235 Works

Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—study protocol for a multicentre randomised controlled trial

Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L. J. DeKoninck, Enrico Lopriore, Wes Onland, Marijn J. Vermeulen, M. Elske van den Akker–van Marle, Leti van Bodegom–Vos, Willem P. de Boode, Anton H. van Kaam, Irwin K. M. Reiss, Graeme R. Polglase, G. Jeroen Hutten, Sandra A. Prins, Estelle E. M. Mulder, Christian V. Hulzebos, Sam J. van Sambeeck, Mayke E. van der Putten, Inge A. Zonnenberg, Stuart B. Hooper & Arjan B. te Pas
Abstract Background International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more...

Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial—study protocol for a multicentre randomised controlled trial

Ronny Knol, Emma Brouwer, Thomas van den Akker, Philip L. J. DeKoninck, Enrico Lopriore, Wes Onland, Marijn J. Vermeulen, M. Elske van den Akker–van Marle, Leti van Bodegom–Vos, Willem P. de Boode, Anton H. van Kaam, Irwin K. M. Reiss, Graeme R. Polglase, G. Jeroen Hutten, Sandra A. Prins, Estelle E. M. Mulder, Christian V. Hulzebos, Sam J. van Sambeeck, Mayke E. van der Putten, Inge A. Zonnenberg, Stuart B. Hooper & Arjan B. te Pas
Abstract Background International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more...

Dynamic 3D measurement based on orthogonal fringe projection and geometric constraints

Qingkang Bao, Jian Li, Xufeng Li, Tianyu Zhang, Hong Zhao & Chunwei Zhang
Geometric constraint algorithms can solve phase ambiguity for fringe projection profilometry. However, they either require multiple cameras or suffer from a small measurement depth range. To overcome these limitations, this letter proposes an algorithm combining orthogonal fringe projection and geometric constraints. A novel scheme is developed to assess the reliabilities of the potential homologous points, which works with depth segmentation to determine the final homologous points. With full consideration of lens distortions, the algorithm reconstructs...

Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai & Wei Han
Abstract In oral and maxillofacial surgery, flap repair is essential to the quality of postoperative life. Still, thrombosis is fatal for the survival of the flaps. Besides, some postoperative thrombotic diseases, such as pulmonary embolism, also intimidate patients’ life. The traditional diagnostic methods are still limited by a large amount of hardware and suffer from inconvenience, delay, and subjectivity. Moreover, the treatments mainly rely upon thrombolytics, such as urokinase (UK) plasminogen activator, which may cause...

Periosteum coverage versus collagen-membrane coverage in periodontally accelerated osteogenic orthodontics: a randomized controlled clinical trial in Class II and Class III malocclusions

Zhigui Ma, Yan Zhu, Yining Zhan, Yufan Zhang, Ahmed Abdelrehem, Bian Wang & Chi Yang
Abstract Background Periodontal accelerated osteogenic orthodontics (PAOO) is a widely-used clinical procedure that combines selective alveolar corticotomy, particulate bone grafting, and the application of orthodontic forces. Different modifications of PAOO such as collagen-membrane coverage can better benefit patients from preventing displacement of grafts. Due to its stability, collagen-membrane coverage gradually gained popularity and became a widely-used procedure in traditional PAOO technique. Objectives To quantitatively investigate the radiographic changes of alveolar bone, periodontal soft tissue changes...

Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification

Kai Sun, Cheng Huang, Jing-zhang Li & Zhan-xiong Luo
Abstract Cervical carcinoma (CC) has been associated with high morbidity, poor prognosis, and high intratumor heterogeneity. Necroptosis is the significant cellular signal pathway in tumors which may overcome tumor cells’ apoptosis resistance. To investigate the relationship between CC and necroptosis, we established a prognostic model based on necroptosis-related genes for predicting the overall survival (OS) of CC patients. The gene expression data and clinical information of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) patients...

Methods of teaching evidence-based practice: a systematic review

Bethany Howard, Basia Diug & Dragan Ilic
Abstract Background To identify the effectiveness of different teaching modalities on student evidence-based practice (EBP) competency. Methods Electronic searches were conducted in MEDLINE, Cochrane central register of controlled trials, PsycINFO, CINAHL, ERIC, A + Education and AEI through to November 2021. We included randomised-controlled trials comparing EBP teaching modes on EBP knowledge, skills, attitudes or behaviour in undergraduate and post-graduate health professions education. Risk of bias was determined using the Cochrane risk of bias tool....

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Annborn Martin, Miroslav Solar, Fabio Silvio Taccone, Josef Dankiewicz … & Paolo Pelosi
Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods Preplanned secondary analysis of the targeted...

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Filippo Sanfilippo, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel-Garcia, Paul J. Young, Glenn Eastwood, Michelle S. Chew, Johan Unden, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Annborn Martin, Miroslav Solar, Fabio Silvio Taccone, Josef Dankiewicz … & Paolo Pelosi
Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO2 with patients’ outcome. Methods Preplanned secondary analysis of the targeted...

Supplementary material from \"New macronarian from the Middle Jurassic of Chongqing, China: phylogenetic and biogeographic implications for neosauropod dinosaur evolution\"

Hui Dai, Chao Tan, Qingyu Ma, Ning Li, Haidong Yu, Can Xiong, Zhaoying Wei, Ping Wang, Jian Yi, Guangbiao Wei, Hailu You & Xinxin Ren
Macronaria is a clade of gigantic body-sized sauropod dinosaurs widely distributed from the Late Jurassic to the Late Cretaceous globally. However, its origin, early diversification, and dispersal are still controversial. Here, we report a new macronarian Yuzhoulong qurenensis gen. et sp. nov. excavated from the Middle Jurassic (Bathonian) Lower Shaximiao Formation. Yuzhoulong qurenensis bears a unique combination of features, such as two accessory fossae that exist on the posterior surface of dorsal diapophyses of anterior...

Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations

Niina Sandholm, Ronja Hotakainen, Jani K Haukka, Fanny Jansson Sigfrids, Emma H. Dahlström, Anni A. Antikainen, Erkka Valo, Anna Syreeni, Elina Kilpeläinen, Anastasia Kytölä, Aarno Palotie, Valma Harjutsalo, Carol Forsblom, Per-Henrik Groop & on behalf of the FinnDiane Study Group
We analyzed whole-exome (WES) and whole-genome sequencing (WGS) data of 481 and 474 individuals with type 1 diabetes, respectively. The phenotypic data consisted of 79 serum lipid and apolipoprotein phenotypes obtained with clinical laboratory measurements and nuclear magnetic resonance spectroscopy.
The available summary statistic include the single variant results, as well as the SKAT and VT results for protein altering and protein truncating variants with a maximum minor allele frequency cutoff of 5%. for...

Joint modeling strategy for using electronic medical records data to build machine learning models: an example of intracerebral hemorrhage

Jianxiang Tang, Xiaoyu Wang, Hongli Wan, Chunying Lin, Zilun Shao, Yang Chang, Hexuan Wang, Yi Wu, Tao Zhang & Yu Du
Abstract Background Outliers and class imbalance in medical data could affect the accuracy of machine learning models. For physicians who want to apply predictive models, how to use the data at hand to build a model and what model to choose are very thorny problems. Therefore, it is necessary to consider outliers, imbalanced data, model selection, and parameter tuning when modeling. Methods This study used a joint modeling strategy consisting of: outlier detection and removal,...

The Suicidal Ideation Attributes Scale-Modified (SIDAS-M): Development and preliminary validation of a new scale for the measurement of suicidal ideation in autistic adults

Darren Hedley, Philip J Batterham, Simon M Bury, Angela Clapperton, Kathleen Denney, Cheryl Dissanayake, Phoenix Fox, Thomas W Frazier, Emma Gallagher, Susan M Hayward, Jo Robinson, Ensu Sahin, Julian Trollor, Mirko Uljarević & Mark A Stokes
The study describes the development and preliminary psychometric validation of the Suicidal Ideation Attributes Scale-Modified (SIDAS-M), a five-item assessment of suicidal ideation for use with autistic adults. Participants (n = 102 autistic adults; 58% women, 34% men, 8% nonbinary; Mage = 41.75, SD = 12.89) completed an online survey including the SIDAS-M at Time 1 and participated in follow-up interviews at Time 2 (~111 days later). A single factor solution provided good to excellent fit...

COMPARE Project

Healthy Working Lives Research Group
In Australia, state, territory and commonwealth governments have established an array of workers' compensation systems that collectively seek to achieve the greatest return to work outcomes at the lowest cost to society. While sharing this important public health objective, these systems differ substantially in approach. There is much variance between the schemes with respect to policy and practice and very little quality published evidence regarding the relative impact of policy settings on return to work...

Mitigating Mortality Anxiety: Identifying Heritage Tourism’s Role in Terror Management

Jiaying Lyu, Lili Wang & Wei Wei
Although terror management theory has been widely studied, little research has empirically examined whether travel functions as a terror management mechanism. Thus, the present research investigated the influence of mortality anxiety on heritage tourism preference and heritage protection intention through two studies. Study 1 shows that as individuals’ general mortality anxiety increases, their tendency to search for meaning in life increases, which fosters their heritage travel preference and heritage protection intention. Study 2, using an...

Extracellular vesicles derived from endometrial epithelial cells deliver exogenous miR-92b-3p to affect the function of embryonic trophoblast cells via targeting TSC1 and DKK3

Renwu Hua, Qiaorui Liu, Weisi Lian, Ting ting Kang, Dengying Gao, Cheng Huang, Yueying Wang & Minggang Lei
Abstract Background Extracellular vesicles (EVs) could mediate embryo-maternal communication to affect embryo implantation by delivering biology information, including microRNA (miRNA), protein, lipid. Our previous research shows that miR-92b-3p was differentially expressed in EVs of uterine flushing fluids during the embryo implantation period. However, the role of miR-92b-3p from EVs in embryo implantation remains elusive. Materials and methods EVs were isolated from porcine endometrial epithelial cells (EECs) by ultracentrifugation. MiR-92b-3p mimics and EVs were used to...

Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection

Binod Rayamajhee, Savitri Sharma, Mark Willcox, Fiona L. Henriquez, Raksheeth Nathan Rajagopal, Gauri Shankar Shrestha, Dinesh Subedi, Bhupesh Bagga & Nicole Carnt
Abstract Introduction Acanthamoeba is an emerging pathogen, infamous for its resilience against antiprotozoal compounds, disinfectants and harsh environments. It is known to cause keratitis, a sight-threatening, painful and difficult to treat corneal infection which is often reported among contact lens wearers and patients with ocular trauma. Acanthamoeba comprises over 24 species and currently 23 genotypes (T1-T23) have been identified. Aims This retrospective study was designed to examine the Acanthamoeba species and genotypes recovered from patients...

Barriers to effective management of primary postpartum haemorrhage following in-hospital births in northwest Ethiopia: healthcare providers’ views using a qualitative approach

Tiruneh Bewket, Fooladi Ensieh, Plummer Virginia & McLelland Gayle
Abstract Background Data showed that postpartum haemorrhage contributed to over 40% of in-hospital deaths of Ethiopian women. However, little is known about the barriers to effective management of primary postpartum haemorrhage. This study aims to explore the views and experiences of maternity healthcare professionals about the barriers to managing primary postpartum haemorrhage following in-hospital births in northwest Ethiopia using the ‘Three Delays’ model as a conceptual framework. Methods A qualitative descriptive study was employed at...

Identification of a novel interaction site between the large hepatitis delta antigen and clathrin that regulates the assembly of genotype III hepatitis delta virus

Wei-Chung Chiou, Hsu-Feng Lu, Jui-Chieh Chen, Yu-Heng Lai, Ming-Fu Chang, Yuan-Li Huang, Ni Tien & Cheng Huang
Abstract Background Hepatitis delta virus (HDV), a satellite virus of hepatitis B virus (HBV), is a small, defective RNA virus strongly associated with the most severe form of hepatitis and progressive chronic liver disease and cirrhosis. Chronic hepatitis D, resulting from HBV/HDV coinfection, is considered to be the most severe form of viral hepatitis and affects 12–20 million people worldwide. Involved in the endocytosis and exocytosis of cellular and viral proteins, clathrin contributes to the...

A scoping review of systems approaches for increasing physical activity in populations

Tracy Nau, Adrian Bauman, Ben J. Smith & William Bellew
Abstract Introduction The past decade has increasingly seen systems approaches as a featured theme in public health studies and policy documents. This trend is evident in the area of physical activity, which is a significant global health risk factor that is addressed in WHO’s Global Action Plan on Physical Activity. We undertook a comprehensive scoping review to characterize the application of systems approaches to physical activity, to develop a typology of the objectives, themes and...

Effect of Number of Retrieved Lymph Nodes on Prognosis in FIGO Stage IA1-IIA2 Cervical Cancer Patients Treated With Primary Radical Surgery

Shan Jiang, Peng Jiang, Tingting Jiang, Yuan Tu, Jingni Zhang, Ning Li, Wei Kong, Yuzhen Huang & Rui Yuan
Background:The influence of the number of removed lymph nodes (RLNs) on patients with early-stage cervical cancer (ESCC) is still questionable. The objective of this study was to explore the prognostic value of RLNs on ESCC patients.Methods:A retrospective study was performed including all ESCC patients who underwent radical surgery from January 2016 to December 2018. Cox regression analysis was performed to verify the correlation between the number of RLNs and the prognosis (recurrence-free survival [RFS], disease-specific...

Impact of NAFLD on clinical outcomes in hepatocellular carcinoma treated with sorafenib: an international cohort study

Jessica Howell, Amit Samani, Binish Mannan, Saur Hajiev, Leila Motedayen Aval, Rebecca Abdelmalak, Vincent C. Tam, Dominik Bettinger, Robert Thimme, Tamar H. Taddei, David E. Kaplan, Max Seidensticker & Rohini Sharma
Background:The impact of nonalcoholic fatty liver disease (NAFLD) on overall survival (OS), treatment response and toxicity in patients with hepatocellular carcinoma (HCC) treated with sorafenib is unknown. We examined the impact of NAFLD on survival and toxicity in an international cohort of patients receiving sorafenib.Methods:Clinical and demographic data were collected from patients consecutively treated at specialist centres in Europe and North America. The impact of NAFLD on OS, sorafenib-specific survival and toxicity compared with other...

Impact of the national hepatitis B immunization program in China: a modeling study

Zhixi Liu, Mengying Li, David W. Hutton, Abram L. Wagner, Ye Yao, Wenlong Zhu, Lingsheng Cao, Shenglan Tang, Jinhua Pan, Yesheng Wang, Qi Zhao, Hong Ren, Ying Wang & Weibing Wang
Abstract Background Elimination of hepatitis B virus (HBV) is a striking challenge for countries with high or moderate disease burden. Therefore, using China as a practical case to share experiences for similar countries may accelerate the achievement of the WHO 2030 target of 90% reduction in HBV-related incidence. We aim to evaluate the impact of national HBV immunization strategies in China; and the feasibility to achieve WHO 2030 targets under different scenarios. Methods We constructed...

Supplementary material from \"Taking a stab at modelling canine tooth biomechanics in mammalian carnivores with beam theory and finite-element analysis\"

Tahlia I. Pollock, Olga Panagiotopoulou, David P. Hocking & Alistair R. Evans
Canine teeth are vital to carnivore feeding ecology, facilitating behaviours related to prey capture and consumption. Forms vary with specific feeding ecologies; however, the biomechanics that drive these relationships have not been comprehensively investigated. Using a combination of beam theory analysis (BTA) and finite-element analysis (FEA) we assessed how aspects of canine shape impact tooth stress, relating this to feeding ecology. The degree of tooth lateral compression influenced tolerance of multidirectional loads, whereby canines with...

Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Sorafenib for Hepatocellular Carcinoma Refractory to Transarterial Chemoembolization: Retrospective Subgroup Analysis of 2 Prospective Trials

YeXing Huang, LiHong Zhang, MinKe He, ZhiCheng Lai, XiaoYun Bu, DongSheng Wen, QiJiong Li, Li Xu, Wei Wei, YaoJun Zhang, ZhongGuo Zhou, MinShan Chen, RongPing Guo, Ming Shi & Anna Kan
Purpose:Sorafenib is recommended for patients with hepatocellular carcinoma refractory to transarterial chemoembolization but with unsatisfactory overall survival and tumor response rate. Previously published studies showed hepatic arterial infusion chemotherapy of oxaliplatin, fluorouracil, and leucovorin was an effective and safe treatment. The aims of this study were to compare the clinical efficacy and safety of oxaliplatin, fluorouracil, and leucovorin-based hepatic arterial infusion chemotherapy with sorafenib in patients with hepatocellular carcinoma refractory to transarterial chemoembolization. Methods: This...

Registration Year

  • 2023
    26
  • 2022
    207
  • 2021
    2

Resource Types

  • Collection
    235

Affiliations

  • Monash University
    235
  • Zhejiang University
    60
  • Huazhong University of Science and Technology
    57
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    53
  • Shanghai Jiao Tong University
    51
  • Shandong University
    49
  • Nanjing Medical University
    48
  • University of Melbourne
    47
  • Sichuan University
    46
  • Fudan University
    40