536 Works

Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender

Jing Zhang, Tineke Fokkema & Bruno Arpino
This study examines the influence of grandparenthood and grandparental childcare on loneliness among Chinese older adults. Using longitudinal data from a nationally representative sample of 9240 individuals from the China Health and Retirement Longitudinal Study (CHARLS), we applied logistic regression to examine the relationship between various grandparental statuses and loneliness with a focus on gender. The grandparental role is a protective factor for loneliness. Providing care to grandchildren was associated with a lower likelihood of...

CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72

Zhenguang Ying, Kaifang Wang, Junfeng Wu, Mingyu Wang, Jing Yang, Xia Wang, Guowei Zhou, Haibin Chen, Hongwu Xu, Stephen Cho Wing Sze, Feng Gao, Chunman Li & Ou Sha
Abstract Background The centrosome is one of the most important non-membranous organelles regulating microtubule organization and progression of cell mitosis. The coiled-coil alpha-helical rod protein 1 (CCHCR1, also known as HCR) gene is considered to be a psoriasis susceptibility gene, and the protein is suggested to be localized to the P-bodies and centrosomes in mammalian cells. However, the exact cellular function of HCR and its potential regulatory role in the centrosomes remain unexplored. Results We...

Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Abstract Background Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies. Rituximab is a second-line choice for the treatment for AE with NSAbs, which can cause B cell depletion via targeting CD20. However, the optimal protocol and dosage of rituximab combined with first-line therapy for NSAbs-associated AE remains unclear so far. In this study, we explored the efficacy and safety of low-dose rituximab combined with first-line treatment for NSAbs-associated...

Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Abstract Background Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies. Rituximab is a second-line choice for the treatment for AE with NSAbs, which can cause B cell depletion via targeting CD20. However, the optimal protocol and dosage of rituximab combined with first-line therapy for NSAbs-associated AE remains unclear so far. In this study, we explored the efficacy and safety of low-dose rituximab combined with first-line treatment for NSAbs-associated...

FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer

Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen & Xin Li
Abstract Background Early metastasis is a key factor contributing to poor breast cancer (BC) prognosis. Circulating tumor cells (CTCs) are regarded as the precursor cells of metastasis, which are ultimately responsible for the main cause of death in BC. However, to date molecular mechanisms underlying CTC formation in BC have been insufficiently defined. Methods RNA-seq was carried out in primary tissues from early-stage BC patients (with CTCs≥5 and CTCs = 0, respectively) and the validation...

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie & Nan Shi
Background:Melanin can be used in biomedical nanomaterials, but its solubility in water and bioavailability are low.Aim:Melanin nanoparticles were prepared and then PEG-natural melanin nanoparticles (NMNP-PEG) were obtained with good performance and optimize their (water solubility, dispersion stability, chelating metal ions, photothermal stability, drug delivery, and biocompatibility), therefore improve the water solubility of melanin and broaden its application scope in biology, medicine, food, and other fields.Methods:MFAK (melanin from apricot kernels) and NMNP-PEG were prepared and characterized...

Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie & Nan Shi
Background:Melanin can be used in biomedical nanomaterials, but its solubility in water and bioavailability are low.Aim:Melanin nanoparticles were prepared and then PEG-natural melanin nanoparticles (NMNP-PEG) were obtained with good performance and optimize their (water solubility, dispersion stability, chelating metal ions, photothermal stability, drug delivery, and biocompatibility), therefore improve the water solubility of melanin and broaden its application scope in biology, medicine, food, and other fields.Methods:MFAK (melanin from apricot kernels) and NMNP-PEG were prepared and characterized...

A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials

Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles & Fan Li
Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based...

The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hongfeng Pan, Zeyi Zhao, Yu Deng, Zhifang Zheng, Ying Huang, Shenghui Huang & Pan Chi
Abstract Purpose The incidence of early-onset colorectal cancer (EO-CRC), which occurs in people under age 50, has been increasing annually. The aim of this study was to provide an up-to-date estimate of the global EO-CRC burden. Methods We used Global Burden of Disease Study data and methodologies to describe changes in the EO-CRC burden from 1990 to 2019, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs). The driving factors for cancer burden variation were...

Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
Mid-infrared (MIR) single-photon detection is emerging as an important technology for various applications. Superconducting nanowire single photon detectors (SNSPDs) fabricated with superconducting films with energy gaps of a few meV are natural broadband single-photon detectors. Recently, extending SNSPDs’ operation wavelengths into the MIR region is highly attractive. γ-Nb₄N₃ has a reduced N content and lower energy gap than the commonly used δ-NbN, making SNSPDs based on γ-Nb₄N₃ film more sensitive to low energy photons. We...

Hemorrhagic fever with renal syndrome caused by destruction of residential area of rodent in a construction site: epidemiological investigation

Xiao Wei, Biao Meng, Hong Peng, Yan Li, Min Liu, Hairui Si, Rui Wu, Hailong Chen, Ying Bai, Qunling Feng, Changjun Wang & Xiangna Zhao
Abstract Background An outbreak of hemorrhagic fever with renal syndrome (HFRS), caused by a Hantavirus, affected nine adult males in the southwest area of Xi’an in November 2020 was analyzed in this study. Methods Clinical and epidemiological data of HFRS patients in this outbreak were retrospectively analyzed. The whole genome of a hantavirus named 201120HV03xa (hv03xa for short) isolated from Apodemus agrarius captured in the construction site was sequenced and analyzed. In addition, nine HFRS...

RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization

Ying Tan, Zongjiang Wang, Tao Liu, Peng Gao, Shitao Xu & Lei Tan
Abstract Background DNA methyltransferase 1 (DNMT1) exerts imperative functions in neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 silencing in NP by regulating microglial M2 polarization. Methods NP rat models were established using chronic constriction injury (CCI) and highly aggressive proliferating immortalized (HAPI) microglia were treated with lipopolysaccharide (LPS) to induce microglia M1 polarization, followed by treatment of DNMT1 siRNA or si-DNMT1/oe-DNMT1, respectively. The pain threshold of CCI rats was assessed...

Effect of electrical impedance-guided PEEP in reducing pulmonary complications after craniotomy: study protocol for a randomized controlled trial

Zihao Zhang, Lianqin Zhang, Jiang Zhu, Jun Dong & Hairui Liu
Abstract Objective The purpose of this study is to explore whether electrical impedance tomography (EIT)-guided individualized positive end-expiratory pressure (PEEP) can reduce the incidence of pulmonary complications within 1 week following a craniotomy compared with a single PEEP (PEEP = 6 cmH2O) from dura suturing to extubation. Methods A randomized controlled trial will be conducted at the Second Affiliated Hospital of Soochou University. Five hundred forty patients undergoing a craniotomy in the supine position will...

Penalized Spline-Involved Tree-based (PenSIT) Learning for estimating an optimal dynamic treatment regime using observational data

Kelly A Speth, Michael R Elliott, Juan L Marquez & Lu Wang
Dynamic treatment regimes are a set of time-adaptive decision rules that can be used to personalize treatment across multiple stages of care. Grounded in causal inference methods, dynamic treatment regimes identify variables that differentiate the treatment effect and may be used to tailor treatments across individuals based on the patient’s own characteristics – thereby representing an important step toward personalized medicine. In this manuscript we introduce Penalized Spline-Involved Tree-based Learning, which seeks to improve upon...

Establishment and application of a CRISPR-Cas12a-based RPA-LFS and fluorescence for the detection of Trichomonas vaginalis

Shan Li, Xiaocen Wang, Yanhui Yu, Songgao Cao, Juan Liu, Panpan Zhao, Jianhua Li, Xichen Zhang, Xin Li, Nan Zhang, Min Sun, Lili Cao & Pengtao Gong
Abstract Background Infection with Trichomonas vaginalis can lead to cervicitis, urethritis, pelvic inflammatory disease, prostatitis and perinatal complications and increased risk of HIV transmission. Here, we used an RPA-based CRISPR-Cas12a assay system in combination with a lateral flow strip (LFS) (referred to as RPA-CRISPR-Cas12a) to establish a highly sensitive and field-ready assay and evaluated its ability to detect clinical samples. Methods We developed a one-pot CRISPR-Cas12a combined with RPA-based field detection technology for T. vaginalis,...

Exploring AI-2-mediated interspecies communications within rumen microbial communities

Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen & Lei Zhang
Abstract Background The rumen is an ecosystem with a complex microbial microflora in which microbes initiate biofilm formation by attaching to plant surfaces for plant degradation and are capable of converting feed to nutrients and energy via microbial processes. Quorum sensing (QS) is a cell-to-cell communication mechanism that allows microbes to synchronize the expression of multiple genes in the group to perform social behaviors such as chemotaxis and biofilm formation using self-synthesized QS signaling molecules....

Supplementary material from \"Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)\"

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial

Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng & Haipeng Xiao
Abstract Background Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to improve immunogenicity. Our previous cluster trial in Birmingham suggested differences between morning and afternoon vaccination for some strains in the influenza vaccine in older adults. Whether this effect is also seen in a younger age group with less likelihood of compromised...

Factors influencing and long-term effects of manual myotomy phenomenon during physiotherapy for congenital muscular torticollis

Zhenhui Zhao, Hansheng Deng, Xin Qiu, Gen Tang, Huijia Zheng, Fang Yang, Futang Gao, Zhengyu Wu, Yuanheng Li, Shuaidan Zeng, Jiaxin Zhao, Yiyuan Sun, Ziheng Zhou, Yu Tang, Zhiwen Cui, Weiqing Li, Xiaodi Chen, Ting Cai, Xian Liu, Shicheng Li, Qisong Yang, Shengping Tang & Zhu Xiong
Abstract Purpose To investigate the factors influencing and long-term effects of manual myotomy (MM) occurring during physiotherapy for congenital muscular torticollis (CMT). Methods We retrospectively collected the clinical data of children with CMT receiving physiotherapy between 2008 and 2018. The children were divided into manual myotomy (MM) and non-manual myotomy (NMM) groups according to whether MM occurred during treatment. We assessed physiotherapy outcomes in children with CMT using craniofacial asymmetry parameters and the Cheng–Tang rating...

The diversity and evolutionary relationships of ticks and tick-borne bacteria collected in China

JunHua Tian, Xin Hou, MiHong Ge, HongBin Xu, Bin Yu, Jing Liu, RenFu Shao, Edward C. Holmes, ChaoLiang Lei & Mang Shi
Abstract Background Ticks (order Ixodida) are ectoparasites, vectors and reservoirs of many infectious agents affecting humans and domestic animals. However, the lack of information on tick genomic diversity leaves significant gaps in the understanding of the evolution of ticks and associated bacteria. Results We collected > 20,000 contemporary and historical (up to 60 years of preservation) tick samples representing a wide range of tick biodiversity across diverse geographic regions in China. Metagenomic sequencing was performed...

Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Qian Zhu, Min Qin, Zixian Wang, Yonglin Wu, Xiaoping Chen, Chen Liu, Qilin Ma, Yibin Liu, Weihua Lai, Hui Chen, Jingjing Cai, Yemao Liu, Fang Lei, Bin Zhang, Shuyao Zhang, Guodong He, Hanping Li, Mingliang Zhang, Hui Zheng, Jiyan Chen, Min Huang & Shilong Zhong
Abstract Background Coronary artery disease (CAD) is a metabolically perturbed pathological condition. However, the knowledge of metabolic signatures on outcomes of CAD and their potential causal effects and impacts on left ventricular remodeling remains limited. We aim to assess the contribution of plasma metabolites to the risk of death and major adverse cardiovascular events (MACE) as well as left ventricular remodeling. Results In a prospective study with 1606 Chinese patients with CAD, we have identified...

Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

Ni Liu, Changwen Yang, Xiaohan Liang, Kai Cao, Jun Xie, Qingming Luo & Haiming Luo
Abstract Background Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation exacerbates brain Aβ burden in APP/PS1 mice. Bifidobacterium is the main producer of SCFAs in the gut flora, but oral administration of Bifidobacterium is ineffective due to strong acids and bile salts in the gastrointestinal tract. Therefore, regulating the levels of SCFAs in the gut is of great significance for AD...

Combination of oral STING agonist MSA-2 and anti-TGF-β/PD-L1 bispecific antibody YM101: a novel immune cocktail therapy for non-inflamed tumors

Ming Yi, Mengke Niu, Yuze Wu, Hong Ge, Dechao Jiao, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Qian Chu & Kongming Wu
Abstract Background Non-inflamed tumors, including immune-excluded and immune-desert tumors, are commonly resistant to anti-PD-1/PD-L1 (α-PD-1/PD-L1) therapy. Our previous study reported the potent antitumor activity of anti-TGF-β/PD-L1 bispecific antibody YM101 in immune-excluded tumors. However, YM101 had limited antitumor activity in immune-desert models. MSA-2 is a novel oral stimulator of interferon genes (STING) agonist, which activates the innate immune system and may synergize with YM101 in overcoming immunotherapy resistance. Methods The dose-dependent effect of MSA-2 on STING...

New onset atrial fibrillation during orthotopic liver transplantation induced by iced saline injection for transpulmonary thermodilution: a case report

Xin Li, Xu Wang & Zheng Guan
Transpulmonary thermodilution is often used to measure extravascular lung water during liver transplantation. Here, the case of new onset atrial fibrillation during orthotopic liver transplantation, which may have been induced by iced saline injection for transpulmonary thermodilution measurement, is described. A 52-year-old male patient underwent orthotopic liver transplantation due to alcoholic cirrhosis combined with portal hypertension. During dissection of the recipient liver, transpulmonary thermodilution was performed. At 3 minutes following iced saline injected, atrial fibrillation...

Highly sensitive terahertz sensing with 3D-printed metasurfaces empowered by a toroidal dipole

Wei Yin, zhonglei shen, Yuqing Cui, Huibo Hao, Hao Zhang, Shengnan Li, Feng Gao, Shuting Fan, Liuyang Zhang & xuefeng chen
Label-free terahertz (THz) sensing with metasurfaces has attracted considerable attention in recent years, however, ultrahigh sensing sensitivity remains to be a huge challenge for practical applications. To improve the sensitivity of these devices, herein we have proposed an out-of-plane metasurface-assisted THz sensor consisting of periodically arranged bar-like meta-atoms. Benefiting from elaborate out-of-plane structures, the proposed THz sensor with high sensing sensitivity of 325 GHz/RIU can be easily fabricated via a simple three-step fabrication process. And,...

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