62 Works

Changes in health care utilization and financial protection after integration of the rural and urban social health insurance schemes in Beijing, China

Zhenyu Shi, Ping He, Dawei Zhu, Feng Lu & Qingyue Meng
Abstract Background China expanded health coverage to residents in informal economic sectors by the rural new cooperative medical scheme (NCMS) for rural population and urban resident basic medical insurance scheme (URBMI) for non-working urban residents. Fragmentation of resident social health insurance schemes exacerbated the health inequity and China started the integration of urban and rural resident medical insurance schemes since 2016. Beijing finished the insurance integration in 2017 and has been implementing a unified urban...

جمال_خاشقجي# #JamalKhashoggi: Unraveling multilingual Twitter sentiment dynamics in a longitudinal comparative analysis of tweets in Arabic and English

Nour Zeid, Thomas Frissen & Sebastian Scherr
In 2018, Jamal Khashoggi, a Saudi journalist who wrote for the Washington Post, was last seen alive entering the Saudi Consulate in Istanbul. Confirmed news of his murder ignited a heated and polarized public debate on Twitter. We use agenda melding as a theoretical lemma and argue that Twitter sentiment flourishes within multilingual, ad hoc public spheres contributing to an emotional agenda. We examined the Twitter sentiment from 2018 to 2021 by looking at the...

A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles

Ting Li, Yu Fu, Zeyi Guo, Honglei Zhu, Hangyu Liao, Xiaoge Niu, Lin Zhou, Shunjun Fu, Yang Li, Shao Li, Lujia Wang, Yizhou Zheng, Lei Feng, Yi Gao & Guolin He
Mesenchymal stem cells (MSCs) have potential role in organ regeneration therapy. Previous work indicating that MSCs confer protection against liver disease. Here, we aimed to determine the potential application in liver regeneration of human placenta-derived MSCs extracellular vesicles (hPMSCs-EVs) via experimental hepatectomy. hPMSCs-EVs were administered intravenously 24 h before 70% partial hepatectomy, the specific composition of hPMSCs-EVs was identified by sequencing and validated by the quantitative polymerase chain reaction, including circ-RBM23. The role of circ-RBM23...

Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model

Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi & Shigeru Miyaki
Abstract Background Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 (SAMP8) that displays a phenotype of accelerated aging. Methods Knees of male SAMP8 and SAM-resistant 1 (SAMR1) mice as control from 6 to 33 weeks of age were evaluated by histological grading systems for joint tissues (cartilage, meniscus, synovium, and subchondral bone), and...

Efficacy and safety of carbon ion radiotherapy for bone sarcomas: a systematic review and meta-analysis

Meng Dong, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Dandan Wang, Yuhang Wang, Junru Chen, Yuhong Ou & Xiaohu Wang
Abstract Objective This study aimed to systematically evaluate and conduct a meta-analysis of the efficacy and safety of carbon ion radiotherapy for bone sarcomas. Methods We searched for articles using the PubMed, Embase, Cochrane Library, and the Web of Science databases from their inception to January 12, 2022. Two researchers independently screened the literature and extracted data based on the inclusion and exclusion criteria. Statistical analyses were performed using STATA version 14.0. Results We searched...

Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Abstract Nitrogen is not only a macronutrient essential for crop growth and development, but also one of the most critical nutrients in farmland ecosystem. Insufficient nitrogen supply will lead to crop yield reduction, while excessive application of nitrogen fertilizer will cause agricultural and eco-environment damage. Therefore, mining low-nitrogen tolerant rice genes and improving nitrogen use efficiency are of great significance to the sustainable development of agriculture. This study was conducted by Genome-wide association study on...

Mapping of Candidate Genes in Response to Low Nitrogen in Rice Seedlings

Jia Li, Wei Xin, Weiping Wang, Shijiao Zhao, Lu Xu, Xingdong Jiang, Yuxuan Duan, Hongliang Zheng, Luomiao Yang, Hualong Liu, Yan Jia, Detang Zou & Jingguo Wang
Abstract Nitrogen is not only a macronutrient essential for crop growth and development, but also one of the most critical nutrients in farmland ecosystem. Insufficient nitrogen supply will lead to crop yield reduction, while excessive application of nitrogen fertilizer will cause agricultural and eco-environment damage. Therefore, mining low-nitrogen tolerant rice genes and improving nitrogen use efficiency are of great significance to the sustainable development of agriculture. This study was conducted by Genome-wide association study on...

Attitudes and personal beliefs about the COVID-19 vaccine among people with COVID-19: a mixed-methods analysis

Monica M. Bennett, Megan Douglas, Briget da Graca, Katherine Sanchez, Mark B. Powers & Ann Marie Warren
Abstract Background Little research is available regarding vaccination attitudes among those recently diagnosed with COVID-19. This is important to investigate, particularly among those experiencing mild-to-moderate illness, given the ongoing need to improve uptake of both initial vaccine series and booster doses, and the divergent ways such an experience could impact attitudes. Methods From September 3 – November 12, 2021, all patients enrolled in Baylor Scott & White’s “COVID-19 Digital Care Journey for Home Monitoring” were...

Littrow 3D measurement based on 2D grating dual-channel equal-optical path interference

yin yunfei, Lin Liu, yu bai, Jiri Jirigalantu, hongzhu Yu, heshig bayan, zhaowu liu & Wenhao Li
We propose a 3D measurement method based on 2D grating dual-channel and Littrow equal-optical path incidence to detect the 3D displacement of a 2D grating in the X-, Y-, and Z-directions. The 2D grating is combined with the Littrow incidence method and a turning element to cause the Littrow diffracted light with frequency f1 to interfere with the reference light at frequency f2, and the displacement data in the X-, Y-, and Z-directions are obtained...

Plant sex affects plant-microbiome assemblies of dioecious Populus cathayana trees under different soil nitrogen conditions

Qingxue Guo, Lin Liu, Jiantong Liu, Helena Korpelainen & Chunyang Li
Abstract Background Dioecious plants have coevolved with diverse plant microbiomes, which are crucial for the fitness and productivity of their host. Sexual dimorphism in morphology, physiology, or gene expression may relate to different microbial compositions that affect male and female fitness in different environments. However, sex-specific impacts on ecological processes that control the microbiome assembly are not well known. In this study, Populus cathayana males and females were planted in different nitrogen conditions. It was...

Tissue S100/calgranulin expression and blood neutrophil-to-lymphocyte ratio (NLR) in dogs with lower urinary tract urothelial carcinoma

Jana Weinekötter, Corinne Gurtner, Martina Protschka, Wolf von Bomhard, Denny Böttcher, Annika Schlinke, Gottfried Alber, Sarah Rösch, Joerg M. Steiner, Johannes Seeger, Gerhard U. Oechtering & Romy M. Heilmann
Abstract Background Urothelial carcinoma (UC) is the most common neoplasm of the canine lower urinary tract, affecting approximately 2% of dogs. Elderly female patients of certain breeds are predisposed, and clinical signs of UC can easily be confused with urinary tract infection or urolithiasis. Diagnosis and treatment are challenging given the lack of disease-specific markers and treatments. The S100A8/A9 complex and S100A12 protein are Ca2+-binding proteins expressed by cells of the innate immune system and...

High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai & Jorge D. Erusalimsky
Abstract Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unclear. In this study we investigated the association between sRAGE and mortality in dexamethasone-treated COVID-19 patients. We studied 89 SARS-CoV-2 positive subjects and 22 controls attending the emergency department of a University...

Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output

Juan P. Wulff, Kevin B. Temeyer, Jason P. Tidwell, Kristie G. Schlechte, Kimberly H. Lohmeyer & Patricia V. Pietrantonio
Abstract Background The cattle fever tick, Rhipicephalus (Boophilus) microplus, is a vector of pathogens causative of babesiosis and anaplasmosis, both highly lethal bovine diseases that affect cattle worldwide. In Ecdysozoa, neuropeptides and their G-protein-coupled receptors play a critical integrative role in the regulation of all physiological processes. However, the physiological activity of many neuropeptides is still unknown in ticks. Periviscerokinins (CAP2b/PVKs) are neuropeptides associated with myotropic and diuretic activities in insects. These peptides have been...

99mTc-methylene diphosphonate SPECT/CT imaging of gout spondylitis: a case report

Yan Wang, Yan Zha, Rongfeng She, Gaofeng Sun, Shuang Li, Lin Liu, Neil Roberts & Yaying Li
Single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging of the gouty spine is rare. We describe a 66-year-old man who presented with pain and numbness in the right lower leg; he reported a 2-month history of intermittent low back pain. Imaging revealed neoplastic lesions of the spine, which were initially regarded as tumors. Thus, the patient underwent surgical removal of the lumbar lesion. However, the postoperative pathological diagnosis was gout spondylitis. In this report, we...

Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus

Roberto Rodriguez-Morales, Paola Gonzalez-Lerma, Anders Yuiska, Ji Heon Han, Yolanda Guerra, Lina Crisostomo, Alex C. Keene, Erik R. Duboue & Johanna E. Kowalko
Abstract Background Aggression is observed across the animal kingdom, and benefits animals in a number of ways to increase fitness and promote survival. While aggressive behaviors vary widely across populations and can evolve as an adaptation to a particular environment, the complexity of aggressive behaviors presents a challenge to studying the evolution of aggression. The Mexican tetra, Astyanax mexicanus exists as an aggressive river-dwelling surface form and multiple populations of a blind cave form, some...

Contribution of School and Family Factors to Racial Disparities in Bullying Involvement

Sabina Low & Lin Liu
Limited research attention has been devoted to disparate vulnerabilities to social-ecological risk factors and how these may explain group differences in bullying by race. To address this gap, the present study used data of early adolescent respondents (Mage = 11.2 years) from 36 public middle schools (N = 2701) to assess the nexus of race, social-ecological risk factors, and bullying perpetration. Multilevel modeling was employed to quantify the racial gap in bullying as well as...

Contribution of School and Family Factors to Racial Disparities in Bullying Involvement

Sabina Low & Lin Liu
Limited research attention has been devoted to disparate vulnerabilities to social-ecological risk factors and how these may explain group differences in bullying by race. To address this gap, the present study used data of early adolescent respondents (Mage = 11.2 years) from 36 public middle schools (N = 2701) to assess the nexus of race, social-ecological risk factors, and bullying perpetration. Multilevel modeling was employed to quantify the racial gap in bullying as well as...

Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Abstract Background Although neoadjuvant anti-PD-1 immunotherapies have shown good efficacy in non-small cell lung cancer (NSCLC) patients, there is still a lack of effective predictive markers. We aimed to develop a pretreatment histologic scoring system to predict the efficacy of neoadjuvant immunotherapy. Methods One hundred forty NSCLC cases were evaluated in this study. Initially, surgical specimens from 31 squamous cell lung cancer patients treated with neoadjuvant anti-PD-1 therapy and their eligible paired pretreatment biopsies were...

Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventricular remodeling remains limited. We aim to assess the contribution of plasma metabolites to the risk of death and major adverse cardiovascular events (MACE) as well as left ventricular remodeling. Results In a prospective study with 1606 Chinese patients with CAD, we have identified...

The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma

Hong-Bo Zeng, Jun-Di Jiang, Rong Li, Jian Li, Wen-Juan Zeng, Xiong-Kai Li, Bin Hu, Fei Zhou, Hai-Ying Yu, Jian-Guo Xie, Zhi-Neng Ning & Xian Wang
ObjectiveTo investigate the pathogenesis of primary angle-closure disease (PACG) by measuring the anatomical structures of the anterior and posterior segments of the eye and inflammatory markers in the peripheral blood.MethodsThis case–control study enrolled patients diagnosed with acute PACG (APACG) and chronic PACG (CPACG). It also enrolled control subjects without PACG. The anterior and posterior anatomical features were measured in all study participants. The levels of interleukin (IL)-6, tumour necrosis factor-α and the neutrophil-to-lymphocyte ratio (NLR)...

Efficacy and safety of high-dose esomeprazole and amoxicillin dual therapy versus bismuth-containing quadruple therapy for Helicobacter pylori infection: a multicenter, randomized controlled clinical trial

Hao Mei, Yan Guo, Jing-Tao Zhao, Jun Yang, Wen-jing Sun, De-kui Zhang, Ping He, Gang Shi, Na-yun Su, Ran Han & Chun-Hui Lan
Background:A high-dose proton pump inhibitor (PPI)-amoxicillin dual therapy has been investigated for treatment of patients with Helicobacter pylori (H. pylori) infection. Currently, the efficacy of this dual therapy remains inconclusive, with controversial findings from various single-center clinical trials.Objectives:To assess the efficacy and safety of high-dose dual therapy (HDDT) compared with the bismuth-containing quadruple therapy (BQT) in treatment-naive patients with H. pylori infection.Design:A multicenter, open-label, randomized controlled clinical trial.Methods:Three hundred and forty treatment-naïve patients with H....

Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia

Hongyu Liu, Ling Yu, Yiling Ding, Mei Peng & Yali Deng
We aimed to explore whether the effect of progesterone on preeclampsia via the PI3K/AKT signaling pathway. First, we studied the role of progesterone in preeclampsia patients and HTR-8/Svneo cells by adding progesterone. Then PI3K inhibitor LY294002 was added. The effects of progesterone on preeclampsia were also studied in animals by constructing a preeclampsia rat model. CCK-8 and Transwell assay were applied to measure cell viability and invasion ability. ELISA was performed to measure progesterone, MMP-2,...

CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis

Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao & Daming Cui
Abstract Background Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles in ferroptosis via several mechanisms, including regulating iron metabolism, glutathione metabolism, lipid peroxidation and mitochondrial-related proteins, there are many novel circRNAs regulating ferroptosis need to be found, and they may become a new molecular treatment target in GBM. Methods The expression levels of circLRFN5, PRRX2...

Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma

Zhuomao Mo, Daiyuan Liu, Yihan Chen, Jin Luo, Wenjing Li, Jiahui Liu, Ling Yu, Bijun Huang & Shijun Zhang
Abstract Background Liver carcinoma generally presents as an immunosuppressive microenvironment that promotes tumor evasion. The intercellular crosstalk of immune cells significantly influences the construction of an immunosuppressive microenvironment. This study aimed to investigate the important interactions between immune cells and their targeting drugs in liver carcinoma, by using single-cell and bulk transcriptomic data. Methods Single-cell and bulk transcriptomic data were retrieved from Gene Expression Omnibus (GSE159977, GSE136103, and GSE125449) and The Cancer Genome Atlas (TGCA-LIHC),...

Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventricular remodeling remains limited. We aim to assess the contribution of plasma metabolites to the risk of death and major adverse cardiovascular events (MACE) as well as left ventricular remodeling. Results In a prospective study with 1606 Chinese patients with CAD, we have identified...

Registration Year

  • 2023
    4
  • 2022
    58

Resource Types

  • Collection
    62

Affiliations

  • Texas A&M University
    62
  • Zhejiang University
    36
  • Capital Medical University
    30
  • Sichuan University
    27
  • Huazhong University of Science and Technology
    24
  • Chinese PLA General Hospital
    23
  • Chinese Academy of Sciences
    18
  • Sun Yat-sen University
    16
  • Southern Medical University
    16
  • China Agricultural University
    15