91 Works

Effect of preoperative CT angiography examination on the clinical outcome of patients with BMI ≥ 25.0 kg/m2 undergoing laparoscopic gastrectomy: study protocol for a multicentre randomized controlled trial

Cheng Meng, Shougen Cao, Xiaodong Liu, Leping Li, Qingsi He, Lijian Xia, Lixin Jiang, Xianqun Chu, Xinjian Wang, Hao Wang, Xizeng Hui, Zuocheng Sun, Shusheng Huang, Quanhong Duan, Daogui Yang, Huanhu Zhang, Yulong Tian, Zequn Li & Yanbing Zhou
Abstract Background Gastric cancer, which is the fifth most common malignancy and the third most common cause of cancer-related death, is particularly predominant in East Asian countries, such as China, Japan and Korea. It is a serious global health issue that causes a heavy financial burden for the government and family. To our knowledge, there are few reports of multicentre randomized controlled trials on the utilization of CT angiography (CTA) for patients who are histologically...

Effect of preoperative CT angiography examination on the clinical outcome of patients with BMI ≥ 25.0 kg/m2 undergoing laparoscopic gastrectomy: study protocol for a multicentre randomized controlled trial

Cheng Meng, Shougen Cao, Xiaodong Liu, Leping Li, Qingsi He, Lijian Xia, Lixin Jiang, Xianqun Chu, Xinjian Wang, Hao Wang, Xizeng Hui, Zuocheng Sun, Shusheng Huang, Quanhong Duan, Daogui Yang, Huanhu Zhang, Yulong Tian, Zequn Li & Yanbing Zhou
Abstract Background Gastric cancer, which is the fifth most common malignancy and the third most common cause of cancer-related death, is particularly predominant in East Asian countries, such as China, Japan and Korea. It is a serious global health issue that causes a heavy financial burden for the government and family. To our knowledge, there are few reports of multicentre randomized controlled trials on the utilization of CT angiography (CTA) for patients who are histologically...

ARG1 and CXCL2 are potential biomarkers target for psoriasis patients

Huilin Wang, Wenjun Chen, Caihua Lie, Yijie Zhang, Jiajia Li, Jilong Meng & Nan Zhang
BackgroundPsoriasis is a common chronic skin inflammatory disease. Understanding the pathogenesis of psoriasis and identifying novel therapeutic targets are under investigation.MethodsGene expression profiles were obtained from GSE13355, GSE30999 and GSE54456 datasets to identify differentially expressed genes (DEGs) between psoriasis and normal controls. Enrichment analysis was used to identify the biological functions and pathways of common genes from three groups of DEGs. Protein-protein interaction (PPI) network was then constructed to identify key genes according to degree...

Machine learning algorithms to identify cluster randomized trials from MEDLINE and EMBASE

Ahmed A. Al-Jaishi, Monica Taljaard, Melissa D. Al-Jaishi, Sheikh S. Abdullah, Lehana Thabane, P. J. Devereaux, Stephanie N. Dixon & Amit X. Garg
Abstract Background Cluster randomized trials (CRTs) are becoming an increasingly important design. However, authors of CRTs do not always adhere to requirements to explicitly identify the design as cluster randomized in titles and abstracts, making retrieval from bibliographic databases difficult. Machine learning algorithms may improve their identification and retrieval. Therefore, we aimed to develop machine learning algorithms that accurately determine whether a bibliographic citation is a CRT report. Methods We trained, internally validated, and externally...

Theoretical, numerical, and experimental studies on controlled synchronization strategy of four-axis variable trajectory equal-thickness screen

Sai Li, Chusheng Liu, Gao Chen, Hao Wang, Hongxi Li & Deyi He
The four-axis variable trajectory equal-thickness screen (FAVTETS) achieves equal-thickness screening by appropriate excitation force generated by four eccentric rotors in synchronized motion. The forced synchronization exciter is characterized by an unsatisfactory synchronization effect due to the wear of transmission parts. Hence, in this paper, the four-axis controlled synchronization of FAVTETS is investigated, and an intelligent control system is proposed. Firstly, research is conducted on the variable trajectory characteristics of FAVTETS. Next, the sliding mode, fuzzy,...

Eating behaviors, dietary patterns and weight status in emerging adulthood and longitudinal associations with eating behaviors in early childhood

Lise Dubois, Brigitte Bédard, Danick Goulet, Denis Prud’homme, Richard E. Tremblay & Michel Boivin
Abstract Background Eating behaviors may contribute to differences in body weight and diet over time. Our study aims to examine how eating behaviors of young adults relate to their current weight status and dietary patterns and to explore longitudinal associations with eating behaviors in early childhood. Methods Study participants are young adults (n = 698) taking part in the Quebec Longitudinal Study of Child Development. At age 22, eating behaviors were assessed using the Adult...

Operationalization of assent for research participation in pre-adolescent children: a scoping review

Florence Cayouette, Katie O’Hearn, Shira Gertsman & Kusum Menon
Abstract Background Seeking assent from children for participation in medical research is an ethical imperative of numerous institutions globally. However, none of these organizations provide specific guidance on the criteria or process to be used when obtaining assent. The primary objective of this scoping review was to determine the descriptions of assent discussed in the literature and the reported criteria used for seeking assent for research participation in pre-adolescent children. Methods Medline and Embase databases...

Predictors of serum vancomycin levels in peritoneal dialysis-associated peritonitis

Erin Deacon, Mark Canney, Brendan McCormick, Pierre Brown, Mohan Biyani & Deborah Zimmerman
Background:Intraperitoneal (IP) vancomycin is often first-line empiric therapy for peritoneal dialysis (PD) peritonitis; however, whether dosing should be adjusted for patient-specific characteristics remains unclear. We sought to identify factors associated with the day 3 vancomycin serum level in patients receiving vancomycin for PD peritonitis.Methods:Retrospective single-centre adult cohort of 58 patients with PD peritonitis treated with IP vancomycin between January 2016 and May 2022. Linear regression was used to examine the association between day 3 vancomycin...

Understanding how and under what circumstances decision coaching works for people making healthcare decisions: a realist review

Junqiang Zhao, Janet Jull, Jeanette Finderup, Maureen Smith, Simone Maria Kienlin, Anne Christin Rahn, Sandra Dunn, Yumi Aoki, Leanne Brown, Gillian Harvey & Dawn Stacey
Abstract Background Decision coaching is non-directive support delivered by a trained healthcare provider to help people prepare to actively participate in making healthcare decisions. This study aimed to understand how and under what circumstances decision coaching works for people making healthcare decisions. Methods We followed the realist review methodology for this study. This study was built on a Cochrane systematic review of the effectiveness of decision coaching interventions for people facing healthcare decisions. It involved...

Understanding how and under what circumstances decision coaching works for people making healthcare decisions: a realist review

Junqiang Zhao, Janet Jull, Jeanette Finderup, Maureen Smith, Simone Maria Kienlin, Anne Christin Rahn, Sandra Dunn, Yumi Aoki, Leanne Brown, Gillian Harvey & Dawn Stacey
Abstract Background Decision coaching is non-directive support delivered by a trained healthcare provider to help people prepare to actively participate in making healthcare decisions. This study aimed to understand how and under what circumstances decision coaching works for people making healthcare decisions. Methods We followed the realist review methodology for this study. This study was built on a Cochrane systematic review of the effectiveness of decision coaching interventions for people facing healthcare decisions. It involved...

Influences on intentions for obstetric practice among family physicians and residents in Canada: an explorative qualitative inquiry

Emily Gard Marshall, Kathleen Horrey, Lauren R. Moritz, Richard Buote, Agnes Grudniewicz, Laurie J. Goldsmith, Ellen Randall, Lori Jones & M Ruth Lavergne
Abstract Background Many family medicine residency graduates indicate a desire to provide obstetric care, but a low proportion of family physicians (FPs) provide obstetric care within their practice. This suggests personal preference alone may not account for the low proportion of FPs who ultimately provide full obstetric care. If decisionmakers plan to augment the number of FPs providing obstetric care, barriers to the provision of such care must first be identified. Within this paper, we...

Deep learning-enabled volumetric cone photoreceptor segmentation in adaptive optics optical coherence tomography images of normal and diseased eyes

Somayyeh Soltanian-Zadeh, Zhuolin Liu, Yan Liu, Ayoub Lassoued, Catherine Cukras, Donald Miller, Daniel Hammer & Sina Farsiu
Objective quantification of photoreceptor cell morphology, such as cell diameter and outer segment length, is crucial for early, accurate, and sensitive diagnosis and prognosis of retinal neurodegenerative diseases. Adaptive optics optical coherence tomography (AO-OCT) provides three-dimensional (3-D) visualization of photoreceptor cells in the living human eye. The current gold standard for extracting cell morphology from AO-OCT images involves the tedious process of 2-D manual marking. To automate this process and extend to 3-D analysis of...

Polarizer-free measurement of the full Stokes vector using a fiber-coupled superconducting nanowire single photon detector with a polarization extinction ratio of ~2

Yue Fei, Tianhao Ji, Guanghao Zhu, Labao Zhang, Lijian Zhang, jingrou tan, qi chen, Yanqiu Guan, Rui Yin & Hao Wang
The characterization and manipulation of the polarization states at single photon level are of great importance in research fields such as quantum information processing and quantum key distribution, where the photons are normally delivered using single mode optical fibers. To date, the demonstrated polarimetry measurement techniques based on a superconducting nanowire single photon detector (SNSPD) require the SNSPD to be either highly sensitive or highly insensitive to the photon’s polarization state, therefore placing an unavoidable...

Psychometric validation of a chinese version of COVID-19 vaccine hesitancy scale: a cross-sectional study

Yiman Huang, Yijin Wu, Zhenwei Dai, Weijun Xiao, Hao Wang, Mingyu Si, Wenjun Wang, Xiaofen Gu, Li Ma, Li Li, Shaokai Zhang, Chunxia Yang, Yanqin Yu, Youlin Qiao & Xiaoyou Su
Abstract Background COVID-19 vaccines have been administered in many countries; however, a sufficient vaccine coverage rate is not guaranteed due to vaccine hesitancy. To improve the uptake rate of COVID-19 vaccine, it is essential to evaluate the rate of vaccine hesitancy and explore relevant factors in different populations. An urgent need is to measure COVID-19 vaccine hesitancy among different population groups, hence a validated scale for measuring COVID-19 vaccine hesitancy is necessary. The present study...

Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu, Wei Liu, Yifan Zheng, Kai Zeng, Hao Wang, Haijun Sun & Jianhua Dai
Abstract Background High mobility group protein B2 (HMGB2) is a multifunctional protein that plays various roles in different cellular compartments. Moreover, HMGB2 serves as a potential prognostic biomarker and therapeutic target for lung adenocarcinoma (LUAD). Methods In this study, the expression pattern, prognostic implication, and potential role of HMGB2 in LUAD were evaluated using the integrated bioinformatics analyses based on public available mRNA expression profiles from The Cancer Genome Atlas and Gene Expression Omnibus databases,...

Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis

Xie Qiu, Wei Liu, Yifan Zheng, Kai Zeng, Hao Wang, Haijun Sun & Jianhua Dai
Abstract Background High mobility group protein B2 (HMGB2) is a multifunctional protein that plays various roles in different cellular compartments. Moreover, HMGB2 serves as a potential prognostic biomarker and therapeutic target for lung adenocarcinoma (LUAD). Methods In this study, the expression pattern, prognostic implication, and potential role of HMGB2 in LUAD were evaluated using the integrated bioinformatics analyses based on public available mRNA expression profiles from The Cancer Genome Atlas and Gene Expression Omnibus databases,...

Working with alcohol prevention in occupational health services: “knowing how” is more important than “knowing that” – the WIRUS OHS study

Mikkel Magnus Thørrisen, Talieh Sadeghi, Tore Bonsaksen, Ian D. Graham & Randi Wågø Aas
Abstract Background Alcohol consumption is a major public health challenge; the majority of employees consume alcohol regularly and a considerable proportion of employees can be characterized as risky drinkers in need of interventions. Occupational health services (OHS) are uniquely positioned for implementing alcohol prevention interventions targeting employees, but rarely do so. Studies have shown that lack of knowledge among OHS personnel is a barrier to alcohol prevention activity. This study aimed to explore OHS personnels’...

Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD): Statistical Analysis Plan of a Registry-Based, Cluster-Randomized Clinical Trial

Stephanie N. Dixon, Kyla L. Naylor, Seychelle Yohanna, Susan McKenzie, Dmitri Belenko, Peter G Blake, Candice Coghlan, Rebecca Cooper, Lori Elliott, Leah Getchell, Vincent Ki, Istvan Mucsi, Gihad Nesrallah, Rachel E. Patzer, Justin Presseau, Marian Reich, Jessica M. Sontrop, Darin Treleaven, Amy D. Waterman, Jeffrey Zaltzman & Amit X. Garg
Background:Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) is a quality improvement intervention designed to enhance access to kidney transplantation and living kidney donation. We conducted a cluster-randomized clinical trial to evaluate the effect of the intervention versus usual care on completing key steps toward receiving a kidney transplant.Objective:To prespecify the statistical analysis plan for the EnAKT LKD trial.Design:The EnAKT LKD trial is a pragmatic, 2-arm, parallel-group, registry-based, open-label, cluster-randomized, superiority, clinical...

Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches

Lin Jiang, Yi-Qian Sun, Ben Michael Brumpton, Arnulf Langhammer, Yue Chen & Xiao-Mei Mai
Abstract Background Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association. Aims We studied the causal association between BMI and lung cancer incidence using observational and MR approaches. Methods We followed up 62,453 cancer-free Norwegian adults from 1995–97 (HUNT2) until 2017. BMI at baseline in HUNT2 was classified as...

The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Abstract Background Case management (CM) is widely utilized to improve health outcomes of cancer patients, enhance their experience of health care, and reduce the cost of care. While numbers of systematic reviews are available on the effectiveness of CM for cancer patients, they often arrive at discordant conclusions that may confuse or mislead the future case management development for cancer patients and relevant policy making. We aimed to summarize the existing systematic reviews on the...

The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Abstract Background Case management (CM) is widely utilized to improve health outcomes of cancer patients, enhance their experience of health care, and reduce the cost of care. While numbers of systematic reviews are available on the effectiveness of CM for cancer patients, they often arrive at discordant conclusions that may confuse or mislead the future case management development for cancer patients and relevant policy making. We aimed to summarize the existing systematic reviews on the...

Multimodality treatment for brain arteriovenous malformation in Mainland China: design, rationale, and baseline patient characteristics of a nationwide multicenter prospective registry

Yu Chen, Heze Han, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yang Zhao, Yukun Zhang, Weitao Jin, Runting Li, Fa Lin, Xiangyu Meng, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Hengwei Jin, Youxiang Li, Dezhi Gao, Shibin Sun, Ali Liu, Shuo Wang … & Yuanli Zhao
Abstract Background Brain arteriovenous malformation (AVM) is an important cause of hemorrhagic stroke in young adults, which can lead to severe neurological impairment. The registry of Multimodality treatment for brain ArTeriovenous malformation in mainland CHina (MATCH) is a national prospective registry to identify the natural history of AVMs in Asian population; to investigate traditional and emerging hemorrhagic predictors; and to explore the superiority of the multidisciplinary assessment in improving the long-term outcomes. Methods Consecutive AVM...

Operationalization of assent for research participation in pre-adolescent children: a scoping review

Florence Cayouette, Katie O’Hearn, Shira Gertsman & Kusum Menon
Abstract Background Seeking assent from children for participation in medical research is an ethical imperative of numerous institutions globally. However, none of these organizations provide specific guidance on the criteria or process to be used when obtaining assent. The primary objective of this scoping review was to determine the descriptions of assent discussed in the literature and the reported criteria used for seeking assent for research participation in pre-adolescent children. Methods Medline and Embase databases...

Influences on intentions for obstetric practice among family physicians and residents in Canada: an explorative qualitative inquiry

Emily Gard Marshall, Kathleen Horrey, Lauren R. Moritz, Richard Buote, Agnes Grudniewicz, Laurie J. Goldsmith, Ellen Randall, Lori Jones & M Ruth Lavergne
Abstract Background Many family medicine residency graduates indicate a desire to provide obstetric care, but a low proportion of family physicians (FPs) provide obstetric care within their practice. This suggests personal preference alone may not account for the low proportion of FPs who ultimately provide full obstetric care. If decisionmakers plan to augment the number of FPs providing obstetric care, barriers to the provision of such care must first be identified. Within this paper, we...

Assessment of the quality and content of clinical practice guidelines (CPGs) for vitamin D and for immigrants using the AGREE-II instrument: a protocol for systematic review

Said Yousef, Lamia Hayawi, Douglas Manuel, Ian Colman, Manny Papadimitropoulos, Alomgir Hossain, Moez AlIslam Faris & George A. Wells
Abstract Introduction Worldwide, more immigrants experience vitamin D (vitD) deficiency than non-immigrants, which is attributed to ethnic variations, place or region of birth, skin pigmentation, clothing style, and resettlement-related changes in diet, physical activity, and sun exposure. Current recommendations in clinical practice guidelines (CPGs) concerning vitD are inadequate to address vitD deficiency among immigrants. CPGs may also lack guidance for physicians on vitD supplementation for immigrants. Moreover, there are concerns about the overall quality of...

Registration Year

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  • 2021
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Affiliations

  • University of Ottawa
    91
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    44
  • Sun Yat-sen University
    42
  • Chinese PLA General Hospital
    42
  • University of Chinese Academy of Sciences
    41
  • Zhejiang University
    40
  • Sichuan University
    40
  • Chinese Academy of Sciences
    37
  • West China Hospital of Sichuan University
    34
  • Nanjing Medical University
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