136 Works

5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo

Sushan Yang, Linxin Wang, Xiping Pan, Yueyun Liang, Yuehan Zhang, Jing Li & Beixian Zhou
Abstract Influenza-related acute lung injury (ALI) is a life-threatening condition that results mostly from uncontrolled replication of influenza virus (IV) and severe proinflammatory responses. The methoxy flavonoid compound 5-methoxyflavone (5-MF) is believed to have superior biological activity in the treatment of cancer. However, the effects and underlying mechanism of 5-MF on IV-mediated ALI are still unclear. Here, we showed that 5-MF significantly improved the survival of mice with lethal IV infection and ameliorated IV-mediated lung...

Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

Hui Wang, Jing Li, Jinnan Liu, Junhong Leng, Weiqin Li, Zhijie Yu, Claudia H. T. Tam, Gang Hu, Ronald C. W. Ma, Zhongze Fang, Ying Wang & Xilin Yang
Abstract Background Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interactive effects of cyclin-dependent kinase 5 regulatory subunit-associated protein1-like 1(CDKAL1) rs7747752 polymorphism with low serum levels of L-carnitine, choline, and betaine for GDM. Methods A nested case-control study of 207 GDM women and their one-to-one, age-matched controls was organized from a prospective cohort of pregnant women in Tianjin, China. Conditional logistic regressions were used to test...

A CT-based nomogram for differentiating invasive fungal disease of the lung from bacterial pneumonia

Meilin Gong, Jingmei Xu, Kang Li, Ke Li, Yuwei Xia, Yang Jing, Jiafei Chen, Jing Li, Jing Yang, Mingshan Du, Wenjing Hou, Yuan Ou, Lian Li & Wei Chen
Abstract Background There is an annual increase in the incidence of invasive fungal disease (IFD) of the lung worldwide, but it is always a challenge for physicians to make an early diagnosis of IFD of the lung. Computed tomography (CT) may play a certain role in the diagnosis of IFD of the lung, however, there are no specific imaging signs for differentiating IFD of lung from bacterial pneumonia (BP). Methods A total of 214 patients...

Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer

Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao & Zaiyi Liu
Abstract Background We proposed an artificial intelligence-based immune index, Deep-immune score, quantifying the infiltration of immune cells interacting with the tumor stroma in hematoxylin and eosin-stained whole-slide images of colorectal cancer. Methods A total of 1010 colorectal cancer patients from three centers were enrolled in this retrospective study, divided into a primary (N = 544) and a validation cohort (N = 466). We proposed the Deep-immune score, which reflected both tumor stroma proportion and the...

Artificial intelligence for quantifying immune infiltrates interacting with stroma in colorectal cancer

Jing Yang, Huifen Ye, Xinjuan Fan, Yajun Li, Xiaomei Wu, Minning Zhao, Qingru Hu, Yunrui Ye, Lin Wu, Zhenhui Li, Xueli Zhang, Changhong Liang, Yingyi Wang, Yao Xu, Qian Li, Su Yao, Dingyun You, Ke Zhao & Zaiyi Liu
Abstract Background We proposed an artificial intelligence-based immune index, Deep-immune score, quantifying the infiltration of immune cells interacting with the tumor stroma in hematoxylin and eosin-stained whole-slide images of colorectal cancer. Methods A total of 1010 colorectal cancer patients from three centers were enrolled in this retrospective study, divided into a primary (N = 544) and a validation cohort (N = 466). We proposed the Deep-immune score, which reflected both tumor stroma proportion and the...

Dynamic 3D measurement based on orthogonal fringe projection and geometric constraints

Qingkang Bao, Jian Li, Xufeng Li, Tianyu Zhang, Hong Zhao & Chunwei Zhang
Geometric constraint algorithms can solve phase ambiguity for fringe projection profilometry. However, they either require multiple cameras or suffer from a small measurement depth range. To overcome these limitations, this letter proposes an algorithm combining orthogonal fringe projection and geometric constraints. A novel scheme is developed to assess the reliabilities of the potential homologous points, which works with depth segmentation to determine the final homologous points. With full consideration of lens distortions, the algorithm reconstructs...

Port Competition and Cooperation Under Emission and Privatization

Kebiao Yuan & Xuefeng Wang
The study considers the competition and cooperation between mixed duopoly ports with service differentiation when both emission tax and partial privatization policies are implemented together. By developing three-game models between government and port enterprises, this paper first studies and compares, under different game scenarios, the optimal emission tax for mixed duopoly ports and privatization level for a semipublic port, as well as the optimal output (or pricing) and emission reduction of semipublic and private ports....

Port Competition and Cooperation Under Emission and Privatization

Kebiao Yuan & Xuefeng Wang
The study considers the competition and cooperation between mixed duopoly ports with service differentiation when both emission tax and partial privatization policies are implemented together. By developing three-game models between government and port enterprises, this paper first studies and compares, under different game scenarios, the optimal emission tax for mixed duopoly ports and privatization level for a semipublic port, as well as the optimal output (or pricing) and emission reduction of semipublic and private ports....

Application of associating liver partition and portal vein ligation for staged hepatectomy for initially unresectable hepatocellular carcinoma

Haoqi Chen, Xiaowen Wang, Wenfeng Zhu, Yang Li, Zhenyu Yu, Hua Li, Yang Yang, Shuguang Zhu, Xiaolong Chen & Genshu Wang
Abstract Objective To evaluate the safety and efficacy of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in the treatment of initially unresectable hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and to preliminarily explore the mechanism of rapid growth of the future liver remnant (FLR). Methods Twenty-four patients with HBV-associated HCC who underwent ALPPS in our hospital from August 2014 to January 2021 were retrospectively studied. Propensity score matching was used to...

Temporal regulation of notch activation improves arteriovenous fistula maturation

Qunying Guo, Guang Chen, Hunter Cheng, Ying Qing, Luan Truong, Quan Ma, Yun Wang & Jizhong Cheng
Abstract Background Arteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive AVF remodeling and neointima formation. In this study we temporally controlled Notch activation to promote AVF maturation while avoiding neointima formation. Methods Temporal Notch activation was controlled by regulating the expression of Notch transcription factor, RBP-Jκ, or dnMAML1 (dominant negative MAML2) in vascular smooth muscle cells (VSMCs). AVF mouse model was...

Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections

Yan-hui Zhang, Xin-zhuan Su, Jian Li, Jia-jian Shi & Li-hua Xie
Abstract Background To understand how Plasmodium falciparum malaria is controlled, it is essential to elucidate the transcriptomic responses of the human host in naturally-exposed populations. Various individual studies of the human transcriptomic responses to naturally transmitted P. falciparum infections have been reported with varying results. Multicohort gene expression analysis by aggregating data from diverse populations into a single analysis will increase the reproducibility and reliability of the results. Methods In this study, discovery cohorts GSE1124-GPL96,...

Multicohort transcriptome analysis of whole blood identifies robust human response signatures in Plasmodium falciparum infections

Yan-hui Zhang, Xin-zhuan Su, Jian Li, Jia-jian Shi & Li-hua Xie
Abstract Background To understand how Plasmodium falciparum malaria is controlled, it is essential to elucidate the transcriptomic responses of the human host in naturally-exposed populations. Various individual studies of the human transcriptomic responses to naturally transmitted P. falciparum infections have been reported with varying results. Multicohort gene expression analysis by aggregating data from diverse populations into a single analysis will increase the reproducibility and reliability of the results. Methods In this study, discovery cohorts GSE1124-GPL96,...

Developing a competence framework for gerontological nursing in China: a two-phase research design including a needs analysis and verification study

Bea L. Dijkman, Marina Hirjaba, Wenwen Wang, Marjo Palovaara, Marjolein Annen, Merle Varik, Ying’ai Cui, Jing Li, Cornelia van Slochteren, Wang Jihong, Chen Feiteng, Yu Luo, Yudong Chen & Wolter Paans
Abstract Background China faces a serious shortage of competent nurses who can address the healthcare needs of older people in an ageing society. Chinese higher education institutes face serious challenges when it comes to developing new curricula that are capable of educating sufficient numbers of competent gerontological nurses. Therefore, the aim of this research study was to identify and verify competencies for gerontological nurses in China that are needed to provide nursing care for the...

Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Abstract Background Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs. To date, existing BRCA1/2 deleterious variants prediction models have been developed in women...

Method for optimizing the capture range of the dispersed fringe sensor

Yang Li, Bo Zhang & ShengQian Wang
Dispersed fringe sensor (DFS) is a phasing sensor based on principle of white-light double-slit interferometry. We theoretically and experimentally analyze characteristics of capture range of the DFS, propose mathematic description of capture range of the DFS and put forward a simple but practical strategy to maximize capture range of the DFS in our project. Finally, the experimental demonstration verifies validities of the mathematic description of capture range of the DFS and the strategy for optimizing...

Machine Learning Radiomics Model for External and Internal Respiratory Motion Correlation Prediction in Lung Tumor

Xiangyu Zhang, Xinyu Song, Guangjun Li, Lian Duan, Guangyu Wang, Guyu Dai, Ying Song, Jing Li & Sen Bai
Objectives: The complexity and specificity of lung tumor motion render it necessary to determine the external and internal correlation individually before applying indirect tumor tracking. However, the correlation cannot be determined from patient respiratory and tumor clinical characteristics before treatment. The purpose of this study is to present a machine learning model for an external/internal correlation prediction that is based on computed tomography (CT) radiomic features. Methods: 4-dimensional computed tomography (4DCT) images of 67 patients...

Quercetin and Luteolin may be the New Effective Drugs for Radiation Pneumonitis: Based on a Systems Pharmacology

Mengmei Zhang, Guangcai Li, Huaqing Hu, Mu Yi, Yang Li, Jihang Luo, Yan Tang, Guangmin Xu, Ze Yang & Xiao Liu
Background: The occurrence of radiation pneumonia not only affects the efficacy of radiotherapy, but also seriously threatens the health of patients undergoing radiotherapy for lung cancer. Studies have suggested that a feining granule is a potentially effective drug for the treatment of radiation pneumonitis, but its mechanism and main components are still unclear. Our study used bioinformatics methods to analyze the main drug Aster tataricus L. f. in feining granules and aims to gain the...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Abstract Background Exome sequencing (ES) is becoming more widely available in prenatal diagnosis. However, data on its clinical utility and integration into clinical management remain limited in practice. Herein, we report our experience implementing prenatal ES (pES) in a large cohort of fetuses with anomalies detected by ultrasonography using a hospital-based in-house multidisciplinary team (MDT) facilitated by a three-step genotype-driven followed by phenotype-driven analysis framework. Methods We performed pES in 1618 fetal cases with positive...

The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma

Hong-Bo Zeng, Jun-Di Jiang, Rong Li, Jian Li, Wen-Juan Zeng, Xiong-Kai Li, Bin Hu, Fei Zhou, Hai-Ying Yu, Jian-Guo Xie, Zhi-Neng Ning & Xian Wang
ObjectiveTo investigate the pathogenesis of primary angle-closure disease (PACG) by measuring the anatomical structures of the anterior and posterior segments of the eye and inflammatory markers in the peripheral blood.MethodsThis case–control study enrolled patients diagnosed with acute PACG (APACG) and chronic PACG (CPACG). It also enrolled control subjects without PACG. The anterior and posterior anatomical features were measured in all study participants. The levels of interleukin (IL)-6, tumour necrosis factor-α and the neutrophil-to-lymphocyte ratio (NLR)...

Multiband tunable exciton-induced transparencies: Exploiting both strong and intermediate coupling in a nanocube-hexagonal-nanoplate heterodimer J-aggregates hybrid

Zhiwei Hu, Ximin Cui, Yang Li, Xiaobo Han & huatian hu
Understanding and mastering the light-light and light-matter interactions in coupled structures have become a significant subject, as it provides versatile tools for manipulating light in both classical and quantum regimes. Mimicking quantum interference effects in pure photonic nanostructures, from weak Fano dip to intense electromagnetically induced transparency, usually requires strong asymmetries in complex geometries and larger interactions between resonances, i.e., in the intermediate coupling regime. Here, we numerically demonstrate a simple and chemically feasible plasmonic...

Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma

Tilman L. B. Hölting, Florencia Cidre-Aranaz, Dana Matzek, Bastian Popper, Severin J. Jacobi, Cornelius M. Funk, Florian H. Geyer, Jing Li, Ignazio Piseddu, Bruno L. Cadilha, Stephan Ledderose, Jennifer Zwilling, Shunya Ohmura, David Anz, Annette Künkele, Frederick Klauschen, Thomas G. P. Grünewald & Maximilian M. L. Knott
Abstract Chimeric fusion transcription factors are oncogenic hallmarks of several devastating cancer entities including pediatric sarcomas, such as Ewing sarcoma (EwS) and alveolar rhabdomyosarcoma (ARMS). Despite their exquisite specificity, these driver oncogenes have been considered largely undruggable due to their lack of enzymatic activity. Here, we show in the EwS model that – capitalizing on neomorphic DNA-binding preferences – the addiction to the respective fusion transcription factor EWSR1-FLI1 can be leveraged to express therapeutic genes....

Clinical application of artificial neural network (ANN) modeling to predict BRCA1/2 germline deleterious variants in Chinese bilateral primary breast cancer patients

Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Yeyuan Huang, Chuan Wang & Fangmeng Fu
Abstract Background Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit from poly (ADP-ribose) polymerase (PARP) inhibitors. However, formal genetic testing could not be carried out for all patients due to extensive use of healthcare resources, which in turn results in high medical costs. To date, existing BRCA1/2 deleterious variants prediction models have been developed in women...

Preparation of a novel monoclonal antibody against active components of PHA-L from Phaseolus vulgaris and its functional characteristics

Peipei Wang, Junmei Hu, Jiaqi Duan, Shitong Min, Congliang Chen, Yue Zhu, Yan Pan, Yitian Wang, Dapeng Wei & Xia Wang
Abstract Background Leukocyte phytohemagglutinin (PHA-L), derived from the L4 tetramer of PHA, has been frequently employed as a mitogen to induce T lymphocyte proliferation in vitro. The biological application of PHA-L in cancer diagnosis and treatment has gained traction in recent years. However, it has been noted that PHA-L obtained using traditional procedures has a massive amount of impurities or toxic components, which interfere with the activity of PHA-L. Preparation of a monoclonal antibody against...

Registration Year

  • 2023
    19
  • 2022
    117

Resource Types

  • Collection
    136

Affiliations

  • Affiliated Hospital of Jiangsu University
    136
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    112
  • Capital Medical University
    102
  • Sun Yat-sen University
    101
  • Fudan University
    99
  • Sichuan University
    95
  • Southern Medical University
    95
  • Chinese Academy of Sciences
    95
  • Shanghai Jiao Tong University
    93
  • Shandong Agricultural University
    83