49 Works

On the use of Earth Observation to support estimates of national greenhouse gas emissions and sinks for the Global stocktake process: lessons learned from ESA-CCI RECCAP2

Ana Bastos, Philippe Ciais, Stephen Sitch, Luiz E. O. C. Aragão, Frédéric Chevallier, Dominic Fawcett, Thais M. Rosan, Marielle Saunois, Dirk Günther, Lucia Perugini, Colas Robert, Zhu Deng, Julia Pongratz, Raphael Ganzenmüller, Richard Fuchs, Karina Winkler, Sönke Zaehle & Clément Albergel
Abstract The Global Stocktake (GST), implemented by the Paris Agreement, requires rapid developments in the capabilities to quantify annual greenhouse gas (GHG) emissions and removals consistently from the global to the national scale and improvements to national GHG inventories. In particular, new capabilities are needed for accurate attribution of sources and sinks and their trends to natural and anthropogenic processes. On the one hand, this is still a major challenge as national GHG inventories follow...

Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Acute lung injury (ALI) is a serious complication in clinical settings. This study aimed to elucidate the immune molecular mechanisms underlying ALI by bioinformatics analysis. Human ALI and six ALI mouse model datasets were collected. Immune cell infiltration between the ALI samples and non-ALI controls was estimated using the ssGSEA algorithm. Least absolute shrinkage and selection operator (LASSO) regression analysis and Wilcoxon test were performed to obtain the significantly different immune cell infiltration types. Immune...

Identification of Immune Infiltration and Effective Immune Biomarkers in Acute Lung Injury by Bioinformatics Analysis

Dandan Ling, Xiang Zhang, Jiamin Wu, Qianyun Xu, Zhiyong He & Jun Zhang
Acute lung injury (ALI) is a serious complication in clinical settings. This study aimed to elucidate the immune molecular mechanisms underlying ALI by bioinformatics analysis. Human ALI and six ALI mouse model datasets were collected. Immune cell infiltration between the ALI samples and non-ALI controls was estimated using the ssGSEA algorithm. Least absolute shrinkage and selection operator (LASSO) regression analysis and Wilcoxon test were performed to obtain the significantly different immune cell infiltration types. Immune...

Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study

Jie Chen, Jiawei Geng, Jiayi Wang, Zhenhua Wu, Tian Fu, Yuhao Sun, Xuejie Chen, Xiaoyan Wang & Therese Hesketh
Background:Social well-being of patients with inflammatory bowel disease (IBD) is garnering increased attention; however, the impact of social isolation remained poorly understood.Objectives:We investigated the joint association of social isolation and IBD with premature deaths to articulate the profound impact of social isolation in IBD prognosis.Design:Longitudinal cohort study.Methods:We leveraged data of 486,014 participants from UK Biobank (including 5791 with IBD), the mean follow-up was 11.84 years. Diagnoses of IBD and its subtypes of Crohn’s disease (CD)...

Supplementary material from \"Soil resistance and recovery during neotropical forest succession\"

Masha T. van der Sande, Jennifer S. Powers, Thom W. Kuyper, Natalia Norden, Beatriz Salgado-Negret, Jarcilene Silva de Almeida, Frans Bongers, Diego Delgado, Daisy H. Dent, Géraldine Derroire, Mario Marcos do Espirito Santo, Juan Manuel Dupuy, Geraldo Wilson Fernandes, Bryan Finegan, Mayra E. Gavito, José Luis Hernández-Stefanoni, Catarina C. Jakovac, Isabel L. Jones, Maria das Dores Magalhães Veloso, Jorge A. Meave, Francisco Mora, Rodrigo Muñoz, Nathalia Pérez-Cárdenas, Daniel Piotto, Esteban Álvarez-Dávila … & Lourens Poorter
The recovery of soil conditions is crucial for successful ecosystem restoration and, hence, for achieving the goals of the UN Decade on Ecosystem Restoration. Here, we assess how soils resist forest conversion and agricultural land use, and how soils recover during subsequent tropical forest succession on abandoned agricultural fields. Our overarching question is how soil resistance and recovery depend on local conditions such as climate, soil type and land-use history. For 300 plots in 21...

The temporal and spatial endophytic fungal community of Huperzia serrata: diversity and relevance to huperzine A production by the host

Zhuhui Shen, Xubing Liu, Jia Yang, Yanli Wang, Kai Yao, Qingmiao Huo, Yanping Fu, Yahui Wei & Bin Guo
Abstract Background Plants maintain the steady-state balance of the mutually beneficial symbiosis relationship with their endophytic fungi through secondary metabolites. Meanwhile endophytic fungi can serve as biological inducers to promote the biosynthesis and accumulation of valuable secondary metabolites in host plants through a variety of ways. The composition and structure of endophytic fungal community are affected by many factors, including tissues, seasons and so on. In this work, we studied the community diversity, temporal and...

The temporal and spatial endophytic fungal community of Huperzia serrata: diversity and relevance to huperzine A production by the host

Zhuhui Shen, Xubing Liu, Jia Yang, Yanli Wang, Kai Yao, Qingmiao Huo, Yanping Fu, Yahui Wei & Bin Guo
Abstract Background Plants maintain the steady-state balance of the mutually beneficial symbiosis relationship with their endophytic fungi through secondary metabolites. Meanwhile endophytic fungi can serve as biological inducers to promote the biosynthesis and accumulation of valuable secondary metabolites in host plants through a variety of ways. The composition and structure of endophytic fungal community are affected by many factors, including tissues, seasons and so on. In this work, we studied the community diversity, temporal and...

Snacking for a reason: detangling effects of socio-economic position and stress on snacking behaviour

Marleen Gillebaart, Caroline Schlinkert, Maartje P. Poelman, Jeroen S. Benjamins & Denise T.D. De Ridder
Abstract Background As snacking can be considered a cornerstone of an unhealthy diet, investigating psychological drivers of snacking behaviour is urgent, and therefore the purpose of this study. Socio-economic position (SEP) and stress are known to affect many behaviours and outcomes, and were therefore focal points in the study. Methods In a cross-sectional survey study, we examined whether Socio-economic position (SEP) would amplify associations between heightened stress levels and self-reported negative-affect related reasons for snacking....

Genetic mechanisms underlying increased microalgal thermotolerance, maximal growth rate, and yield on light following adaptive laboratory evolution

Robin Barten, Dirk-Jan M. van Workum, Emma de Bakker, Judith Risse, Michelle Kleisman, Sofia Navalho, Sandra Smit, Rene H. Wijffels, Harm Nijveen & Maria J. Barbosa
Abstract Background Adaptive laboratory evolution (ALE) is a powerful method for strain optimization towards abiotic stress factors and for identifying adaptation mechanisms. In this study, the green microalga Picochlorum sp. BPE23 was cultured under supra-optimal temperature to force genetic adaptation. The robustness and adaptive capacity of Picochlorum strains turned them into an emerging model for evolutionary studies on abiotic stressors such as temperature, salinity, and light. Results Mutant strains showed an expanded maximal growth temperature...

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway

Huahua Zhang, Junli Liu, Qingqing Dang, Xueru Wang, Jie Chen, Xiaoyin Lin, Na Yang, Juan Du, Haiyan Shi, Yong Liu & Jiming Han
Abstract Background Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progression of various malignancies, however, the role of RPL5 in colon cancer remains is still unclear. Methods Data from TCGA and GTEx databases were used to analyze the RPL5 expression in pan-cancer. The expression level of RPL5 in clinical colon cancer tissue samples and human colon cancer cell lines was detected by western...

Progression-free survival as surrogate endpoint of overall survival in esophageal squamous cell carcinoma: a real-world data and literature-based analysis

Weiming Han, Lan Wang, Chen Li, Junqiang Chen, Wencheng Zhang, Xin Wang, Qingsong Pang, Yidian Zhao, Xinchen Sun, Kaixian Zhang, Gaofeng Li, Ling Li, Xueying Qiao, Miaoling Liu, Yadi Wang, Lei Deng, Wenqing Wang, Nan Bi, Tao Zhang, Wei Deng, Wenjie Ni, Xiao Chang, Zongmei Zhou, Jun Liang, Qinfu Feng … & Zefen Xiao
Background:The surrogacy of progression-free survival (PFS) for overall survival (OS) in esophageal squamous cell carcinoma (ESCC) remains unelucidated. This study aimed to determine the validity of PFS as a surrogate endpoint for OS in ESCC patients treated with definitive radiotherapy or definitive chemoradiotherapy (dRT/dCRT), as well as characterize the prognostic factors and survival of such patients.Methods:A total of 3662 patients from 10 cancer centers were enrolled. One-, 2-, and 3-year PFS (PFS12, PFS24, and PSF36,...

Plasma proteome profiling identifies changes associated to AD but not to FTD

R. Babapour Mofrad, M. del Campo, C. F. W. Peeters, L. H. H. Meeter, H. Seelaar, M. Koel-Simmelink, I. H. G. B. Ramakers, H. A. M. Middelkoop, P. P. De Deyn, J. A. H. R. Claassen, J. C. van Swieten, C. Bridel, J. J. M. Hoozemans, P. Scheltens, W. M. van der Flier, Y. A. L. Pijnenburg & Charlotte E. Teunissen
Abstract Background Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of Tau (FTLD-Tau) or TAR DNA binding43 (FTLD-TDP) proteins. Plasma biomarkers are strongly needed for specific diagnosis and potential treatment monitoring of FTD. We aimed to identify specific FTD plasma biomarker profiles discriminating FTD from AD and controls, and between FTD pathological subtypes. In addition, we compared plasma results with results in post-mortem frontal cortex of FTD cases to...

Designing synthetic consortia of Trichoderma strains that improve antagonistic activities against pathogens and cucumber seedling growth

Dazhi Hao, Bo Lang, Yongkun Wang, Xinhua Wang, Tong Liu & Jie Chen
Abstract Background Trichoderma spp. are important agricultural biocontrol microorganisms that are often used as effective components of microbial fungicides and microbial biofertilizers. However, most of these products are prepared by a single strain in monoculture, which significantly limits the biocontrol efficiency and stability of Trichoderma products. Therefore, the establishment of a design and screening approach for consortia with multi-Trichoderma strains for co-culture is of great importance to overcome the shortage of traditional Trichoderma biocontrol products....

Lake level evidence for a mid-Holocene East Asian summer monsoon maximum and the impact of an abrupt late-Holocene drought event on prehistoric cultures in north-central China

Zhiping Zhang, Zhongwei Shen, Shanjia Zhang, Jie Chen, Shengqian Chen, Dongxue Li, Shuai Zhang, Xiangjun Liu, Duo Wu, Yongwei Sheng, Qiuhong Tang, Fahu Chen & Jianbao Liu
Uncertainty regarding the timing of the highest Holocene water level of enclosed Dali Lake in northern China has led to controversy about whether the East Asian summer monsoon (EASM) peaked in the early Holocene or the mid-Holocene. Therefore, a record combining a reliable chronology with unambiguous lake level indicators is essential to resolve the issue. In this study, we established a temporal sequence of well-preserved paleolake shorelines at different elevations around Dali Lake using quartz...

Snacking for a reason: detangling effects of socio-economic position and stress on snacking behaviour

Marleen Gillebaart, Caroline Schlinkert, Maartje P. Poelman, Jeroen S. Benjamins & Denise T.D. De Ridder
Abstract Background As snacking can be considered a cornerstone of an unhealthy diet, investigating psychological drivers of snacking behaviour is urgent, and therefore the purpose of this study. Socio-economic position (SEP) and stress are known to affect many behaviours and outcomes, and were therefore focal points in the study. Methods In a cross-sectional survey study, we examined whether Socio-economic position (SEP) would amplify associations between heightened stress levels and self-reported negative-affect related reasons for snacking....

Tailoring and optimizing fatty acid production by oleaginous yeasts through the systematic exploration of their physiological fitness

Zeynep Efsun Duman-Özdamar, Vitor A. P. Martins dos Santos, Jeroen Hugenholtz & Maria Suarez-Diez
Abstract Background The use of palm oil for our current needs is unsustainable. Replacing palm oil with oils produced by microbes through the conversion of sustainable feedstocks is a promising alternative. However, there are major technical challenges that must be overcome to enable this transition. Foremost among these challenges is the stark increase in lipid accumulation and production of higher content of specific fatty acids. Therefore, there is a need for more in-depth knowledge and...

Designing synthetic consortia of Trichoderma strains that improve antagonistic activities against pathogens and cucumber seedling growth

Dazhi Hao, Bo Lang, Yongkun Wang, Xinhua Wang, Tong Liu & Jie Chen
Abstract Background Trichoderma spp. are important agricultural biocontrol microorganisms that are often used as effective components of microbial fungicides and microbial biofertilizers. However, most of these products are prepared by a single strain in monoculture, which significantly limits the biocontrol efficiency and stability of Trichoderma products. Therefore, the establishment of a design and screening approach for consortia with multi-Trichoderma strains for co-culture is of great importance to overcome the shortage of traditional Trichoderma biocontrol products....

N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Shangeng Weng & Xiang Zhang
Abstract Background Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. Hence, there is an urgent need to enhance the sensitivity of PC to gemcitabine (GEM). Results We demonstrated that SH3BP5-AS1 was significantly upregulated in GEM-resistant PC and predicted a poorer prognosis. SH3BP5-AS1 stability was regulated by ALKBH5/IGF2BP1-mediated m6A modification. Loss of SH3BP5-AS1 reduced PC cell migration...

N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Shangeng Weng & Xiang Zhang
Abstract Background Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. Hence, there is an urgent need to enhance the sensitivity of PC to gemcitabine (GEM). Results We demonstrated that SH3BP5-AS1 was significantly upregulated in GEM-resistant PC and predicted a poorer prognosis. SH3BP5-AS1 stability was regulated by ALKBH5/IGF2BP1-mediated m6A modification. Loss of SH3BP5-AS1 reduced PC cell migration...

Supplementary material from \"Soil resistance and recovery during neotropical forest succession\"

Masha T. van der Sande, Jennifer S. Powers, Thom W. Kuyper, Natalia Norden, Beatriz Salgado-Negret, Jarcilene Silva de Almeida, Frans Bongers, Diego Delgado, Daisy H. Dent, Géraldine Derroire, Mario Marcos do Espirito Santo, Juan Manuel Dupuy, Geraldo Wilson Fernandes, Bryan Finegan, Mayra E. Gavito, José Luis Hernández-Stefanoni, Catarina C. Jakovac, Isabel L. Jones, Maria das Dores Magalhães Veloso, Jorge A. Meave, Francisco Mora, Rodrigo Muñoz, Nathalia Pérez-Cárdenas, Daniel Piotto, Esteban Álvarez-Dávila … & Lourens Poorter
The recovery of soil conditions is crucial for successful ecosystem restoration and, hence, for achieving the goals of the UN Decade on Ecosystem Restoration. Here, we assess how soils resist forest conversion and agricultural land use, and how soils recover during subsequent tropical forest succession on abandoned agricultural fields. Our overarching question is how soil resistance and recovery depend on local conditions such as climate, soil type and land-use history. For 300 plots in 21...

Microaerobic metabolism of lactate and propionate enhances vitamin B12 production in Propionibacterium freudenreichii

Alexander Dank, Gabriela Biel, Tjakko Abee & Eddy J. Smid
Abstract Background Propionibacterium freudenreichii is used in biotechnological applications to produce vitamin B12. Although cultured mainly in anaerobic conditions, microaerobic conditions can greatly enhance biomass formation in P. freudenreichii. Since B12 yields may be coupled to biomass formation, microaerobic conditions show great potential for increasing B12 yields in P. freudenreichii. Results Here we show biomass formation increases 2.7 times for P. freudenreichii grown in microaerobic conditions on lactate versus anaerobic conditions (1.87 g/L vs 0.70...

Tailoring and optimizing fatty acid production by oleaginous yeasts through the systematic exploration of their physiological fitness

Zeynep Efsun Duman-Özdamar, Vitor A. P. Martins dos Santos, Jeroen Hugenholtz & Maria Suarez-Diez
Abstract Background The use of palm oil for our current needs is unsustainable. Replacing palm oil with oils produced by microbes through the conversion of sustainable feedstocks is a promising alternative. However, there are major technical challenges that must be overcome to enable this transition. Foremost among these challenges is the stark increase in lipid accumulation and production of higher content of specific fatty acids. Therefore, there is a need for more in-depth knowledge and...

Patient-related healthcare costs for diarrhoea, Guillain Barré syndrome and invasive non-typhoidal salmonellosis in Gondar, Ethiopia, 2020

Coen P. A. van Wagenberg, T. Guadu Delele & Arie H. Havelaar
Abstract Background Globally, foodborne diseases result in a significant disease burden with low- and middle-income countries disproportionately affected. Estimates of healthcare costs related to foodborne disease can aid decision makers to take action to mitigate risks and prevent illness. However, only limited data on the African continent are available, especially related to more severe sequelae. We provide estimates of direct and indirect (non)-medical costs of patients with diarrhoea, Guillain-Barré syndrome (GBS), and invasive non-typhoidal salmonellosis...

dynamAedes: a unified modelling framework for invasive Aedes mosquitoes

Daniele Da Re, Wim Van Bortel, Friederike Reuss, Ruth Müller, Sebastien Boyer, Fabrizio Montarsi, Silvia Ciocchetta, Daniele Arnoldi, Giovanni Marini, Annapaola Rizzoli, Gregory L’Ambert, Guillaume Lacour, Constantianus J. M. Koenraadt, Sophie O. Vanwambeke & Matteo Marcantonio
Abstract Mosquito species belonging to the genus Aedes have attracted the interest of scientists and public health officers because of their capacity to transmit viruses that affect humans. Some of these species were brought outside their native range by means of trade and tourism and then colonised new regions thanks to a unique combination of eco-physiological traits. Considering mosquito physiological and behavioural traits to understand and predict their population dynamics is thus a crucial step...

dynamAedes: a unified modelling framework for invasive Aedes mosquitoes

Daniele Da Re, Wim Van Bortel, Friederike Reuss, Ruth Müller, Sebastien Boyer, Fabrizio Montarsi, Silvia Ciocchetta, Daniele Arnoldi, Giovanni Marini, Annapaola Rizzoli, Gregory L’Ambert, Guillaume Lacour, Constantianus J. M. Koenraadt, Sophie O. Vanwambeke & Matteo Marcantonio
Abstract Mosquito species belonging to the genus Aedes have attracted the interest of scientists and public health officers because of their capacity to transmit viruses that affect humans. Some of these species were brought outside their native range by means of trade and tourism and then colonised new regions thanks to a unique combination of eco-physiological traits. Considering mosquito physiological and behavioural traits to understand and predict their population dynamics is thus a crucial step...

Registration Year

  • 2022
    49

Resource Types

  • Collection
    49

Affiliations

  • Wageningen University & Research
    49
  • Zhejiang University
    16
  • Sun Yat-sen University
    15
  • Fudan University
    14
  • Shanghai Jiao Tong University
    13
  • Central South University
    12
  • Ministry of Education of the People's Republic of China
    12
  • Sun Yat-sen Memorial Hospital
    12
  • Anhui Medical University
    12
  • West China Hospital of Sichuan University
    11