Abstract Background Tau-PET is a prognostic marker for cognitive decline in Alzheimer’s disease, and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus, tau-PET may allow precision-medicine prediction of individual tau-related cognitive trajectories, which can be important for determining patient-specific cognitive endpoints in clinical trials. Here, we aimed to examine whether tau-PET in cognitive-domain-specific brain regions, identified via fMRI meta-analyses, allows the prediction of domain-specific cognitive decline. Further, we aimed to determine whether tau-PET-informed...

To achieve a higher cycling uptake, it is essential for planners to know what kind of cycling infrastructure to plan and where, that is, through which types of urban environments. In this paper, we provide a deeper understanding of cycling demand and cycling route choices and infer insights into cyclists’ latent preferences and dispreferences concerning both infrastructure attributes and the spatial characteristics of route surroundings. Hereto, this study has collected, map-matched, geovisualized, and examined a...

Background:Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies investigating the prevalence of cSVD in low- and middle-income countries (LMICs) are expanding but have not been systematically assessed.Aim:This study aims to systematically review the prevalence of cSVD in LMICs.Results:Articles were searched from the Ovid MEDLINE and EMBASE databases from 1 January 2000...

Abstract Background Tau-PET is a prognostic marker for cognitive decline in Alzheimer’s disease, and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus, tau-PET may allow precision-medicine prediction of individual tau-related cognitive trajectories, which can be important for determining patient-specific cognitive endpoints in clinical trials. Here, we aimed to examine whether tau-PET in cognitive-domain-specific brain regions, identified via fMRI meta-analyses, allows the prediction of domain-specific cognitive decline. Further, we aimed to determine whether tau-PET-informed...

To achieve a higher cycling uptake, it is essential for planners to know what kind of cycling infrastructure to plan and where, that is, through which types of urban environments. In this paper, we provide a deeper understanding of cycling demand and cycling route choices and infer insights into cyclists’ latent preferences and dispreferences concerning both infrastructure attributes and the spatial characteristics of route surroundings. Hereto, this study has collected, map-matched, geovisualized, and examined a...

Background:Cerebral small vessel disease (cSVD) is a major cause of stroke and dementia. Previous studies on the prevalence of cSVD are mostly based on single geographically defined cohorts in high-income countries. Studies investigating the prevalence of cSVD in low- and middle-income countries (LMICs) are expanding but have not been systematically assessed.Aim:This study aims to systematically review the prevalence of cSVD in LMICs.Results:Articles were searched from the Ovid MEDLINE and EMBASE databases from 1 January 2000...

Background:Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs.Aims:To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs.Design:TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted...

Background:Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs.Aims:To test whether amlodipine has a beneficial effect on microvascular function when compared to either losartan or atenolol, and whether losartan has a beneficial effect when compared to atenolol in patients with symptomatic SVDs.Design:TREAT-SVDs is an investigator-led, prospective, open-label, randomised crossover trial with blinded endpoint assessment (PROBE design) conducted...