175 Works

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang & Xiong Lei
Abstract Background Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to explore the advantage of robotic surgery in left colectomy by comparing open, laparoscopic, and robotic surgery. Methods A retrospective analysis was performed on the clinical data of patients with radical left colectomy for colon cancer who were admitted to the...

Comparison of open, laparoscopic, and robotic left colectomy for radical treatment of colon cancer: a retrospective analysis in a consecutive series of 211 patients

Zhixiang Huang, Taiyuan Li, Genghua Zhang, Zhen Zhou, Haoran Shi, Cheng Tang, Lingling Yang & Xiong Lei
Abstract Background Robotic surgery has been widely used in the radical treatment of colonic cancer. However, it is unclear what advantages the robotic approach offers over other approaches in left colectomy. This study aims to explore the advantage of robotic surgery in left colectomy by comparing open, laparoscopic, and robotic surgery. Methods A retrospective analysis was performed on the clinical data of patients with radical left colectomy for colon cancer who were admitted to the...

Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Abstract Background Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested...

Oral arsenic and retinoic acid for high-risk acute promyelocytic leukemia

Ya-Fang Ma, Ying Lu, Qian Wu, Yin-Jun Lou, Min Yang, Jie-Yu Xu, Cai-Hong Sun, Li-Ping Mao, Gai-Xiang Xu, Li Li, Jian Huang, Huai-Yu Wang, Li-Jiang Lou, Hai-Tao Meng, Jie-Jing Qian, Wen-Juan Yu, Ju-Ying Wei, Zhen-Yu Li, Xue-Lu Zhu, Xiao-Yan Yan, Su-Ning Chen, Jie Jin & Hong-Hu Zhu
Abstract Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk patients. We evaluated oral arsenic and ATRA without chemotherapy as an outpatient consolidation therapy and no maintenance for high-risk APL. We conducted a multicenter, single-arm, phase 2 study with consolidation phases. The consolidation therapy included Realgar–Indigo naturalis formula (60 mg/kg daily...

Cov2clusters: genomic clustering of SARS-CoV-2 sequences

Benjamin Sobkowiak, Kimia Kamelian, James E. A. Zlosnik, John Tyson, Anders Gonçalves da Silva, Linda M. N. Hoang, Natalie Prystajecky & Caroline Colijn
Abstract Background The COVID-19 pandemic remains a global public health concern. Advances in sequencing technologies has allowed for high numbers of SARS-CoV-2 whole genome sequence (WGS) data and rapid sharing of sequences through global repositories to enable almost real-time genomic analysis of the pathogen. WGS data has been used previously to group genetically similar viral pathogens to reveal evidence of transmission, including methods that identify distinct clusters on a phylogenetic tree. Identifying clusters of linked...

Targeted delivery and ROS-responsive release of Resolvin D1 by platelet chimeric liposome ameliorates myocardial ischemia–reperfusion injury

Xueyi Weng, Haipeng Tan, Zheyong Huang, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Weiyan Li, Guangrui Zhu, Zhiqing Pang, Yanan Song, Juying Qian & Junbo Ge
Abstract Resolvin D1 (RvD1) has been shown to provide effective protection against ischemia–reperfusion injury in multiple vital organs such as the heart, brain, kidney. However, the clinical translational potential of systemic administration of RvD1 in the treatment of ischemia–reperfusion injury is greatly limited due to biological instability and lack of targeting ability. Combining the natural inflammatory response and reactive oxygen species (ROS) overproduction after reperfusion injury, we developed a platelet-bionic, ROS-responsive RvD1 delivery platform. The...

Oxetan-3-ols (1b,1d)

Juan Rojas
Raw and processed data of characterised oxetan-3-ols (1b,1d).

List of the populations of the various rotamers of 2,2,3,3,4,4,5,5-octafluoropentan-1-ol in Chloroform at 298.15 K

Alexandre Dumon
Table containing the Boltzmann averaged populations of 2,2,3,3,4,4,5,5-octafluoropentan-1-ol in Chloroform at 298.15 K to average the chemical shifts.

Dataset for paper: \"3D printability assessment of poly(octamethylene maleate (anhydride) citrate) and poly(ethylene glycol) diacrylate copolymers for biomedical application\"

Dominic Wales
This dataset contains the raw data that were used for the journal publication "3D printability assessment of poly(octamethylene maleate (anhydride) citrate) and poly(ethylene glycol) diacrylate copolymers for biomedical application".

Growth Rescue Experiments - Proteins

Anna Barnard
Raw data from WT and mutant full length Phd expression and culture growth in Salmonella.

Populations of the various rotamers set at the wb97xd/aug-cc-pvdz level

Alexandre Dumon
Boltzmann averaged populations of the sets (i), (ii) and (iii) of 2-2-3-3-4-4-5-5-octafluoropentan-1-ol in Chloroform at 298.15 K

Examples of inverted or hemispherical carbon?

Henry Rzepa
Gaussian 16 calculations

Incorporating a gender lens into nutrition and health-related policies in Fiji: analysis of policies and stakeholder perspectives

Briar L. McKenzie, Gade Waqa, Sarah Mounsey, Claire Johnson, Mark Woodward, Kent Buse, Anne Marie Thow, Rachael McLean & Jacqui Webster
Abstract Background Gender equality, zero hunger and healthy lives and well-being for all, are three of the Sustainable Development Goals (SDGs) that underpin Fiji’s National Development Plan. Work towards each of these goals contributes to the reduction of non-communicable diseases (NCDs). There are gender differences in NCD burden in Fiji. It is, however, unclear whether a gender lens could be more effectively included in nutrition and health-related policies. Methods This study consisted of three components:...

Identifying Child Anxiety Through Schools-identification to intervention (iCATS-i2i): protocol for a cluster randomised controlled trial to compare screening, feedback and intervention for child anxiety problems to usual school practice

Tessa Reardon, Obioha C. Ukoumunne, Mara Violato, Susan Ball, Paul Brown, Tamsin Ford, Alastair Gray, Claire Hill, Bec Jasper, Michael Larkin, Ian Macdonald, Fran Morgan, Jack Pollard, Michelle Sancho, Falko F. Sniehotta, Susan H. Spence, Paul Stallard, Jason Stainer, Lucy Taylor, Victoria Williamson, Emily Day, Jennifer Fisk, Iheoma Green, Gemma Halliday, Ciara Hennigan … & Cathy Creswell
Abstract Background Systematically screening for child anxiety problems, and offering and delivering a brief, evidence-based intervention for children who are identified as likely to benefit would minimise common barriers that families experience in accessing treatment. We have developed a short parent-report child anxiety screening questionnaire, and procedures for administering screening questionnaires, sharing screening outcomes with families, and offering and delivering a brief parent-led online intervention (OSI: Online Support and Intervention for child anxiety) through schools....

Medium-chain triglycerides may improve memory in non-demented older adults: a systematic review of randomized controlled trials

Panagiotis Giannos, Konstantinos Prokopidis, Irene Lidoriki, Konstantinos K. Triantafyllidis, Konstantinos S. Kechagias, Kamil Celoch, Darren G. Candow, Sergej M. Ostojic & Scott C. Forbes
Abstract Background Ketosis has been exploited for its neuroprotective impact and treatment of neurological conditions via ketone production. Exogenous medium-chain triglyceride (MCT) supplementation may induce nutritional ketosis. The aim of this systematic review is to explore the effects of MCTs on memory function in older adults without cognitive impairment. Methods A systematic literature search of PubMed, Cochrane Library, Scopus, and Web of Science was employed from inception until April 2022 for randomized controlled trials (RCTs)...

Implementation of a medicine management plan (MMP) to reduce medication-related harm (MRH) in older people post-hospital discharge: a randomised controlled trial

Khalid Ali, Ekow A. Mensah, Eugene Ace McDermott, Frances A. Kirkham, Jennifer Stevenson, Victoria Hamer, Nikesh Parekh, Rebekah Schiff, Tischa Van Der Cammen, Stephen Nyangoma, Sally Fowler-Davis, Graham Davies, Heather Gage & Chakravarthi Rajkumar
Abstract Background Medication-related harm (MRH) is an escalating global challenge especially among older adults. The period following hospital discharge carries high-risk for MRH due to medication discrepancies, limited patient/carer education and support, and poor communication between hospital and community professionals. Discharge Medical Service (DMS), a newly introduced NHS scheme, aims to reduce post-discharge MRH through an electronic communication between hospital and community pharmacists. Our study team has previously developed a risk-prediction tool (RPT) for MRH...

The effectiveness of postpartum interventions aimed at improving women’s mental health after medical complications of pregnancy: a systematic review and meta-analysis

Jie Shang, Nadila Dolikun, Xuanchen Tao, Puhong Zhang, Mark Woodward, Maree L. Hackett & Amanda Henry
Abstract Background Postpartum mental disorders including depression and anxiety are common. Medical complications of pregnancy, such as preeclampsia and gestational diabetes, are thought to increase the risk of mental disorders postpartum. However, it is unclear which interventions may be effective for preventing and/or treating postpartum mental disorders following a medically complicated pregnancy. We aimed to systematically review published literature on the effectiveness of postpartum interventions to improve women’s mental health after medical complications of pregnancy....

Dumon

Henry Rzepa
Portal project

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Abstract Background Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and...

An evaluation of the implementation of interventions to reduce postoperative infections and optimise antibiotic use across the surgical pathway in India: a mixed-methods exploratory study protocol

Shalini Ahuja, Sanjeev Singh, Esmita Charani, Surya Surendran, Vrinda Nampoothiri, Fabia Edathadathil, Anu George, Andrew Leather, Carolyn Tarrant, Alison Holmes, Nick Sevdalis & Gabriel Birgand
Abstract Introduction Postoperative infections represent a significant burden of disease, demanding antibiotic prescriptions, and are contributing to antimicrobial resistance. The burden of infection as a surgical complication is greater in low- and middle-income countries (LMICs). We report the protocol of a pilot study for the co-design, implementation and evaluation of two infection prevention and control (IPC) and antimicrobial stewardship (AMS) interventions across the surgical pathway in a teaching hospital in India. Methods and analysis The...

Amidation

Henry Rzepa
Portal project

International Society for Peritoneal Dialysis practice recommendations: Prescribing high-quality goal-directed peritoneal dialysis

Edwina Brown, Edwina A Brown, Peter G Blake, Neil Boudville, Simon Davies, Javier de Arteaga, Jie Dong, Fred Finkelstein, Marjorie Foo, Helen Hurst, David W Johnson, Mark Johnson, Adrian Liew, Thyago Moraes, Jeff Perl, Rukshana Shroff, Isaac Teitelbaum, Angela Yee-Moon Wang & Bradley Warady
The International Society for Peritoneal Dialysis last published a guideline on prescribing peritoneal dialysis (PD) in 2006. This focused on clearance of toxins and used a measure of waste product removal by dialysis using urea as an example. This guideline suggested that a specific quantity of small solute removal was needed to achieve dialysis ‘adequacy’. It is now generally accepted, however, that the well-being of the person on dialysis is related to many different factors...

Registration Year

  • 2022
    175

Resource Types

  • Collection
    175

Affiliations

  • Imperial College London
    175
  • Zhejiang University
    14
  • Southern Medical University
    12
  • Fudan University
    11
  • Sun Yat-sen University
    10
  • Johns Hopkins University
    9
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    9
  • Sichuan University
    8
  • University of Nottingham
    8
  • University of Oxford
    8