811 Works


Catherine Francis
GWAS results files as described in Francis et al. Nature Communications 2022 AORTIC DISTENSIBILITY GENOME-WIDE ASSOCIATIONS SUGGEST CAUSAL RELATIONSHIPS WITH AORTIC ANEURYSMS AND BRAIN WHITE MATTER HYPERINTENSITIES (reference awaited). We present genome-wide associations of ascending and descending aortic distensibility and area derived from cardiac magnetic resonance imaging (MRI) data of up to 32,590 Caucasian individuals in UK Biobank. For details of file formats and contents please see README files.

Supplementary material from \"Epidemiological dynamics of bacteriocin competition and antibiotic resistance\"

Sonja Lehtinen, Nicholas J. Croucher, François Blanquart & Christophe Fraser
Bacteriocins, toxic peptides involved in the competition between bacterial strains, are extremely diverse. Previous work on bacteriocin dynamics has highlighted the role of non-transitive ‘rock–paper–scissors’ competition in maintaining the coexistence of different bacteriocin profiles. The focus to date has primarily been on bacteriocin interactions at the within-host scale (i.e. within a single bacterial population). Yet in species such as Streptococcus pneumoniae, with relatively short periods of colonization and limited within-host diversity, ecological outcomes are also...

Estimating health system opportunity costs: the role of non-linearities and inefficiency

Karla Hernandez-Villafuerte, Bernarda Zamora, Yan Feng, David Parkin, Nancy Devlin & Adrian Towse
Abstract Background Empirical estimates of health system opportunity costs have been suggested as a basis for the cost-effectiveness threshold to use in Health Technology Assessment. Econometric methods have been used to estimate these in several countries based on data on spending and mortality. This study examines empirical evidence on four issues: non-linearity of the relationship between spending and mortality; the inclusion of outcomes other than mortality; variation in the efficiency with which expenditures generate health...

Worldwide cancer statistics of adults over 75 years old in 2019: a systematic analysis of the global burden of disease study 2019

Danhong Xiang, Shiwei Hu, Tianxiang Mai, Xinlu Zhang, Lan Zhang, Shengjie Wang, Keyi Jin & Jian Huang
Abstract Background and purpose Cancer has become one of the major killers of humanity due to the number of people over the age of 75 increasing with population ageing. The aim of this study was to analyse the incidence and mortality rates in people over 75 of 29 cancer types in 204 countries and regions, as well as the trends from 1990 to 2019. Methods Twenty-nine cancer types were collected from the Global Burden of...

An evaluation of the implementation of interventions to reduce postoperative infections and optimise antibiotic use across the surgical pathway in India: a mixed-methods exploratory study protocol

Shalini Ahuja, Sanjeev Singh, Esmita Charani, Surya Surendran, Vrinda Nampoothiri, Fabia Edathadathil, Anu George, Andrew Leather, Carolyn Tarrant, Alison Holmes, Nick Sevdalis & Gabriel Birgand
Abstract Introduction Postoperative infections represent a significant burden of disease, demanding antibiotic prescriptions, and are contributing to antimicrobial resistance. The burden of infection as a surgical complication is greater in low- and middle-income countries (LMICs). We report the protocol of a pilot study for the co-design, implementation and evaluation of two infection prevention and control (IPC) and antimicrobial stewardship (AMS) interventions across the surgical pathway in a teaching hospital in India. Methods and analysis The...

Research protocol for impact assessment of a project to scale up food policies in the Pacific

Dori Patay, Kathy Trieu, Briar McKenzie, Shanthi Ramanathan, Alexis Hure, Colin Bell, Anne-Marie Thow, Steven Allender, Erica Reeve, Aliyah Palu, Mark Woodward, Gade Waqa & Jacqui Webster
Abstract Background One of the challenges for countries implementing food policy measures has been the difficulty in demonstrating impact and retaining stakeholder support. Consequently, research funded to help countries overcome these challenges should assess impact and translation into practice, particularly in low-resource settings. However, there are still few attempts to prospectively, and comprehensively, assess research impact. This protocol describes a study co-created with project implementers, collaborative investigators and key stakeholders to optimize and monitor the...

A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

Yasmine Sommerer, Olena Ohlei, Valerija Dobricic, Derek H. Oakley, Tanja Wesse, Sanaz Sedghpour Sabet, Ilja Demuth, Andre Franke, Bradley T. Hyman, Christina M. Lill & Lars Bertram
Abstract Epigenome-wide association studies (EWAS) assessing the link between DNA methylation (DNAm) and phenotypes related to structural brain measures, cognitive function, and neurodegenerative diseases are becoming increasingly more popular. Due to the inaccessibility of brain tissue in humans, several studies use peripheral tissues such as blood, buccal swabs, and saliva as surrogates. To aid the functional interpretation of EWAS findings in such settings, there is a need to assess the correlation of DNAm variability across...

A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Andrea Cappozzo, Cathal McCrory, Oliver Robinson, Anna Freni Sterrantino, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Licia Iacoviello, Fulvio Ricceri, Sabina Sieri, Paolo Chiodini, Gareth J. McKay, Amy Jayne McKnight, Frank Kee, Ian S. Young, Bernadette McGuinness, Eileen M. Crimmins, Thalida Em Arpawong, Rose Anne Kenny, Aisling O’Halloran, Silvia Polidoro, Giuliana Solinas, Paolo Vineis, Francesca Ieva … & Giovanni Fiorito
Abstract Background Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD). DNAm surrogate of exposures predicts diseases and longevity better than self-reported or measured exposures in many cases. Consequently, disease prediction models based on blood DNAm surrogates may outperform current state-of-the-art prediction models. This study aims to develop novel DNAm surrogates for cardiovascular diseases (CVD) risk factors and develop a composite...

FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson & A. R. Lingford-Hughes
Abstract Background Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems with opiate withdrawal. Preclinical and preliminary clinical evidence suggests that the GABA-B agonist, baclofen, has the desired properties to facilitate opiate detoxification and prevent relapse. This study aims to understand whether there are any safety issues in administering baclofen to opioid-dependent individuals receiving methadone....

Association between fluid balance and mortality for heart failure and sepsis: a propensity score-matching analysis

Bufan Zhang, Shaohua Guo, Zean Fu, Naishi Wu & Zhigang Liu
Abstract Background Fluid resuscitation is necessary to correct the sepsis-induced hypoperfusion, which is contradictory to the treatment of heart failure. This study explored the association between fluid balance (FB) of the first 24 h after ICU admission and mortality in critically ill patients with heart failure and sepsis. Methods Data were extracted from the Medical Information Mart for Intensive Care database. The locally weighted scatterplot smoothing (Lowess) method was used to demonstrate the relationship between...

Association between fluid balance and mortality for heart failure and sepsis: a propensity score-matching analysis

Bufan Zhang, Shaohua Guo, Zean Fu, Naishi Wu & Zhigang Liu
Abstract Background Fluid resuscitation is necessary to correct the sepsis-induced hypoperfusion, which is contradictory to the treatment of heart failure. This study explored the association between fluid balance (FB) of the first 24 h after ICU admission and mortality in critically ill patients with heart failure and sepsis. Methods Data were extracted from the Medical Information Mart for Intensive Care database. The locally weighted scatterplot smoothing (Lowess) method was used to demonstrate the relationship between...

Bifunctional anti-PD-L1/TGF-βRII agent SHR-1701 in advanced solid tumors: a dose-escalation, dose-expansion, and clinical-expansion phase 1 trial

Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han, Dong Yan, Xinshuai Wang, Pan Liu, Linna Wang, Xiaojing Zhang, Suxia Luo, Tianshu Liu & Lin Shen
Abstract Background Dual inhibition of PD-1/PD-L1 and TGF-β pathways is a rational therapeutic strategy for malignancies. SHR-1701 is a new bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor II. This first-in-human trial aimed to assess SHR-1701 in pretreated advanced solid tumors and find the population who could benefit from SHR-1701. Methods This was a dose-escalation, dose-expansion, and clinical-expansion phase 1 study. Dose escalation was initiated...

Dioxane tetraketone - an ACS molecule of the week with a mystery

Henry Rzepa
Gaussian 16 calculations

Calibration: Decarboxylation of 3-Carboxybenzisoxazole and 5-nitro,3-carboxybenzisoxazole

Henry Rzepa
KIE calculations

Meyer-Schuster Rearrangement of Propargylic Alcohols Mediated by Phosphorus-Containing Brønsted Acid Catalysts

Silvia Diez-Gonzalez
Raw NMR data for new compoundsincluded in Orgaic & Biomolecualr Chemistry article: https://doi.org/10.1039/D2OB01259F

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury

Tianyi Wang, Tingting Zhou, Mingming Xu, Shuo Wang, Anqi Wu, Mingyang Zhang, You Lang Zhou & Jiahai Shi
Abstract The incidence of myocardial ischaemia‒reperfusion injury (MIRI) is increasing every year, and there is an urgent need to develop new therapeutic approaches. Nrf2 is thought to play a protective role during MIRI and it is regulated by microRNAs (miRNAs). This study focused on PLGA nanoparticles camouflaged by platelet membrane vesicles (PMVs) (i.e., PMVs@PLGA complexes) carrying microRNA inhibitors, which regulate Nrf2 and can play a therapeutic role in the MIRI process. In vitro and in...

Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Isabelle Coales, Stergios Tsartsalis, Nurun Fancy, Maria Weinert, Daniel Clode, David Owen & Paul M. Matthews
Abstract Sex differences have been identified in many diseases associated with dysregulated immune responses, including Alzheimer’s disease (AD), for which approximately two-thirds of patients are women. An accumulating body of research indicates that microglia may play a causal role in the pathogenesis of this disease. We hypothesised that sex differences in the transcriptome of human myeloid cells may contribute to the sex difference observed in AD prevalence. To explore this, we assessed bulk and single-nuclear...

The effectiveness of postpartum interventions aimed at improving women’s mental health after medical complications of pregnancy: a systematic review and meta-analysis

Jie Shang, Nadila Dolikun, Xuanchen Tao, Puhong Zhang, Mark Woodward, Maree L. Hackett & Amanda Henry
Abstract Background Postpartum mental disorders including depression and anxiety are common. Medical complications of pregnancy, such as preeclampsia and gestational diabetes, are thought to increase the risk of mental disorders postpartum. However, it is unclear which interventions may be effective for preventing and/or treating postpartum mental disorders following a medically complicated pregnancy. We aimed to systematically review published literature on the effectiveness of postpartum interventions to improve women’s mental health after medical complications of pregnancy....

Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis

Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee & Simanti Datta
Abstract Background The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during chronic HBV infection remains largely unknown. We investigated the mechanism by which HBV inhibits the formation of cytolytic complement membrane-attack complex (MAC) and studied its impact on MAC-mediated microbicidal activity and disease pathogenesis. Methods Blood/liver tissues were collected from chronically HBV-infected patients and controls. HepG2hNTCP cells...

Atropisomerisation in dichloropolysiphenol

Henry Rzepa
Gaussian calculations

Unexpected Isomerization of Oxetane-Carboxylic Acids – a computational study

Henry Rzepa
Gaussian 16 calculations.

Land use and soil characteristics affect soil organisms differently from above-ground assemblages

Victoria J. Burton, Sara Contu, Adriana De Palma, Samantha L. L. Hill, Harald Albrecht, James S. Bone, Daniel Carpenter, Ronald Corstanje, Pallieter De Smedt, Mark Farrell, Helen V. Ford, Lawrence N. Hudson, Kelly Inward, David T. Jones, Agnieszka Kosewska, Nancy F. Lo-Man-Hung, Tibor Magura, Christian Mulder, Maka Murvanidze, Tim Newbold, Jo Smith, Andrew V. Suarez, Sasha Suryometaram, Béla Tóthmérész, Marcio Uehara-Prado … & Andy Purvis
Abstract Background Land-use is a major driver of changes in biodiversity worldwide, but studies have overwhelmingly focused on above-ground taxa: the effects on soil biodiversity are less well known, despite the importance of soil organisms in ecosystem functioning. We modelled data from a global biodiversity database to compare how the abundance of soil-dwelling and above-ground organisms responded to land use and soil properties. Results We found that land use affects overall abundance differently in soil...

Insulin Pumps and Hybrid Close Loop Systems Within Hospital: A Scoping Review and Practical Guidance From the Joint British Diabetes Societies for Inpatient Care

Parizad Avari, Alistair Lumb, Daniel Flanagan, Gerry Rayman, Shivani Misra, Pratik Choudhary & Ketan Dhatariya
This article is the second of a two-part series providing a scoping review and summary of the Joint British Diabetes Societies for Inpatient Care (JBDS-IP) guidelines on the use of diabetes technology in people with diabetes admitted to hospital. The first part reviewed the use of continuous glucose monitoring (CGM) in hospital. In this article, we focus on the use of continuous subcutaneous insulin infusion (CSII; insulin pumps) and hybrid closed-loop systems in hospital. JBDS-IP...

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  • Imperial College London
  • Zhejiang University
  • Fudan University
  • Capital Medical University
  • Southern Medical University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Sun Yat-sen University
  • Sichuan University
  • Peking University
  • Johns Hopkins University