308 Works

A CT-based nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodule according to the 2021 WHO classification

Qilong Song, Biao Song, Xiaohu Li, Bin Wang, Yuan Li, Wu Chen, Zhaohua Wang, Xu Wang, Yongqiang Yu, Xuhong Min & Dongchun Ma
Abstract Purpose To establish a nomogram for predicting the risk of adenocarcinomas in patients with subsolid nodules (SSNs) according to the 2021 WHO classification. Methods A total of 656 patients who underwent SSNs resection were retrospectively enrolled. Among them, 407 patients were assigned to the derivation cohort and 249 patients were assigned to the validation cohort. Univariate and multi-variate logistic regression algorithms were utilized to identity independent risk factors of adenocarcinomas. A nomogram based on...

Manipulating electromagnetic waves in a cavity-waveguide system with nontrivial and trivial modes

Jiong Xu, XiaoFei Zang, Xudong Zhan, Kun Liu & Yiming Zhu
The coupled cavity-waveguide approach provides a flexible platform to design integrated photonic devices that are widely applied in optical communications and information processing. Topological photonic crystals that can excite the nontrivial edge state (ES) and corner state (CS), have unprecedented capability in manipulating electromagnetic (EM) waves, leading to a variety of unusual functionalities that are impossible to achieve with conventional cavity-waveguide systems. In this paper, two-dimensional photonic crystals consisting of a topological ES waveguide, a...

Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Abstract Background Most cancer disability-adjusted life year (DALY) studies worldwide have used broad, generic disability weights (DWs); however, differences exist among populations and types of cancers. Using breast cancer as example, this study aimed to estimate the population-level DALYs in females in China and the impact of screening as well as applying local DWs. Methods Using multisource data, a prevalence-based model was constructed. (1) Overall years lived with disability (YLDs) were estimated by using numbers...

Brewster metasurfaces for ultrabroadband reflectionless absorption at grazing incidence

huiying fan, Hongchen Chu, hao luo, Yun Lai, Lei Gao & jie luo
Previous reflectionless metasurfaces based on balanced electric and magnetic responses in engineered resonant meta-atoms become ineffective at oblique incident angles and usually have strong reflection at grazing incidence, where the impedance becomes near-zero or divergent. Here, by introducing the concept of anomalous generalized Brewster effect to metasurfaces, we demonstrate an exceptional resonance-free Brewster metasurface that exhibits ultra-broadband zero reflection at grazing incidence. The anomalous generalized Brewster effect is obtained via combining the mechanisms of the...

Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study

Jie Chen, Jiawei Geng, Jiayi Wang, Zhenhua Wu, Tian Fu, Yuhao Sun, Xuejie Chen, Xiaoyan Wang & Therese Hesketh
Background:Social well-being of patients with inflammatory bowel disease (IBD) is garnering increased attention; however, the impact of social isolation remained poorly understood.Objectives:We investigated the joint association of social isolation and IBD with premature deaths to articulate the profound impact of social isolation in IBD prognosis.Design:Longitudinal cohort study.Methods:We leveraged data of 486,014 participants from UK Biobank (including 5791 with IBD), the mean follow-up was 11.84 years. Diagnoses of IBD and its subtypes of Crohn’s disease (CD)...

Electroacupuncture alleviates cognitive dysfunction and neuronal pyroptosis in septic mice

Yan Li, Zhaoying Li, Fujuan He, Chenguang Qin, Rui Fan, Fangxiang Zhang & Bin Wang
Background:Sepsis is defined as organ dysfunction caused by an uncontrolled response to infection and is followed by a high incidence of cognitive dysfunction, which can severely affect patients’ quality of life. Previous studies have suggested that electroacupuncture (EA) is protective against sepsis-associated cognitive dysfunction and that pyroptosis plays a vital role in cognitive function. The aim of this study was to investigate the effect of EA on cognition and neuronal pyroptosis in a mouse model...

Evaluate the immune-related eRNA models and signature score to predict the response to immunotherapy in thyroid carcinoma

Pu Wu, Jinyuan Shi, Zhiyuan Wang, Wei Sun & Hao Zhang
Abstract Background The functional alterations of eRNAs have been reported to be correlated with tumorigenesis. However, the roles of eRNAs in thyroid cancer (THCA) remain still unclear. This study aimed to construct an immune-related eRNA prognostic signature that could effectively predict the survival and prognosis for THCA. Methods The Weighted Gene Co-Expression Network Analysis (WGCNA) was performed to identify THCA-specific immune-related hub genes and immune-related eRNAs were obtained using Pearson correlation analysis. Univariate and least...

Relationship between body composition and bone mineral density in postmenopausal women with type 2 diabetes mellitus

Lei Gao, Ping Zhang, Yan Wang, Wei Zhang, Jian Zhao, Ying Liu, Jing Liu & Shaoqiang He
Abstract Background The aim of the study were to analyze the lumbar volumetric bone mineral density (BMD), fat distribution and changes of skeletal muscle with quantitative computed tomography (QCT) in postmenopausal women with type 2 diabetes mellitus (T2DM), and to evaluate the relationship between body composition and BMD. Methods One hundred seventy-seven postmenopausal women with T2DM and 136 postmenopausal women without diabetes were included in the study and were divided into two groups according to...

A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials

Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles & Fan Li
Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based...

Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Abstract Background Sorbus sensu stricto (Sorbus s.s.) is a genus with important economical values because of its beautiful leaves, and flowers and especially the colorful fruits. It belongs to the tribe Maleae of the family Rosaceae, and comprises about 90 species mainly distributed in China. There is on-going dispute about its infrageneric classification and species delimitation as the species are morphologically similar. With the aim of shedding light on the circumscription of taxa within the...

Complete chloroplast genomes of Sorbus sensu stricto (Rosaceae): comparative analyses and phylogenetic relationships

Chenqian Tang, Xin Chen, Yunfei Deng, Liyang Geng, Jianhui Ma & Xueyan Wei
Abstract Background Sorbus sensu stricto (Sorbus s.s.) is a genus with important economical values because of its beautiful leaves, and flowers and especially the colorful fruits. It belongs to the tribe Maleae of the family Rosaceae, and comprises about 90 species mainly distributed in China. There is on-going dispute about its infrageneric classification and species delimitation as the species are morphologically similar. With the aim of shedding light on the circumscription of taxa within the...

Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation

Guangxing Shui, Zheyi Cai, Feng Wang, Ting Chen, Xueyuan Huang, Yun Cai & Xiuhua Mi
Abstract Background Simiao pill module (SMM), a traditional Chinese medicine formula, has been widely used to treat gout and gouty arthritis. The goal of this study was to investigate the effects of SMM on epithelial-mesenchymal transition (EMT) and activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome in a mouse model of potassium oxonate (PO)-induced chronic hyperuricemic nephropathy (HN). Methods Mice were randomly divided into the following four groups: control, HN model (PO), febuxostat...

Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization

Jianling Bao, Wenjing Qi, Chang Sun, Mengxiao Tian, Hongjie Jiao, Gang Guo, Baoping Guo, Yuan Ren, Huajun Zheng, Yuezhu Wang, Mei Yan, Zhaoxia Zhang, Donald P. McManus, Jun Li & Wenbao Zhang
Abstract Background Inflammatory bowel disease (IBD) is a chronic idiopathic disease characterized by inflammation-related epithelial barrier damage in the intestinal tract. Helminth infection reduces autoimmune disease symptoms through regulation of inflammatory responses based on hygiene theory. However, the underlying mechanisms remain unclear. Methods BALB/c mice were infected with microcysts of E. granulosus sensu stricto and drank water containing 3.5% dextran sodium sulfate (DSS) at the 100th day post-infection. After 7 days of drinking DSS, the...

Deciphering chloramphenicol biotransformation mechanisms and microbial interactions via integrated multi-omics and cultivation-dependent approaches

Jiayu Zhang, Xiaoyan Li, Uli Klümper, Huaxin Lei, Thomas U. Berendonk, Fangliang Guo, Ke Yu, Chao Yang & Bing Li
Abstract Background As a widely used broad-spectrum antibiotic, chloramphenicol is prone to be released into environments, thus resulting in the disturbance of ecosystem stability as well as the emergence of antibiotic resistance genes. Microbes play a vital role in the decomposition of chloramphenicol in the environment, and the biotransformation processes are especially dependent on synergistic interactions and metabolite exchanges among microbes. Herein, the comprehensive chloramphenicol biotransformation pathway, key metabolic enzymes, and interspecies interactions in an...

Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Abstract Background The cultivated Camellia sasanqua forms a divergent double flower pattern, and the stamen petaloid is a vital factor in the phenomenon. However, the regulation mechanism remains largely unclear. Results Here, a comprehensive comparative transcriptome analysis of the wild-type, “semi-double”, “peony double”, and “rose double” was performed. The cluster analysis of global gene expression level showed petal and stamen difficulty separable in double flower. The crucial pathway and genes related to double flower patterns...

A polarization tunable transmitted full-color display enabling switchable bright and dark states

Xufeng Gao, Qi Wang, Shijie Zhang, Ruijin Hong, Dawei Zhang & Songlin Zhuang
Although structural colors based on nanostructures have attracted many researchers’ attentions due to their superior durability and high resolution, most previous reports focused on the static and dynamic structural colors in reflection mode and few researchers focus on the static and dynamic transmission colors for high-saturation RGB models. Here, the hybrid Al-Si3N4 nanogratings with the top SiO2 capping layer and the bottom MgF2 layer that can switch full-hue and high-saturation transmitted structural colors on and...

Measuring Disaggregation Quality

Ryan Casey, Feng Gao, Michael Kirschenheiter, Siyi Li & Shailendra Pandit
We construct a modified measure of disaggregation quality (MDQ) based on the disaggregation quality (DQ) measure from Chen et al. Both are parsimonious measures of disclosure quality in the annual report using the percentage of nonmissing financial statement items in Compustat. However, we take additional screening steps to minimize counting errors by resolving missing values due to GAAP changes over time and using a more comprehensive set of accounting equations from Casey et al. We...

Directional amplified spontaneous emissions from Ag nanohole array with high diffraction orders

Yujun liu, Fanzhou lv, Jiamin Xiao, Dongda Wu, Junqiao La, Xiaoli Yin, Yi Wang & Wenxin Wang
Surface plasmon excitations in metallic hole array have been extensively studied in the context of light-matter interaction since the generated Bloch surface plasmon polariton (Bloch-SPP) exhibits unique properties of nanoscale light confinement, near-field enhancements, and long-range metal surface propagation. In this work, we experimentally demonstrate a plasmonic device that exhibits highly directional emission in visible light, using Ag film with thickness of 100 nm is deposited on the subwavelength porous alumina array as a plasmonic...

Predictive Value of Adenoid-Nasopharyngeal Ratio in the Diagnosis of Secretory Otitis Media

Ping Li, Tao Li, Liang Yu, Aiping Chen, Yisha Wu, Yuzhu Wan & Li Shi
ObjectivesTo explore the associated factors of otitis media with effusion (OME) and analyze the diagnostic value of the adenoid-nasopharyngeal (A/N) ratio to OME.MethodsPatients with adenoid hypertrophy (AH) recently in 2 years were collected, including sex, age, duration, with/without rhinosinusitis, and examination results, including Cone Beam Computerized Tomography (CBCT) sinus imaging, tympanometry, pure tone audiometry (PTA), blood test, and allergen detection. According to Liden/Jerger’s classification, the patients were divided into two groups: Type B and type...

Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer’s disease

Huimin Cai, Yana Pang, Qi Wang, Wei Qin, Cuibai Wei, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping Wei & Longfei Jia
Abstract Background Neuronal- and astrocyte-derived exosomes have been identified as an optimal source for screening biomarkers for Alzheimer’s disease (AD). However, few studies focus on the bulk exosome population isolated from plasma of AD. This study investigated whether proteins in bulk exosomes can aid in the diagnosis of AD. Methods The plasma exosomes were collected by ultracentrifuge. Protein samples were extracted from exosomes. Cerebrospinal fluid levels of amyloid β (Aβ)42 and phosphorylated tau (P-tau)181 were...

Palladium-catalyzed transfer hydrogenation of terminal alkynes using ethanol as the hydrogen donor

Jie Hui & Feng Wang
A ligand-promoted, palladium-catalyzed transfer hydrogenation of terminal alkynes using ethanol as the hydrogen donor is developed. The chemical selectivity control is achieved based on ligand regulation. The use of triethanolamine and tetrahydrofuran at 80 °C under N2 is found to be critical for the transfer hydrogenation of terminal alkynes. The general applicability of this procedure is highlighted by the synthesis of 27 terminal alkenes in moderate to good yields.

Comprehensive analysis of the differences between left- and right-side colorectal cancer and respective prognostic prediction

Mengye Niu, Chengyang Chen, Xian Gao, Yi Guo, Bingzhou Zhang, Xin Wang, Shihao Chen, Xupeng Niu, Chao Zhang, Like Li, Zhongxin Li, Zengren Zhao & Xia Jiang
Abstract Background Previous studies have reported that the tumor heterogeneity and complex oncogenic mechanisms of proximal and distal colon cancer (CRC) are divergent. Therefore, we aim to analyze the differences between left-sided CRC (L_cancer) and right-sided CRC (R_cancer), as well as constructing respective nomograms. Methods We enrolled 335 colon cancer patients (146 L_cancer patients and 189 R_cancer patients) from The Cancer Genome Atlas (TCGA) data sets, and 102 pairs of color cancer tissue and adjacent...

Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors

Pei Zhang, Yang Du, Hua Bai, Zhijie Wang, Jianchun Duan, Xin Wang, Jia Zhong, Rui Wan, Jiachen Xu, Xiran He, Di Wang, Kailun Fei, Ruofei Yu, Jie Tian & Jie Wang
Abstract Background Although immune checkpoint inhibitors (ICIs) have influenced the treatment paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive resistance may limit the long-term efficacy of ICIs. New therapeutic strategies with other drug combinations are hence warranted to enhance the antitumor efficacy of ICIs. As a novel tumor suppressor, histone deacetylase (HDAC) inhibitor tucidinostat has been successfully confirmed to act against hematological malignancies. However, the underlying mechanisms of action for tucidinostat...

OCT based four-dimensional cardiac imaging of living chick embryo using impedance signal as the gating for post-acquisition synchronization

Yushu Ma, Chuanxi Li, Huiwen Jiang, Yuqian Zhao, JIAN LIU, Yao Yu, Yi Wang, Wenbo Shi & Zhenhe Ma
Four-dimensional (4-D) imaging of embryonic heart is valuable for the study of in vivo cardiac morphology and function during development. Optical coherence tomography (OCT) is a non-invasive imaging modality with high spatial resolution suitable for early embryonic heart imaging. However, most commonly used OCT systems cannot provide direct 4-D imaging due to acquisition speed limitations. We proposed a retrospective gating 4-D reconstruction method based on spectral domain OCT. A special circuit was designed to measure...

Low lipoprotein(a) concentration is associated with atrial fibrillation: a large retrospective cohort study

Junjie Tao, Xinlei Yang, Qingkai Qiu, Feng Gao, Wenchong Chen, Lijuan Hu, Yuan Xu, Yingping Yi, Hui Hu & Long Jiang
Abstract Background and aims The role of serum lipoprotein(a) [Lp(a)] levels in atrial fibrillation (AF) is still uncertain, especially in the Chinese population. Here, we aimed to elucidate the potential relationship between Lp(a) quantiles and AF. Methods All data were collected through inpatients with electronic health records from the Second Affiliated Hospital of Nanchang University, Jiangxi Province, China. The propensity score matching (PSM) method was used to match control and case groups. Interactions between AF,...

Registration Year

  • 2023
  • 2022
  • 2021
  • 2020

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  • Second Hospital of Anhui Medical University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Fudan University
  • Zhejiang University
  • Sichuan University
  • Shanghai Jiao Tong University
  • Huazhong University of Science and Technology
  • Sun Yat-sen University
  • Shandong University
  • Peking University