150 Works

Hearing loss and depressive symptoms in older Chinese: whether social isolation plays a role

Hao Huang, Jiao Wang, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Tong Zhu, Wei Sen Zhang & Lin Xu
Abstract Background Existing evidence links hearing loss to depressive symptoms, with the extent of association and underlying mechanisms remaining inconclusive. We conducted a cross-sectional study to examine the association of hearing loss with depressive symptoms and explored whether social isolation mediated the association. Methods Eight thousand nine hundred sixty-two participants from Guangzhou Biobank Cohort Study were included. Data on self-reported hearing status, the 15-item Geriatric Depression Scale (GDS-15), social isolation and potential confounders were collected...

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop

Yongzhen Mo, Yumin Wang, Yian Wang, Xiangying Deng, Qijia Yan, Chunmei Fan, Shuai Zhang, Shanshan Zhang, Zhaojian Gong, Lei Shi, Qianjin Liao, Can Guo, Yong Li, Guiyuan Li, Zhaoyang Zeng, Weihong Jiang, Wei Xiong & Bo Xiang
Abstract Background Circular RNAs (circRNAs) act as gene expression regulators and are involved in cancer progression. However, their functions have not been sufficiently investigated in nasopharyngeal carcinoma (NPC). Methods The expression profiles of circRNAs in NPC cells within different metastatic potential were reanalyzed. Quantitative reverse transcription PCR and in situ hybridization were used to detect the expression level of circPVT1 in NPC cells and tissue samples. The association of expression level of circPVT1 with clinical...

Heart-targeting exosomes from human cardiosphere-derived cells improve the therapeutic effect on cardiac hypertrophy

Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li & Yan Wang
Abstract Exosomes of human cardiosphere-derived cells (CDCs) are very promising for treating cardiovascular disorders. However, the current challenge is inconvenient delivery methods of exosomes for clinical application. The present study aims to explore the potential to enhance the therapeutic effect of exosome (EXO) from human CDCs to myocardial hypertrophy. A heart homing peptide (HHP) was displayed on the surface of exosomes derived from CDCs that were forced to express the HHP fused on the N-terminus...

Diagnostic and prognostic value of ventilatory power in pulmonary hypertension

Xin Li, Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Qin Luo & Zhihong Liu
Abstract Background Ventilatory power is a novel index which could reflect both ventilation efficiency and peripheral blood flow. However, its clinical value in pulmonary hypertension (PH) is rarely discussed. In the present study, we aimed to investigate the diagnostic and prognostic value of ventilatory power as well as its association with disease severity in PH. Methods Consecutive patients with normal hemodynamics and patients diagnosed with PH between September, 2012 and December, 2020 in Fuwai hospital...

Predictors of early response to balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension

Xin Li, Yi Zhang, Qi Jin, Qin Luo, Qing Zhao, Tao Yang, Qixian Zeng, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao & Zhihong Liu
Background:To achieve favorable hemodynamics, the number of balloon pulmonary angioplasty (BPA) sessions varied significantly among patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Increased BPA sessions burdened patients financially and psychologically. We aim to identify baseline characteristics that could predict early BPA response.Methods:Consecutive patients who were diagnosed with inoperable CTEPH and received BPA between May 2018 and October 2021 at Fuwai Hospital were retrospectively collected. Patients were categorized into ‘Early BPA responders’ or ‘Non-early BPA...

Predictors of early response to balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension

Xin Li, Yi Zhang, Qi Jin, Qin Luo, Qing Zhao, Tao Yang, Qixian Zeng, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao & Zhihong Liu
Background:To achieve favorable hemodynamics, the number of balloon pulmonary angioplasty (BPA) sessions varied significantly among patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Increased BPA sessions burdened patients financially and psychologically. We aim to identify baseline characteristics that could predict early BPA response.Methods:Consecutive patients who were diagnosed with inoperable CTEPH and received BPA between May 2018 and October 2021 at Fuwai Hospital were retrospectively collected. Patients were categorized into ‘Early BPA responders’ or ‘Non-early BPA...

Optimizing Drug Response Study Design in Patient-Derived Tumor Xenografts

Jessica Weiss, Nhu-An Pham, Melania Pintilie, Ming Li, Geoffrey Liu, Frances A Shepherd, Ming-Sound Tsao & Wei Xu
Patient-derived tumor xenograft (PDX) models were used to evaluate the effectiveness of preclinical anticancer agents. A design using 1 mouse per patient per drug (1 × 1 × 1) was considered practical for large-scale drug efficacy studies. We evaluated modifiable parameters that could increase the statistical power of this design based on our consolidated PDX experiments. Real studies were used as a reference to investigate the relationship between statistical power with treatment effect size, inter-mouse...

High-efficiency liquid luminescent solar concentrator based on CsPbBr3 quantum dots

Shaohua Li, Zida Zheng, Yi Zhang, Yue Liu, Xueyun Liu & Xiaowei Zhang
Performance degradation is still a challenge for the development of conventional polymer luminescent solar concentrator (LSC). Liquid LSC (L-LSC) may be an alternative due to polymerization-free fabrication. Here, we have prepared a CsPbBr3 quantum dots (QDs)-based L-LSC by injecting the QDs solution into a self-assembly quartz glass mold. The as-fabricated L-LSC performance is evaluated by optical characterization and photo-electrical measurement. The external quantum efficiency of the L-LSC is up to 13.44%. After coupling the commercial...

Targeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy

Kai Sun, Dandan Li, Aoyun Xia, Hua Zhao, Qin Wen, Sisi Jia, Jiafeng Wang, Guili Yang, Danhua Zhou, Cuihong Huang, Hui Wang, Zhiqiang Chen & Tao Guo
Abstract Background The mining of new allelic variation and the induction of new genetic variability are the basis for improving breeding efficiency. Results In this study, in total, 3872 heavy ion-irradiated M2 generation rice seeds and individual leaves were collected. The grain length was between 8 and 10.22 mm. The grain width was between 1.54 and 2.87 mm. The results showed that there was extensive variation in granulotype. The allelic variation in GS3 and GW5...

ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells

Zijie Gao, Jianye Xu, Yang Fan, Zongpu Zhang, Huizhi Wang, Mingyu Qian, Ping Zhang, Lin Deng, Jie Shen, Hao Xue, Rongrong Zhao, Teng Zhou, Xing Guo & Gang Li
Abstract Background Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to the complexity of heterogeneity, culminating in preferential resistance to radiotherapy. ARP2/3 (actin-related protein-2/3) complexes (ARPs) are associated with cancer migration, invasion and differentiation, while the implications of ARPs in the phenotype and resistance to radiotherapy of GSCs remain unclear. Methods We screened the expression of...

Genomic characteristics of two breast malignant phyllodes tumors during pregnancy and lactation identified through whole-exome sequencing

Tinge Lei, Mengjia Shen, Xu Deng, Yongqiang Shi, Yan Peng, Hui Wang & Tongbing Chen
Abstract Background The genomic landscape of breast malignant phyllodes tumors (PTs) is not well defined, especially pregnancy-related malignant PTs. To clarify this topic, whole-exome next-generation sequencing (NGS) was performed on tumor samples and paired normal breast tissues from two pregnancy-related malignant PTs, followed by a functional analysis of the genetic alterations. Methods DNA from malignant PT samples and matched normal breast tissues of both patients were subjected to molecular profiling. NGS of the whole-exome was...

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang & Huachun Zhang
ObjectiveThis systematic review and meta-analysis aimed to evaluate the effect of respiratory muscle training on respiratory muscle strength, lung function, cardiopulmonary fitness, and quality of life for chronic kidney disease patients.MethodsPubMed, Embase, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials published randomized controlled trials that evaluated the effect of respiratory muscle training for chronic kidney disease patients from inception to December 2021, and rerun on September 2022. The quality of included...

Effect of respiratory muscle training in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials

Fan Zhang, Hui Wang, Yan Bai, Liuyan Huang & Huachun Zhang
ObjectiveThis systematic review and meta-analysis aimed to evaluate the effect of respiratory muscle training on respiratory muscle strength, lung function, cardiopulmonary fitness, and quality of life for chronic kidney disease patients.MethodsPubMed, Embase, Web of Science Core Collection, and Cochrane Central Register of Controlled Trials published randomized controlled trials that evaluated the effect of respiratory muscle training for chronic kidney disease patients from inception to December 2021, and rerun on September 2022. The quality of included...

Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass

Jiang-Wei Xia, Lin Zhang, Jin Li, Cheng-Da Yuan, Xiao-Wei Zhu, Yu Qian, Saber Khederzadeh, Jia-Xuan Gu, Lin Xu, Jian-Hua Gao, Ke-Qi Liu, David Karasik, Shu-Yang Xie, Guo-Bo Chen & Hou-Feng Zheng
Abstract Background Birth weight is considered not only to undermine future growth, but also to induce lifelong diseases; the aim of this study is to explore the relationship between birth weight and adult bone mass. Methods We performed multivariable regression analyses to assess the association of birth weight with bone parameters measured by dual-energy X-ray absorptiometry (DXA) and by quantitative ultrasound (QUS), independently. We also implemented a systemic Mendelian randomization (MR) analysis to explore the...

Quantum and quasi-classical effects in the strong field ionization and subsequent excitation of nitrogen molecules

Liang Xu, Qi Lu, Vladimir Tikhonchuk, Bin Zhou, Runzhe Yang, Qingqing Liang, He Feng, Rostyslav Danylo, Aurelien Houard & Andre Mysyrowicz
The processes leading to the N2+ lasing are rather complex and even the population distribution after the pump laser excitation is unknown. In this paper, we study the population distribution at electronic and vibrational levels in N2+ driven by ultra-short laser pulse at the wavelengths of 800 nm and 400 nm by using the quantum-mechanical time-domain incoherent superposition model based on the time-dependent Schrodinger equation and the quasi-classical model assuming instantaneous ionization injection described by...

Chicken miR-126-5p negatively regulates antiviral innate immunity by targeting TRAF3

Jie Wang, Yuqiang Cheng, Longlong Wang, Aixi Sun, Zhenyu Lin, Wenxian Zhu, Zhaofei Wang, Jingjiao Ma, Henan Wang, Yaxian Yan & Jianhe Sun
Abstract Innate immunity plays an essential role in preventing the invasion of pathogenic microorganisms. However, innate immunity is a double-edged sword, whose excessive activation is detrimental to immune homeostasis and even leads to a “cytokine storm” of the infected host. The host develops a series of negative regulatory mechanisms to balance the immune response. Here, we report a negative regulatory mechanism of chicken innate immunity mediated by miRNA. In the GEO database, we found that...

Al₂O₃-YAG:Ce/YAG composite ceramic phosphor in a transmissive configuration for high-brightness laser-driven lighting

Pengfei Sang, Le Zhang, Jian Kang, yanbin li, shiwei chen, peng yang, Bingheng Sun, Yang Li & Hao Chen
High-power, high-brightness laser lighting promotes new requirements for light-conversion materials, such as high thermal conductivity, high saturation threshold and compact encapsulation. In this paper, we designed and fabricated a novel composite structure ceramic including a 1.0×1.0 mm2 Al₂O₃-YAG:Ce ceramic and a φ=16.0 mm transparent YAG ceramic for the transmissive configuration in laser lighting. When pumped by blue laser from 0~60 W mm2, all the samples exhibited no luminous saturation phenomenon, and the 10.0 wt.%Al₂O₃-YAG:Ce/YAG composite...

Bioactive isopimarane and 3,4-seco isopimarane diterpenoids from Isodon amethystoides

Chenliang Zhao, Lang Zhou, Wenjian Xie, Lihan Zhao, Chiyuan Zhang, Kang He, Jianghai Ye, Jingjie Zhang, Lutai Pan, Juan Zou & Hongjie Zhang
Abstract Isodon amethystoides (Lamiaceae) is a popular plant in folk medicine in the southern provinces of China. Our phytochemical investigation of the twigs and leaves of this plant led to the discovery of five new diterpenoids with isopimarane and 3,4-seco isopimarane scaffolds [isoamethinols A–E (1–5)], along with the known compound 3,4-seco isopimara-4(18),7,15-triene-3-oic acid methylester (6). The chemical structures of these compounds, including the absolute configurations of the new diterpenoids, were determined by comprehensive spectroscopic analyses...

Bioactive isopimarane and 3,4-seco isopimarane diterpenoids from Isodon amethystoides

Chenliang Zhao, Lang Zhou, Wenjian Xie, Lihan Zhao, Chiyuan Zhang, Kang He, Jianghai Ye, Jingjie Zhang, Lutai Pan, Juan Zou & Hongjie Zhang
Abstract Isodon amethystoides (Lamiaceae) is a popular plant in folk medicine in the southern provinces of China. Our phytochemical investigation of the twigs and leaves of this plant led to the discovery of five new diterpenoids with isopimarane and 3,4-seco isopimarane scaffolds [isoamethinols A–E (1–5)], along with the known compound 3,4-seco isopimara-4(18),7,15-triene-3-oic acid methylester (6). The chemical structures of these compounds, including the absolute configurations of the new diterpenoids, were determined by comprehensive spectroscopic analyses...

Assessment of performance for a key indicator of One Health: evidence based on One Health index for zoonoses in Sub-Saharan Africa

Han-Qing Zhao, Si-Wei Fei, Jing-Xian Yin, Qin Li, Tian-Ge Jiang, Zhao-Yu Guo, Jing-Bo Xue, Le-Fei Han, Xiao-Xi Zhang, Shang Xia, Yi Zhang, Xiao-Kui Guo & Kokouvi Kassegne
Abstract Background Zoonoses are public health threats that cause severe damage worldwide. Zoonoses constitute a key indicator of One Health (OH) and the OH approach is being applied for zoonosis control programmes of zoonotic diseases. In a very recent study, we developed an evaluation system for OH performance through the global OH index (GOHI). This study applied the GOHI to evaluate OH performance for zoonoses in sub-Saharan Africa. Methods The framework for the OH index...

Silicon Bowtie Structure Based Adjustable Non-rigid All Nonmetal Metamaterials Terahertz Filter

Danni Hao, Yi Zhang, Dongxun Yang, Rui Li, Zhao Dan, Zhenzhen Zhang, Shuai Wang, Wei Jin, Hao Tian & Jiaying Duan
Silicon bowtie structure based all-nonmetal metamaterial (ANM) terahertz device has been developed, which has comparable efficiency to that of their metallic counterparts, and better compatibility with modern semiconductor fabrication processes. Moreover, with the same structure but highly tunable ANM is successfully fabricated through integrating with a flexible substrate, it demonstrates large tunability over a wide frequency range. Such a device can be used in terahertz systems for numerous applications, and potentially be a promising substitute...

Lifestyle behaviors and mental health during the coronavirus disease 2019 pandemic among college students: a web-based study

Yi Zhang, Shuman Tao, Yang Qu, Xingyue Mou, Hong Gan, Panfeng Zhou, Zhuoyan Zhu, Xiaoyan Wu & Fangbiao Tao
Abstract Background After emerging in China, the novel coronavirus disease 2019 (COVID-19) quickly spread to all parts of the country and became a global public health emergency. The Chinese government immediately took a series of protective and quarantine measures to prevent the spread of the virus, and these measures may have negative effects on behavior and psychological health. This study aimed to examine the associations between factors related to COVID-19 measures and mental health symptoms...

Using beam-offset optical coherence tomography to reconstruct backscattered photon profiles in scattering media

weiming xu & Hui Wang
To image the underlying structures of a scattering medium, raster scanning imaging technologies capture least scattered photons (LSPs) and reject multiple scattered photons (MSPs) in backscattered photons. However, MSPs can still squeeze into the images, resulting in limited imaging depth, degraded contrast, and significantly reduced lateral resolution. Great efforts have been made to understand how MSPs affect imaging performance through modeling, but the techniques for visualizing the backscattered photon profile (BSPP) in scattering media during...

Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence

Qing Ma, Hui Wang, Edmund T. Rolls, Shitong Xiang, Jiong Li, Yuzhu Li, Qiongjie Zhou, Wei Cheng & Fei Li
Abstract Background Gestational age (GA) is associated with later cognition and behavior. However, it is unclear how specific cognitive domains and brain structural development varies with the stepwise change of gestational duration. Methods This large-scale longitudinal cohort study analyzed 11,878 early adolescents’ brain volume maps at 9–10 years (baseline) and 5685 at 11–12 years (a 2-year follow-up) from the Adolescent Brain Cognitive Development (ABCD) study. According to gestational age, adolescents were divided into five categorical...

Willingness of patients with cancer pain to participate in end-of-life decisions: a multi-center cross-sectional study from three coastal provinces in southern China

Xi Ke, Hongyu Zhu, Yu Zhang, Ling Yang, Simei Shi, Fang Zhu & Huiyu Luo
Abstract Background Little is known about patients’ intention for participation in end-of-life decisions (EOLD) in three coastal provinces in southern China. This study aimed to explore the willingness of patients with cancer pain to participate in EOLD and potential influencing factors. Methods A multi-center cross-sectional study was performed in three coastal provinces in southern China. Two hundred and thirty patients with cancer pain were recruited and consented to fill out the questionnaires. The patients’ willingness...

Registration Year

  • 2022
    150

Resource Types

  • Collection
    150

Affiliations

  • Jiangsu Cancer Hospital
    150
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    110
  • Nanjing Medical University
    110
  • Shanghai Jiao Tong University
    108
  • Zhejiang University
    100
  • Peking University
    100
  • Capital Medical University
    99
  • Huazhong University of Science and Technology
    86
  • West China Hospital of Sichuan University
    84
  • Jiangsu Province Hospital
    78