lymphocytes correlate with molecular traits of triple-negative breast cancer

Guan-Hua Su, Yi Xiao, Lin Jiang, Ren-Cheng Zheng, He Wang, Yan Chen, Ya-Jia Gu, Chao You & Zhi-Ming Shao
Abstract Background Tumor-infiltrating lymphocytes (TILs) have become a promising biomarker for assessing tumor immune microenvironment and predicting immunotherapy response. However, the assessment of TILs relies on invasive pathological slides. Methods We retrospectively extracted radiomics features from magnetic resonance imaging (MRI) to develop a radiomic cohort of triple-negative breast cancer (TNBC) (n = 139), among which 116 patients underwent transcriptomic sequencing. This radiomic cohort was randomly divided into the training cohort (n = 98) and validation...

What is the purpose of clinical trial monitoring?

Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood & Garry Meakin
Abstract Background The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitoring tools on a strong easily communicated foundation, we identified the need to define monitoring in accessible language. Methods In a three-step process, the material from sources that describe clinical trial monitoring were synthesised into principles of monitoring. A poll regarding...

What is the purpose of clinical trial monitoring?

Sharon B. Love, Victoria Yorke-Edwards, Elizabeth Ward, Rebecca Haydock, Katie Keen, Katie Biggs, Gosala Gopalakrishnan, Lucy Marsh, Lydia O’Sullivan, Lisa Fox, Estelle Payerne, Kerenza Hood & Garry Meakin
Abstract Background The sources of information on clinical trial monitoring do not give information in an accessible language and do not give detailed guidance. In order to enable communication and to build clinical trial monitoring tools on a strong easily communicated foundation, we identified the need to define monitoring in accessible language. Methods In a three-step process, the material from sources that describe clinical trial monitoring were synthesised into principles of monitoring. A poll regarding...

Electric field responsive nanotransducers for glioblastoma

Akhil Jain, Isobel Jobson, Michaela Griffin, Ruman Rahman, Stuart Smith & Frankie J. Rawson
Abstract Background Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTFields rely on alternating current (AC) electric fields (EF) leading to the disruption of dipole alignment and induced dielectrophoresis (DEP) during cytokinesis. Although TTFields have a favourable side effect profile, particularly compared to cytotoxic chemotherapy, survival benefits remain limited (~ 4.9 months) after an extensive treatment...

Equipment-free, unsupervised high intensity interval training elicits significant improvements in the physiological resilience of older adults

Tanvir S Sian, Thomas B Inns, Amanda Gates, Brett Doleman, Joseph J Bass, Philip J Atherton, Jonathan N Lund & Bethan E Phillips
Abstract Background Reduced cardiorespiratory fitness (CRF) is an independent risk factor for dependency, cognitive impairment and premature mortality. High-intensity interval training (HIIT) is a proven time-efficient stimulus for improving both CRF and other facets of cardiometabolic health also known to decline with advancing age. However, the efficacy of equipment-free, unsupervised HIIT to improve the physiological resilience of older adults is not known. Methods Thirty independent, community-dwelling older adults (71(SD: 5) years) were randomised to 4...

Non-suicidal self-injury and its relation to suicide through acquired capability: investigating this causal mechanism in a mainly late-diagnosed autistic sample

Rachel L. Moseley, Nicola J. Gregory, Paula Smith, Carrie Allison, Sarah Cassidy & Simon Baron-Cohen
Abstract Background Non-suicidal self-injury (NSSI) has been linked with a higher risk of suicide attempts in autistic and non-autistic people. In the general population, NSSI may confer acquired capability for suicide by eroding one’s fear and avoidance of pain and death. The present study aimed to explore acquired capability as the mediator of increased suicide risk conferred by NSSI in autistic and non-autistic adults. Methods Autistic and non-autistic adults (n = 314, n = 312)...

Parent Training for ADHD: No Generalization of Effects From Clinical to Neuropsychological Outcomes in a Randomized Controlled Trial

Rikke Lambek, Edmund J. S. Sonuga-Barke, Anne-Mette Lange, Daniel J. Carroll, David Daley & Per Hove Thomsen
Objective:We examined whether neuropsychological function in ADHD can be improved by the New Forest Parenting Programme (NFPP), that combines standard parenting strategies with self-regulatory skills training, or predict ADHD and quality of life (QoL) treatment effects.Method:Participants were 93 medication-naive preschool children with ADHD (3–7 years) randomized to either NFPP (n = 49) or treatment as usual (TAU; n = 44) in a recent randomized trial. Laboratory measures of executive function, reaction time variability, and delay...

Diagnostic accuracy of serum ascites albumin gradient (SAAG) in a contemporary unselected medical cohort

Mohsan Subhani, Abhishek Sheth, Naaventhan Palaniyappan, Peuish Sugathan, Emilie A Wilkes & Guruprasad P Aithal
ObjectivesTo describe the different aetiologies of ascites and test the validity of serum ascites albumin gradient (SAAG) and cytology in a contemporary unselected medical cohort.MethodsAll adult patients admitted to Nottingham University Hospitals, UK, between 1 May 2013 and 30 April 2018 with new-onset radiologically-confirmed ascites were included. Data were analysed to determine the distribution of different aetiologies of ascites and the diagnostic accuracy of SAAG in portal hypertension and cytology in malignancy as underlying causes...

Understanding Barriers and Facilitators to Online and App Activities for People Living With Dementia and Their Supporters

Abigail R. Lee, Orii McDermott & Martin Orrell
BackgroundStigma often surrounds people with dementia when it comes to use of computer technology, although evidence does not always support this. More understanding is needed to investigate attitudes and experience in relation to computer technology use among those living with dementia and their readiness to use it to support self-management.MethodsAn online self-report questionnaire was completed by adults living with a dementia diagnosis and those living with them. Questions explored how long the participants had been...

Predicting falls in older adults: an umbrella review of instruments assessing gait, balance, and functional mobility

D. Beck Jepsen, K. Robinson, G. Ogliari, M. Montero-Odasso, N. Kamkar, J. Ryg, E. Freiberger & Masud Tahir
Abstract Background To review the validated instruments that assess gait, balance, and functional mobility to predict falls in older adults across different settings. Methods Umbrella review of narrative- and systematic reviews with or without meta-analyses of all study types. Reviews that focused on older adults in any settings and included validated instruments assessing gait, balance, and functional mobility were included. Medical and allied health professional databases (MEDLINE, PsychINFO, Embase, and Cochrane) were searched from inception...

Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Abstract Background Systematically screening for child anxiety problems, and offering and delivering a brief, evidence-based intervention for children who are identified as likely to benefit would minimise common barriers that families experience in accessing treatment. We have developed a short parent-report child anxiety screening questionnaire, and procedures for administering screening questionnaires, sharing screening outcomes with families, and offering and delivering a brief parent-led online intervention (OSI: Online Support and Intervention for child anxiety) through schools....

Registration Year

  • 2023
    2
  • 2022
    63

Resource Types

  • Collection
    65

Affiliations

  • University of Nottingham
    65
  • Huazhong University of Science and Technology
    10
  • Henan University
    8
  • North West Agriculture and Forestry University
    8
  • West China Second University Hospital of Sichuan University
    8
  • Zhejiang University
    8
  • Sichuan University
    8
  • University of Oxford
    8
  • Nottingham University Hospitals NHS Trust
    8
  • Ministry of Education of the People's Republic of China
    6