4,365 Works

Prevalence and influence factors of occupational exposure to blood and body fluids in registered Chinese nurses: a national cross-sectional study

Lihui Zhang, Qi Li, Ling Guan, Lu Fan, Yunxia Li, Zhiyun Zhang & Sue Yuan
Abstract Background Occupational exposure to blood and body fluids poses a threat to medical providers and to nurses especially. This harm is not only physical, but psychology as well and can ultimately impact patient safety. This study aims to understand the prevalence of occupational exposure to blood and body fluids among Chinese registered nurses and explores the factors that influence this exposure. Methods A cross-sectional online survey was conducted for 31 province-level divisions in China,...

Circular polarization detector based on polarization holography

Yuanying Zhang, Qi Zhang, xiaochuan jiang, Zheng Shujun, Jinhong Li, Xianmiao Xu, Yang Yi, Zhiyun Huang & Xiaodi Tan
We propose and experimentally demonstrate the generation of a circular polarization detector based on planar polarization holography. The detector is designed by constructing the interference field according to the null reconstruction effect (NRE). We create the multiplexed holograms which feature the combination of two sets of hologram patterns and operate with opposite circular polarization beams. In a few seconds, the exposure operation allows the polarization multiplexed holograms element to be generated, with functionality equivalent to...

Multiband tunable exciton-induced transparencies: Exploiting both strong and intermediate coupling in a nanocube-hexagonal-nanoplate heterodimer J-aggregates hybrid

Zhiwei Hu, Ximin Cui, Yang Li, Xiaobo Han & huatian hu
Understanding and mastering the light-light and light-matter interactions in coupled structures have become a significant subject, as it provides versatile tools for manipulating light in both classical and quantum regimes. Mimicking quantum interference effects in pure photonic nanostructures, from weak Fano dip to intense electromagnetically induced transparency, usually requires strong asymmetries in complex geometries and larger interactions between resonances, i.e., in the intermediate coupling regime. Here, we numerically demonstrate a simple and chemically feasible plasmonic...

Multiband tunable exciton-induced transparencies: Exploiting both strong and intermediate coupling in a nanocube-hexagonal-nanoplate heterodimer J-aggregates hybrid

Zhiwei Hu, Ximin Cui, Yang Li, Xiaobo Han & huatian hu
Understanding and mastering the light-light and light-matter interactions in coupled structures have become a significant subject, as it provides versatile tools for manipulating light in both classical and quantum regimes. Mimicking quantum interference effects in pure photonic nanostructures, from weak Fano dip to intense electromagnetically induced transparency, usually requires strong asymmetries in complex geometries and larger interactions between resonances, i.e., in the intermediate coupling regime. Here, we numerically demonstrate a simple and chemically feasible plasmonic...

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal

Jifeng Yu, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Wei Zhang, Li Zhang, Gui Zhao, Xiaoping Tu, Liang Peng, Sijin Liu, Xing Bai, Yongping Song, Zhongxing Jiang, Ruliang Zhang & Wenzhi Tian
Abstract A novel recombinant SIRPα-Fc fusion protein, IMM01, was constructed and produced using an in-house developed CHO-K1 cell expression system, and the anti-tumor mechanism of IMM01 targeting the CD47-SIRPα pathway was explored. The phagocytosis and in vitro anti-tumor activity of IMM01 were evaluated by antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC) assays. In vivo mouse tumor model studies were used to explore therapeutic efficacy as well as the mechanism of...

Supplementary material from \"Functional and phylogenetic relationships link predators to plant diversity via trophic and non-trophic pathways\"

Jing-Ting Chen, Ming-Qiang Wang, Yi Li, Douglas Chesters, Arong Luo, Wei Zhang, Peng-Fei Guo, Shi-Kun Guo, Qing-Song Zhou, Ke-Ping Ma, Goddert von Oheimb, Matthias Kunz, Nai-Li Zhang, Xiao-Juan Liu, Helge Bruelheide, Andreas Schuldt & Chao-Dong Zhu
Human-induced biodiversity loss negatively affects ecosystem function, but the interactive effects of biodiversity change across trophic levels remain insufficiently understood. We sampled arboreal spiders and lepidopteran larvae across seasons in 2 years in a subtropical tree diversity experiment, and then disentangled the links between tree diversity and arthropod predator diversity by deconstructing the pathways among multiple components of diversity (taxonomic, phylogenetic and functional) with structural equation models. We found that herbivores were major mediators of...

Synthesis, ring-opening polymerization, and properties of benzoxazines based on o- and p-hydroxybenzyl alcohols

Menglei Zhen, Hecheng Zhen, Xiaoting Zuo, Zeyun Wu, Zhiyun Li, Yanfang Liu & Mingtao Run
Two series of bifunctional benzoxazines were synthesized from o- and p-hydroxybenzyl alcohols (oHBA and pHBA), three aliphatic diamines containing ether linkage (Jeffamines D230 and D400 and 4,7,10-trioxa-1,13-tridecanediamine (TTDDA)), and paraformaldehyde. The chemical structures of the benzoxazines were confirmed by 1H and 13C nuclear magnetic resonance and Fourier transform infrared (FTIR) spectroscopy. The ring-opening polymerization of the benzoxazines was studied by differential scanning calorimetry and FTIR, respectively. oHBA-based benzoxazines respectively exhibit lower onset temperatures of ring-opening...

A survey of resident physicians’ perceptions of competency-based education in standardized resident training in China: a preliminary study

Qi Chen, Ming Li, Na Wu, Xue Peng, GuangMin Tang, Heng Cheng, LiuLing Hu, Bin Yang & ZhongLi Liao
Abstract Background Understanding resident physicians’ perceptions of competency-based medical education(CBME) may help improve approaches for implementing such education in standardized resident training (SRT). We conducted surveys of residents in China to identify their perceptions of CBME and determine the degree to which such education impacts their career plans. Methods Questionnaire contained a total of 24 questions, which were answered using multiple choice or yes/no, was distributed to residents who were undergoing SRT, regardless of specialty,...

The prognostic value of tumor mutational burden related 6-gene-based Risk Score in laryngeal cancer patients

Dong Yang, Juan Liu, Naibin Liu, Chunlei Yin, Huan Zhang & Jianhua Xu
Abstract Background Laryngeal cancer (LC) is the second frequent malignant head and neck cancer around world, while LC patients’ prognosis is unsatisfactory. This study aims to investigate the prognostic value of tumor mutation burden (TMB)-related genes in LC. Methods LC data was downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. TMB values of all samples were calculated basing on mutation data. The differentially expressed genes (DEGs) between LC samples with distinct TMB...

Combination therapy with budesonide and N-acetylcysteine ameliorates LPS-induced ALI by attenuating neutrophil recruitment through the miR-196b-5p/Socs3 molecular axis

Yang Li, Huimin Yu, Meifen Lv, Qiaofen Li, Kaiwen Zou & Shaokun Lv
Abstract Background Neutrophil infiltration accelerates the inflammatory response and is highly correlated to the development of acute lung injury (ALI). Budesonide (BUD) and N-acetylcysteine (NAC) both inhibit the inflammatory response to alleviate ALI, so we further investigated whether their combination is better for ALI. Methods In this study, we investigated the effect and mechanism of Combined BUD and NAC therapy on LPS-induced ALI. Rat ALI model and neutrophil abnormal activation model were established by lipopolysaccharide...

Ultraviolet-to-Infrared Broadband Photodetector and Imaging Application based on Perovskite Single Crystal

Meng Xu, Xinyue Wang, Jiexin Weng, Jingling Shen, Yanbing Hou & Bo Zhang
The organic-inorganic hybrid perovskite CH3NH3PbBr3(MAPbBr3) has been well developed in the X-ray to visible light band due to its superior optoelectronic properties, but this material is rarely studied in the infrared band. In this paper, a UV-NIR broadband optical detector based on MAPbBr3 single crystal is studied, and the response range can reach the near-infrared region. In the visible light band, the optical response of the device is mainly caused by the photoelectric effect; in...

Exploration of the role of Cuproptosis genes and their related long non-coding RNA in clear cell renal cell carcinoma: a comprehensive bioinformatics study

Dian Xia, Qi Liu, Wen Jiao, Longfei Peng, Qi Wang, ZhouTing Tuo & Liangkuan Bi
Abstract Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We constructed a model for the prediction of clinical prognosis and immunotherapy response through integrative analysis of gene expression datasets from...

RBM10 regulates alternative splicing of lncRNA Neat1 to inhibit the invasion and metastasis of NSCLC

Shan Cong, Xin Di, Ranwei Li, Yingshu Cao, Xin Jin, Chang Tian, Min Zhao & Ke Wang
Abstract Background Non-small cell lung cancer (NSCLC) accounts for more than 85% of the total cases with lung cancer. NSCLC is characterized by easy metastasis, which often spreads to bones, brains and livers. RNA-binding motif protein 10 (RBM10) is an alternative splicing (AS) regulator frequently mutated in NSCLC. We found that there were multiple peak binding sites between RBM10 and long non-coding RNA nuclear enriched abundant transcript 1 (LncRNA Neat1) by crosslinking-immunprecipitation and high-throughput sequencing...

Assessing soil microbes that drive fairy ring patterns in temperate semiarid grasslands

Jiahuan Li, Lizhu Guo, Gail W. T. Wilson, Adam B. Cobb, Kun Wang, Li Liu, Huan Zhao & Ding Huang
Abstract Background Fairy rings occur in diverse global biomes; however, there is a critical knowledge gap regarding drivers of fairy rings in grassland ecosystems. Grassland fairy rings are characterized belowground by an expanding mycelial front and aboveground by vigorous vegetation rings that develop concentrically with each growing season. We evaluated fairy ring dynamics in a field study conducted in semiarid grasslands to elucidate above- and belowground interactions driving distinct vegetation patterns. We followed this initial...

PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Abstract Background Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secretion in hepatocellular carcinoma (HCC) cells. Methods Quantitative real-time polymerase chain reaction (RT-qPCR) analyzed the expression of PRR34-AS1. We assessed the function of PRR34-AS1 on the biological changes of THLE-3 cells and HCC cells. The downstream interaction between RNAS was assessed by...

Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA

Xubo Gong, Piaoping Kong, Teng Yu, Xibin Xiao, Lin Wang, Yiwen Sang, Xiang Li, Bin Zhang, Zhihua Tao & Weiwei Liu
Abstract Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death rates. Although all-trans retinoic acid (RA) induces complete remission in a high proportion of patients with APL, there are limited treatments for APL patients with RA resistance. Here we report an atypical APL patient, with an APL-like disease that developed very slowly without anti-leukemia therapy for nearly 2 years. During that time, the patient only...

A study protocol for a randomized controlled trial to assess the efficacy of Baduanjin exercise on older adults with sarcopenia in China

Shengnan Yue, Jing Zhang, Jiaxin Li, Yanwei Hao, Shaofeng Wang, Tianyu Liu, Wen Zhong, Chongli Chen, Fei Wang & Bin Li
Abstract Background Accompanied by the decline of physiological functions, the decrease of physical activity, and comorbidities, older adults are susceptible to sarcopenia because of accelerated loss of muscle mass. Resistance training is recommended by different clinical practice guidelines. However, most older adults have difficulty in taking recommended high-load resistance training programs, and there are limited exercise options form them. Baduanjin, a traditional Chinese mind-body exercise with relatively low intensity and simple movements, has the potential...

Immune-related histologic phenotype in pretreatment tumour biopsy predicts the efficacy of neoadjuvant anti-PD-1 treatment in squamous lung cancer

Pei Yuan, Changyuan Guo, Lin Li, Yun Ling, Lei Guo & Jianming Ying
Abstract Background Although neoadjuvant anti-PD-1 immunotherapies have shown good efficacy in non-small cell lung cancer (NSCLC) patients, there is still a lack of effective predictive markers. We aimed to develop a pretreatment histologic scoring system to predict the efficacy of neoadjuvant immunotherapy. Methods One hundred forty NSCLC cases were evaluated in this study. Initially, surgical specimens from 31 squamous cell lung cancer patients treated with neoadjuvant anti-PD-1 therapy and their eligible paired pretreatment biopsies were...

RBCK1 is an endogenous inhibitor for triple negative breast cancer via hippo/YAP axis

Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu & Ting Zhuang
Abstract Background Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, it is important and necessary to find new therapeutic targets for TNBC. Recent genomic studies implicated the Hippo / Yap signal is over activated in TNBC, manifesting it plays a key role in TNBC carcinogenesis and cancer progression. RBCK1 was...

Association between living arrangements and cognitive decline in older adults: A nationally representative longitudinal study in China

Yifan Yu, Junqi Lv, Jing Liu, Yueqiao Chen, Kejin Chen & Yanfang Yang
Abstract Background Living arrangements are critical to the survival and well-being of older people, especially in China where the filial piety culture demands adult children care for and serve their parents. The study aimed to explore the association between living arrangements and cognitive decline among older people in China. Methods Participants included 6,074 older adults over 60 years old (49.65% male, mean age 67.2 years [range 60–98]) from four waves (2011–2018) of the China Health...

Re-interpretation of the mechanism of type 2 diabetes mellitus based on a framework of psychosomatic medicine: a real-world study

Wenjiao Min, Bo Zhou, Zhengyu Li, Nie Tang, Xu Zhang, Jinxiang Wang, Yuexin Chen, Yaling Zhou, Ruhan A, Lei Tang, Gang Li & Xueli Sun
Abstract Objective Using bipolar disorder (BD) as a control, we explored the possible developmental process of impaired glucose metabolism rhythm. Methods In total, 441 subjects (77, 162, 134, 54, and 14 in the pre-diabetes [pre-DM], DM, BD, BD + pre-DM, and BD + DM groups, respectively) and 160 controls were included. All subjects were assessed using the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI). The hypothalamic-pituitary-adrenal (HPA) and hypothalamic–pituitary–thyroid (HPT) axes were measured. Results Cluster analysis...

Vascular endothelial growth factor and the risk of venous thromboembolism: a genetic correlation and two-sample Mendelian randomization study

Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Biyan Wang, Qiuyue Tian, Xiaoni Meng, Jinxia Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang & Youxin Wang
Abstract Background The relationship between vascular endothelial growth factor (VEGF) and the risk of venous thromboembolism (VTE) has always been one of the concerns in the medical field. However, the causal inferences from published observational studies on this issue may be affected by confounders or reverse causality. We performed a two-sample bidirectional Mendelian randomization (MR) to infer the associations between VEGF and VTE. Methods Summary statistics from genome-wide association studies (GWAS) for VEGF and VTE...

Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis

Hao Wang, Lijun Song, Mingan Li, Zhenghan Yang & Zhen-Chang Wang
Hemodialysis (HD) is the most regularly applied replacement therapy for end-stage renal disease, but it may result in brain injuries. The correlation between cerebral blood flow (CBF) alteration and iron deposition has not been investigated in patients undergoing HD. Ferritin level may be a dominant factor in CBF and iron deposition change. We hypothesize that ferritin level might be the key mediator between iron deposition and CBF alteration. The correlation in the putamen was estimated...

Willingness of patients with cancer pain to participate in end-of-life decisions: a multi-center cross-sectional study from three coastal provinces in southern China

Xi Ke, Hongyu Zhu, Yu Zhang, Ling Yang, Simei Shi, Fang Zhu & Huiyu Luo
Abstract Background Little is known about patients’ intention for participation in end-of-life decisions (EOLD) in three coastal provinces in southern China. This study aimed to explore the willingness of patients with cancer pain to participate in EOLD and potential influencing factors. Methods A multi-center cross-sectional study was performed in three coastal provinces in southern China. Two hundred and thirty patients with cancer pain were recruited and consented to fill out the questionnaires. The patients’ willingness...

Tailoring Lithium Fluoride Interface for Dendrite-Free Lithium Anode to Prolong the Cyclic Stability of Lithium–Sulfur Pouch Cells

Li Zhang, Yu Jiao, Fan Wang, Mingjie Zhou, Yin Hu, Yichao Yan, Fei Li, Tianyu Lei, Bo Chen & Wei Chen
Abstract Lithium–sulfur (Li–S) cells have been regarded as attractive alternatives to achieve higher energy densities because of their theoretical specific energy far beyond the lithium-ion cells. However, the achieved results of Li–S cells are exaggerating the cycle performance in their pouch formats because the considerable works are based on the coin cells where flood electrolyte and endless Li supply ensure the Li metal with nature structure features, resulting in a negligible effect on cycle performance...

Registration Year

  • 2023
  • 2022
  • 2021
  • 2020
  • 2019
  • 2018

Resource Types

  • Collection


  • Chinese Academy of Sciences
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Zhejiang University
  • Shanghai Jiao Tong University
  • University of Chinese Academy of Sciences
  • Fudan University
  • Capital Medical University
  • Sichuan University
  • Sun Yat-sen University
  • Huazhong University of Science and Technology