68 Works

Skilled Nursing Facility Participation in Bundled Payments Was Related to Small Increases in Nurse Staffing Levels

Meiling Ying, Helena Temkin-Greener, Caroline P. Thirukumaran, Karen E. Joynt Maddox, Robert G. Holloway & Yue Li
Medicare implemented Bundled Payments for Care Improvement (BPCI) Model 3 in 2013, in which participating skilled nursing facilities (SNFs) were accountable for episode costs. We performed comparative interrupted time series analyses to evaluate associations between SNF BPCI participation and nurse staffing levels, using Medicare claims, resident assessments, and facility-level and market-level files of 2010–2017. For persistent-participating SNFs, BPCI was associated with improved certified nursing assistant (CNA) staffing levels (differential change = .03 hours, p =...

Skilled Nursing Facility Participation in Bundled Payments Was Related to Small Increases in Nurse Staffing Levels

Meiling Ying, Helena Temkin-Greener, Caroline P. Thirukumaran, Karen E. Joynt Maddox, Robert G. Holloway & Yue Li
Medicare implemented Bundled Payments for Care Improvement (BPCI) Model 3 in 2013, in which participating skilled nursing facilities (SNFs) were accountable for episode costs. We performed comparative interrupted time series analyses to evaluate associations between SNF BPCI participation and nurse staffing levels, using Medicare claims, resident assessments, and facility-level and market-level files of 2010–2017. For persistent-participating SNFs, BPCI was associated with improved certified nursing assistant (CNA) staffing levels (differential change = .03 hours, p =...

Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
In this Letter we present the analytical and numerical investigation to characterize the formation of quadratic doubly periodic waves, originating from coherent modulation instability in a dispersive quadratic media in the regime of cascading second-harmonic generation. Such an endeavor has not been undertaken before despite the growing relevance of double-periodic solutions as the precursor of highly localized wave structures. Unlike the case with cubic nonlinearity, the periodicity of these quadratic nonlinear waves can be also...

Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments

Jun Su, Yue Li, Qing Liu, Gang Peng, Chaoying Qin & Yang Li
Abstract Background Glioblastoma (GBM) is the most common primary malignant brain tumor that leads to lethality. Several studies have demonstrated that mitochondria play an important role in GBM and that mitochondria-related genes (MRGs) are potential therapeutic targets. However, the role of MRGs in GBM remains unclear. Methods Differential expression and univariate Cox regression analyses were combined to screen for prognostic differentially-expressed (DE)-MRGs in GBM. Based on LASSO Cox analysis, 12 DE-MRGs were selected to construct...

Attention to visual motion suppresses neuronal and behavioral sensitivity in nearby feature space

Sang-Ah Yoo, Julio C. Martinez-Trujillo, Stefan Treue, John K. Tsotsos & Mazyar Fallah
Abstract Background Feature-based attention prioritizes the processing of the attended feature while strongly suppressing the processing of nearby ones. This creates a non-linearity or “attentional suppressive surround” predicted by the Selective Tuning model of visual attention. However, previously reported effects of feature-based attention on neuronal responses are linear, e.g., feature-similarity gain. Here, we investigated this apparent contradiction by neurophysiological and psychophysical approaches. Results Responses of motion direction-selective neurons in area MT/MST of monkeys were recorded...

Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Abstract Background β-Farnesene is a sesquiterpene with versatile industrial applications. The production of β-farnesene from waste lipid feedstock is an attractive method for sustainable production and recycling waste oil. Yarrowia lipolytica is an unconventional oleaginous yeast, which can use lipid feedstock and has great potential to synthesize acetyl-CoA-derived chemicals. Results In this study, we engineered Y. lipolytica to produce β-farnesene from lipid feedstock. To direct the flux of acetyl-CoA, which is generated from lipid β-oxidation,...

Comparison of international guidelines for diagnosis of hepatocellular carcinoma and implications for transplant allocation in liver transplantation candidates with gadoxetic acid enhanced liver MRI versus contrast enhanced CT: a prospective study with liver explant histopathological correlation

Devang Odedra, Ali Babaei Jandaghi, Rajesh Bhayana, Khaled Y. Elbanna, Osvaldo Espin-Garcia, Sandra E. Fischer, Anand Ghanekar, Gonzalo Sapisochin & Kartik S. Jhaveri
Abstract Objectives To compare the diagnostic performance of international hepatocellular carcinoma (HCC) guidelines with gadoxetic acid-enhanced MRI (EOB-MRI) and contrast-enhanced Computed tomography (CECT) and their impact on liver transplant (LT) allocation in cirrhotic patients with explant histopathology correlation. Methods In this prospective single-centre ethics-approved study, 101 cirrhotic patients were consecutively enrolled with informed consent from the pre-LT clinic. They underwent CECT and EOB-MRI alternately at three monthly intervals until LT or removal from LT list....

Predicting falls in older adults: an umbrella review of instruments assessing gait, balance, and functional mobility

D. Beck Jepsen, K. Robinson, G. Ogliari, M. Montero-Odasso, N. Kamkar, J. Ryg, E. Freiberger & Masud Tahir
Abstract Background To review the validated instruments that assess gait, balance, and functional mobility to predict falls in older adults across different settings. Methods Umbrella review of narrative- and systematic reviews with or without meta-analyses of all study types. Reviews that focused on older adults in any settings and included validated instruments assessing gait, balance, and functional mobility were included. Medical and allied health professional databases (MEDLINE, PsychINFO, Embase, and Cochrane) were searched from inception...

Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD): Statistical Analysis Plan of a Registry-Based, Cluster-Randomized Clinical Trial

Stephanie N. Dixon, Kyla L. Naylor, Seychelle Yohanna, Susan McKenzie, Dmitri Belenko, Peter G Blake, Candice Coghlan, Rebecca Cooper, Lori Elliott, Leah Getchell, Vincent Ki, Istvan Mucsi, Gihad Nesrallah, Rachel E. Patzer, Justin Presseau, Marian Reich, Jessica M. Sontrop, Darin Treleaven, Amy D. Waterman, Jeffrey Zaltzman & Amit X. Garg
Background:Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) is a quality improvement intervention designed to enhance access to kidney transplantation and living kidney donation. We conducted a cluster-randomized clinical trial to evaluate the effect of the intervention versus usual care on completing key steps toward receiving a kidney transplant.Objective:To prespecify the statistical analysis plan for the EnAKT LKD trial.Design:The EnAKT LKD trial is a pragmatic, 2-arm, parallel-group, registry-based, open-label, cluster-randomized, superiority, clinical...

The impact of funding models on the integration of registered nurses in primary health care teams: protocol for a multi-phase mixed-methods study in Canada

Maria Mathews, Sarah Spencer, Lindsay Hedden, Julia Lukewich, Marie-Eve Poitras, Emily Gard Marshall, Judith Belle Brown, Shannon Sibbald & Alison A. Norful
Abstract Background Family practice registered nurses co-managing patient care as healthcare professionals in interdisciplinary primary care teams have been shown to improve access, continuity of care, patient satisfaction, and clinical outcomes for patients with chronic diseases while being cost-effective. Currently, however, it is unclear how different funding models support or hinder the integration of family practice nurses into existing primary health care systems and interdisciplinary practices. This has resulted in the underutilisation of family practice...

Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Abstract Background: Hospital readmissions are one of the costliest challenges facing healthcare systems, but conventional models fail to predict readmissions well. Many existing models use exclusively manually-engineered features, which are labor intensive and dataset-specific. Our objective was to develop and evaluate models to predict hospital readmissions using derived features that are automatically generated from longitudinal data using machine learning techniques. Methods: We studied patients discharged from acute care facilities in 2015 and 2016 in Alberta,...

A novel nomogram to stratify quality of life among advanced cancer patients with spinal metastatic disease after examining demographics, dietary habits, therapeutic interventions, and mental health status

Yue Li, Ze Long, Xiuju Wang, Mingxing Lei, Chunzi Liu, Xiaolin Shi & Yaosheng Liu
Abstract Background It would be very helpful to stratify patients and direct patient selection if risk factors for quality of life were identified in a particular population. Nonetheless, it is still challenging to forecast the health-related quality of life among individuals with spinal metastases. The goal of this study was to stratify patient’s populations for whom the assessment of quality of life should be encouraged by developing and validating a nomogram to predict the quality...

Evidence on the social, economic, and environmental impact of interventions that facilitate bamboo industry development for sustainable livelihoods: a systematic map protocol

Lucy Binfield, Tamara L. Britton, Chunping Dai & John Innes
Abstract Background Bamboo has been identified as a potential instrument for socioeconomic development due to its fast growth, perceived environmental benefits, promising material properties, myriad applications, and relative underdevelopment as a global industrial product. Many projects and interventions have been carried out that aim to utilize bamboo’s social and environmental potential in development. However, critical evaluations that demonstrate this effect using real-world evidence and outcomes are rare, and existing case studies have not been collated...

Systematic review: preoperative psychological factors and total hip arthroplasty outcomes

John P. O’Connor, Paige Holden & Joel J. Gagnier
Abstract Background Total hip arthroplasties (THA) are cost-effective interventions for patients with osteoarthritis refractory to physical therapy or medical management. Most individuals report positive surgical outcomes with reduction in pain and improved joint function. Multiple recent studies demonstrated the influence of patient mental health on surgical success. We sought to determine the relationship between patient preoperative psychological factors and postoperative THA outcomes, specifically pain and function. Methods PubMed, EMBASE and Cochrane Reviews databases were queried...

Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports

Nakeya Dewaswala, David Chen, Huzefa Bhopalwala, Vinod C. Kaggal, Sean P. Murphy, J. Martijn Bos, Jeffrey B. Geske, Bernard J. Gersh, Steve R. Ommen, Philip A. Araoz, Michael J. Ackerman & Adelaide M. Arruda-Olson
Abstract Background Cardiac magnetic resonance (CMR) imaging is important for diagnosis and risk stratification of hypertrophic cardiomyopathy (HCM) patients. However, collection of information from large numbers of CMR reports by manual review is time-consuming, error-prone and costly. Natural language processing (NLP) is an artificial intelligence method for automated extraction of information from narrative text including text in CMR reports in electronic health records (EHR). Our objective was to assess whether NLP can accurately extract diagnosis...

Attention to visual motion suppresses neuronal and behavioral sensitivity in nearby feature space

Sang-Ah Yoo, Julio C. Martinez-Trujillo, Stefan Treue, John K. Tsotsos & Mazyar Fallah
Abstract Background Feature-based attention prioritizes the processing of the attended feature while strongly suppressing the processing of nearby ones. This creates a non-linearity or “attentional suppressive surround” predicted by the Selective Tuning model of visual attention. However, previously reported effects of feature-based attention on neuronal responses are linear, e.g., feature-similarity gain. Here, we investigated this apparent contradiction by neurophysiological and psychophysical approaches. Results Responses of motion direction-selective neurons in area MT/MST of monkeys were recorded...

Machine learning algorithms to identify cluster randomized trials from MEDLINE and EMBASE

Ahmed A. Al-Jaishi, Monica Taljaard, Melissa D. Al-Jaishi, Sheikh S. Abdullah, Lehana Thabane, P. J. Devereaux, Stephanie N. Dixon & Amit X. Garg
Abstract Background Cluster randomized trials (CRTs) are becoming an increasingly important design. However, authors of CRTs do not always adhere to requirements to explicitly identify the design as cluster randomized in titles and abstracts, making retrieval from bibliographic databases difficult. Machine learning algorithms may improve their identification and retrieval. Therefore, we aimed to develop machine learning algorithms that accurately determine whether a bibliographic citation is a CRT report. Methods We trained, internally validated, and externally...

Targeted OUM1/PTPRZ1 silencing and synergetic CDT/enhanced chemical therapy toward uveal melanoma based on a dual-modal imaging-guided manganese metal–organic framework nanoparticles

Yue Li, Fang Li, Hui Pan, Xiaolin Huang, Jie Yu, Xueru Liu, Qinghao Zhang, Caiwen Xiao, He Zhang & Leilei Zhang
Abstract Metastasis and chemical resistance are the most serious problems in the treatment of highly aggressive uveal melanoma (UM). The newly identified lncRNA OUM1 is overexpressed in UM, functions as a catalyst and regulates protein tyrosine phosphatase (PTP) activity by binding to PTP receptor type Z1 (PTPRZ1), which plays an important role in cell proliferation, metastasis and chemotherapy resistance in the UM microenvironment. Hence, siRNAs that selectively knocking down the lncRNA OUM1 (siOUM1) and its...

A multi-country study on the impact of sex and age on oral features of COVID-19 infection in adolescents and young adults

Heba Jafar Sabbagh, Wafaa Abdelaziz, Maryam Quritum, Rana Abdullah Alamoudi, Nada Abu Bakr AlKhateeb, Joud Abourdan, Nafeesa Qureshi, Shabnum Qureshi, Ahmed H. N. Hamoud, Nada Mahmoud, Ruba Odeh, Nuraldeen Maher Al-Khanati, Rawiah Jaber, Abdulrahman Loaie Balkhoyor, Mohammed Shabi, Morenike Oluwatoyin Folayan, Omolola Alade, Noha Gomaa, Raqiya Alnahdi, Nawal A. Mahmoud, Hanane El Wazziki, Manal Alnaas, Bahia Samodien, Rawa A. Mahmoud, Nour Abu Assab … & Maha El Tantawi
Abstract Background Oral diseases are features of COVID-19 infection. There is, however, little known about oral diseases associated with COVID-19 in adolescents and young adults (AYA). Therefore, the aim of this study was to assess oral lesions’ association with COVID-19 infection in AYA; and to identify if sex and age will modify these associations. Methodology Data was collected for this cross-sectional study between August 2020 and January 2021 from 11-to-23 years old participants in 43-countries...

Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Abstract Background: Hospital readmissions are one of the costliest challenges facing healthcare systems, but conventional models fail to predict readmissions well. Many existing models use exclusively manually-engineered features, which are labor intensive and dataset-specific. Our objective was to develop and evaluate models to predict hospital readmissions using derived features that are automatically generated from longitudinal data using machine learning techniques. Methods: We studied patients discharged from acute care facilities in 2015 and 2016 in Alberta,...

Pump-guided nonlinear film for phase conjugation

Pengyu Fu & Yue Li
It is known that phase conjugation technique is achieved by the nonlinearity of materials, and widely adopted in various applications, such as high-resolution imaging, signal amplification, and target detecting. Here, we have proposed a field-enhancement method for the degenerate four wave mixing (FWM) for phase conjugation purpose. In this method, a thin metasurface with nonlinear property is utilized to confine and guide the pumps, achieving the enhanced FWM within a flexible structure. Compared to existing...

SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He & Fang Wang
Abstract Background Genes related to the SWItch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex are frequently mutated across cancers. SWI/SNF-mutant tumors are vulnerable to synthetic lethal inhibitors. However, the landscape of SWI/SNF mutations and their associations with tumor mutational burden (TMB), microsatellite instability (MSI) status, and response to immune checkpoint inhibitors (ICIs) have not been elucidated in large real-world Chinese patient cohorts. Methods The mutational rates and variation types of six SWI/SNF complex genes (ARID1A, ARID1B, ARID2,...

Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Abstract Background β-Farnesene is a sesquiterpene with versatile industrial applications. The production of β-farnesene from waste lipid feedstock is an attractive method for sustainable production and recycling waste oil. Yarrowia lipolytica is an unconventional oleaginous yeast, which can use lipid feedstock and has great potential to synthesize acetyl-CoA-derived chemicals. Results In this study, we engineered Y. lipolytica to produce β-farnesene from lipid feedstock. To direct the flux of acetyl-CoA, which is generated from lipid β-oxidation,...

Facing hierarchy: a qualitative study of residents’ experiences in an obstetrical simulation scenario

Adam B. Garber, Glenn Posner, Taylor Roebotham, M. Dylan Bould & Taryn Taylor
Abstract Background Residents in surgical specialties face a steep hierarchy when managing medical crises. Hierarchy can negatively impact patient safety when team members are reluctant to speak up. Yet, simulation has scarcely been previously utilized to qualitatively explore the way residents in surgical specialities navigate this challenge. The study aimed to explore the experiences of residents in one surgical specialty, obstetrics and gynecology (Ob/Gyn), when challenging hierarchy, with the goal of informing future interventions to...

Bell’s palsy misdiagnosis: characteristics of occult tumors causing facial paralysis

Eun-Jae Chung, Damir Matic, Kevin Fung, S. Danielle MacNeil, Anthony C. Nichols, Ruba Kiwan, KengYeow Tay & John Yoo
Abstract Objective The aim of this study was to report the incidence and clinical course of a series of patients who were misdiagnosed with Bell’s palsy and were eventually proven to have occult neoplasms. Methods Two hundred forty patients with unilateral facial paralysis who were assessed at the facial nerve reanimation clinic, Victoria Hospital, London Health Science Centre, from 2008 through 2017 were reviewed. Persistent paralysis without recovery was the presenting complaint. Results Nine patients...

Registration Year

  • 2022
    68

Resource Types

  • Collection
    68

Affiliations

  • Western University
    68
  • Tianjin Medical University Cancer Institute and Hospital
    18
  • Shandong Agricultural University
    18
  • Xuzhou Medical College
    16
  • Tianjin University of Traditional Chinese Medicine
    16
  • Tianjin Medical University General Hospital
    15
  • Sixth Affiliated Hospital of Sun Yat-sen University
    15
  • Sun Yat-sen University
    15
  • Northwest University
    15
  • Henry Ford Hospital
    15