261 Works

The Long-Term Consequences of Early Life Exposure to Tsunami and Conflict on Adolescents in Sri Lanka

Delan Devakumar, Laura Busert, Manoji Gitanjali Sathiadas, Pushpika Jayawardana, Angela Arulpragasam, Clive Osmond, Caroline H. D. Fall, Jonathan C. K. Wells & V. Pujitha Wickramasinghe
The consequences for adolescent health due to early life exposure to natural disasters combined with war are not known. We collected data from adolescents aged 12-13 years in Sri Lanka whose mothers were pregnant during the Indian Ocean tsunami in 2004 in a tsunami-affected region (n = 22), conflict-affected region (n = 35), conflict-plus-tsunami-affected region (n = 29), or controls in areas unaffected by either (n = 24). Adjusted BMI-for-age z-scores were 1.3 (95% confidence...

Intimate Partner Violence During COVID-19 Restrictions: A Study of 30 Countries From the I-SHARE Consortium

Linda Campbell, Rayner K. J. Tan, Maximiliane Uhlich, Joel M. Francis, Kristen Mark, Naomi Miall, Stefano Eleuteri, Amanda Gabster, Simukai Shamu, Leona Plášilová, Elizabeth Kemigisha, Adesola Olumide, Priya Kosana, Felipe Hurtado-Murillo, Elin C. Larsson, Amanda Cleeve, Soraya Calvo González, Gabriela Perrotta, Victoria Fernández Albamonte, Lucía Blanco, Johanna Schröder, Adedamola Adebayo, Jacqueline Hendriks, Hanna Saltis, Michael Marks … & Joseph D Tucker
Intimate partner violence (IPV) causes substantial physical and psychological trauma. Restrictions introduced in response to the COVID-19 pandemic, including lockdowns and movement restrictions, may exacerbate IPV risk and reduce access to IPV support services. This cross-sectional study examines IPV during COVID-19 restrictions in 30 countries from the International Sexual HeAlth and REproductive Health (I-SHARE) study conducted from July 20th, 2020, to February, 15th, 2021. IPV was a primary outcome measure adapted from a World Health...

Rapid desensitization through immunoadsorption during cardiopulmonary bypass. A novel method to facilitate human leukocyte antigen incompatible heart transplantation

Richard W Issitt, Eamonn Cudworth, Mario Cortina-Borja, Arun Gupta, Delordson Kallon, Richard Crook, Michael Shaw, Alex Robertson, Victor T Tsang, Sophie Henwood, Vivek Muthurangu, Neil J Sebire, Michael Burch & Matthew Fenton
BackgroundAnti-human leukocyte antigen (HLA)-antibody production represents a major barrier to heart transplantation, limiting recipient compatibility with potential donors and increasing the risk of complications with poor waiting-list outcomes. Currently there is no consensus to when desensitization should take place, and through what mechanism, meaning that sensitized patients must wait for a compatible donor for many months, if not years. We aimed to determine if intraoperative immunoadsorption could provide a potential desensitization methodology.MethodsAnti-HLA antibody-containing whole blood...

Access to employment: A comparison of autistic, neurodivergent and neurotypical adults’ experiences of hiring processes in the United Kingdom

Jade Davies, Brett Heasman, Adam Livesey, Amy Walker, Elizabeth Pellicano & Anna Remington
Autistic people face high unemployment rates. One reason for this may be that hiring processes are inaccessible. This study aimed to establish autistic people’s unique experiences of hiring processes in the United Kingdom, by comparing them to the experiences of non-autistic neurodivergent people and neurotypical people. Using qualitative and quantitative data from 225 autistic, 64 non-autistic neurodivergent and 88 neurotypical adults, we identified a series of (dis)similarities in participants’ views and experiences of recruitment for...

'Infecting Minds' Vaccine Hesitancy Project: Resources, Materials and Outputs

Philippa Matthews, Sally Frampton, Elizabeth Burns, David Gimson, Lorna Robinson, Welcome Mbokazi, Luthando Zuma, Noma Majozi, Sean Elias, Kingsley Orievulu & Janet Seeley
This is a collection containing resources generated through the 'Infecting Minds' project.
'Infecting Minds' brings together teams in the UK and South Africa to study vaccine hesitancy, between 2022-2023. We are interested in understanding barriers to vaccination, learning how beliefs and behaviours around vaccines develop, persist and spread in different settings, and taking a view of vaccination that is informed by historical narratives to better inform current and future approaches.
Our team is...

Understanding and Improving Older People’s Well-Being through Social Prescribing Involving the Cultural Sector: Interviews from a Realist Evaluation

Jordan Gorenberg, Stephanie Tierney, Geoff Wong, Amadea Turk, Sebastien Libert, Caroline Potter, Kathryn Eccles, Shona Forster, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw & Kamal R. Mahtani
Social prescribing is a non-clinical approach to addressing social, environmental, and economic factors affecting how people feel physical and/or emotionally. It involves connecting people to “community assets” (e.g., local groups, organizations, and charities) that can contribute to positive well-being. We sought to explain in what ways, for whom, and why the cultural sector can support social prescribing with older people. We conducted semi-structured interviews with 28 older people (aged 60+) and 25 cultural sector staff....

Understanding and Improving Older People’s Well-Being through Social Prescribing Involving the Cultural Sector: Interviews from a Realist Evaluation

Jordan Gorenberg, Stephanie Tierney, Geoff Wong, Amadea Turk, Sebastien Libert, Caroline Potter, Kathryn Eccles, Shona Forster, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw & Kamal R. Mahtani
Social prescribing is a non-clinical approach to addressing social, environmental, and economic factors affecting how people feel physical and/or emotionally. It involves connecting people to “community assets” (e.g., local groups, organizations, and charities) that can contribute to positive well-being. We sought to explain in what ways, for whom, and why the cultural sector can support social prescribing with older people. We conducted semi-structured interviews with 28 older people (aged 60+) and 25 cultural sector staff....

Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis

Cyrus Daruwalla, Vahid Shaygannejad, Serkan Ozakbas, Eva Kubala Havrdova, Dana Horakova, Raed Alroughani, Cavit Boz, Francesco Patti, Marco Onofrj, Alessandra Lugaresi, Sara Eichau, Marc Girard, Alexandre Prat, Pierre Duquette, Bassem Yamout, Samia J Khoury, Seyed Aidin Sajedi, Recai Turkoglu, Ayse Altintas, Olga Skibina, Katherine Buzzard, Pierre Grammond, Rana Karabudak, Anneke van der Walt, Helmut Butzkueven … & J William L Brown
Background:The prognostic significance of non-disabling relapses in people with relapsing-remitting multiple sclerosis (RRMS) is unclear.Objective:To determine whether early non-disabling relapses predict disability accumulation in RRMS.Methods:We redefined mild relapses in MSBase as ‘non-disabling’, and moderate or severe relapses as ‘disabling’. We used mixed-effects Cox models to compare 90-day confirmed disability accumulation events in people with exclusively non-disabling relapses within 2 years of RRMS diagnosis to those with no early relapses; and any early disabling relapses. Analyses...

The Influence of Comorbidity and Perceived Complexity on Outcomes of Referrals to Children and Young Person Mental Health Services (UK): A Mixed Methods Vignette Study

Georgia R Byrne, Roz Shafran, Katy Whadcock & Sophie D Bennett
Children and young people (CYP) with long-term physical conditions (LTCs) are four times more likely to develop mental health disorders yet many cannot access Children and Young People’s Mental Health Services (CYPMHS) or evidence-based interventions. This study aimed to understand the reasons for this; presence of an LTC neurodevelopmental disorder, or service requirements. 79 CYP mental health practitioners were randomly assigned to read vignettes depicting a hypothetical referral letter for a child with a mental...

Risk of thyroid dysfunction associated with mRNA and inactivated COVID-19 vaccines: a population-based study of 2.3 million vaccine recipients

Carlos King Ho Wong, David Tak Wai Lui, Xi Xiong, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Ching Lung Cheung, Chi Ho Lee, Yu Cho Woo, Ivan Chi Ho Au, Matthew Shing Hin Chung, Franco Wing Tak Cheng, Kathryn Choon Beng Tan & Ian Chi Kei Wong
Abstract Background In view of accumulating case reports of thyroid dysfunction following COVID-19 vaccination, we evaluated the risks of incident thyroid dysfunction following inactivated (CoronaVac) and mRNA (BNT162b2) COVID-19 vaccines using a population-based dataset. Methods We identified people who received COVID-19 vaccination between 23 February and 30 September 2021 from a population-based electronic health database in Hong Kong, linked to vaccination records. Thyroid dysfunction encompassed anti-thyroid drug (ATD)/levothyroxine (LT4) initiation, biochemical picture of hyperthyroidism/hypothyroidism, incident...

Experiences of the Data Monitoring Committee for the RECOVERY trial, a large-scale adaptive platform randomised trial of treatments for patients hospitalised with COVID-19

Peter A. G. Sandercock, Janet Darbyshire, David DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Natalie Staplin, Adilia Warris, Janet Wittes & Jonathan R. Emberson
Abstract Aim To inform the oversight of future clinical trials during a pandemic, we summarise the experiences of the Data Monitoring Committee (DMC) for the Randomised Evaluation of COVID therapy trial (RECOVERY), a large-scale randomised adaptive platform clinical trial of treatments for hospitalised patients with COVID-19. Methods and findings During the first 24 months of the trial (March 2020 to February 2022), the DMC oversaw accumulating data for 14 treatments in adults (plus 10 in...

Public beliefs about the consequences of living with obesity in the Republic of Ireland and Northern Ireland

Eleni Spyreli, L McGowan, E Heery, A Kelly, H Croker, C Lawlor, R O’Neill, CC Kelleher, M McCarthy, P Wall & MM Heinen
Abstract Background This study aimed to capture public beliefs about living with obesity, examine how these beliefs have changed over time and to explore whether certain characteristics were associated with them in a nationally representative sample of adults from the Republic of Ireland (RoI) and Northern Ireland (NI). Methods A cross-sectional survey employed a random quota sampling approach to recruit a nationally representative sample of 1046 adults across NI and RoI. Telephone interviews captured information...

Implementing service transformation for children and adolescents with eating disorders across England: the theory, politics, and pragmatics of large-scale service reform

Ivan Eisler, Mima Simic, Peter Fonagy & Rachel Bryant-Waugh
Abstract Background Eating disorders are among the most serious mental health problems affecting children and young people and without appropriate treatment often have a protracted course with high levels of morbidity and mortality. While considerable progress has been made in recent years in developing effective evidence-based outpatient treatments, these are not always readily available. In England, until recently, the usual care pathway for young people with an eating disorder was referral from primary care to...

Early brass from the Foyemiaowan-Xindiantai cemetery, 265–439 ce: the origin and diffusion of brass in ancient China

Qiangbing Wei, Yanxiang Li, Thilo Rehren, Honglian Ma, Xiuhui Li & Jianli Chen
Abstract The Foyemiaowan-Xindiantai cemetery, with more than 10,000 tombs, is located in north-west Gansu Province. The cemetery was active during the Sixteen-State Period of the Western Jin Dynasty (265–439 CE). As the largest ancient tomb group in the Dunhuang region, its cultural core is still mainly based on the cultural tradition of the Central Plains. Metal objects were texturally and chemically analyzed by optical microscopy (OM), scanning electron microscopy coupled with energy-dispersive spectrometry (SEM–EDS), and...

Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Abstract EGFR-TKI targeted therapy is one of the most effective treatments for lung cancer patients harboring EGFR activating mutations. However, inhibition response is easily attenuated by drug resistance, which is mainly due to bypass activation or downstream activation. Herein, we established osimertinib-resistant cells by stepwise dose-escalation in vitro and an osimertinib-resistant patient-derived xenograft model through persistent treatment in vivo. Phosphorylated proteomics identified that MEK1 and AKT1/2 were abnormally activated in resistant cells compared with parental...

Supplementary Information for \"Parametric Analysis of an Efficient Boundary Condition to Control Outlet Flow Rates in Large Arterial Networks\"

Sharp C. Y. Lo, Jon McCullough & Peter Coveney
This collection is Supplementary Information for the paper titled “Parametric Analysis of an Efficient Boundary Condition to Control Outlet Flow Rates in Large Arterial Networks” by Sharp C. Y. Lo, Jon W. S. McCullough, and Peter V. Coveney (2022). The corresponding author is Prof. Peter V. Coveney (p.v.coveney@ucl.ac.uk).
Please find the contents at the bottom of this page.

Factors impacting participation in research during the COVID-19 pandemic: results from a survey of patients in the ophthalmology outpatient department

Dalia Abdulhussein, Timothy E. Yap, Haider Manzar, Serge Miodragovic & Francesca Cordeiro
Abstract Background Understanding public and patient attitudes to clinical research is paramount to successful recruitment. The COVID-19 pandemic has led to additional hurdles in achieving this. Our aim is to understand the current factors and attitudes towards clinical trial participation in order to assist in recruitment to clinical trials. Methods We conducted face-to-face interviews with patients in the outpatient department at a tertiary eye hospital facilitated by a 32-item questionnaire developed by the research team....

A genetic model for central chondrosarcoma evolution correlates with patient outcome

William Cross, Iben Lyskjær, Tom Lesluyes, Steven Hargreaves, Anna-Christina Strobl, Christopher Davies, Sara Waise, Shadi Hames-Fathi, Dahmane Oukrif, Hongtao Ye, Fernanda Amary, Roberto Tirabosco, Craig Gerrand, Toby Baker, David Barnes, Christopher Steele, Ludmil Alexandrov, Gareth Bond, Paul Cool, Nischalan Pillay, Peter Van Loo & Adrienne M. Flanagan
Abstract Background Central conventional chondrosarcoma (CS) is the most common subtype of primary malignant bone tumour in adults. Treatment options are usually limited to surgery, and prognosis is challenging. These tumours are characterised by the presence and absence of IDH1 and IDH2 mutations, and recently, TERT promoter alterations have been reported in around 20% of cases. The effect of these mutations on clinical outcome remains unclear. The purpose of this study was to determine if...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Abstract Background Acute pancreatitis (AP) is a common digestive disease with increased incidence globally but without internationally licenced pharmacological therapy. Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current study tests whether the early administration of CQCQD will result in improved clinical outcomes in predicted MSAP/SAP patients. Methods...

Segregationally stabilised plasmids improve production of commodity chemicals in glucose-limited continuous fermentation

James R. Allen, Mario A. Torres-Acosta, Naresh Mohan, Gary J. Lye & John M. Ward
Abstract Background The production of chemicals via bio-based routes is held back by limited easy-to-use stabilisation systems. A wide range of plasmid stabilisation mechanisms can be found in the literature, however, how these mechanisms effect genetic stability and how host strains still revert to non-productive variants is poorly understood at the single-cell level. This phenomenon can generate difficulties in production-scale bioreactors as different populations of productive and non-productive cells can arise. To understand how to...

Association between rheumatoid factor and metabolic syndrome in general population

Lan Li, Donglai Feng, Jing Zeng, Peng Ye, Yao Chen & Dong Wei
Abstract Background Rheumatoid arthritis, metabolic syndrome (MS) and cardiovascular disease (CVD) are mutually connected. We aim to investigate the association between rheumatoid factor (RF) and MS in general population, explore the potential value of RF for assessment of metabolic status, and further provide a reference to the establishment of CVD primary prevention for this population. Methods We assessed the health check-up subjects, accordance with the inclusive criteria, from 1 January 2015 to 31 October 2021...

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Blanca Rodríguez-Fernández, Natalia Vilor-Tejedor, Eider M. Arenaza-Urquijo, Gonzalo Sánchez-Benavides, Marc Suárez-Calvet, Grégory Operto, Carolina Minguillón, Karine Fauria, Gwendlyn Kollmorgen, Ivonne Suridjan, Manuel Castro de Moura, David Piñeyro, Manel Esteller, Kaj Blennow, Henrik Zetterberg, Immaculata De Vivo, José Luis Molinuevo, Arcadi Navarro, Juan Domingo Gispert, Aleix Sala-Vila & Marta Crous-Bou
Abstract Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer’s disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted in the context of the...

Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case–control study from the PARADIGM registry

Ki-Bum Won, Byoung Kwon Lee, Fay Y. Lin, Martin Hadamitzky, Yong-Jin Kim, Ji Min Sung, Edoardo Conte, Daniele Andreini, Gianluca Pontone, Matthew J. Budoff, Ilan Gottlieb, Eun Ju Chun, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro de Araújo Gonçalves, Jonathon A. Leipsic, Sang-Eun Lee, Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Daniel S. Berman, Jagat Narula … & Hyuk-Jae Chang
Abstract Background The baseline coronary plaque burden is the most important factor for rapid plaque progression (RPP) in the coronary artery. However, data on the independent predictors of RPP in the absence of a baseline coronary plaque burden are limited. Thus, this study aimed to investigate the predictors for RPP in patients without coronary plaques on baseline coronary computed tomography angiography (CCTA) images. Methods A total of 402 patients (mean age: 57.6 ± 10.0 years,...

Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis

Yanhong Bao, Shuiyin Wu, Tianze Yang, Zi Wang, Yiming Wang, Xiuyun Jiang & Hongxia Ma
Abstract Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis. As a potential zoonotic pathogen, MAP also seriously threatens human health and social security. At present, long non-coding RNA (lncRNA) has attracted wide attention as an useful biomarker in various diseases. Therefore, our study analyzed the lncRNA expression profiles and lncRNA-mRNA regulatory network of MAP infected bovine monocytes-macrophages and uninfected bovine cells by high-throughput sequencing. A total of 4641 differentially expressed lncRNAs genes...

Registration Year

  • 2023
    45
  • 2022
    215
  • 2020
    1

Resource Types

  • Collection
    261

Affiliations

  • University College London
    261
  • Zhejiang University
    45
  • Huazhong Agricultural University
    41
  • Chinese Academy of Sciences
    41
  • North West Agriculture and Forestry University
    37
  • Fudan University
    37
  • Sun Yat-sen University
    35
  • Guangzhou Medical University
    29
  • Guizhou University
    29
  • Capital Medical University
    28