6 Works

Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...

Mitochondrial phylogenomics of Acanthocephala: nucleotide alignments produce long-branch attraction artefacts

Jin-Wei Gao, Xi-Ping Yuan, Hao Wu, Chuan-Yu Xiang, Min Xie, Rui Song, Zhong-Yuan Chen, Yuan-An Wu & Dong-Sheng Ou
Abstract Background Classification of the Acanthocephala, a clade of obligate endoparasites, remains unresolved because of insufficiently strong resolution of morphological characters and scarcity of molecular data with a sufficient resolution. Mitochondrial genomes may be a suitable candidate, but they are available for a small number of species and their suitability for the task has not been tested thoroughly. Methods Herein, we sequenced the first mitogenome for the large family Rhadinorhynchidae: Micracanthorhynchina dakusuiensis. These are also...

Mitochondrial phylogenomics of Acanthocephala: nucleotide alignments produce long-branch attraction artefacts

Jin-Wei Gao, Xi-Ping Yuan, Hao Wu, Chuan-Yu Xiang, Min Xie, Rui Song, Zhong-Yuan Chen, Yuan-An Wu & Dong-Sheng Ou
Abstract Background Classification of the Acanthocephala, a clade of obligate endoparasites, remains unresolved because of insufficiently strong resolution of morphological characters and scarcity of molecular data with a sufficient resolution. Mitochondrial genomes may be a suitable candidate, but they are available for a small number of species and their suitability for the task has not been tested thoroughly. Methods Herein, we sequenced the first mitogenome for the large family Rhadinorhynchidae: Micracanthorhynchina dakusuiensis. These are also...

Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats

Aihua Deng, Fengying Liu, Xuchong Tang, Yun Wang, Peng Xie, Qifu Yang & Bing Xiao
Abstract Background The “multiple-hit” hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism. Methods Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the...

Registration Year

  • 2022
    6

Resource Types

  • Collection
    6

Affiliations

  • Huazhong University of Science and Technology
    6
  • Hunan University of Arts and Science
    6
  • Shanghai Jiao Tong University
    6
  • Zhengzhou University
    6
  • Nanjing Medical University
    6
  • Sun Yat-sen University
    4
  • Fudan University
    4
  • University of Freiburg
    3
  • Affiliated Hospital of Jiangsu University
    3
  • Baylor College of Medicine
    3