Abstract Background LncRNA PCED1B-AS1 (PCED1B-AS1) promotes glioma. This study aimed to investigate its role in osteosarcoma (OS). Methods The study included 60 OS patients. Accumulation of miR-10a and PCED1B-AS1 in tissues from OS patients and cell lines was determined by RT-qPCR. Cell transfections were performed for interaction analysis. Participation of PCED1B-AS1 siRNA silencing and miR-10a overexpression in proliferation, invasion, and migration of U2OS and MG-63 cells was analyzed by cell proliferation assay and Transwell assay....

Abstract Background Prophylactic antibiotic use during delivery is common in routine obstetric practice to prevent infection globally, especially in low- and middle-income countries. In China, however, little is currently known about the national estimates for prophylactic antibiotic use during delivery. Therefore, we aimed to describe the prevalence of prophylactic antibiotic use and guideline adherence using national data in China. Methods This cross-sectional study analyzed a national dataset from the China Labor and Delivery Survey in...

Abstract Background Prophylactic antibiotic use during delivery is common in routine obstetric practice to prevent infection globally, especially in low- and middle-income countries. In China, however, little is currently known about the national estimates for prophylactic antibiotic use during delivery. Therefore, we aimed to describe the prevalence of prophylactic antibiotic use and guideline adherence using national data in China. Methods This cross-sectional study analyzed a national dataset from the China Labor and Delivery Survey in...

PurposeTo explore the life experiences of patients who have been discharged after undergoing extracorporeal membrane oxygenation (ECMO) support.DesignA qualitative descriptive approach was used.MethodsPatients who have undergone ECMO support and have been discharged were recruited. Thirteen participants were involved in this study. The data were collected through a semi-structured interview and analyzed using the Colaizzi method.FindingsFour major themes in life experiences were reported by the participants: changes in physical function, changes in psychological state, active adaptation...

Spatiotemporal optical vortices (STOVs) carrying transverse orbital angular momentum (OAM) are of rapidly growing interest for the field of optics due to the new degree of freedom that can be exploited. In this paper, we propose cylindrical vector two dimensional STOVs (2D-STOVs) containing two orthogonal transverse OAMs in both x-t and y-t planes for the first time, and investigate the tightly focusing of such fields using the Richards-Wolf vectorial diffraction theory. Highly confined spatiotemporal wavepackets...

Abstract Background Chromosomal aneuploidy is the most common birth defect. However, the developmental mechanism and gene expression profile of fetuses with chromosomal aneuploidy are relatively unknown, and the maternal immune changes induced by fetal aneuploidy remain unclear. The inability to obtain the placenta multiple times in real-time is a bottleneck in research on aneuploid pregnancies. Plasma cell-free DNA (cfDNA) carries the gene expression profile information of its source cells and may be used to evaluate...

Pulses as short as 44 fs (6 optical cycles) with a spectral width of 120 nm are generated from a mode-locked solid-state laser near 2 µm employing an orthorhombic Tm:GdScO3 perovskite crystal. The average power amounts to 188 mW at a repetition rate of ~ 77.6 MHz. The strong inhomogeneous line broadening in GdScO3 suggests optimum conditions for few-optical-cycle pulse generation of rare-earth ion doped GdScO3 bulk lasers.

Some asymptomatic individuals carrying SARS-CoV-2 can transmit the virus and contribute to outbreaks of COVID-19. Here, we use detailed surveillance data gathered during COVID-19 resurgences in six cities of China at the beginning of 2021 to investigate the relationship between asymptomatic proportion and age. Epidemiological data obtained before mass vaccination provide valuable insights into the nature of pathogenicity of SARS-CoV-2. The data were collected by multiple rounds of city-wide PCR testing with contact tracing, where...

Abstract Background Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants in SARS-CoV-2 infection-naïve population. Methods A matched case-control study was conducted among people aged ≥ 3 years between 2 December 2021 and 13 May 2022. Cases were SARS-CoV-2-infected individuals, individuals with severe/critical COVID-19, or COVID-19-related deaths. Controls were selected from consecutively test-negative individuals at the same time as cases were diagnosed and were exact-matched...

Abstract Background Recently, Zika virus (ZIKV) re-emerged in India and was potentially associated with microcephaly. However, the molecular mechanisms underlying ZIKV pathogenesis remain to be explored. Results Herein, we performed a comprehensive RNA-sequencing analysis on ZIKV-infected JEG-3, U-251 MG, and HK-2 cells versus corresponding uninfected controls. Combined with a series of functional analyses, including gene annotation, pathway enrichment, and protein–protein interaction (PPI) network analysis, we defined the molecular characteristics induced by ZIKV infection in different...

Pulses as short as 44 fs (6 optical cycles) with a spectral width of 120 nm are generated from a mode-locked solid-state laser near 2 µm employing an orthorhombic Tm:GdScO3 perovskite crystal. The average power amounts to 188 mW at a repetition rate of ~ 77.6 MHz. The strong inhomogeneous line broadening in GdScO3 suggests optimum conditions for few-optical-cycle pulse generation of rare-earth ion doped GdScO3 bulk lasers.

Abstract Objectives To quantitatively assess periodontal soft tissue changes, including gingival thickness and keratinized gingiva width after periodontally accelerated osteogenic orthodontics (PAOO) surgery by digital measurements. Methods This study enrolled 15 maxillaries with 89 anterior teeth and 16 mandibles with 94 anterior teeth from Chinese adult patients with skeletal Angle Class III malocclusion for whom PAOO surgery was proposed during orthodontic treatment. Intraoral scanning and cone beam computed tomography (CBCT) examinations were performed before PAOO...

Whole slide imaging scans a microscope slide into a high-resolution digital image, and it paves the way from pathology to digital diagnostics. However, most of them rely on bright-field and fluorescence imaging with sample labels. In this work, we designed sPhaseStation, which is a dual-view transport of intensity phase microscopy-based whole slide quantitative phase imaging system for label-free samples. sPhaseStation relies on a compact microscopic system with two imaging recorders that can capture both under...

Abstract Background Gliomas are highly complex and heterogeneous tumors, rendering prognosis prediction challenging. The advent of deep learning algorithms and the accessibility of multi-omic data represent a new approach for the identification of survival-sensitive subtypes. Herein, an autoencoder-based approach was used to identify two survival-sensitive subtypes using RNA sequencing (RNA-seq) and DNA methylation (DNAm) data from The Cancer Genome Atlas (TCGA) dataset. The subtypes were used as labels to build a support vector machine model...

Abstract Background Gliomas are highly complex and heterogeneous tumors, rendering prognosis prediction challenging. The advent of deep learning algorithms and the accessibility of multi-omic data represent a new approach for the identification of survival-sensitive subtypes. Herein, an autoencoder-based approach was used to identify two survival-sensitive subtypes using RNA sequencing (RNA-seq) and DNA methylation (DNAm) data from The Cancer Genome Atlas (TCGA) dataset. The subtypes were used as labels to build a support vector machine model...

The existing research has explored the effects of growth mindset intervention on individuals in Western culture. This study sought to determine whether growth mindset intervention has a positive impact on adolescents in economically disadvantaged areas of China. Participants in this study were 324 junior high school students who were randomly divided into the intervention group and the control group. The intervention group received six weeks of intervention classes designed to help students learn, internalize, and...

The friction and wear properties of self-lubricating fabric composites were closely related to fiber properties. In this paper, polyimide (PI), polyetheretherketone (PEEK), polyisophthalamide (PMIA) and cyclic aramid (Aramid III) fibers were selected as reinforcing fibers to compare and investigate the friction and wear properties of self-lubricating fabric composites at high temperature. The tribological behavior of self-lubricating fabric composites was evaluated by ball-on-disk friction test. The wear mechanism was investigated by scanning electron microscope and mechanical...

Dynamic range, the ratio of maximum detectable amplitude and the noise level, is of great importance in characterizing the performance of interferometric fiber-optic sensor (IFOS). Here we analysis the dependence of dynamic range on carrier frequency and repetition frequency in time-division-multiplexing (TDM) IFOS array using heterodyne demodulation. A novel demodulation method with higher carrier frequency and upgraded algorithm is proposed to improve the dynamic rang at least 2 times. In the simulation and experiment, the...

Dynamic range, the ratio of maximum detectable amplitude and the noise level, is of great importance in characterizing the performance of interferometric fiber-optic sensor (IFOS). Here we analysis the dependence of dynamic range on carrier frequency and repetition frequency in time-division-multiplexing (TDM) IFOS array using heterodyne demodulation. A novel demodulation method with higher carrier frequency and upgraded algorithm is proposed to improve the dynamic rang at least 2 times. In the simulation and experiment, the...

Dynamic range, the ratio of maximum detectable amplitude and the noise level, is of great importance in characterizing the performance of interferometric fiber-optic sensor (IFOS). Here we analysis the dependence of dynamic range on carrier frequency and repetition frequency in time-division-multiplexing (TDM) IFOS array using heterodyne demodulation. A novel demodulation method with higher carrier frequency and upgraded algorithm is proposed to improve the dynamic rang at least 2 times. In the simulation and experiment, the...

In this study, cold atmospheric pressure plasma jet was adopted to glass fibers surface modification with tetraethyl orthosilicate as a precursor. To enhance the interfacial bonding forces of glass fiber reinforced polypropylene (GFRP) composites, SiOx nanoparticles were polymerized on the fiber surfaces. The effect of two factors (the distance between nozzle and fiber (D) and the treatment time (T)) on the interfacial bonding behavior of GFRP composites was studied. The modified fibers and composites properties,...

Tensile strained GeSn alloys are being extensively explored as a potential gain medium for lasers compatible with complementary metal-oxide-semiconductor (CMOS) technology. Despite having achieved drastically improved lasing characteristics by harnessing tensile strain, the current methods of introducing a sizeable tensile strain into GeSn lasers require complex fabrication processes, thus reducing the viability of the lasers for practical applications. The geometric strain amplification is a simple technique that can concentrate residual and small tensile strain into...

Abstract Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. COPD is associated with accelerated lung aging. Circadian clock is believed to play important roles in COPD. Although the circadian molecular clock regulates cellular senescence, there is no information available regarding the impact of COPD. The aim of this study is to investigate the role of the circadian clock protein BMAL1 and CLOCK in cellular senescence in order to understand the cellular mechanisms of...

Abstract Background Vascular calcification is a major cause of the high morbidity and mortality of cardiovascular diseases and is closely associated with the intestinal microbiota. Short-chain fatty acids (SCFAs) are derived from the intestinal microbiota and can also regulate intestinal microbiota homeostasis. However, it remains unclear whether exogenous supplementation with propionate, a SCFA, can ameliorate vascular calcification by regulating the intestinal microbiota. This study was conducted to explore the roles of propionate and the intestinal...

Abstract Background Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells’ fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion...