38 Works

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Tsolanku Sidney Maliehe, Melusi Mbambo, Londeka Sibusisiwe Ngidi, Jabulani Siyabonga Emmanuel Shandu, Ofentse Jacob Pooe, Peter Masoko & Tlou Nelson Selepe
Abstract Background The emergence of drug resistance among pathogens has resulted in renewed interest in bioprospecting for natural microbial products. Methods This study aimed to bioprospecting endophytic actinobacterium associated with Aloe ferox Mill for its antibacterial activity. Endophytic actinomycetes were isolated from the gel of A. ferox Mill by surface sterilization technique using actinomycete isolation agar. The isolate with a promising antibacterial activity was identified using 16S rRNA sequence analysis. The minimum inhibitory concentration (MIC)...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

Prescribing Trends of Oral Anticoagulants from 2010 to 2020 in Shanghai, China: A Retrospective Study

Chi Zhang, Jia Wang, Ya Yang, Er-Li Ma, Hou-Wen Lin, Bing-Long Liu & Zhi-Chun Gu
AimNon-vitamin K antagonist oral anticoagulants (NOACs) were developed as an alternative to warfarin to prevent thromboembolism in patients with atrial fibrillation (AF), prosthetic heart valves, venous thromboembolism (VTE), or other thrombotic disorders. The aim of this study is to explore the trends in prescribing OACs, including warfarin and NOACs, in Shanghai, China.MethodsPrescription data of OACs were retrospectively collected from Rx Analysis System from 2010 to 2020 in Shanghai, China. Comparisons were made on the trends...

Prescribing Trends of Oral Anticoagulants from 2010 to 2020 in Shanghai, China: A Retrospective Study

Chi Zhang, Jia Wang, Ya Yang, Er-Li Ma, Hou-Wen Lin, Bing-Long Liu & Zhi-Chun Gu
AimNon-vitamin K antagonist oral anticoagulants (NOACs) were developed as an alternative to warfarin to prevent thromboembolism in patients with atrial fibrillation (AF), prosthetic heart valves, venous thromboembolism (VTE), or other thrombotic disorders. The aim of this study is to explore the trends in prescribing OACs, including warfarin and NOACs, in Shanghai, China.MethodsPrescription data of OACs were retrospectively collected from Rx Analysis System from 2010 to 2020 in Shanghai, China. Comparisons were made on the trends...

Association between water, sanitation and hygiene (WASH) and child undernutrition in Ethiopia: a hierarchical approach

Biniyam Sahiledengle, Pammla Petrucka, Abera Kumie, Lillian Mwanri, Girma Beressa, Daniel Atlaw, Yohannes Tekalegn, Demisu Zenbaba, Fikreab Desta & Kingsley Emwinyore Agho
Abstract Background Undernutrition is a significant public health challenge and one of the leading causes of child mortality in a wide range of developing countries, including Ethiopia. Poor access to water, sanitation, and hygiene (WASH) facilities commonly contributes to child growth failure. There is a paucity of information on the interrelationship between WASH and child undernutrition (stunting and wasting). This study aimed to assess the association between WASH and undernutrition among under-five-year-old children in Ethiopia....

An analysis of past and future heatwaves based on a heat-associated mortality threshold: towards a heat health warning system

Thandi Kapwata, Michael T. Gebreslasie & Caradee Y. Wright
Abstract Heatwaves can have severe impacts on human health extending from illness to mortality. These health effects are related to not only the physical phenomenon of heat itself but other characteristics such as frequency, intensity, and duration of heatwaves. Therefore, understanding heatwave characteristics is a crucial step in the development of heat-health warning systems (HHWS) that could prevent or reduce negative heat-related health outcomes. However, there are no South African studies that have quantified heatwaves...

Prognostic markers in patients with chronic lymphocytic leukaemia on targeted therapy, chemoimmunotherapy with anti-CD20 monoclonal antibody: a systematic review and meta-analysis of prognostic factors

Zekhethelo A. Mkhwanazi, Tawanda M. Nyambuya, Snenhlanhla A. Mfusi & Bongani B. Nkambule
Abstract Combination chemoimmunotherapy (CIT) consisting of anti-CD20 has improved the progression-free survival (PFS) and overall survival (OS) of patients with chronic lymphocytic leukaemia (CLL). We performed a comprehensive synthesis of prognostic factors in patients with CLL on combined CIT with anti-CD20 antibodies compared with standard chemotherapy alone or targeted therapy. We searched the MEDLINE and academic search complete electronic databases as well as clinicaltrials.gov (from inception up to 01 August 2022) for randomised controlled trials...

Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case–control study from Uganda and South Africa

Anisha Tyagi, Yao Tong, Dustin J Rabideau, Zahra Reynolds, Tulio De Oliveira, Richard Lessells, Gideon Amanyire, Catherine Orrell, Stephen Asiimwe, Benjamin Chimukangara, Jennifer Giandhari, Sureshnee Pillay, Jessica E Haberer & Mark J Siedner
BackgroundRelationships between distinct antiretroviral therapy (ART) adherence patterns and risk of drug resistance are not well understood.MethodsWe conducted a nested case–control analysis within a longitudinal cohort study of individuals initiating efavirenz-based ART. Primary outcomes of interest, measured at 6 and 12 months after treatment initiation, were: 1) virologic suppression, 2) virologic failure with resistance, and 3) virologic failure without resistance. Our primary exposure of interest was ART adherence, measured over the 6 months before each...

Association between water, sanitation and hygiene (WASH) and child undernutrition in Ethiopia: a hierarchical approach

Biniyam Sahiledengle, Pammla Petrucka, Abera Kumie, Lillian Mwanri, Girma Beressa, Daniel Atlaw, Yohannes Tekalegn, Demisu Zenbaba, Fikreab Desta & Kingsley Emwinyore Agho
Abstract Background Undernutrition is a significant public health challenge and one of the leading causes of child mortality in a wide range of developing countries, including Ethiopia. Poor access to water, sanitation, and hygiene (WASH) facilities commonly contributes to child growth failure. There is a paucity of information on the interrelationship between WASH and child undernutrition (stunting and wasting). This study aimed to assess the association between WASH and undernutrition among under-five-year-old children in Ethiopia....

Genotyping and biofilm formation of Mycoplasma hyopneumoniae and their association with virulence

Yuzi Wu, Yanfei Yu, Lizhong Hua, Yanna Wei, Yuan Gan, Hafizah Yousuf Chenia, Yixuan Wang, Xing Xie, Jia Wang, Maojun Liu, Guoqing Shao, Qiyan Xiong & Zhixin Feng
Abstract Mycoplasma hyopneumoniae, the causative agent of swine respiratory disease, demonstrates differences in virulence. However, factors associated with this variation remain unknown. We herein evaluated the association between differences in virulence and genotypes as well as phenotype (i.e., biofilm formation ability). Strains 168 L, RM48, XLW-2, and J show low virulence and strains 232, 7448, 7422, 168, NJ, and LH show high virulence, as determined through animal challenge experiments, complemented with in vitro tracheal mucosa...

Linking migration and microbiota at a major stopover site in a long-distance avian migrant

Nikki Thie, Ammon Corl, Sondra Turjeman, Ron Efrat, Pauline L. Kamath, Wayne M. Getz, Rauri C. K. Bowie & Ran Nathan
Abstract Migration is one of the most physical and energetically demanding periods in an individual bird’s life. The composition of the bird’s gut or cloacal microbiota can temporarily change during migration, likely due to differences in diets, habitats and other environmental conditions experienced en route. However, how physiological condition, migratory patterns, and other drivers interact to affect microbiota composition of migratory birds is still unclear. We sampled the cloacal bacterial microbiota of a long-distance migrant,...

Bioprospecting of endophytic actinobacterium associated with Aloe ferox mill for antibacterial activity

Tsolanku Sidney Maliehe, Melusi Mbambo, Londeka Sibusisiwe Ngidi, Jabulani Siyabonga Emmanuel Shandu, Ofentse Jacob Pooe, Peter Masoko & Tlou Nelson Selepe
Abstract Background The emergence of drug resistance among pathogens has resulted in renewed interest in bioprospecting for natural microbial products. Methods This study aimed to bioprospecting endophytic actinobacterium associated with Aloe ferox Mill for its antibacterial activity. Endophytic actinomycetes were isolated from the gel of A. ferox Mill by surface sterilization technique using actinomycete isolation agar. The isolate with a promising antibacterial activity was identified using 16S rRNA sequence analysis. The minimum inhibitory concentration (MIC)...

Barriers and facilitators to HIV prevention interventions for reducing risky sexual behavior among youth worldwide: a systematic review

Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana & Maggie Zgambo
Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

Barriers and facilitators to HIV prevention interventions for reducing risky sexual behavior among youth worldwide: a systematic review

Fungai Mbengo, Esther Adama, Amanda Towell-Barnard, Arvin Bhana & Maggie Zgambo
Abstract Background Interventions aimed at reducing risky sexual behavior are considered an important strategy for averting Human Immunodeficiency Virus (HIV) infection among youth (15–24 years) who continue to be at risk of the disease. Enhancing intervention success requires a comprehensive understanding of the barriers and facilitators to interventions targeting youth. However, there is lack of a systematic review of both quantitative and qualitative studies to comprehensively identify and synthesize barriers and facilitators to HIV prevention...

‘If I am playing football, I forget that I have this virus’: the challenges and coping strategies of adolescents with perinatally acquired HIV in KwaZulu-Natal, South Africa

Marian Loveday, Jennifer Furin, Sindisiwe Hlangu, Thabile Mthethwa & Tasneem Naidoo
Abstract Background Adolescents who have acquired HIV perinatally (ALHIV) face unique challenges in taking lifelong antiretroviral therapy (ART), but little is known about what factors affect their adherence over the course of their lifelong treatment journey. Methods We conducted a qualitative study with ALHIV who had periods of poor adherence to ART in KwaZulu-Natal, South Africa using Participant-generated Visual Methodologies (PVM). Participants used photography to represent their perspectives and experiences. Results 14 individuals participated in...

Patient journey and resources mapping to implement a praziquantel mass drug administration program for children aged 5 years and below in resource-limited settings

Mhlengi Vella Ncube, Muhubiri Kabuyaya & Moses John Chimbari
Abstract Background The early childhood development of millions of children in some low- and medium-income countries may be compromised by schistosomiasis infections contracted at the age of 5 years and below. Currently, there are no standard guidelines for treating schistosomiasis in children that are 5 years and younger using praziquantel (PZQ), the only drug that the World Health Organization (WHO) recommends for treating schistosomiasis. The review is on processes and resources involved in the treatment...

Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data

Sean M. Hughes, Claire N. Levy, Ronit Katz, Erica M. Lokken, Melis N. Anahtar, Melissa Barousse Hall, Frideborg Bradley, Philip E. Castle, Valerie Cortez, Gustavo F. Doncel, Raina Fichorova, Paul L. Fidel, Keith R. Fowke, Suzanna C. Francis, Mimi Ghosh, Loris Y. Hwang, Mariel Jais, Vicky Jespers, Vineet Joag, Rupert Kaul, Jordan Kyongo, Timothy Lahey, Huiying Li, Julia Makinde, Lyle R. McKinnon … & Florian Hladik
Abstract Background Hormonal changes during the menstrual cycle play a key role in shaping immunity in the cervicovaginal tract. Cervicovaginal fluid contains cytokines, chemokines, immunoglobulins, and other immune mediators. Many studies have shown that the concentrations of these immune mediators change throughout the menstrual cycle, but the studies have often shown inconsistent results. Our understanding of immunological correlates of the menstrual cycle remains limited and could be improved by meta-analysis of the available evidence. Methods...

A healthcare workers’ mHealth adoption instrument for the developing world

Michael Addotey-Delove, Richard E. Scott & Maurice Mars
Abstract Introduction Healthcare workers’ adoption of mHealth is critical to the success or failure of clinician based mHealth services in the developing world. mHealth adoption is affected or promoted by certain factors, some of which are peculiar to the developing world. Identifying these factors and evaluating them will help develop a valid and reliable measuring instrument for more successful prediction of mHealth adoption in the future. The aim of this study was to design and...

Barriers and enablers to emergency obstetric and newborn care services use in Wolaita Zone, Southern Ethiopia: a qualitative case study

Mihiretu Alemayehu, Bereket Yakob & Nelisiwe Khuzwayo
Abstract Background Globally, 11.4 million untreated obstetric complications did not receive Emergency Obstetric and Newborn Care (EmONC) services yearly, with the highest burden in low and middle-income countries. Half of the Ethiopian women with obstetric complications did not receive EmONC services. However, essential aspects of the problem have not been assessed in depth. This study, therefore, explored the various aspects of barriers and enablers to women’s EmONC services utilization in southern Ethiopia. Methodology A qualitative...

The effects of Trichoderma atroviride pretreatment on the biogas production from anaerobic digestion of water hyacinth

Obianuju Patience Ilo, S’phumelele Lucky Nkomo, Ntandoyenkosi Malusi Mkhize, Onisimo Mutanga & Mulala Danny Simatele
Water hyacinth is an invasive alien plant with several impacts on the environment, economy and society. The plant’s high degree of proliferation makes its mitigation difficult and sometimes complex. However, existing evidence suggests that water hyacinth is a sustainable substrate for biogas production. Using the pretreatment processes for the optimisation conditions for biogas production from water hyacinth, this study analysed the effects of moisture content (60%, 70% and 75%) on Trichoderma atroviride pretreatment of water...

The effects of Trichoderma atroviride pretreatment on the biogas production from anaerobic digestion of water hyacinth

Obianuju Patience Ilo, S’phumelele Lucky Nkomo, Ntandoyenkosi Malusi Mkhize, Onisimo Mutanga & Mulala Danny Simatele
Water hyacinth is an invasive alien plant with several impacts on the environment, economy and society. The plant’s high degree of proliferation makes its mitigation difficult and sometimes complex. However, existing evidence suggests that water hyacinth is a sustainable substrate for biogas production. Using the pretreatment processes for the optimisation conditions for biogas production from water hyacinth, this study analysed the effects of moisture content (60%, 70% and 75%) on Trichoderma atroviride pretreatment of water...

Dietary patterns and childhood stunting in Zimbabwe

Anesu Marume, Moherndran Archary & Saajida Mahomed
Abstract Background Diet is one important predictor of children’s growth, and often dietary interventions can assist with reversing adverse nutrition outcomes. Traditionally research has focused on individual food items or food classes to generate an understanding of disease risk. Dietary patterns provide a holistic approach to understanding the relationship between exposure and outcome. Method A matched case-control study was conducted. Caregivers of 450 children (225 cases, 225 controls) aged 6–59 months were asked to describe...

A healthcare workers’ mHealth adoption instrument for the developing world

Michael Addotey-Delove, Richard E. Scott & Maurice Mars
Abstract Introduction Healthcare workers’ adoption of mHealth is critical to the success or failure of clinician based mHealth services in the developing world. mHealth adoption is affected or promoted by certain factors, some of which are peculiar to the developing world. Identifying these factors and evaluating them will help develop a valid and reliable measuring instrument for more successful prediction of mHealth adoption in the future. The aim of this study was to design and...

Communication Skills (CS) training of physicians in China and its role in actual challenges of patient-physician relationship: a cross-sectional survey

Junfeng Du, Gwendolyn Mayer, Elisabetta Posenato, Svenja Hummel, Ali Zafar, Till Bärnighausen & Jobst-Hendrik Schultz
Abstract Background The Chinese healthcare system is affected by frequent disputes between physicians and patients. Although recent reforms have contributed towards improving the patient-physician relationship, distrust in physicians is still high. Communication skills (CS) training of physicians holds the key to improving patient confidence and diffusing stressful situations. This survey reports on the status of CS training in medical education in China, and the experiences and attitudes of physicians towards CS training. Methods A cross-sectional...

Antiretroviral therapy adherence patterns, virological suppression, and emergence of drug resistance: A nested case–control study from Uganda and South Africa

Anisha Tyagi, Yao Tong, Dustin J Rabideau, Zahra Reynolds, Tulio De Oliveira, Richard Lessells, Gideon Amanyire, Catherine Orrell, Stephen Asiimwe, Benjamin Chimukangara, Jennifer Giandhari, Sureshnee Pillay, Jessica E Haberer & Mark J Siedner
BackgroundRelationships between distinct antiretroviral therapy (ART) adherence patterns and risk of drug resistance are not well understood.MethodsWe conducted a nested case–control analysis within a longitudinal cohort study of individuals initiating efavirenz-based ART. Primary outcomes of interest, measured at 6 and 12 months after treatment initiation, were: 1) virologic suppression, 2) virologic failure with resistance, and 3) virologic failure without resistance. Our primary exposure of interest was ART adherence, measured over the 6 months before each...

Registration Year

  • 2022
    38

Resource Types

  • Collection
    38

Affiliations

  • University of KwaZulu-Natal
    38
  • Jiangsu Academy of Agricultural Sciences
    4
  • Sun Yat-sen University
    4
  • Zhejiang University
    4
  • Jilin University
    4
  • Huazhong University of Science and Technology
    4
  • Inner Mongolia Agricultural University
    4
  • University of Minnesota
    4
  • Southwest University
    4
  • Oak Ridge National Laboratory
    4